Previous studies have reported a relationship between exposure to metals and polycyclic aromatic hydrocarbons(PAHs)and blood glucose levels,but whether the mechanisms are mediated by amino acids remains to be elucidat...Previous studies have reported a relationship between exposure to metals and polycyclic aromatic hydrocarbons(PAHs)and blood glucose levels,but whether the mechanisms are mediated by amino acids remains to be elucidated.We conducted a three-wave repeated measurement study involving 201 elderly individuals(aged≥50 years)from five communities in Beijing,China.We simultaneously measured eightmetals in both blood and urine,six monohydroxy PAHs in urine,and 23 amino acids in blood.Linear mixed-effects and sparse partial least squares models were used to evaluate the individual effects,and Bayesian kernel machine regression was employed to mixture effects.Mediation analysis was further used to explore whether amino acids mediators mediate the association.We observed significant associations of selenium and strontium with increased blood glucose.Additionally,blood copper,urinary nickel,as well as urinary 1+9 hydroxyphenanthrene,were associated with irregular blood glucose regulation.Moreover,we found that amino acids such as leucine,proline,and alanine may mediate the associations.This study is the first to investigate the effect of metals and PAHs on blood glucose homeostasis,while also exploring the mediating role of amino acids,offering new insights into the impact of metals and PAHs on blood glucose regulation.展开更多
Precision medicine, often termed “personalized medicine,” aims to enhance the categorization and timing of healthcare interventions by leveraging biological data and biomarkers at the molecular level, including dise...Precision medicine, often termed “personalized medicine,” aims to enhance the categorization and timing of healthcare interventions by leveraging biological data and biomarkers at the molecular level, including disease pathways, genet-ics, proteomics, and metabolomics (Schleidgen et al. 2013). Over the past decades, with the continuous advancement of omics technologies, numerous studies have utilized vari-ous methods such as genomics, transcriptomics, proteom-ics, and others to investigate personalized biomarkers and therapeutic targets for a variety of diseases including cancer, diabetes, asthma, and so on. In addition to genetics, environ-mental exposures profoundly affect human health, exhibiting significant intra-individual variability and influencing the success of interventions (Goetz and Schork 2018). Conse-quently, conducting comprehensive investigations into indi-vidual-level precise environmental exposures is valuable for understanding individual health and interactions with the environment.展开更多
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2023ZD0513200)the National Natural Science Foundation of China(Nos.82404278 and 82404365)China Postdoctoral Science Foundation(Nos.2023M730317 and 2023T160066).
文摘Previous studies have reported a relationship between exposure to metals and polycyclic aromatic hydrocarbons(PAHs)and blood glucose levels,but whether the mechanisms are mediated by amino acids remains to be elucidated.We conducted a three-wave repeated measurement study involving 201 elderly individuals(aged≥50 years)from five communities in Beijing,China.We simultaneously measured eightmetals in both blood and urine,six monohydroxy PAHs in urine,and 23 amino acids in blood.Linear mixed-effects and sparse partial least squares models were used to evaluate the individual effects,and Bayesian kernel machine regression was employed to mixture effects.Mediation analysis was further used to explore whether amino acids mediators mediate the association.We observed significant associations of selenium and strontium with increased blood glucose.Additionally,blood copper,urinary nickel,as well as urinary 1+9 hydroxyphenanthrene,were associated with irregular blood glucose regulation.Moreover,we found that amino acids such as leucine,proline,and alanine may mediate the associations.This study is the first to investigate the effect of metals and PAHs on blood glucose homeostasis,while also exploring the mediating role of amino acids,offering new insights into the impact of metals and PAHs on blood glucose regulation.
基金National Natural Science Foundation of China(82404365,82404278)Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0513200)+8 种基金the Fundamental Research Funds for the Central Universities(No.3332023042)Peking Union Medical College Graduate Innovation Fund(No.2019-1004-02)the China Postdoctoral Science Foundation(Nos.2023M730317,and 2023T160066)the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301)The special fund of State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants(SEPKL-EHIAEC-202205)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2022-JKCS-11)CAMS Innovation Fund for Medical Sciences(No.2022-I2M-JB-003)China Medical Board(Grant No.15-230)China Prospective cohort study of Air pollution and health effects in Typical areas(C-PAT)(Grant No.MEE-EH-20190802).
文摘Precision medicine, often termed “personalized medicine,” aims to enhance the categorization and timing of healthcare interventions by leveraging biological data and biomarkers at the molecular level, including disease pathways, genet-ics, proteomics, and metabolomics (Schleidgen et al. 2013). Over the past decades, with the continuous advancement of omics technologies, numerous studies have utilized vari-ous methods such as genomics, transcriptomics, proteom-ics, and others to investigate personalized biomarkers and therapeutic targets for a variety of diseases including cancer, diabetes, asthma, and so on. In addition to genetics, environ-mental exposures profoundly affect human health, exhibiting significant intra-individual variability and influencing the success of interventions (Goetz and Schork 2018). Conse-quently, conducting comprehensive investigations into indi-vidual-level precise environmental exposures is valuable for understanding individual health and interactions with the environment.
