In January 2015,the first quantum homomorphic signature scheme was proposed creatively.However,only one verifier is allowed to verify a signature once in this scheme.In order to support repeatable verification for gen...In January 2015,the first quantum homomorphic signature scheme was proposed creatively.However,only one verifier is allowed to verify a signature once in this scheme.In order to support repeatable verification for general scenario,we propose a new quantum homomorphic signature scheme with repeatable verification by introducing serial verification model and parallel verification model.Serial verification model solves the problem of signature verification by combining key distribution and Bell measurement.Parallel verification model solves the problem of signature duplication by logically treating one particle of an EPR pair as a quantum signature and physically preparing a new EPR pair.These models will be beneficial to the signature verification of general scenarios.Scheme analysis shows that both intermediate verifiers and terminal verifiers can successfully verify signatures in the same operation with fewer resource consumption,and especially the verified signature in entangled states can be used repeatedly.展开更多
On the base of controllable variable stiffness property,variable stiffness composites were the main components of functional materials in aerospace.However,the relatively low mechanical strength,stiffness range,and re...On the base of controllable variable stiffness property,variable stiffness composites were the main components of functional materials in aerospace.However,the relatively low mechanical strength,stiffness range,and response rate restricted the application of variable stiffness composite.In this work,the novel variable stiffness composite system with characteristics of repeatable high load bearing and response rate was successfully prepared via the double-layer anisotropic structure to solve the bottlenecks of variable stiffness composites.The novel variable stiffness composite systems were composed of variable stiffness layer of polycaprolactone(PCL)and the driven layer of silicone elastomer with alcohol,which continuously changed Young’s modulus from 0.1 to 7.263 MPa(72.63 times variation)in 200 s and maintained maximum weight of 11.52 times its own weight(8.5 g).Attributed to the relatively high variable stiffness range and load bearing value of variable stiffness composite system,the repeatable response process led to the efficient high load driven as“muscle”and diversified precise grab of objects with different shapes as“gripper”,owning widespread application prospects in the field of bionics.展开更多
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se...Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.展开更多
The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:tho...The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.展开更多
When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,whi...When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.展开更多
The emission of anomalous X-ray pulsars(AXPs)and soft gamma-ray repeaters(SGRs)is believed to be powered by the dissipation of their strong magnetic fields,which coined the name“magnetar”.By combining timing and ene...The emission of anomalous X-ray pulsars(AXPs)and soft gamma-ray repeaters(SGRs)is believed to be powered by the dissipation of their strong magnetic fields,which coined the name“magnetar”.By combining timing and energy observational results,the magnetar model can be easily appreciated.From a timing perspective,the magnetic field strengths of AXPs and SGRs,which are calculated under the assumption of dipole radiation,are extremely strong.From an energy perspective,the X-ray/soft gamma-ray luminosities of AXPs and SGRs are larger than their rotational energy loss rates(i.e.,L_(x>E_(rot)).It is thus reasonable to assume that the high-energy radiation comes from magnetic energy decay,and the magnetar model has been extensively discussed(or accepted).However,we argue that:(ⅰ)Calculating magnetic fields by assuming that rotational energy loss is dominated by dipole radiation(i.e.,E_(rot)■E_(μ))may be controversial,and we suggest that the energies carried by outflowing particles should also be considered.(ⅱ)The fact that X-ray luminosity is greater than the rotational energy loss rate does not necessarily mean that the emission energy comes from the magnetic field decaying,which requires further observational testing.Furthermore,some observational facts conflict with the“magnetar”model,such as observations of anti-magnetars,high magnetic field pulsars,and radio and X-ray observations of AXPs/SGRs.Therefore,we propose a crusted strange star model as an alternative,which can explain many more observational facts of AXPs/SGRs.展开更多
Objective Junctophilin-2(JPH2)is an essential structural protein that maintains junctional membrane complexes(JMCs)in cardiomyocytes by tethering the plasma membrane to the sarcoplasmic reticulum,thereby facilitating ...Objective Junctophilin-2(JPH2)is an essential structural protein that maintains junctional membrane complexes(JMCs)in cardiomyocytes by tethering the plasma membrane to the sarcoplasmic reticulum,thereby facilitating excitationcontraction(E-C)coupling.Mutations in JPH2 have been associated with hypertrophic cardiomyopathy(HCM),but the molecular mechanisms governing its membrane-binding properties and the functional relevance of its membrane occupation and recognition nexus(MORN)repeat motifs remain incompletely understood.This study aimed to elucidate the structural basis of JPH2 membrane association and its implications for HCM pathogenesis.Methods A recombinant N-terminal fragment of mouse JPH2(residues 1-440),encompassing the MORN repeats and an adjacent helical region,was purified under near-physiological buffer conditions.X-ray crystallography was employed to determine the structure of the JPH2 MORN-Helix domain.Sequence conservation analysis across species and junctophilin isoforms was performed to assess the evolutionary conservation of key structural features.Functional membrane-binding assays were conducted using liposome co-sedimentation and cell-based localization studies in COS7 and HeLa cells.In addition,site-directed mutagenesis targeting positively charged residues and known HCM-associated mutations,including R347C,was used to evaluate their effects on membrane interaction and subcellular localization.Results The crystal structure of the mouse JPH2 MORN-Helix domain was resolved at 2.6Å,revealing a compact,elongated architecture consisting of multiple tandem MORN motifs arranged in a curved configuration,forming a continuous hydrophobic core stabilized by alternating aromatic residues.A C-terminalα-helix further reinforced structural integrity.Conservation analysis identified the inner groove of the MORN array as a highly conserved surface,suggesting its role as a protein-binding interface.A flexible linker segment enriched in positively charged residues,located adjacent to the MORN motifs,was found to mediate direct electrostatic interactions with negatively charged phospholipid membranes.Functional assays demonstrated that mutation of these basic residues impaired membrane association,while the HCM-linked R347C mutation completely abolished membrane localization in cellular assays,despite preserving the overall MORN-Helix fold in structural modeling.Conclusion This study provides structural insight into the membrane-binding mechanism of the cardiomyocyte-specific protein JPH2,highlighting the dual roles of its MORN-Helix domain in membrane anchoring and protein interactions.The findings clarify the structural basis for membrane targeting via a positively charged linker and demonstrate that disruption of this interaction—such as that caused by the R347C mutation—likely contributes to HCM pathogenesis.These results not only enhance current understanding of JPH2 function in cardiac E-C coupling but also offer a structural framework for future investigations into the assembly and regulation of JMCs in both physiological and disease contexts.展开更多
BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on th...BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC tissues.METHODS This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in HCC.Clustered regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell growth.Functional enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in HCC.Drug sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC cells.RESULTS The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC tissues.The integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA splicing.Significant enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen species.Drug sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and GDC0810.Overexpressed PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC tissues.PSMD6 is essential for the growth of HCC cells and may be involved in ribosome biogenesis and RNA splicing.展开更多
In this study,we searched for dispersed repeats(DRs)in the rice(Oryza sativa)genome using the iterative procedure(IP)method.The results revealed that the O.sativa genome contained 79 DR families,comprising 992739 DNA ...In this study,we searched for dispersed repeats(DRs)in the rice(Oryza sativa)genome using the iterative procedure(IP)method.The results revealed that the O.sativa genome contained 79 DR families,comprising 992739 DNA repeats,of which 496762 and 495977 were identified on the forward and reverse DNA strands,respectively.The detected DRs were,on average,374 bp in length and occupied 66.4%of the O.sativa genome.Totally 61%of DRs,identified by the IP method,overlapped with previously annotated dispersed repeats(ADRs)detected using the Extensive De Novo TE Annotator(EDTA)pipeline.展开更多
On 18 November 2024,Chinese President Xi Jinping delivered a speech titled Building a Just World of Common Development at Session I of the 19th Group of 20(G20)Summit in Rio de Janeiro,Brazil.Xi Jinping has repeatedly...On 18 November 2024,Chinese President Xi Jinping delivered a speech titled Building a Just World of Common Development at Session I of the 19th Group of 20(G20)Summit in Rio de Janeiro,Brazil.Xi Jinping has repeatedly underscored the importance of promoting common development at G20 summits.Edited excerpts of his speeches on this topic since 2016 follow.展开更多
Rorippa indica is a wild oilseed crop of Brassicaceae with good environmental adaptability and strong stress resistance.This plant has become an important wild relative species for rapeseed(Brassica napus L.)and is us...Rorippa indica is a wild oilseed crop of Brassicaceae with good environmental adaptability and strong stress resistance.This plant has become an important wild relative species for rapeseed(Brassica napus L.)and is used to improve its agronomic traits,with important development and utilization value.However,the research of R.indica genetics is still lacking.And no mitochondrial genome(mitogenome)in the genus Rorippa has been expounded.To analyze the structural characteristics of the R.indica mitogenome,second-generation and third-generation sequencing techniques were made to assemble its mitogenome.The results showed that its mitogenome is composed of a single master circle DNA molecule,with 59 genes(33 protein-coding,23 tRNA,and 3 ribosomal RNA genes)annotated.The length of the circular genome is 219,775 bp,with aGCcontent of 45.24%.Themitochondrial genome contains 55 SSRs,17 tandem repeats,and 252 scattered repeat sequences,with scattered repeat sequences accounting for 77.78%.The top two codons with the highest expression levels are TTT and AUU.Moreover,377 RNA editing sites were forecasted in the R.indica mitogenome.And 22 collinear gene fragments were discriminated in the R.indica chloroplast andmitogenomes,with a total 13,153 bp length,accounting for 4.08%of the mitogenome sequence.The longest gene migration fragment is 2186 bp,and the shortest fragment is 42 bp.Furthermore,12 genes undergo complete migration between the two genomes,and 10 genes undergo partial migration.Systematic evolutionary analysis shows that R.indica and Brassica napus are grouped,indicating a close genetic relationship between the two.Herein,the R.indica mitogenome was sequenced and annotated,and it was compared with other Brassicaceae mitogenomes.A genomic data foundation was supplied for elucidating the R.indica origin and evolution.展开更多
Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression...Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression in rice remains unclear.Here,we construct a map of 137,629 polymorphic STRs in the rice(Oryza sativa L.)genome using a population-scale resequencing dataset.A genome-wide survey encompassing 4726 accessions shows that the occurrence frequency,mutational patterns,chromosomal distribution,and functional properties of STRs are correlated with the sequences and lengths of repeat motifs.Leveraging a transcriptome dataset from 127 rice accessions,we identify 44,672 expression STRs(eSTRs)by modeling gene expression in response to the length variation of STRs.These eSTRs are notably enriched in the regulatory regions of genes with active transcriptional signatures.Population analysis identifies numerous STRs that have undergone genetic divergence among different rice groups and 1726 tagged STRs that may be associated with agronomic traits.By editing the(ACT)_(7) STR in OsFD1 promoter,we further experimentally validate its role in regulating gene expression and phenotype.Our study highlights the contribution of STRs to transcriptional regulation in plants and establishes the foundation for their potential use as alternative targets for genetic improvement.展开更多
Objective:To investigate the delivery modes of women with repeat pregnancies involving uterine scars and their effects on both mothers and neonates.Methods:A study was conducted on 100 patients treated at Shenzhen Mat...Objective:To investigate the delivery modes of women with repeat pregnancies involving uterine scars and their effects on both mothers and neonates.Methods:A study was conducted on 100 patients treated at Shenzhen Maternity and Child Healthcare Hospital from July 2023 to July 2024.The participants were divided into a control group and an observation group,with 50 cases in each.The division was based on the indications for prior cesarean section,cervical maturity,postpartum complications,and thickness of the cesarean scar.The control group underwent cesarean delivery,while the observation group experienced vaginal delivery.The two groups were compared in terms of intrapartum blood loss,postpartum blood loss within 2 hours,length of hospital stay,Apgar scores at 1-minute post-birth,and incidences of neonatal fever and jaundice.Results:The observation group had significantly lower intrapartum blood loss,postpartum blood loss within 2 hours,and shorter hospital stays compared to the control group(P<0.05).Additionally,the Apgar scores at 1 minute post-birth were significantly higher in the observation group(P<0.05).The incidence of neonatal fever and jaundice was significantly lower in the observation group(P<0.05).These differences were statistically significant.Conclusion:Vaginal delivery has high clinical value for women with repeat pregnancies involving uterine scars.It reduces maternal intrapartum and postpartum blood loss,shortens hospital stays,improves neonatal Apgar scores,and decreases the incidences of neonatal fever and jaundice.This method is worthy of clinical application and promotion.展开更多
Background: In recent years, Burkina Faso has faced increasing insecurity and terrorist attacks. The police, gendarmerie, and justice services are very often in demand to carry out criminal investigations, which are s...Background: In recent years, Burkina Faso has faced increasing insecurity and terrorist attacks. The police, gendarmerie, and justice services are very often in demand to carry out criminal investigations, which are slowed down or incomplete due to the absence of DNA analysis on biological samples from crime scenes and on apprehended suspects. The purpose of this study was to evaluate the contribution of DNA analysis to the resolution of criminal cases in Burkina Faso. Methodology: This study was carried out from June 2019 to July 2020. Three (03) crimes were investigated, and DNA analysis was performed on biological samples from the crime scene, suspects, and victims using the AmpFlSTR® identifiler® Direct kit on the ABI 3130 Genetic Analyzer. Results: In the explosion case, the alleles found in the victim were the same as those identified in the blood trace from the crime scene. In the armed robbery case, there was a perfect match between the DNA profile of the blood trail and that of suspect 2 for all 15 STRs analyzed. In the murder case, the DNA profile of the murdered man’s son and the DNA profile of the biological trace were identical. Conclusion: The DNA analyses carried out in criminal cases have identified the perpetrators of the crimes. Their guilt or innocence will be confirmed by the investigators during the interrogations and hearings.展开更多
Pyrola atropurpurea Franch is an important annual herbaceous plant.Few genomic analyses have been conducted on this plant,and chloroplast genome research will enrich its genomics basis.This study is based on high-thro...Pyrola atropurpurea Franch is an important annual herbaceous plant.Few genomic analyses have been conducted on this plant,and chloroplast genome research will enrich its genomics basis.This study is based on high-throughput sequencing technology and Bioinformatics methods to obtain the sequence,structure,and other characteristics of the P.atropurpurea chloroplast genome.The result showed that the chloroplast genome of P.atropurpurea has a double-stranded circular structure with a total length of 172,535 bp and a typical four-segment structure.The genome has annotated a total of 132 functional genes,including 43 tRNAs,8 rRNAs,76 protein-coding genes,and 5 pseudo-genes.In total,358 SSR loci were checked out,mainly composed of mononucleotide and trinucleotide repeat.There are three types of scattered repetitive sequences,totaling 4223,including 2452 forward repeats,1763 palindrome repeats,and eight reverse repeats.The optimal codon usage frequency is relatively high with AT usage preference in this genome.Chloroplast genome comparative analysis in the family Ericaceae shows that the overall sequence is more complex,and there are more variations in the gene interval region.The collinearity analysis indicated that there is a complex rearrangement of species between different genera in Ericaceae.The selection pressure analysis showed that the protein-encoding genes rpl33 and rps16 were positively selected among the seven medicinal plants in Ericaceae.The maximum likelihood tree shows that the genetic relationship among P.atropurpurea,Pyrola rotundifolia,and Chimaphila japonica is relatively close.Therefore,an important data basis was provided for species identification,genetic diversity,and phylogenetic studies of P.atropurpurea and even this genus of plants.展开更多
BACKGROUND The feasibility and safety of radiofrequency ablation(RFA)for oligometastatic colorectal liver metastases(CRLM)have been well established.However,the role of RFA in multiple metastases after first-line chem...BACKGROUND The feasibility and safety of radiofrequency ablation(RFA)for oligometastatic colorectal liver metastases(CRLM)have been well established.However,the role of RFA in multiple metastases after first-line chemotherapy failure remains underexplored.AIM To assess long-term survival and factors affecting outcomes of RFA in patients with multiple refractory CRLM.METHODS A retrospective study was conducted on patients who underwent ablation of CRLM at our institution between January 2015 and June 2024.A total of 80 patients were included,with 42 individuals receiving single-session ablation and 38 underwent repeat ablation.Enhanced computed tomography imaging was utilized to evaluate procedural efficacy 24 hours post-RFA,followed by follow-up scans every 3-4 months.Progression-free survival(PFS)and overall survival(OS)rates were compared at endpoint using Kaplan-Meier curves.Cox regression was used to identify the factors associated with OS and PFS.RESULTS The technical success rate was recorded at 98.7%.At endpoint,42(52.5%)patients achieved tumor-free survival,while 28(35%)remained alive with residual tumors present.No significant OS/PFS differences existed between single-session(median follow-up 29.5 months,median PFS 24.5 months)and repeat ablation(30 months,14 months)cohorts(P>0.05).Multivariate analysis showed that larger tumor size(P<0.001)and older age(P=0.01)were associated with worse OS.The median PFS was 13.5 months,with tumor size emerging as the only independent predictor(P=0.04).CONCLUSION For patients with multiple refractory CRLM,both single-session ablation and repeat ablation can increase the proportion of patients achieving tumor-free status.However,careful consideration is necessary for ablation of metastases larger than 2.7 cm.展开更多
With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power i...With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power interference can severely degrade SAR imaging and signal processing,often rendering target detection impossible.This highlights the urgent need for robust anti-interference solutions in both the signal processing and image processing domains.While current methods address interference across various domains,techniques such as waveform modification and spatial filtering typically increase the system costs and complexity.To overcome these limitations,we propose a novel approach that leverages the multi-domain characteristics of interference to efficiently suppress narrowband interference and repeater modulation interference.Specifically,narrowband interference is mitigated using notch filtering,a signal processing technique that effectively filters out unwanted frequencies,while repeater modulation interference is addressed through strong signal amplitude normalization,which enhances both the signal and image processing quality.These methods were validated through tests on real SAR data,demonstrating significant improvements in the imaging performance and system robustness.Our approach offers valuable insights for advancing anti-interference technologies in SAR systems and provides a cost-effective solution to enhance their resilience in complex electronic warfare environments.展开更多
In the visual‘teach-and-repeat’task,a mobile robot is expected to perform path following based on visual memory acquired along a route that it has traversed.Following a visually familiar route is also a critical nav...In the visual‘teach-and-repeat’task,a mobile robot is expected to perform path following based on visual memory acquired along a route that it has traversed.Following a visually familiar route is also a critical navigation skill for foraging insects,which they accomplish robustly despite tiny brains.Inspired by the mushroom body structure in the insect brain and its well-understood associative learning ability,we develop an embodied model that can accomplish visual teach-and-repeat efficiently.Critical to the performance is steering the robot body reflexively based on the relative familiarity of left and right visual fields,eliminating the need for stopping and scanning regularly for optimal directions.The model is robust against noise in visual processing and motor control and can produce performance comparable to pure pursuit or visual localisation methods that rely heavily on the estimation of positions.The model is tested on a real robot and also shown to be able to correct for significant intrinsic steering bias.展开更多
In repeated zero-sum games,instead of constantly playing an equilibrium strategy of the stage game,learning to exploit the opponent given historical interactions could typically obtain a higher utility.However,when pl...In repeated zero-sum games,instead of constantly playing an equilibrium strategy of the stage game,learning to exploit the opponent given historical interactions could typically obtain a higher utility.However,when playing against a fully adaptive opponent,one would have dificulty identifying the opponent's adaptive dynamics and further exploiting its potential weakness.In this paper,we study the problem of optimizing against the adaptive opponent who uses no-regret learning.No-regret learning is a classic and widely-used branch of adaptive learning algorithms.We propose a general framework for online modeling no-regret opponents and exploiting their weakness.With this framework,one could approximate the opponent's no-regret learning dynamics and then develop a response plan to obtain a significant profit based on the inferences of the opponent's strategies.We employ two system identification architectures,including the recurrent neural network(RNN)and the nonlinear autoregressive exogenous model,and adopt an efficient greedy response plan within the framework.Theoretically,we prove the approximation capability of our RNN architecture at approximating specific no-regret dynamics.Empirically,we demonstrate that during interactions at a low level of non-stationarity,our architectures could approximate the dynamics with a low error,and the derived policies could exploit the no-regret opponent to obtain a decent utility.展开更多
基金This project was supported by the National Natural Science Foundation of China(No.61571024)the National Key Research and Development Program of China(No.2016YFC1000307)for valuable helps.
文摘In January 2015,the first quantum homomorphic signature scheme was proposed creatively.However,only one verifier is allowed to verify a signature once in this scheme.In order to support repeatable verification for general scenario,we propose a new quantum homomorphic signature scheme with repeatable verification by introducing serial verification model and parallel verification model.Serial verification model solves the problem of signature verification by combining key distribution and Bell measurement.Parallel verification model solves the problem of signature duplication by logically treating one particle of an EPR pair as a quantum signature and physically preparing a new EPR pair.These models will be beneficial to the signature verification of general scenarios.Scheme analysis shows that both intermediate verifiers and terminal verifiers can successfully verify signatures in the same operation with fewer resource consumption,and especially the verified signature in entangled states can be used repeatedly.
基金the project of the National Key Research and Development Program of China(2018YFA0703300)the National Natural Science Foundation of China(52105302,52175271,52021003,and 91848204)+1 种基金the team of Innovation and entrepreneurship of Jilin Province(20210509047RQ,20210508057RQ)the Program for JLU Science and Technology Innovative Research Team(2017TD-04).
文摘On the base of controllable variable stiffness property,variable stiffness composites were the main components of functional materials in aerospace.However,the relatively low mechanical strength,stiffness range,and response rate restricted the application of variable stiffness composite.In this work,the novel variable stiffness composite system with characteristics of repeatable high load bearing and response rate was successfully prepared via the double-layer anisotropic structure to solve the bottlenecks of variable stiffness composites.The novel variable stiffness composite systems were composed of variable stiffness layer of polycaprolactone(PCL)and the driven layer of silicone elastomer with alcohol,which continuously changed Young’s modulus from 0.1 to 7.263 MPa(72.63 times variation)in 200 s and maintained maximum weight of 11.52 times its own weight(8.5 g).Attributed to the relatively high variable stiffness range and load bearing value of variable stiffness composite system,the repeatable response process led to the efficient high load driven as“muscle”and diversified precise grab of objects with different shapes as“gripper”,owning widespread application prospects in the field of bionics.
基金supported by the National Natural Science Foundation of China, No.61932008Natural Science Foundation of Shanghai, No.21ZR1403200 (both to JC)。
文摘Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.
基金supported by the National Natural Science Foundation of China(Grant Nos.32072048 and U2004204)National Key Research and Development Program of China(Grant No.2023YFF1001200)+2 种基金China Rice Research Institute Basal Research Fund(Grant No.CPSIBRF-CNRRI-202404)Academician Workstation of National Nanfan Research Institute(Sanya),Chinese Agricultural Academic Science(CAAS),(Grant Nos.YBXM2422 and YBXM2423)Agricultural Science and Technology Innovation Program of CAAS,China.
文摘The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.
文摘When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.
基金supported by the National Natural Science Foundation of China(12273008,12025303,12403046)the National SKA Program of China(2022SKA0130104)+3 种基金the Natural Science and Technology Foundation of Guizhou Province(QiankehejichuMS[2025]266,[2023]024,ZK[2022]304)the Foundation of Guizhou Provincial Education Department(KY(2020)003)the Academic New Seedling Fund Project of Guizhou Normal University([2022]B18)the Major Science and Technology Program of Xinjiang Uygur Autonomous Region(2022A03013-4).
文摘The emission of anomalous X-ray pulsars(AXPs)and soft gamma-ray repeaters(SGRs)is believed to be powered by the dissipation of their strong magnetic fields,which coined the name“magnetar”.By combining timing and energy observational results,the magnetar model can be easily appreciated.From a timing perspective,the magnetic field strengths of AXPs and SGRs,which are calculated under the assumption of dipole radiation,are extremely strong.From an energy perspective,the X-ray/soft gamma-ray luminosities of AXPs and SGRs are larger than their rotational energy loss rates(i.e.,L_(x>E_(rot)).It is thus reasonable to assume that the high-energy radiation comes from magnetic energy decay,and the magnetar model has been extensively discussed(or accepted).However,we argue that:(ⅰ)Calculating magnetic fields by assuming that rotational energy loss is dominated by dipole radiation(i.e.,E_(rot)■E_(μ))may be controversial,and we suggest that the energies carried by outflowing particles should also be considered.(ⅱ)The fact that X-ray luminosity is greater than the rotational energy loss rate does not necessarily mean that the emission energy comes from the magnetic field decaying,which requires further observational testing.Furthermore,some observational facts conflict with the“magnetar”model,such as observations of anti-magnetars,high magnetic field pulsars,and radio and X-ray observations of AXPs/SGRs.Therefore,we propose a crusted strange star model as an alternative,which can explain many more observational facts of AXPs/SGRs.
文摘Objective Junctophilin-2(JPH2)is an essential structural protein that maintains junctional membrane complexes(JMCs)in cardiomyocytes by tethering the plasma membrane to the sarcoplasmic reticulum,thereby facilitating excitationcontraction(E-C)coupling.Mutations in JPH2 have been associated with hypertrophic cardiomyopathy(HCM),but the molecular mechanisms governing its membrane-binding properties and the functional relevance of its membrane occupation and recognition nexus(MORN)repeat motifs remain incompletely understood.This study aimed to elucidate the structural basis of JPH2 membrane association and its implications for HCM pathogenesis.Methods A recombinant N-terminal fragment of mouse JPH2(residues 1-440),encompassing the MORN repeats and an adjacent helical region,was purified under near-physiological buffer conditions.X-ray crystallography was employed to determine the structure of the JPH2 MORN-Helix domain.Sequence conservation analysis across species and junctophilin isoforms was performed to assess the evolutionary conservation of key structural features.Functional membrane-binding assays were conducted using liposome co-sedimentation and cell-based localization studies in COS7 and HeLa cells.In addition,site-directed mutagenesis targeting positively charged residues and known HCM-associated mutations,including R347C,was used to evaluate their effects on membrane interaction and subcellular localization.Results The crystal structure of the mouse JPH2 MORN-Helix domain was resolved at 2.6Å,revealing a compact,elongated architecture consisting of multiple tandem MORN motifs arranged in a curved configuration,forming a continuous hydrophobic core stabilized by alternating aromatic residues.A C-terminalα-helix further reinforced structural integrity.Conservation analysis identified the inner groove of the MORN array as a highly conserved surface,suggesting its role as a protein-binding interface.A flexible linker segment enriched in positively charged residues,located adjacent to the MORN motifs,was found to mediate direct electrostatic interactions with negatively charged phospholipid membranes.Functional assays demonstrated that mutation of these basic residues impaired membrane association,while the HCM-linked R347C mutation completely abolished membrane localization in cellular assays,despite preserving the overall MORN-Helix fold in structural modeling.Conclusion This study provides structural insight into the membrane-binding mechanism of the cardiomyocyte-specific protein JPH2,highlighting the dual roles of its MORN-Helix domain in membrane anchoring and protein interactions.The findings clarify the structural basis for membrane targeting via a positively charged linker and demonstrate that disruption of this interaction—such as that caused by the R347C mutation—likely contributes to HCM pathogenesis.These results not only enhance current understanding of JPH2 function in cardiac E-C coupling but also offer a structural framework for future investigations into the assembly and regulation of JMCs in both physiological and disease contexts.
基金Supported by National Natural Science Foundation of China,No.82160762Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230267+2 种基金China Undergraduate Innovation and Entrepreneurship Training Program,No.S202410598060XChina Undergraduate Innovation and Entrepreneurship Training Program,No.X202410598360Future Academic Star of Guangxi Medical University,No.WLXSZX24074.
文摘BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC tissues.METHODS This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in HCC.Clustered regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell growth.Functional enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in HCC.Drug sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC cells.RESULTS The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC tissues.The integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA splicing.Significant enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen species.Drug sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and GDC0810.Overexpressed PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC tissues.PSMD6 is essential for the growth of HCC cells and may be involved in ribosome biogenesis and RNA splicing.
基金supported by the Russian Science Foundation,Russia(Grant No.24-24-00031).
文摘In this study,we searched for dispersed repeats(DRs)in the rice(Oryza sativa)genome using the iterative procedure(IP)method.The results revealed that the O.sativa genome contained 79 DR families,comprising 992739 DNA repeats,of which 496762 and 495977 were identified on the forward and reverse DNA strands,respectively.The detected DRs were,on average,374 bp in length and occupied 66.4%of the O.sativa genome.Totally 61%of DRs,identified by the IP method,overlapped with previously annotated dispersed repeats(ADRs)detected using the Extensive De Novo TE Annotator(EDTA)pipeline.
文摘On 18 November 2024,Chinese President Xi Jinping delivered a speech titled Building a Just World of Common Development at Session I of the 19th Group of 20(G20)Summit in Rio de Janeiro,Brazil.Xi Jinping has repeatedly underscored the importance of promoting common development at G20 summits.Edited excerpts of his speeches on this topic since 2016 follow.
基金supported by the Jiangxi Province Higher Education Teaching Research Project(JXJG-22-23-3,NSJG-21-25)Jiangxi Province Key Laboratory of Oil Crops Biology(YLKFKT202203).
文摘Rorippa indica is a wild oilseed crop of Brassicaceae with good environmental adaptability and strong stress resistance.This plant has become an important wild relative species for rapeseed(Brassica napus L.)and is used to improve its agronomic traits,with important development and utilization value.However,the research of R.indica genetics is still lacking.And no mitochondrial genome(mitogenome)in the genus Rorippa has been expounded.To analyze the structural characteristics of the R.indica mitogenome,second-generation and third-generation sequencing techniques were made to assemble its mitogenome.The results showed that its mitogenome is composed of a single master circle DNA molecule,with 59 genes(33 protein-coding,23 tRNA,and 3 ribosomal RNA genes)annotated.The length of the circular genome is 219,775 bp,with aGCcontent of 45.24%.Themitochondrial genome contains 55 SSRs,17 tandem repeats,and 252 scattered repeat sequences,with scattered repeat sequences accounting for 77.78%.The top two codons with the highest expression levels are TTT and AUU.Moreover,377 RNA editing sites were forecasted in the R.indica mitogenome.And 22 collinear gene fragments were discriminated in the R.indica chloroplast andmitogenomes,with a total 13,153 bp length,accounting for 4.08%of the mitogenome sequence.The longest gene migration fragment is 2186 bp,and the shortest fragment is 42 bp.Furthermore,12 genes undergo complete migration between the two genomes,and 10 genes undergo partial migration.Systematic evolutionary analysis shows that R.indica and Brassica napus are grouped,indicating a close genetic relationship between the two.Herein,the R.indica mitogenome was sequenced and annotated,and it was compared with other Brassicaceae mitogenomes.A genomic data foundation was supplied for elucidating the R.indica origin and evolution.
基金supported by the National Natural Science Foundation of China(32172010)the Major Program of Guangdong Basic and Applied Basic Research(2019B030302006).
文摘Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression in rice remains unclear.Here,we construct a map of 137,629 polymorphic STRs in the rice(Oryza sativa L.)genome using a population-scale resequencing dataset.A genome-wide survey encompassing 4726 accessions shows that the occurrence frequency,mutational patterns,chromosomal distribution,and functional properties of STRs are correlated with the sequences and lengths of repeat motifs.Leveraging a transcriptome dataset from 127 rice accessions,we identify 44,672 expression STRs(eSTRs)by modeling gene expression in response to the length variation of STRs.These eSTRs are notably enriched in the regulatory regions of genes with active transcriptional signatures.Population analysis identifies numerous STRs that have undergone genetic divergence among different rice groups and 1726 tagged STRs that may be associated with agronomic traits.By editing the(ACT)_(7) STR in OsFD1 promoter,we further experimentally validate its role in regulating gene expression and phenotype.Our study highlights the contribution of STRs to transcriptional regulation in plants and establishes the foundation for their potential use as alternative targets for genetic improvement.
文摘Objective:To investigate the delivery modes of women with repeat pregnancies involving uterine scars and their effects on both mothers and neonates.Methods:A study was conducted on 100 patients treated at Shenzhen Maternity and Child Healthcare Hospital from July 2023 to July 2024.The participants were divided into a control group and an observation group,with 50 cases in each.The division was based on the indications for prior cesarean section,cervical maturity,postpartum complications,and thickness of the cesarean scar.The control group underwent cesarean delivery,while the observation group experienced vaginal delivery.The two groups were compared in terms of intrapartum blood loss,postpartum blood loss within 2 hours,length of hospital stay,Apgar scores at 1-minute post-birth,and incidences of neonatal fever and jaundice.Results:The observation group had significantly lower intrapartum blood loss,postpartum blood loss within 2 hours,and shorter hospital stays compared to the control group(P<0.05).Additionally,the Apgar scores at 1 minute post-birth were significantly higher in the observation group(P<0.05).The incidence of neonatal fever and jaundice was significantly lower in the observation group(P<0.05).These differences were statistically significant.Conclusion:Vaginal delivery has high clinical value for women with repeat pregnancies involving uterine scars.It reduces maternal intrapartum and postpartum blood loss,shortens hospital stays,improves neonatal Apgar scores,and decreases the incidences of neonatal fever and jaundice.This method is worthy of clinical application and promotion.
文摘Background: In recent years, Burkina Faso has faced increasing insecurity and terrorist attacks. The police, gendarmerie, and justice services are very often in demand to carry out criminal investigations, which are slowed down or incomplete due to the absence of DNA analysis on biological samples from crime scenes and on apprehended suspects. The purpose of this study was to evaluate the contribution of DNA analysis to the resolution of criminal cases in Burkina Faso. Methodology: This study was carried out from June 2019 to July 2020. Three (03) crimes were investigated, and DNA analysis was performed on biological samples from the crime scene, suspects, and victims using the AmpFlSTR® identifiler® Direct kit on the ABI 3130 Genetic Analyzer. Results: In the explosion case, the alleles found in the victim were the same as those identified in the blood trace from the crime scene. In the armed robbery case, there was a perfect match between the DNA profile of the blood trail and that of suspect 2 for all 15 STRs analyzed. In the murder case, the DNA profile of the murdered man’s son and the DNA profile of the biological trace were identical. Conclusion: The DNA analyses carried out in criminal cases have identified the perpetrators of the crimes. Their guilt or innocence will be confirmed by the investigators during the interrogations and hearings.
基金supported by the Education Reform Program of Jiangxi Provincial Department of Education(JXJG-22-23-3,JXJG-23-23-5)the“Biology and Medicine”Discipline Construction Project of Nanchang NormalUniversity(100/20149)+2 种基金Jiangxi Province Key Laboratory of Oil Crops Biology(YLKFKT202203)the Education Reform Program of Nanchang Normal University(NSJG-21-25)Nanchang Key Laboratory of Comprehensive Research and Development of Brasenia schreberi(32060078).
文摘Pyrola atropurpurea Franch is an important annual herbaceous plant.Few genomic analyses have been conducted on this plant,and chloroplast genome research will enrich its genomics basis.This study is based on high-throughput sequencing technology and Bioinformatics methods to obtain the sequence,structure,and other characteristics of the P.atropurpurea chloroplast genome.The result showed that the chloroplast genome of P.atropurpurea has a double-stranded circular structure with a total length of 172,535 bp and a typical four-segment structure.The genome has annotated a total of 132 functional genes,including 43 tRNAs,8 rRNAs,76 protein-coding genes,and 5 pseudo-genes.In total,358 SSR loci were checked out,mainly composed of mononucleotide and trinucleotide repeat.There are three types of scattered repetitive sequences,totaling 4223,including 2452 forward repeats,1763 palindrome repeats,and eight reverse repeats.The optimal codon usage frequency is relatively high with AT usage preference in this genome.Chloroplast genome comparative analysis in the family Ericaceae shows that the overall sequence is more complex,and there are more variations in the gene interval region.The collinearity analysis indicated that there is a complex rearrangement of species between different genera in Ericaceae.The selection pressure analysis showed that the protein-encoding genes rpl33 and rps16 were positively selected among the seven medicinal plants in Ericaceae.The maximum likelihood tree shows that the genetic relationship among P.atropurpurea,Pyrola rotundifolia,and Chimaphila japonica is relatively close.Therefore,an important data basis was provided for species identification,genetic diversity,and phylogenetic studies of P.atropurpurea and even this genus of plants.
基金Supported by National Natural Science Foundation of China,No.82027803 and No.81971623Key Research and Development Project of Zhejiang Province,No.2024C03092.
文摘BACKGROUND The feasibility and safety of radiofrequency ablation(RFA)for oligometastatic colorectal liver metastases(CRLM)have been well established.However,the role of RFA in multiple metastases after first-line chemotherapy failure remains underexplored.AIM To assess long-term survival and factors affecting outcomes of RFA in patients with multiple refractory CRLM.METHODS A retrospective study was conducted on patients who underwent ablation of CRLM at our institution between January 2015 and June 2024.A total of 80 patients were included,with 42 individuals receiving single-session ablation and 38 underwent repeat ablation.Enhanced computed tomography imaging was utilized to evaluate procedural efficacy 24 hours post-RFA,followed by follow-up scans every 3-4 months.Progression-free survival(PFS)and overall survival(OS)rates were compared at endpoint using Kaplan-Meier curves.Cox regression was used to identify the factors associated with OS and PFS.RESULTS The technical success rate was recorded at 98.7%.At endpoint,42(52.5%)patients achieved tumor-free survival,while 28(35%)remained alive with residual tumors present.No significant OS/PFS differences existed between single-session(median follow-up 29.5 months,median PFS 24.5 months)and repeat ablation(30 months,14 months)cohorts(P>0.05).Multivariate analysis showed that larger tumor size(P<0.001)and older age(P=0.01)were associated with worse OS.The median PFS was 13.5 months,with tumor size emerging as the only independent predictor(P=0.04).CONCLUSION For patients with multiple refractory CRLM,both single-session ablation and repeat ablation can increase the proportion of patients achieving tumor-free status.However,careful consideration is necessary for ablation of metastases larger than 2.7 cm.
文摘With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power interference can severely degrade SAR imaging and signal processing,often rendering target detection impossible.This highlights the urgent need for robust anti-interference solutions in both the signal processing and image processing domains.While current methods address interference across various domains,techniques such as waveform modification and spatial filtering typically increase the system costs and complexity.To overcome these limitations,we propose a novel approach that leverages the multi-domain characteristics of interference to efficiently suppress narrowband interference and repeater modulation interference.Specifically,narrowband interference is mitigated using notch filtering,a signal processing technique that effectively filters out unwanted frequencies,while repeater modulation interference is addressed through strong signal amplitude normalization,which enhances both the signal and image processing quality.These methods were validated through tests on real SAR data,demonstrating significant improvements in the imaging performance and system robustness.Our approach offers valuable insights for advancing anti-interference technologies in SAR systems and provides a cost-effective solution to enhance their resilience in complex electronic warfare environments.
基金support from the Huawei Technologies Co.,Ltd.[grant number YBN2020045132].
文摘In the visual‘teach-and-repeat’task,a mobile robot is expected to perform path following based on visual memory acquired along a route that it has traversed.Following a visually familiar route is also a critical navigation skill for foraging insects,which they accomplish robustly despite tiny brains.Inspired by the mushroom body structure in the insect brain and its well-understood associative learning ability,we develop an embodied model that can accomplish visual teach-and-repeat efficiently.Critical to the performance is steering the robot body reflexively based on the relative familiarity of left and right visual fields,eliminating the need for stopping and scanning regularly for optimal directions.The model is robust against noise in visual processing and motor control and can produce performance comparable to pure pursuit or visual localisation methods that rely heavily on the estimation of positions.The model is tested on a real robot and also shown to be able to correct for significant intrinsic steering bias.
基金the Science and Technology Innovation 2030-"New Generation Artificial Intelligence"Major Project(No.2018AAA0100901)。
文摘In repeated zero-sum games,instead of constantly playing an equilibrium strategy of the stage game,learning to exploit the opponent given historical interactions could typically obtain a higher utility.However,when playing against a fully adaptive opponent,one would have dificulty identifying the opponent's adaptive dynamics and further exploiting its potential weakness.In this paper,we study the problem of optimizing against the adaptive opponent who uses no-regret learning.No-regret learning is a classic and widely-used branch of adaptive learning algorithms.We propose a general framework for online modeling no-regret opponents and exploiting their weakness.With this framework,one could approximate the opponent's no-regret learning dynamics and then develop a response plan to obtain a significant profit based on the inferences of the opponent's strategies.We employ two system identification architectures,including the recurrent neural network(RNN)and the nonlinear autoregressive exogenous model,and adopt an efficient greedy response plan within the framework.Theoretically,we prove the approximation capability of our RNN architecture at approximating specific no-regret dynamics.Empirically,we demonstrate that during interactions at a low level of non-stationarity,our architectures could approximate the dynamics with a low error,and the derived policies could exploit the no-regret opponent to obtain a decent utility.
