Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical,biological,and medical fields.However,certain critical requirements,such as high-intensity laser beam...Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical,biological,and medical fields.However,certain critical requirements,such as high-intensity laser beams,sophisticated electrode designs,additional electric sources,or low-conductive media,significantly impede their flexibility and adaptability,thus hindering their practical applications.Here,we report innovative photopyroelectric tweezers(PPT)that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability,enabling diverse manipulation in various working scenarios.These PPTs allow for remote and programmable manipulation of objects with diverse materials(polymer,inorganic,and metal),different phases(bubble,liquid,and solid),and various geometries(sphere,cuboid,and wire).Furthermore,the PPT is not only adaptable to high-conductivity media but also applicable to both portable macroscopic manipulation platforms and microscopic manipulation systems,enabling cross-scale manipulations for solid objects,liquid droplets,and biological samples.The high-level flexibility and adaptability of the PPT extend to broad applications in manipulating hydrogel robots,sorting particles,assembling cells,and stimulating cells.By surpassing the limitations of conventional tweezers,the PPT bridges the gap between macroscopic and microscopic manipulations,offering a revolutionary tool in robotics,colloidal science,biomedical fields,and beyond.展开更多
To eliminate anomalies and improve the performance of a space station remote manipulator(SSRM) used in a dynamically changeable thermal environment, we analyze the thermodynamic behavior of an SSRM that considers an i...To eliminate anomalies and improve the performance of a space station remote manipulator(SSRM) used in a dynamically changeable thermal environment, we analyze the thermodynamic behavior of an SSRM that considers an integrated thermal protection system(ITPS). Solar radiative heat gain and loss become equally significant as conductive heat transfers through the interior of the SSRM on orbit. A thermodynamic model of the SSRM with a sandwich ITPS structure is established on the coupling between harmonic drive and changeable thermal environment. A motion precision is proposed to evaluate thermodynamic behavior under continuously changeable thermal circumstances. Simulation results indicate that the ITPS with a corrugated sandwich structure reduces the maximum amplitude of angular position errors to 41.6%, which helps improve the motion precision of the SSRM. The feasible regions for the SSRM in the Low Earth Orbit(LEO) and Geostationary Earth Orbit(GEO) are analyzed, which shows that the proportion of feasible region in LEO is significantly larger than that in GEO.展开更多
Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical ...Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.展开更多
基金support provided by the National Natural Science Foundation of China(52261160380,52022102)Shenzhen Medical Research Fund(B230245),National Key R&D Programof China(2017YFA0701303)+2 种基金the Youth Innovation Promotion Association of CAS(Y2023100)Guangdong Regional Joint Fund-Key Project(2021B1515120076)the Fundamental Research Program of Shenzhen(RCJC20221008092729033,JCYJ20220818101800001).
文摘Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical,biological,and medical fields.However,certain critical requirements,such as high-intensity laser beams,sophisticated electrode designs,additional electric sources,or low-conductive media,significantly impede their flexibility and adaptability,thus hindering their practical applications.Here,we report innovative photopyroelectric tweezers(PPT)that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability,enabling diverse manipulation in various working scenarios.These PPTs allow for remote and programmable manipulation of objects with diverse materials(polymer,inorganic,and metal),different phases(bubble,liquid,and solid),and various geometries(sphere,cuboid,and wire).Furthermore,the PPT is not only adaptable to high-conductivity media but also applicable to both portable macroscopic manipulation platforms and microscopic manipulation systems,enabling cross-scale manipulations for solid objects,liquid droplets,and biological samples.The high-level flexibility and adaptability of the PPT extend to broad applications in manipulating hydrogel robots,sorting particles,assembling cells,and stimulating cells.By surpassing the limitations of conventional tweezers,the PPT bridges the gap between macroscopic and microscopic manipulations,offering a revolutionary tool in robotics,colloidal science,biomedical fields,and beyond.
基金supported by the National Natural Science Foundation of China(Grant No.11272171)Education Ministry Doctoral Fund of China(Grant No.20120002110070)
文摘To eliminate anomalies and improve the performance of a space station remote manipulator(SSRM) used in a dynamically changeable thermal environment, we analyze the thermodynamic behavior of an SSRM that considers an integrated thermal protection system(ITPS). Solar radiative heat gain and loss become equally significant as conductive heat transfers through the interior of the SSRM on orbit. A thermodynamic model of the SSRM with a sandwich ITPS structure is established on the coupling between harmonic drive and changeable thermal environment. A motion precision is proposed to evaluate thermodynamic behavior under continuously changeable thermal circumstances. Simulation results indicate that the ITPS with a corrugated sandwich structure reduces the maximum amplitude of angular position errors to 41.6%, which helps improve the motion precision of the SSRM. The feasible regions for the SSRM in the Low Earth Orbit(LEO) and Geostationary Earth Orbit(GEO) are analyzed, which shows that the proportion of feasible region in LEO is significantly larger than that in GEO.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00208427)supported by the Korea Basic Science Institute(National research Facilities and Equipment Center)grant fun-ded by the Korea government(MSIT)(No.RS-2024-00402412)+1 种基金supported by the Nano&Material Technology Develop-ment Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2024-00407093)supported by a Korea University Grant.
文摘Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.
