Pulmonary arterial hypertension(PAH)is a devastating disease characterized by perivascular inflammation,immune dysregulation,and vascular remodeling.Recent studies have unveiled a potential link between the gut microb...Pulmonary arterial hypertension(PAH)is a devastating disease characterized by perivascular inflammation,immune dysregulation,and vascular remodeling.Recent studies have unveiled a potential link between the gut microbiome and PAH pathogenesis,suggesting that microbial dysbiosis and increased intestinal permeability may contribute to the inflammatory pathology in PAH and ultimately disease progression.This perspective highlights the emerging evidence of the role of leaky gut in PAH,the interplay between microbiota-induced immune responses,and the activation of endogenous retroviruses like human endogenous retrovirus K.Understanding these complex interactions opens new interdisciplinary avenues for research and therapeutic interventions,potentially transforming PAH management through microbiome-targeted strategies.展开更多
基金support from National Institutes of Health(NIH)grants 1U54AG089334-01,R01 HL158714,R01 HL087118,R01 HL138473,and R01 HL122887support from the National Institute on Aging(NIA)fellowship under Resource Centers for Minority Aging Research grant P30 AG059307+2 种基金support from the Leona M.and Harry B.Helmsley Charitable Trust(grant no.G-2004-03820)the Innovative Medicines Accelerator(grant no.IMA-1051)the RAMBAM-Stanford International Collaboration grant at Stanford University.
文摘Pulmonary arterial hypertension(PAH)is a devastating disease characterized by perivascular inflammation,immune dysregulation,and vascular remodeling.Recent studies have unveiled a potential link between the gut microbiome and PAH pathogenesis,suggesting that microbial dysbiosis and increased intestinal permeability may contribute to the inflammatory pathology in PAH and ultimately disease progression.This perspective highlights the emerging evidence of the role of leaky gut in PAH,the interplay between microbiota-induced immune responses,and the activation of endogenous retroviruses like human endogenous retrovirus K.Understanding these complex interactions opens new interdisciplinary avenues for research and therapeutic interventions,potentially transforming PAH management through microbiome-targeted strategies.
