The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs posses...The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.展开更多
Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researche...Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researches on partial relieving pressure were completed for the entry with U-steel arched yielding support. The relieving pressure parameters, technology process and results of springing blasting by boreholes and excavating pockets in the two sides of entry were introduced. It is demonstrated that springing will not be shaped under the condition of single borehole arrangement after exploded, the arrangement by a group, it will make borehole bottom form springing in 0.6-0.8 m in diameter, that convergence of two sides and roof to floor have some increments by using springing blasting for reliving pressure. This kind of method for reliving pressure is not suitable to use in the deep mine, and that the convergence of two sides obviously declined by excavating pocket in two sides, it can be still used in the entry with metal support, while maintenance of entry in deep mines is difficult, and can not be supported by bolt or bolt with wire mesh.展开更多
To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： T...To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： The blood pressure-decreasing effects of single administration and 14-day consecutive administration of Compound Mistletoe Fluidextract （CMF） in SHR and RHD were investigated and compared with that of Niuhuang Jiangya Wan （牛黄降压丸 Bezoar Hypertension-relieving Pills）. Results： Both single administration and 14-day consecutive administration of CMF had significant hypotensive effects in SHR and RHD. Conclusion： The hypotensive action of CMF is gradual, but lasts for a longer period, with a dose-effect relationship in a range of doses.展开更多
Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough v...Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.展开更多
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a...Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.展开更多
Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and m...Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,展开更多
Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through m...Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through methods such as changing positions and manual pressing,but the efficacy is limited.Hence alternative therapies for sedation and analgesia in unsedated colonoscopy warrant further study.Electroacupuncture(EA)can simplify the procedure of anesthesia and analgesia,while the efficacy of EA on unsedated colonoscopy remains unclear.Therefore,a well-designed randomized controlled trial is needed to demonstrate the potential efficacy of acupuncture in unsedated colonoscopy,particularly for pain relief.Methods In this prospective randomized sham-controlled trial,105 eligible participants will be recruited and randomly assigned to either EA group(n=35),sham EA group(n=35),or control group(n=35)in a 1:1:1 ratio.The EA group will receive acupuncture intervention on bilateral Hegu(LI4),Neiguan(PC6),Zusanli(ST36),and Shenmen(HT7),with LI4 and PC6 on both sides connected to the EA device.The sham EA group will received non transdermal needling on points of no meridian,and deliberately connect the needle to the incorrect output socket of EA device to block the stimulation.The needling will conducted from 30 min before the unsedated colonoscopy to the end of the colonoscopy,the whole retention time would be approximately 40 min.The participants in the control group will not receive any acupuncture intervention.All participants of the three groups will not receive any other treatment.Primary outcomes:Numerical Rating Scale(NRS)reported by participants and Face Pain Scale Revised(FPS-R)evaluated by observers of four areas of the participants during the unsedated colonoscopy.Secondary outcomes:tolerance reported by endoscopists,tolerance reported by participants,satisfaction reported by endoscopists,satisfaction reported by participants,adverse events during the unsedated colonoscopy,postoperative discomfort,unsedated colonoscopy smoothness(cecal insertion time,unwinding time,success rate of one-time intubation).Both intention-to-treat(ITT)and per-protocol(PP)analyses will be performed to assess the efficacy of EA.Discussion The trial will explore the efficacy of relieving pain,improving tolerability,and reducing undesirable adverse events of EA for unsedated colonoscopy.The results of this trial will provide sound evidence for promoting the clinical application of EA for unsedated colonoscopy.Trial registration ClinicalTrials.gov Identifier:ChiCTR2300069903,retrospectively registered on March 16,2023.展开更多
Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine ...Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.展开更多
Micron-sized silicon(μSi)is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant reserves.However,the volume expansion that occurs during cyclin...Micron-sized silicon(μSi)is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant reserves.However,the volume expansion that occurs during cycling leads to the accumulation of undesirable stresses,resulting in pulverization of silicon microparticles and shortened lifespan of the batteries.Herein,a composite film of Cu-PET-Cu is proposed as the current collector(CC)forμSi anodes to replace the conventional Cu CC.Cu-PET-Cu CC is prepared by depositing Cu on both sides of a polyethylene terephthalate(PET)film.The PET layer promises good ductility of the film,permitting the Cu-PET-Cu CC to accommodate the volumetric changes of silicon microparticles and facilitates the stress release through ductile deformation.As a result,theμSi electrode with Cu-PET-Cu CC retains a high specific capacity of 2181 mA h g^(-1),whereas theμSi electrode with Cu CC(μSi/Cu)exhibits a specific capacity of 1285 mA h g^(-1)after 80 cycles.The stress relieving effect of CuPET-Cu was demonstrated by in-situ fiber optic stress monitoring and multi-physics simulations.This work proposes an effective stress relief strategy at the electrode level for the practical implementation ofμSi anodes.展开更多
Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circul...Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation） in treating patients with cardiac syndrome X （CSX）. Methods： The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment （32 patients）, and the control group treated with conventional treatment （19 patients） like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results： After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group （P〈0.05）; the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group （P〈0.05）. The treadmill exercise test showed that the maximal metabolic equivalent （Max MET）, the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively （P〈0.05）. Conclusion： The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.展开更多
Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbos...Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group （778 ± 202 mm3, both P〈0.05）. The combination group had the highest tumor inhibition rate （47.7%）, followed by the hWRCP group （35.2%） and 5-FU group （28.3%）. The 5-FU group had a lower body weight increase （1.37± 2.06 g versus 5.60± 0.72 g, P〈0.05） and a lower spleen index （4.064 ± 1.774 rag/10 g versus 5.294 ± 1.796 mg/10 g） as compared with the control group, whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52 ± 1.80 g （P〈0.05） and spleen index of 7.036 ± 1.599 mg/10 g （P〈0.05）. The spleen indices in the hWRCP, mWRCP, and IWRCP group were all significantly higher than that in the 5-FU group （P〈0.01 or P〈0.05）. No significant differences in body weight change were observed in WRCP groups compared with the control group （P〉0.05）. Conclusioa： The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants. KEYWORDS breast cancer, warming and relieving cold phlegm formula, 5-fluorouracil, angiogenesis展开更多
In the evaluation of Chinese berbs(A),ear-acupuncture(B) and epidural morphine(C) to relieve postoperative pain and abdominal distension,sixteen male patients with primary liver cancer were observed.This study was con...In the evaluation of Chinese berbs(A),ear-acupuncture(B) and epidural morphine(C) to relieve postoperative pain and abdominal distension,sixteen male patients with primary liver cancer were observed.This study was conducted by means of orthogonal experiment and double blind,randomized design.展开更多
Synthesis technology and properties of cordierite from solid waste resources/Tan Qitong,Zhao Huizhong,Yu Jun,Zhang Han,Tan Liqiang//Naihuo Cailiao.-2024,58(3):185 Abstract:To effectively utilize solid waste resources ...Synthesis technology and properties of cordierite from solid waste resources/Tan Qitong,Zhao Huizhong,Yu Jun,Zhang Han,Tan Liqiang//Naihuo Cailiao.-2024,58(3):185 Abstract:To effectively utilize solid waste resources and relieve resource constraints,cordierite refractory raw materials were prepared according to the chemical composition of cordierite,using 12 mass%fused magnesia dust powder,40 mass%fused corundum dust powder and 48 mass%quartz tailings as starting materials.展开更多
OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastere...OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.展开更多
The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the...The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the reduction of chlorophyll content, the accumulation of MDA(malondiadehyde) and the elevation of relative membrane penetrability (RMP). After adding 10 mg . L-1 La to the solution, the activities of SOD and CAT in the leaves of Hydrocharis dubia B L. Backer increases compared with those of the single treatment of Ni, while the activity of POD decreases. It reveals that la enhances the abilities of scavenging the activated oxygen in the plant and alleviates the damage to the membranes. The soluble protein content with Ni and La compound treatment is higher than that of single Ni does, and proline content is contrary to the soluble protein content. So La improves the resistance of Hydrocharis dubia B. L. Backer to the stress of Ni. However, La can aggravate the damage to the cells under the extremely high concentration of Ni treatment.展开更多
The mechanical properties as well as microstructure of Cu-30.6 wt% Zn alloys containing 0.01 wt% lead has been investigated. The brass alloy was cast and then cold rolled at various percentage reductions: 20%, 25%, 30...The mechanical properties as well as microstructure of Cu-30.6 wt% Zn alloys containing 0.01 wt% lead has been investigated. The brass alloy was cast and then cold rolled at various percentage reductions: 20%, 25%, 30%, 35% and 40% followed by stress relieving annealed at 450℃. Hardness, ultimate tensile strength (UTS) and impact toughness values were evaluated at every stage of reduction. It was discovered that the strength, hardness and impact energy all increased with increased percentage reduction. Finally, the optical microscope of the samples was done and the result achieved correlated with the mechanical properties.展开更多
Objective:To study the effect of Alpinia officinarum Hance(A.officinarum) 80% alcohol extract on the primary dysmenorrhea.Methods:A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins.Female...Objective:To study the effect of Alpinia officinarum Hance(A.officinarum) 80% alcohol extract on the primary dysmenorrhea.Methods:A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins.Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A.officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F_(2α)(PGF_(2α)),prostaglandin E_2(PGE_2) and Ca^(2+) in the uterus were observed in oxytocin-induced female mice.Results:The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A.officinarum 80% alcohol extract and the level of PGF_(2α),PGE_2 and Ca^(2+) in mice uterus was significantly decreased(P<0.05,P<0.01) in groups of mice treated with middle and high dosage of A.officinarum 80% alcohol extract compared with that of model group.Conclusions:These findings suggest that A.Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.展开更多
文摘The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.
基金Supported by the Key Project of the National Natural Science Foundation （50490273）
文摘Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researches on partial relieving pressure were completed for the entry with U-steel arched yielding support. The relieving pressure parameters, technology process and results of springing blasting by boreholes and excavating pockets in the two sides of entry were introduced. It is demonstrated that springing will not be shaped under the condition of single borehole arrangement after exploded, the arrangement by a group, it will make borehole bottom form springing in 0.6-0.8 m in diameter, that convergence of two sides and roof to floor have some increments by using springing blasting for reliving pressure. This kind of method for reliving pressure is not suitable to use in the deep mine, and that the convergence of two sides obviously declined by excavating pocket in two sides, it can be still used in the entry with metal support, while maintenance of entry in deep mines is difficult, and can not be supported by bolt or bolt with wire mesh.
文摘To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： The blood pressure-decreasing effects of single administration and 14-day consecutive administration of Compound Mistletoe Fluidextract （CMF） in SHR and RHD were investigated and compared with that of Niuhuang Jiangya Wan （牛黄降压丸 Bezoar Hypertension-relieving Pills）. Results： Both single administration and 14-day consecutive administration of CMF had significant hypotensive effects in SHR and RHD. Conclusion： The hypotensive action of CMF is gradual, but lasts for a longer period, with a dose-effect relationship in a range of doses.
文摘Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.
基金Poly U(G-YBGQ G-SB81+3 种基金 G-YZ95)the Research Grant Council of Hong Kong(15101014)ITSP-Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/012/16GD)Shenzhen Basic Research Program(JCYJ20160331141459373)
文摘Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.
文摘Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,
基金Supported by National Basic Evidence-based Capacity Building Project of Traditional Chinese Medicine([2019]130)Natural Science Foundation of Liaoning Province:2024-MS-042+1 种基金Xingliao Talent Program Medical Master Project:YXMJ-QNMZY-10Liaoning University of Traditional Chinese Medicine Key Laboratory of Traditional Chinese Medicine Theory and Application of Ministry of Education open fund project:zyzx2302.
文摘Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through methods such as changing positions and manual pressing,but the efficacy is limited.Hence alternative therapies for sedation and analgesia in unsedated colonoscopy warrant further study.Electroacupuncture(EA)can simplify the procedure of anesthesia and analgesia,while the efficacy of EA on unsedated colonoscopy remains unclear.Therefore,a well-designed randomized controlled trial is needed to demonstrate the potential efficacy of acupuncture in unsedated colonoscopy,particularly for pain relief.Methods In this prospective randomized sham-controlled trial,105 eligible participants will be recruited and randomly assigned to either EA group(n=35),sham EA group(n=35),or control group(n=35)in a 1:1:1 ratio.The EA group will receive acupuncture intervention on bilateral Hegu(LI4),Neiguan(PC6),Zusanli(ST36),and Shenmen(HT7),with LI4 and PC6 on both sides connected to the EA device.The sham EA group will received non transdermal needling on points of no meridian,and deliberately connect the needle to the incorrect output socket of EA device to block the stimulation.The needling will conducted from 30 min before the unsedated colonoscopy to the end of the colonoscopy,the whole retention time would be approximately 40 min.The participants in the control group will not receive any acupuncture intervention.All participants of the three groups will not receive any other treatment.Primary outcomes:Numerical Rating Scale(NRS)reported by participants and Face Pain Scale Revised(FPS-R)evaluated by observers of four areas of the participants during the unsedated colonoscopy.Secondary outcomes:tolerance reported by endoscopists,tolerance reported by participants,satisfaction reported by endoscopists,satisfaction reported by participants,adverse events during the unsedated colonoscopy,postoperative discomfort,unsedated colonoscopy smoothness(cecal insertion time,unwinding time,success rate of one-time intubation).Both intention-to-treat(ITT)and per-protocol(PP)analyses will be performed to assess the efficacy of EA.Discussion The trial will explore the efficacy of relieving pain,improving tolerability,and reducing undesirable adverse events of EA for unsedated colonoscopy.The results of this trial will provide sound evidence for promoting the clinical application of EA for unsedated colonoscopy.Trial registration ClinicalTrials.gov Identifier:ChiCTR2300069903,retrospectively registered on March 16,2023.
基金supported by the National Natural Science Foundation of China General Program(82174377)National Traditional Chinese Medicine Advantageous Specialty Construction Project(GZY-ZY[2024]90).
文摘Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.
基金supported by the the National Key R&D Program of China(2022YFB3803500)the Natural Science Foundation of Hubei Province(2021CFA066).
文摘Micron-sized silicon(μSi)is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant reserves.However,the volume expansion that occurs during cycling leads to the accumulation of undesirable stresses,resulting in pulverization of silicon microparticles and shortened lifespan of the batteries.Herein,a composite film of Cu-PET-Cu is proposed as the current collector(CC)forμSi anodes to replace the conventional Cu CC.Cu-PET-Cu CC is prepared by depositing Cu on both sides of a polyethylene terephthalate(PET)film.The PET layer promises good ductility of the film,permitting the Cu-PET-Cu CC to accommodate the volumetric changes of silicon microparticles and facilitates the stress release through ductile deformation.As a result,theμSi electrode with Cu-PET-Cu CC retains a high specific capacity of 2181 mA h g^(-1),whereas theμSi electrode with Cu CC(μSi/Cu)exhibits a specific capacity of 1285 mA h g^(-1)after 80 cycles.The stress relieving effect of CuPET-Cu was demonstrated by in-situ fiber optic stress monitoring and multi-physics simulations.This work proposes an effective stress relief strategy at the electrode level for the practical implementation ofμSi anodes.
基金Priority Project of Tianjin Science Technical Commission (No. 05YFGDSF02200)Yan De-xin Foundation Project (No. 05-012)
文摘Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation） in treating patients with cardiac syndrome X （CSX）. Methods： The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment （32 patients）, and the control group treated with conventional treatment （19 patients） like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results： After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group （P〈0.05）; the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group （P〈0.05）. The treadmill exercise test showed that the maximal metabolic equivalent （Max MET）, the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively （P〈0.05）. Conclusion： The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.
基金Supported by the National Natural Science Foundation of China (No.30801495)
文摘Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group （778 ± 202 mm3, both P〈0.05）. The combination group had the highest tumor inhibition rate （47.7%）, followed by the hWRCP group （35.2%） and 5-FU group （28.3%）. The 5-FU group had a lower body weight increase （1.37± 2.06 g versus 5.60± 0.72 g, P〈0.05） and a lower spleen index （4.064 ± 1.774 rag/10 g versus 5.294 ± 1.796 mg/10 g） as compared with the control group, whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52 ± 1.80 g （P〈0.05） and spleen index of 7.036 ± 1.599 mg/10 g （P〈0.05）. The spleen indices in the hWRCP, mWRCP, and IWRCP group were all significantly higher than that in the 5-FU group （P〈0.01 or P〈0.05）. No significant differences in body weight change were observed in WRCP groups compared with the control group （P〉0.05）. Conclusioa： The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants. KEYWORDS breast cancer, warming and relieving cold phlegm formula, 5-fluorouracil, angiogenesis
文摘In the evaluation of Chinese berbs(A),ear-acupuncture(B) and epidural morphine(C) to relieve postoperative pain and abdominal distension,sixteen male patients with primary liver cancer were observed.This study was conducted by means of orthogonal experiment and double blind,randomized design.
文摘Synthesis technology and properties of cordierite from solid waste resources/Tan Qitong,Zhao Huizhong,Yu Jun,Zhang Han,Tan Liqiang//Naihuo Cailiao.-2024,58(3):185 Abstract:To effectively utilize solid waste resources and relieve resource constraints,cordierite refractory raw materials were prepared according to the chemical composition of cordierite,using 12 mass%fused magnesia dust powder,40 mass%fused corundum dust powder and 48 mass%quartz tailings as starting materials.
基金Supported by Special Project of National Clinical Research Base of TCM (No. JDZX2012140)Innovation Team Development Plan of the Ministry of Education (No. IRT1276)
文摘OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.
文摘The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the reduction of chlorophyll content, the accumulation of MDA(malondiadehyde) and the elevation of relative membrane penetrability (RMP). After adding 10 mg . L-1 La to the solution, the activities of SOD and CAT in the leaves of Hydrocharis dubia B L. Backer increases compared with those of the single treatment of Ni, while the activity of POD decreases. It reveals that la enhances the abilities of scavenging the activated oxygen in the plant and alleviates the damage to the membranes. The soluble protein content with Ni and La compound treatment is higher than that of single Ni does, and proline content is contrary to the soluble protein content. So La improves the resistance of Hydrocharis dubia B. L. Backer to the stress of Ni. However, La can aggravate the damage to the cells under the extremely high concentration of Ni treatment.
文摘The mechanical properties as well as microstructure of Cu-30.6 wt% Zn alloys containing 0.01 wt% lead has been investigated. The brass alloy was cast and then cold rolled at various percentage reductions: 20%, 25%, 30%, 35% and 40% followed by stress relieving annealed at 450℃. Hardness, ultimate tensile strength (UTS) and impact toughness values were evaluated at every stage of reduction. It was discovered that the strength, hardness and impact energy all increased with increased percentage reduction. Finally, the optical microscope of the samples was done and the result achieved correlated with the mechanical properties.
基金supported by the key project supported of Hainan Province(Grant No.ZDZX2013008)Natural Science Foundation of China(Grant No.2014 81403006)
文摘Objective:To study the effect of Alpinia officinarum Hance(A.officinarum) 80% alcohol extract on the primary dysmenorrhea.Methods:A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins.Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A.officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F_(2α)(PGF_(2α)),prostaglandin E_2(PGE_2) and Ca^(2+) in the uterus were observed in oxytocin-induced female mice.Results:The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A.officinarum 80% alcohol extract and the level of PGF_(2α),PGE_2 and Ca^(2+) in mice uterus was significantly decreased(P<0.05,P<0.01) in groups of mice treated with middle and high dosage of A.officinarum 80% alcohol extract compared with that of model group.Conclusions:These findings suggest that A.Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.
