BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotr...BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotrexate.CASE SUMMARY A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week.Due to widespread distribution and continuous enlargement,multimodal imaging of the lesions led to the diagnosis of RPC.Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide,but the progression was immediately terminated by a single dose of intravitreal methotrexate.A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate.CONCLUSION Systemic immunosuppressants should be given upon RPC diagnosis.Intravitreal methotrexate immediately halted progression and may be considered for sightthreatening cases as part of the initial therapy.展开更多
Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin's work schedule during the National Day holiday Ea month ago.From October 1 to 8,he maintaineda relentless pace,not just logging miles but a...Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin's work schedule during the National Day holiday Ea month ago.From October 1 to 8,he maintaineda relentless pace,not just logging miles but alsoswitching between roles.One moment,he was a regal emperor commanding the historic grounds of Xi'an,Shaanxi Province in northwest China.展开更多
基金the National Natural Science Foundation of China,No.81800847and the Tenth“Academic Star”project of Peking University People's Hospital,No.RS2018-05.
文摘BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotrexate.CASE SUMMARY A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week.Due to widespread distribution and continuous enlargement,multimodal imaging of the lesions led to the diagnosis of RPC.Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide,but the progression was immediately terminated by a single dose of intravitreal methotrexate.A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate.CONCLUSION Systemic immunosuppressants should be given upon RPC diagnosis.Intravitreal methotrexate immediately halted progression and may be considered for sightthreatening cases as part of the initial therapy.
文摘Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin's work schedule during the National Day holiday Ea month ago.From October 1 to 8,he maintaineda relentless pace,not just logging miles but alsoswitching between roles.One moment,he was a regal emperor commanding the historic grounds of Xi'an,Shaanxi Province in northwest China.
