Focused on the current situation,monitoring system,technical management regulation,process,system composition,and information publication of the earthquake information release,we summarized the construction and develo...Focused on the current situation,monitoring system,technical management regulation,process,system composition,and information publication of the earthquake information release,we summarized the construction and development of China’s earthquake information release system and expected its future.In general,China’s earthquake information release systems is able to publish auto-results with MS≥3.0 from 1 to 3 minutes,M_S≥6.0 in global from 2 to 30 minutes,and formal results with MS≥3.0 in China from 8 to 30 minutes,MS≥6.0 in global from 20 to 60 minutes.These earthquake information is released by various channels such as short message,website,microblog,mobile application,etc.展开更多
Binding and releasing ligands are critical for the biological functions of many proteins,so it is important to determine these highly dynamic processes.Although there are experimental techniques to determine the struc...Binding and releasing ligands are critical for the biological functions of many proteins,so it is important to determine these highly dynamic processes.Although there are experimental techniques to determine the structure of a protein-ligand complex,it only provides a static picture of the system.With the rapid increase of computing power and improved algorithms,molecular dynamics(MD)simulations have diverse of superiority in probing the binding and release process.However,it remains a great challenge to overcome the time and length scales when the system becomes large.This work presents an enhanced sampling tool for ligand binding and release,which is based on iterative multiple independent MD simulations guided by contacts formed between the ligand and the protein.From the simulation results on adenylate kinase,we observe the process of ligand binding and release while the conventional MD simulations at the same time scale cannot.展开更多
基金the Network Center Seismic Network Department daily operation and maintenance funding support(1950411001)
文摘Focused on the current situation,monitoring system,technical management regulation,process,system composition,and information publication of the earthquake information release,we summarized the construction and development of China’s earthquake information release system and expected its future.In general,China’s earthquake information release systems is able to publish auto-results with MS≥3.0 from 1 to 3 minutes,M_S≥6.0 in global from 2 to 30 minutes,and formal results with MS≥3.0 in China from 8 to 30 minutes,MS≥6.0 in global from 20 to 60 minutes.These earthquake information is released by various channels such as short message,website,microblog,mobile application,etc.
基金supported by the National Natural Science Foundation of China(No.91953101)the Strategic Priority Research Program of the Chinese Academy of Science(XDB37040202)the Hefei National Science Center Pilot Project Funds,and the New Concept Medical Research Fund of USTC。
文摘Binding and releasing ligands are critical for the biological functions of many proteins,so it is important to determine these highly dynamic processes.Although there are experimental techniques to determine the structure of a protein-ligand complex,it only provides a static picture of the system.With the rapid increase of computing power and improved algorithms,molecular dynamics(MD)simulations have diverse of superiority in probing the binding and release process.However,it remains a great challenge to overcome the time and length scales when the system becomes large.This work presents an enhanced sampling tool for ligand binding and release,which is based on iterative multiple independent MD simulations guided by contacts formed between the ligand and the protein.From the simulation results on adenylate kinase,we observe the process of ligand binding and release while the conventional MD simulations at the same time scale cannot.
