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On n-relator 3-manifolds Which Are Handlebodies
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作者 雷逢春 高大新 《Northeastern Mathematical Journal》 CSCD 2001年第1期53-56,共4页
Let H be a handlebody, J={J 1, …, J n} a collection of 2 sided pairwise disjoint simple closed curves on H. The 3 manifold obtained from H by attaching 2 handles to H along the curves in J is called an n re... Let H be a handlebody, J={J 1, …, J n} a collection of 2 sided pairwise disjoint simple closed curves on H. The 3 manifold obtained from H by attaching 2 handles to H along the curves in J is called an n relator 3 manifold, and is denoted as H J. In this paper, a sufficient and necessary condition for H J to be a handlebody is described. 展开更多
关键词 HANDLEBODY n relator 3 manifold
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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation 被引量:2
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作者 Yafan Bai Hui Ma +5 位作者 Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li 《Neural Regeneration Research》 SCIE CAS 2025年第8期2325-2336,共12页
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0... Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury. 展开更多
关键词 antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury
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Autophagy-targeting modulation to promote peripheral nerve regeneration 被引量:1
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作者 Yan Chen Hongxia Deng Nannan Zhang 《Neural Regeneration Research》 SCIE CAS 2025年第7期1864-1882,共19页
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat... Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulate axonal outgrowth and myelin regeneration.However,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic injuries.Consequently,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve regeneration.Our current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and inflammation.These actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve injuries.This review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this process.We hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies. 展开更多
关键词 AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration
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Coupling and Spatial Disparities of Regional Economy and Ecosystem in High-Quality Town Development 被引量:2
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作者 Xinyi Ren Xiaowen Tan +2 位作者 Dan Luo Rongxin Lu Chien-Chi Chu 《Research in Ecology》 2025年第1期15-29,共15页
This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expan... This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expansion with environmental protection,a comprehensive evaluation index system is constructed,encompassing two key dimensions:regional economy and ecological environment.Using panel data from 2013 to 2022,the coupling coordination degree model is employed to quantify the interactions and synergy between these dimensions.Additionally,spatial econometric methods are applied to calculate both global and local Moran’s Index,revealing spatial clustering patterns,regional disparities,and heterogeneity.The relative development model further identifies critical factors influencing regional coordination,with a focus on the lagging development of basic infrastructure and public services.The findings demonstrate a positive temporal trend toward improved regional coordination and reduced development gaps,with a spatial pattern characterized by higher coupling degrees in eastern and central regions compared to western areas.Based on these results,this study proposes actionable strategies to enhance coordinated development,emphasizing ecological conservation,the establishment of green production and consumption systems,ecological restoration,and strengthened municipal collaboration.This revised abstract emphasizes the study’s purpose,methods,and key findings more clearly while maintaining a professional and concise tone.Finally,based on the above analysis results,the corresponding coordinated development suggestions of regional economy and ecological environment are given from the aspects of ecological environment protection measures,green production and consumption system construction,ecological environment restoration and municipal coordination. 展开更多
关键词 Regional Economies Ecological Environment Coupling Coordination Degree Spatiotemporal Distribution Characteristics Relative Development Model
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Factors Influencing the Efficacy of Chinese Medicinals 被引量:1
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作者 Qichao Liang Yun Jiang +1 位作者 Liguo Liang Hualong Liang 《Chinese Medicine and Natural Products》 2025年第2期73-85,共13页
This paper thoroughly explores the multifaceted factors influencing the efficacy of Chinese medicinals and categorizes them into three main groups:medicinal related factors,patient related factors,and practitioner rel... This paper thoroughly explores the multifaceted factors influencing the efficacy of Chinese medicinals and categorizes them into three main groups:medicinal related factors,patient related factors,and practitioner related factors.Regarding medicinal related factors,the place of origin,growing environment,harvesting time,storage conditions,quality control,dosage form selection,compatibility of medicinals,precise dosing,decoction methods,and administration routes all significantly impact efficacy.The place of origin determines the authenticity of medicinals,the growing environment affects their composition,harvesting time influences potency,improper storage leads to deterioration,quality control forms the foundation of efficacy,dosage forms and compatibility of medicinals affect absorption,dosing and decoction methods require precision,and administration routes should be tailored to individuals.Patient related factors include psychological state,individual differences,background,and disease condition.Psychological state affects treatment compliance,individual differences determine medicine responses,background influences patients’understanding of Chinese medicinals,and disease condition directly reflects efficacy.Practitioner related factors encompass theoretical knowledge,clinical experience,inherited practices,psychological state,and professional ethics.Theoretical knowledge guides medication use,clinical experience enhances efficacy,inherited practices influence prescribing styles,psychological state affects doctor–patient communication,and professional ethics ensure medical quality.These interrelated factors collectively influence the efficacy of Chinese medicinals,emphasizing the need for comprehensive consideration in clinical applications to achieve optimal therapeutic outcomes. 展开更多
关键词 Chinese medicinals efficacy of Chinese medicinals influencing factors medicinal related factors patient related factors practitioner related factors authentic medicinal materials
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Seasonal population trend and relative occurrence of pests and their natural enemies among cotton species and cultivars in India 被引量:1
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作者 NAGRARE V.S. NAIKWADI Bhausaheb +4 位作者 FAND Babasaheb B. NAIK V.Chinna Babu TENGURI Prabhulinga GOKTE‑NARKHEDKAR Nandini WAGHMARE V.N. 《Journal of Cotton Research》 2025年第2期178-192,共15页
Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pest... Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers. 展开更多
关键词 COTTON PESTS Population trend Relative occurrence CULTIVARS Natural enemies
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Distribution,species richness,and relative importance of different plant life forms across drylands in China 被引量:1
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作者 Shuran Yao Weigang Hu +16 位作者 Mingfei Ji Abraham Allan Degen Qiajun Du Muhammad Adnan Akram Yuan Sun Ying Sun Yan Deng Longwei Dong Haiyang Gong Qingqing Hou Shubin Xie Xiaoting Wang Jinzhi Ran Bernhard Schmid Qinfeng Guo Karl J.Niklas Jianming Deng 《Plant Diversity》 2025年第2期273-281,共9页
Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen... Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale. 展开更多
关键词 DRYLANDS Environmental gradients Plant life forms Relative importance Species richness THRESHOLD
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Effective implementation of controlled blasting methodology during excavation of hard rock in the close proximity of earthen dam and tunnel 被引量:1
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作者 Prakash K.Palei Vijay K.Ghodake +5 位作者 S.Santhosh Kumar R.S.Gurjar Chaman Singh M.Meena Rizwan Ali R.S.Kankara 《Defence Technology(防务技术)》 2025年第6期306-316,共11页
The present technical paper outlines the details of the controlled blasting techniques used to optimize blasting pattern for excavation of hard rock near the Bhira Earthen Dam in Maharashtra,India.In this connection,a... The present technical paper outlines the details of the controlled blasting techniques used to optimize blasting pattern for excavation of hard rock near the Bhira Earthen Dam in Maharashtra,India.In this connection,a series of experimental blasts were conducted by adjusting various blast design parameters at project site.The safe charge weight per delay was kept between 0.125 and 0.375 kg.The outcomes of these experimental blasts were analyzed to recommend optimized blasting patterns and methods for the overall excavation process during actual blasting operations.Blast design parameters,including the maximum quantity of explosive per delay,hole depth,burden and spacing between holes were optimized by using a site-specific attenuation equation,taking into account the proximity of the dam and tunnel from the blasting area.Peak particle velocity(PPV)level of 10 mm/s and 50 mm/s respectively were adopted as the safe vibration level for ensuring safety of the Bhira Earthen Dam and the nearby tunnel from the adverse effects of blast vibrations by analyzing the dominant frequency of ground vibrations observed and also by reviewing various international standards.Frequency of the ground vibrations observed on the dam and tunnel from majority of the blasts was found to be more than 10 Hz and 50 Hz respectively.During the entire period of blasting,the blast vibrations were recorded to be far lower than the safe vibration level set for these structures.Maximum Vibration level of about 0.8 mm/s and 35 mm/s were observed on dam and tunnel respectively which are far lower than the safe vibration level adopted for these structures.Hence,the entire excavation work was completed successfully and safely,without endangering the safety of dam or tunnel. 展开更多
关键词 Controlled blasting Civil structure Ground vibration Attenuation relation
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Machine learning-based grayscale analyses for lithofacies identification of the Shahejie formation,Bohai Bay Basin,China 被引量:1
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作者 Yu-Fan Wang Shang Xu +4 位作者 Fang Hao Hui-Min Liu Qin-Hong Hu Ke-Lai Xi Dong Yang 《Petroleum Science》 2025年第1期42-54,共13页
It is of great significance to accurately and rapidly identify shale lithofacies in relation to the evaluation and prediction of sweet spots for shale oil and gas reservoirs.To address the problem of low resolution in... It is of great significance to accurately and rapidly identify shale lithofacies in relation to the evaluation and prediction of sweet spots for shale oil and gas reservoirs.To address the problem of low resolution in logging curves,this study establishes a grayscale-phase model based on high-resolution grayscale curves using clustering analysis algorithms for shale lithofacies identification,working with the Shahejie For-mation,Bohai Bay Basin,China.The grayscale phase is defined as the sum of absolute grayscale and relative amplitude as well as their features.The absolute grayscale is the absolute magnitude of the gray values and is utilized for evaluating the material composition(mineral composition+total organic carbon)of shale,while the relative amplitude is the difference between adjacent gray values and is used to identify the shale structure type.The research results show that the grayscale phase model can identify shale lithofacies well,and the accuracy and applicability of this model were verified by the fitting relationship between absolute grayscale and shale mineral composition,as well as corresponding re-lationships between relative amplitudes and laminae development in shales.Four lithofacies are iden-tified in the target layer of the study area:massive mixed shale,laminated mixed shale,massive calcareous shale and laminated calcareous shale.This method can not only effectively characterize the material composition of shale,but also numerically characterize the development degree of shale laminae,and solve the problem that difficult to identify millimeter-scale laminae based on logging curves,which can provide technical support for shale lithofacies identification,sweet spot evaluation and prediction of complex continental lacustrine basins. 展开更多
关键词 SHALE Machine learning Absolute grayscale Relative amplitude Grayscale phase model Lithofacies identification
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A model for predicting marine shale gas sweet spots based on relative sea-level changes and its application 被引量:1
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作者 Hongyan Wang Zhensheng Shi +2 位作者 Xi Yang Qun Zhao Changmin Guo 《Energy Geoscience》 2025年第2期142-154,共13页
Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sw... Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity. 展开更多
关键词 Shale gas Sweet spot Relative sea-level change Wufeng-longmaxi shale Southern sichuan basin
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Effects of discrete fracture networks on simulating hydraulic fracturing,induced seismicity and trending transition of relative modulus in coal seams 被引量:1
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作者 Xin Zhang Guangyao Si +3 位作者 Qingsheng Bai Joung Oh Biao Jiao Wu Cai 《International Journal of Coal Science & Technology》 2025年第1期263-278,共16页
Discrete fracture network(DFN)commonly existing in natural rock masses plays an important role in geological complexity which can influence rock fracturing behaviour during fluid injection.This paper simulated the hyd... Discrete fracture network(DFN)commonly existing in natural rock masses plays an important role in geological complexity which can influence rock fracturing behaviour during fluid injection.This paper simulated the hydraulic fracturing process in lab-scale coal samples with DFNs and the induced seismic activities by the discrete element method(DEM).The effects of DFNs on hydraulic fracturing,induced seismicity and elastic property changes have been concluded.Denser DFNs can comprehensively decrease the peak injection pressure and injection duration.The proportion of strong seismic events increases first and then decreases with increasing DFN density.In addition,the relative modulus of the rock mass is derived innovatively from breakdown pressure,breakdown fracture length and the related initiation time.Increasing DFN densities among large(35–60 degrees)and small(0–30 degrees)fracture dip angles show opposite evolution trends in relative modulus.The transitional point(dip angle)for the opposite trends is also proportionally affected by the friction angle of the rock mass.The modelling results have much practical meaning to infer the density and geometry of pre-existing fractures and the elastic property of rock mass in the field,simply based on the hydraulic fracturing and induced seismicity monitoring data. 展开更多
关键词 Discrete fracture network Hydraulic fracturing Discrete element method Induced seismicity Relative modulus
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New Features and New Challenges of U.S.-Europe Relations Under Trump 2.0 被引量:1
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作者 Zhao Huaipu 《Contemporary World》 2025年第3期47-52,共6页
During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 202... During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment. 展开更多
关键词 new features turbulent period Trump U S Europe relations presidential election new challenges UNCERTAINTIES transatlantic alliance
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Relative vacuum reduction innovative processes applied in primary magnesium production-Comprehensive analysis of thermodynamics,resource,energy flow,and carbon emission 被引量:1
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作者 Xiaolong Li Tingan Zhang +3 位作者 Yan Liu Junhua Guo Jingzhong Xu Yuanyuan Liang 《Journal of Magnesium and Alloys》 2025年第7期3134-3149,共16页
Magnesium and magnesium alloys,serving as crucial lightweight structural materials and hydrogen storage elements,find extensive applications in space technology,aviation,automotive,and magnesium-based hydrogen industr... Magnesium and magnesium alloys,serving as crucial lightweight structural materials and hydrogen storage elements,find extensive applications in space technology,aviation,automotive,and magnesium-based hydrogen industries.The global production of primary magnesium has reached approximately 1.2 million tons per year,with anticipated diversification in future applications and significant market demand.Nevertheless,approximately 80%of the world’s primary magnesium is still manufactured through the Pidgeon process,grappling with formidable issues including high energy consumption,massive carbon emission,significant resource depletion,and environmental pollution.The implementation of the relative vacuum method shows potential in breaking through technological challenges in the Pidgeon process,facilitating clean,low-carbon continuous magnesium smelting.This paper begins by introducing the principles of the relative vacuum method.Subsequently,it elucidates various innovative process routes,including relative vacuum ferrosilicon reduction,aluminum thermal reduction co-production of spinel,and aluminum thermal reduction co-production of calcium aluminate.Finally,and thermodynamic foundations of the relative vacuum,a quantitative analysis of the material,energy flows,carbon emission,and production cost for several new processes is conducted,comparing and analyzing them against the Pidgeon process.The study findings reveal that,with identical raw materials,the relative vacuum silicon thermal reduction process significantly decreases raw material consumption,energy consumption,and carbon dioxide emissions by 15.86%,30.89%,and 26.27%,respectively,compared to the Pidgeon process.The relative vacuum process,using magnesite as the raw material and aluminum as the reducing agent,has the lowest magnesium-to-feed ratio,at only 3.385.Additionally,its energy consumption and carbon dioxide emissions are the lowest,at 1.817 tce/t Mg and 7.782 t CO_(2)/t Mg,respectively.The energy consumption and carbon emissions of the relative vacuum magnesium smelting process co-producing calcium aluminate(12CaO·7Al_(2)O_(3),3CaO·Al_(2)O_(3),and CaO·Al_(2)O_(3))are highly correlated with the consumption of dolomite in the raw materials.When the reduction temperature is around 1473.15 K,the critical volume fraction of magnesium vapor for different processes varies within the range of 5%–40%.Production cost analysis shows that the relative vacuum primary magnesium smelting process has significant economic benefits.This paper offers essential data support and theoretical guidance for achieving energy efficiency,carbon reduction in magnesium smelting,and the industrial adoption of innovative processes. 展开更多
关键词 Magnesium smelting Relative vacuum reduction process THERMODYNAMICS Resource and energy flow Carbon emission
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Clinical efficacy and mechanism of Bletilla striata and Chinese herbal compounds in treatment of peptic ulcer 被引量:1
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作者 Yi-Tong Sun Fang Zhou +1 位作者 Hong-Xin Zheng Jing-Dong Xiao 《World Journal of Gastroenterology》 2025年第30期23-32,共10页
Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affec... Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use. 展开更多
关键词 Bletilla striata Related traditional Chinese medicine compound formulations Peptic ulcer Mechanism of action Clinical efficacy
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MiR-340-5p affects the proliferation and transfer of gastric cancer cells by targeting lncRNA HCG11 and NRF2 expression 被引量:1
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作者 Rina Su Wei Luan +3 位作者 Kai Zhang Shuai Liu Xiaoqing Zhang Yanwei Gao 《Oncology and Translational Medicine》 2025年第1期29-35,共7页
Objective:The aim of the study was to investigate the expression and biological role of nuclear factor erythroid–related factor 2(NRF2)in gastric cancer cells.Methods:Western blotting(WB)and reverse transcription-pol... Objective:The aim of the study was to investigate the expression and biological role of nuclear factor erythroid–related factor 2(NRF2)in gastric cancer cells.Methods:Western blotting(WB)and reverse transcription-polymerase chain reaction(RT-PCR)were used to detect the expression of NRF2 in the tumor tissues of patients with gastric cancer and MKN45 cells.NRF2 was transfected into MKN45 gastric cancer cells,and apoptosis was detected using flow cytometry.The 3-(4,5-dimethylthiazole-2-yl)-2.5-dipheny-tetrazolium bromide(MTT)assay was per-formed to detect cell proliferation.Transwell and scratch experiments were performed to detect cell invasion and migration rates.WB blot-ting was performed to detect Bcl-2,COX-2,PEG2,Bax,and Cyt-C protein expression.RT-PCR was used to detect Bcl-2,COX-2,PEG2,Bax,Cyt-C,miR-340-5p,lncRNA HCG11,and NRF2 mRNA expression.Results:NRF2 expression increased in gastric cancer tissues and in the MKN45 gastric cancer cell model.Compared with the blank group,the shNRF2 knockdown group showed a significant increase in the MKN45 gastric cancer cell apoptosis rate(p<0.05)and a sig-nificant decrease in invasion and migration rates(p<0.05).WB and RT-PCR showed that,in the shNRF2 knockdown group,Bcl-2 protein and mRNA,miR-340-5p,and lncRNA HCG11 expression was significantly increased,whereas COX-2,PEG2,Bax,and Cyt-C protein and mRNA expression was significantly reduced(p<0.05).In the NRF2 overexpression group,Bcl-2 protein and mRNA expression was sig-nificantly reduced,whereas COX-2,PEG2,Bax,and Cyt-C protein and mRNA expression was significantly increased(p<0.05).The op-posite was observed for the NRF2 overexpression group.When miR-340-5p mimics were transfected into MKN45 gastric cancer cells,NRF2 and HCG11 expression significantly reduced(p<0.05).When the miR-340-5p inhibitor was transfected into MKN45 gastric cancer cells,NRF2 and HCG11 expression significantly increased(p<0.05).Conclusions:The invasion,migration,abnormal proliferation,and apoptosis of MKN45 gastric cancer cells are closely related to an im-balance in NRF2 expression,suggesting that MiR-340-5p may target and regulate the lncRNA HCG11,thereby inhibiting NRF2 expression. 展开更多
关键词 Gastric cancer Nuclear factor erythroid 2 related factor 2(NRF2) Apoptosis COX-2/PEG 2 signaling pathway
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Statistical analysis on the validity of the cold plasma approximation for chorus waves based on Van Allen Probe observations and their effects on radiation belt electrons
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作者 AoJun Ren Jiang Yu +2 位作者 Jing Wang ZuZheng Chen XiaoMan Liu 《Earth and Planetary Physics》 EI CAS 2025年第1期159-170,共12页
Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric electrons.Previous ... Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric electrons.Previous quantitative analyses often simplified the chorus dispersion relation by using the cold plasma assumption.However,the applicability of the cold plasma assumption is doubtful,especially during geomagnetic disturbances.We here present a systematic statistical analysis on the validity of the cold plasma dispersion relation of chorus waves based on observations from the Van Allen Probes over the period from 2012 to 2018.The statistical results show that the observed magnetic field intensities deviate substantially from those calculated from the cold plasma dispersion relation and that they become more pronounced with an increase in geomagnetic activity or a decrease in background plasma density.The region with large deviations is mainly concentrated in the nightside and expands in both the radial and azimuthal directions as the geomagnetic activity increases or the background plasma density decreases.In addition,the bounce-averaged electron scattering rates are computed by using the observed and cold plasma dispersion relation of chorus waves.Compared with usage of the cold plasma dispersion relation,usage of the observed dispersion relation considerably lowers the minimum resonant energy of electrons and lowers the scattering rates of electrons above tens of kiloelectronvolts but enhances those below.Furthermore,these differences are more pronounced with the enhancement of geomagnetic activity or the decrease in background plasma density. 展开更多
关键词 chorus waves cold plasma approximation dispersion relations scattering rates
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Sino-British Scientific Interactions and the Early Development of China's Nuclear Industry
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作者 LIU Xiao SUN Yihong 《自然辩证法通讯》 北大核心 2025年第7期65-75,共11页
This study investigates the establishment of scientific links between the People's Republic of China(PRC)and the United Kingdom(UK)in the mid-2Oth century,focusing on the early development of China's nuclear i... This study investigates the establishment of scientific links between the People's Republic of China(PRC)and the United Kingdom(UK)in the mid-2Oth century,focusing on the early development of China's nuclear industry.Sino-British scientific interactions took place across multiple dimensions,involving various institutions and individuals.Around 1949,UK-trained Chinese nuclear scientists returned to China,bringing advanced technological knowledge and extensive practical experience.The PRC regarded the UK as a crucial gateway to overcoming the technological blockade imposed by the United States(and later the Soviet Union)and sought to establish scientific relations with the UK through semi-official and unofficial channels.Specifically,these connections manifested in the interactions between the Chinese Academy of Sciences(CAS)and the Royal Society of London,the guiding role of the Chinese Charge d'Affaires Office in London in facilitating scientific and technological exchanges,and the technology investigations led by the Ministry of Foreign Trade in the name of trade.Additionally,the Sino-British scientific network extended to the international arena,allowing China to engage in nuclear-related global organizations and events.This study highlights the significant British influence on the early development of China's nuclear industry,revealing the extent of its British influence.It argues that China's urgent need for nuclear science and industrial advancement was a key driver of its scientific engagement withthe UK. 展开更多
关键词 Sino-British relations Scientific interactions Nuclear industry Cold War
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The Ordering of Unicyclic Graphs with Minimal Matching Energies
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作者 DONG Bo LI Huan WANG Ligong 《数学进展》 北大核心 2025年第5期951-972,共22页
The concept of matching energy was proposed by Gutman and Wagner firstly in 2012. Let G be a simple graph of order n and λ1, λ2, . . . , λn be the zeros of its matching polynomial. The matching energy of a graph G ... The concept of matching energy was proposed by Gutman and Wagner firstly in 2012. Let G be a simple graph of order n and λ1, λ2, . . . , λn be the zeros of its matching polynomial. The matching energy of a graph G is defined as ME(G) = Pni=1 |λi|. By the famous Coulson’s formula, matching energies can also be calculated by an improper integral depending on a parameter. A k-claw attaching graph Gu(k) refers to the graph obtained by attaching k pendent edges to the graph G at the vertex u, where u is called the root of Gu(k). In this paper, we use some theories of mathematical analysis to obtain a new technique to compare the matching energies of two k-claw attaching graphs Gu(k) and Hv(k) with the same order, that is, limk→∞[ME(Gu(k)) − ME(Hv(k))] = ME(G − u) − ME(H − v). By the technique, we finally determine unicyclic graphs of order n with the 9th to 13th minimal matching energies for all n ≥ 58. 展开更多
关键词 matching energy unicyclic graph quasi-order relation k-claw attaching graph
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海外英文期刊中国共产党研究成果题录(2018年)
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作者 王野(整理) 《国外理论动态》 北大核心 2025年第4期F0003-F0003,共1页
1.X.Zhang,M.S.Brown and D.0'Brien,"‘No CCP,No New China’:Pastoral Power in Official Narratives in China",The China Quarterly,Vol.235,2018,pp.784-803.2.L.Yang,"China's Think Tank Fever:Changing... 1.X.Zhang,M.S.Brown and D.0'Brien,"‘No CCP,No New China’:Pastoral Power in Official Narratives in China",The China Quarterly,Vol.235,2018,pp.784-803.2.L.Yang,"China's Think Tank Fever:Changing Relations between the Communist Party of China and Intellectuals".China:An International Journal,Vol.16,No.2.2018,pp.12-30. 展开更多
关键词 official narratives Communist Party China relations intellectuals pastoral power
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High-brightness and Monodisperse Quaternary CuInZnS@ZnS Quantum Dots with Tunable and Long-lived Emission
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作者 CHEN Zi ZHANG Aidi +5 位作者 GONG Ke LIU Haihua YU Gang SHAN Qingsong LIU Yong ZENG Haibo 《无机材料学报》 北大核心 2025年第4期433-439,I0017-I0021,共12页
As an essential candidate for environment-friendly luminescent quantum dots(QDs),CuInS-based QDs have attracted more attention in recent years.However,several drawbacks still hamper their industrial applications,such ... As an essential candidate for environment-friendly luminescent quantum dots(QDs),CuInS-based QDs have attracted more attention in recent years.However,several drawbacks still hamper their industrial applications,such as lower photoluminescence quantum yield(PLQY),complex synthetic pathways,uncontrollable emission spectra,and insufficient photostability.In this study,CuInZnS@ZnS core/shell QDs was prepared via a one-pot/three-step synthetic scheme with accurate and tunable control of PL spectra.Then their ensemble spectroscopic properties during nucleation formation,alloying,and ZnS shell growth processes were systematically investigated.PL peaks of these QDs can be precisely manipulated from 530 to 850 nm by controlling the stoichiometric ratio of Cu/In,Zn^(2+)doping and ZnS shell growth.In particular,CuInZnS@ZnS QDs possess a significantly long emission lifetime(up to 750 ns),high PLQY(up to 85%),and excellent crystallinity.Their spectroscopic evolution is well validated by Cu-deficient related intragap emission model.By controlling the stoichiometric ratio of Cu/In,two distinct Cu-deficient related emission pathways are established based on the differing oxidation states of Cu defects.Therefore,this work provides deeper insights for fabricating high luminescent ternary or quaternary-alloyed QDs. 展开更多
关键词 quantum dot CuInS ALLOYING core/shell ensemble spectroscopic Cu-deficient related emission
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