A family of one-dimensional(1D) elliptic boundary-value problems with periodic and rapidly-oscillating piecewise-smooth coefficients is considered. The coefficients depend on the local or fast variables corresponding ...A family of one-dimensional(1D) elliptic boundary-value problems with periodic and rapidly-oscillating piecewise-smooth coefficients is considered. The coefficients depend on the local or fast variables corresponding to two different structural scales. A finite number of imperfect contact conditions are analyzed at each of the scales. The reiterated homogenization method(RHM) is used to construct a formal asymptotic solution. The homogenized problem, the local problems, and the corresponding effective coefficients are obtained. A variational formulation is derived to obtain an estimate to prove the proximity between the solutions of the original problem and the homogenized problem. Numerical computations are used to illustrate both the convergence of the solutions and the gain of the effective properties of a three-scale heterogeneous 1D laminate with respect to their two-scale counterparts. The theoretical and practical ideas exposed here could be used to mathematically model multidimensional problems involving multiscale composite materials with imperfect contact at the interfaces.展开更多
The authors study homogenization of some nonlinear partial differential equations of the form -div (?(hx, h2x,Duh)) =f, where a is periodic in the first two arguments and monotone in the third. In particular the case ...The authors study homogenization of some nonlinear partial differential equations of the form -div (?(hx, h2x,Duh)) =f, where a is periodic in the first two arguments and monotone in the third. In particular the case where a satisfies degenerated structure conditions is studied. It is proved that uh converges weakly in W01,1 (?) to the unique solution of a limit problem as h ? '. Moreover, explicit expressions for the limit problem are obtained.展开更多
Cilia are indispensable for organ development and function,and their dysfunction causes a range of syndromic diseases known as ciliopathies,including obesity,cystic kidney disease,situs inversus,and male infertility(R...Cilia are indispensable for organ development and function,and their dysfunction causes a range of syndromic diseases known as ciliopathies,including obesity,cystic kidney disease,situs inversus,and male infertility(Reiter and Leroux,2017;Wallmeier et al.,2020).To date,over 180 ciliopathy-associated genes have been identified(Reiter and Leroux,2017),yet the underlying mechanisms remain poorly understood.展开更多
基金Project supported by the Desenvolvimento e Aplicaoes de Mtodos Matemticos de Homogeneizaao(CAPES)(No.88881.030424/2013-01)the Homogeneizao Reiterada Aplicada a Meios Dependentes de Múltiplas Escalas con Contato Imperfeito Entre as Fases(CNPq)(Nos.450892/2016-6and 303208/2014-7)the Caracterizacin de Propiedades Efectivas de Tejidos Biolgicos Sanos y Cancerosos(CONACYT)(No.2016–01–3212)
文摘A family of one-dimensional(1D) elliptic boundary-value problems with periodic and rapidly-oscillating piecewise-smooth coefficients is considered. The coefficients depend on the local or fast variables corresponding to two different structural scales. A finite number of imperfect contact conditions are analyzed at each of the scales. The reiterated homogenization method(RHM) is used to construct a formal asymptotic solution. The homogenized problem, the local problems, and the corresponding effective coefficients are obtained. A variational formulation is derived to obtain an estimate to prove the proximity between the solutions of the original problem and the homogenized problem. Numerical computations are used to illustrate both the convergence of the solutions and the gain of the effective properties of a three-scale heterogeneous 1D laminate with respect to their two-scale counterparts. The theoretical and practical ideas exposed here could be used to mathematically model multidimensional problems involving multiscale composite materials with imperfect contact at the interfaces.
文摘The authors study homogenization of some nonlinear partial differential equations of the form -div (?(hx, h2x,Duh)) =f, where a is periodic in the first two arguments and monotone in the third. In particular the case where a satisfies degenerated structure conditions is studied. It is proved that uh converges weakly in W01,1 (?) to the unique solution of a limit problem as h ? '. Moreover, explicit expressions for the limit problem are obtained.
基金supported by grants from the National Key Research and Development Program of China(2019YFA0802704)the National Natural Science Foundation of China(31771620)+2 种基金the Natural Science Foundation of Chongqing,China(CSTB2022NSCQMSX1424)Research Startup Fund of Southwest University(SWU117064)Open Research Fund of National Health Commission Key Laboratory of Birth Defects Prevention&Henan Key Laboratory of Population Defects Prevention(ZD202302)。
文摘Cilia are indispensable for organ development and function,and their dysfunction causes a range of syndromic diseases known as ciliopathies,including obesity,cystic kidney disease,situs inversus,and male infertility(Reiter and Leroux,2017;Wallmeier et al.,2020).To date,over 180 ciliopathy-associated genes have been identified(Reiter and Leroux,2017),yet the underlying mechanisms remain poorly understood.
