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Potential mechanisms of non-coding RNA regulation in Alzheimer's disease 被引量:1
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作者 Yue Sun Xinping Pang +5 位作者 Xudong Huang Dinglu Liu Jingyue Huang Pengtao Zheng Yanyu Wei Chaoyang Pang 《Neural Regeneration Research》 2026年第1期265-280,共16页
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica... Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies. 展开更多
关键词 Alzheimer's disease biomarkers circular RNA long non-coding RNA MICRORNA ncRNA regulation NEURODEGENERATION non-coding RNA PATHOGENESIS therapeutic targets
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Emotion regulation habits and emotional states of college students during lockdown:A cross-sectional survey
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作者 Shu-Xin Zhao Tao Han +7 位作者 Wei-Zhi Bi Le-Le Fei Lu-Luan Han Yu-Lin Wang Zhi-Guang Ping Chong-Jian Wang Chang-Fu Hao Yong-Juan Xin 《World Journal of Psychiatry》 2026年第1期244-255,共12页
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ... BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation. 展开更多
关键词 Emotional states Emotion regulation habits College students Coronavirus disease 2019 Lockdown PREVALENCE
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Recent Advances in Regulation Strategy and Catalytic Mechanism of Bi-Based Catalysts for CO_(2) Reduction Reaction
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作者 Jianglong Liu Yunpeng Liu +5 位作者 Shunzheng Zhao Baotong Chen Guang Mo Zhongjun Chen Yuechang Wei Zhonghua Wu 《Nano-Micro Letters》 2026年第1期647-697,共51页
Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespr... Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application. 展开更多
关键词 Bismuth-based catalysts CO_(2)reduction reaction regulation strategy Catalytic mechanism REVIEW
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Ethical and legal risks with hierarchical regulation of artificial intelligence in China’s medical field
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作者 Xin Xing Hao Qiu 《History and Philosophy of Medicine》 2026年第1期22-31,共10页
Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de... Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management. 展开更多
关键词 medical artificial intelligence ethical risks legal risks legal layered regulation
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Cell Phf8[ˈfeɪt]control:Epigenetic regulation during oligodendroglial development
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作者 Marco Kremp Michael Wegner 《Neural Regeneration Research》 2026年第3期1110-1111,共2页
Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a... Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli. 展开更多
关键词 insulating neuronal axons myelinating glial cells neural stem cells oligodendroglial development progenitor cells opcs emerge CELL epigenetic regulation saltatory conduction action potentialsduring
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Retraction:Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA
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作者 Oncology Research Editorial Office 《Oncology Research》 2025年第4期991-991,共1页
The published article titled“Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA”has been retracted from Oncology Research,... The published article titled“Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA”has been retracted from Oncology Research,Vol.26,No.2,2018,pp.209–217. 展开更多
关键词 RHOA PROCAINE colon cancer cells erk mapk fak pathways regulation rhoa migration PROLIFERATION regulation
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The reforms in the field of technical regulation and standardization in Uzbekistan
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作者 Umid Shodjalilov 《China Standardization》 2025年第5期44-44,共1页
Uzbekistan Institute of Standards(UIS),founded in 1969,is the national standardization body of Uzbekistan.There are over 32,000 national standards in Uzbekistan.Last year,UIS revised the working regulations of all tec... Uzbekistan Institute of Standards(UIS),founded in 1969,is the national standardization body of Uzbekistan.There are over 32,000 national standards in Uzbekistan.Last year,UIS revised the working regulations of all technical committees,which were established in accordance with the organizational structure of ISO.At present,UIS has standardization training courses covering 54 directions,and more than 1,700 experts have received relevant training.UIS ranks the 95th in terms of the Quality Infrastructure for Sustainable Development(QI4SD)and 80th in terms of the Global Quality Infrastructure Index(GQII).It is a member of ISO and an associate member of IEC.In the UIS,40 experts have participated in the activities of various ISO technical committees,and 251 experts have participated in the discussion of IEC projects as observer members. 展开更多
关键词 quality infrastructure technical committees national standards ISO Uzbekistan Institute Standards STANDARDIZATION technical regulation revised working regulations
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Adopting Inclusive Legal Regulation for Digital Finance in the Context of Generative AI
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作者 Zeng Wenge Ren Tingyu 《Contemporary Social Sciences》 2025年第1期120-141,共22页
Driven by the dual forces of China’s financial powerhouse strategy and advancements in artificial intelligence,digital finance has experienced rapid growth,rendering traditional financial legal regulations inadequate... Driven by the dual forces of China’s financial powerhouse strategy and advancements in artificial intelligence,digital finance has experienced rapid growth,rendering traditional financial legal regulations inadequate to meet its regulatory demands.Key challenges include lagging legislative regulation,limited applicability of the standard regulations,and diminished effectiveness of the supervisory regulations.These challenges stem from the“single-entity”regulatory approach which is inadequate to meet its regulatory needs of mixed operations of digital finance,the misalignment between“static”administrative regulations and the dynamic evolution of financial technology(fintech),and the uneven allocation of regulatory resources,which constrain regulatory precision.To achieve a dynamic balance between the development of digital finance and its regulation,the adoption of inclusive legal regulation is imperative.The technological empowerment theory integrates the principles of finance with the“people-centered”concept and the social good,which thereby safeguards the rights and interests of digital finance consumers.As a pivotal standard for shaping inclusive legal regulation,digital justice should not only uphold fairness in the regulation of processes but also advance the organic integration of scenario-based justice and the principles of Law 3.0.In the future,China should foster multi-stakeholder collaborative governance to ensure the orderly allocation of the regulators’power.This effort should be supported by a comprehensive toolkit of technological regulations,which can dynamically balance incentive regulation with binding regulation while simultaneously enabling the efficient flow of regulatory resources within specific application scenarios.Such strategies would provide a viable pathway toward the goal of achieving inclusive legal regulation in digital finance. 展开更多
关键词 generative artificial intelligence digital finance financial regulation inclusive legal regulation financial powerhouse
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Distributed Cooperative Regulation for Networked Re-Entrant Manufacturing Systems
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作者 Chenguang Liu Qing Gao +1 位作者 Wei Wang Jinhu Lü 《IEEE/CAA Journal of Automatica Sinica》 2025年第3期636-638,共3页
Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the p... Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation. 展开更多
关键词 production line networked re entrant manufacturing systems three tier architecture production linethe distributed cooperative regulation hyperbolic partial differential equations pdes based distributed cooperative regulation problem manufacturing layer
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Is Meeting 24-Hour Movement Guidelines Associated with Emotion Regulation among Children and Adolescents?
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作者 Shanshan Xu Liang Hu 《International Journal of Mental Health Promotion》 2025年第6期771-785,共15页
Background:The Canadian 24-h movement guidelines(24-HMG)emphasize the holistic consideration of physical activity(PA),sedentary behavior,and sleep in shaping health outcomes.This study aimed to examine the association... Background:The Canadian 24-h movement guidelines(24-HMG)emphasize the holistic consideration of physical activity(PA),sedentary behavior,and sleep in shaping health outcomes.This study aimed to examine the associations between meeting 24-HMG and emotion regulation-related indicators among children and adolescents.Methods:A total of 534 Chinese children and adolescents aged 12.94±1.10 years(49.81%males)participated in this study and completed self-report measures assessing 24-h movement behaviors,emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Results:Only 7.12% of theparticipants adhered to two or all three guidelines.The number of guidelines met was positively associated with the use of emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Compared with meeting none of the guidelines,participants whomet one ormore guidelines reported significantly better performance in these outcomes.Conclusion:Meeting 24-HMG was associated with superior emotion regulation in children and adolescents.The importance of engaging in regular PA,limiting recreational screen time,and getting enough sleep should be highlighted for fostering emotion regulation in this demographic. 展开更多
关键词 24-hour movement guidelines emotion regulation strategies emotion regulation flexibility regulatory emotional self-efficacy
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Research progress of structural regulation and composition optimization to strengthen absorbing mechanism in emerging composites for efficient electromagnetic protection 被引量:4
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作者 Pengfei Yin Di Lan +7 位作者 Changfang Lu Zirui Jia Ailing Feng Panbo Liu Xuetao Shi Hua Guo Guanglei Wu Jian Wang 《Journal of Materials Science & Technology》 2025年第1期204-223,共20页
With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electro... With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electronic instruments.Therefore,the design and preparation of electromagnetic absorbing composites represent an efficient approach to mitigate the current hazards of electromagnetic radiation.However,traditional electromagnetic absorbers are difficult to satisfy the demands of actual utilization in the face of new challenges,and emerging absorbents have garnered increasing attention due to their structure and performance-based advantages.In this review,several emerging composites of Mxene-based,biochar-based,chiral,and heat-resisting are discussed in detail,including their synthetic strategy,structural superiority and regulation method,and final optimization of electromagnetic absorption ca-pacity.These insights provide a comprehensive reference for the future development of new-generation electromagnetic-wave absorption composites.Moreover,the potential development directions of these emerging absorbers have been proposed as well. 展开更多
关键词 Microwave absorption Structural regulation Performance optimization Emerging composites Synthetic strategy
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Regulation of chlorophyll and carotenoid metabolism in citrus fruit 被引量:2
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作者 Yingxiao Lu Xinchen Shen +7 位作者 Yuche Li Yanna Xu Yuhan Chen Yishan Chen Xiaoli Hu Xiaolong Li Xuepeng Sun Jinli Gong 《Horticultural Plant Journal》 2025年第3期951-962,共12页
Chlorophyll degradation and carotenoid accumulation are essential processes of fruit maturation in many horticultural plants,and play a crucial role in fruit color and quality.The pathways of chlorophyll and carotenoi... Chlorophyll degradation and carotenoid accumulation are essential processes of fruit maturation in many horticultural plants,and play a crucial role in fruit color and quality.The pathways of chlorophyll and carotenoid biosynthesis and degradation are well understood,and key regulatory genes controlling these pathways have been identified in citrus.This article reviewed the recent research on chlorophyll and carotenoid metabolism in citrus fruits,encompassing the metabolic pathways,transcriptional regulation,influencing factors,and the interplay between chlorophyll and carotenoid metabolism,aiming to provide insights into the molecular regulatory mechanisms governing the coloration of citrus fruits. 展开更多
关键词 Citrus fruit CAROTENOID CHLOROPHYLL regulation PLASTID
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Regulation mechanism of active magnesium oxide on precipitation of lanthanum hydroxide 被引量:1
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作者 Jianwei Zhao Haiqing Hao +4 位作者 Yanyan Zhao Meng Wang Xu Sun Zongyu Feng Xiaowei Huang 《Journal of Rare Earths》 2025年第6期1264-1271,I0007,共9页
Precipitation is often used for the preparation of La(OH)_(3)with precipitants of liquid alkali and ammonia.To solve the problems of high cost and wastewater pollution caused by common precipitants,the active MgO synt... Precipitation is often used for the preparation of La(OH)_(3)with precipitants of liquid alkali and ammonia.To solve the problems of high cost and wastewater pollution caused by common precipitants,the active MgO synthesized by pyrolysis was used as the precipitant to prepare La(OH)_(3).The species distribution of LaCl_(3)and LaCl_(3)-MgCl_(2)mixed system solution was calculated,and the kinetic analysis of the precipi-tation process was carried out to confirm the key factors influencing the precipitation of La(OH)_(3).The results show that La(OH)_(3)with D_(50)of 5.57μm,a specific surface area of 25.70 m^(2)/g,a rod-like shape,and MgO content of 0.044 wt%,was successfully prepared by adding active MgO.The precipitation ratio of La reaches 99.92%.The La(OH)_(3)precipitation is controlled by the diffusion process.The activity of MgO has a significant influence on MgO content in the precipitate.The preparation of La(OH)_(3)by active MgO provides a potential way for an eco-friendly preparation method of rare earth. 展开更多
关键词 Active magnesium oxide PRECIPITATION Lanthanum hydroxide regulation Rare earths
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Co-regulation effect of solvation and interface of pyridine derivative enabling highly reversible zinc anode 被引量:1
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作者 Binrui Xu Guangbin Wang +3 位作者 Yong Liu Quanan Li Fengzhang Ren Jianmin Ma 《Journal of Materials Science & Technology》 2025年第1期1-9,共9页
The poor reversibility and stability of Zn anodes greatly restrict the practical application of aqueous Zn-ion batteries(AZIBs),resulting from the uncontrollable dendrite growth and H_(2)O-induced side reactions durin... The poor reversibility and stability of Zn anodes greatly restrict the practical application of aqueous Zn-ion batteries(AZIBs),resulting from the uncontrollable dendrite growth and H_(2)O-induced side reactions during cycling.Electrolyte additive modification is considered one of the most effective and simplest methods for solving the aforementioned problems.Herein,the pyridine derivatives(PD)including 2,4-dihydroxypyridine(2,4-DHP),2,3-dihydroxypyridine(2,3-DHP),and 2-hydroxypyrdine(2-DHP),were em-ployed as novel electrolyte additives in ZnSO_(4)electrolyte.Both density functional theory calculation and experimental findings demonstrated that the incorporation of PD additives into the electrolyte effectively modulates the solvation structure of hydrated Zn ions,thereby suppressing side reactions in AZIBs.Ad-ditionally,the adsorption of PD molecules on the zinc anode surface contributed to uniform Zn deposi-tion and dendrite growth inhibition.Consequently,a 2,4-DHP-modified Zn/Zn symmetrical cell achieved an extremely long cyclic stability up to 5650 h at 1 mA cm^(-2).Furthermore,the Zn/NH_(4)V_(4)O_(10)full cell with 2,4-DHP-containing electrolyte exhibited an outstanding initial capacity of 204 mAh g^(-1),with a no-table capacity retention of 79%after 1000 cycles at 5 A g^(-1).Hence,this study expands the selection of electrolyte additives for AZIBs,and the working mechanism of PD additives provides new insights for electrolyte modification enabling highly reversible zinc anode. 展开更多
关键词 Zn anode Pyridine derivative Electrolyte additive Solvation regulation Interface modification
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Modeling and control of automatic voltage regulation for a hydropower plant using advanced model predictive control 被引量:1
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作者 Ebunle Akupan Rene Willy Stephen Tounsi Fokui 《Global Energy Interconnection》 2025年第2期269-285,共17页
Fluctuating voltage levels in power grids necessitate automatic voltage regulators(AVRs)to ensure stability.This study examined the modeling and control of AVR in hydroelectric power plants using model predictive cont... Fluctuating voltage levels in power grids necessitate automatic voltage regulators(AVRs)to ensure stability.This study examined the modeling and control of AVR in hydroelectric power plants using model predictive control(MPC),which utilizes an extensive mathe-matical model of the voltage regulation system to optimize the control actions over a defined prediction horizon.This predictive feature enables MPC to minimize voltage deviations while accounting for operational constraints,thereby improving stability and performance under dynamic conditions.Thefindings were compared with those derived from an optimal proportional integral derivative(PID)con-troller designed using the artificial bee colony(ABC)algorithm.Although the ABC-PID method adjusts the PID parameters based on historical data,it may be difficult to adapt to real-time changes in system dynamics under constraints.Comprehensive simulations assessed both frameworks,emphasizing performance metrics such as disturbance rejection,response to load changes,and resilience to uncertainties.The results show that both MPC and ABC-PID methods effectively achieved accurate voltage regulation;however,MPC excelled in controlling overshoot and settling time—recording 0.0%and 0.25 s,respectively.This demonstrates greater robustness compared to conventional control methods that optimize PID parameters based on performance criteria derived from actual system behavior,which exhibited settling times and overshoots exceeding 0.41 s and 5.0%,respectively.The controllers were implemented using MATLAB/Simulink software,indicating a significant advancement for power plant engineers pursuing state-of-the-art automatic voltage regulations. 展开更多
关键词 Automatic voltage regulation Artificial bee colony Evolutionary techniques Model predictive control PID controller HYDROPOWER
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Effects on the receptivity of thin endometrium treated with acupuncture therapy for menstruation regulation and pregnancy promotion:A pragmatic randomized controlled exploratory study 被引量:1
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作者 Chen-si ZHENG Hui-sheng YANG +2 位作者 Ming-zhao HAO Si-yu LIU Yi-gong FANG 《World Journal of Acupuncture-Moxibustion》 2025年第1期50-57,共8页
Objective:This study aimed to explore the clinical effect of acupuncture therapy for menstruation regu-lation and pregnancy promotion on thin endometrium in the real world.Design:This study is a single-center pragmati... Objective:This study aimed to explore the clinical effect of acupuncture therapy for menstruation regu-lation and pregnancy promotion on thin endometrium in the real world.Design:This study is a single-center pragmatic randomized controlled trial blinded to the statisticians.Using the“blockrand”software package,based on the age(≥35,<35),37 patients were randomized into an intervention group(19 cases)and a control group(18 cases).After reassignment regarding patient preference,21 patients were included in the intervention group and 16 in the control group.Setting:The trial was executed in the Specialty Outpatient Clinic,Acupuncture-Moxibustion Hospital of China Academy of Chinese Medical Sciences,from March 1,2019,to September 30,2020.Participants:The study included 37 patients with thin endometrium and without previous acupuncture treatment.Intervention:The intervention group was administered acupuncture for menstruation regulation and pregnancy promotion and a small-dose of progynova(2 mg daily),while the control group was adminis-tered a large-dose of progynova(4 mg daily).Interventions started from Day 5 of menstruation until the end of ovulation under B-ultrasound monitoring.The intervention lasted for three menstrual cycles.Measurements:Primary outcomes were changes in endometrial thickness between baseline and after intervention completion and the difference between the two groups after intervention.The secondary outcomes were endometrial and subendometrial blood flow,serum estradiol levels,menstrual conditions,and adverse reactions.Results:(1)Comparison of each indicator before and after intervention completion in the two groups:in the intervention group,the differences were significant in endometrial thickness,menstrual score,estra-diol(E2)level in ovulatory period,the pulsatility index(PI)and resistance index(RI)of uterine artery,the ratio of peak systolic velocity to end-diastolic velocity(S/D),the endometrial vascular index(VI),flow index(FI),and vascular flow index(VFI)and volume(P<0.01).In the control group,significant changes were observed in endometrial thickness,menstrual score,and E2 before and after the interven-tion(P<0.05),and no differences were observed in uterine artery PI,RI,S/D and endometrial VI,FI,VFI,and volume(P>0.05).Compared with the control group,the intervention group showed significant differences in endometrial thickness,menstrual score,E2,uterine artery PI,RI,S/D,and endometrial VI,FI,VFI,and volume after intervention(P<0.01).No adverse reactions were reported in the intervention group.In contrast,the control group had two cases of nausea and gastrointestinal discomfort after med-ication,eight cases of breast distention during medication,and one case of breast nodules enlarged by 1 cm after trial completion. 展开更多
关键词 RECEPTIVITY Thin endometrium Acupuncture Menstruation regulation and pregnancy promotion
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Doubly-Fed Pumped Storage Units Participation in Frequency Regulation Control Strategy for New Energy Power Systems Based on Model Predictive Control 被引量:1
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作者 Yuanxiang Luo Linshu Cai Nan Zhang 《Energy Engineering》 2025年第2期765-783,共19页
Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluct... Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system. 展开更多
关键词 Doubly-fed pumped storage unit model predictive control proportional-differential control link frequency regulation
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Compartmentalized regulation of organelle integrity in neurodegenerative diseases:lessons from the Drosophila motor neuron
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作者 Hyun Sung 《Neural Regeneration Research》 SCIE CAS 2025年第1期195-196,共2页
Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell body.For this reason,their maintenance relies on spatiotemporal regulati... Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell body.For this reason,their maintenance relies on spatiotemporal regulation of organelle distribution between the somatodendritic and axonal domains.Although some organelles,such as mitochondria and smooth endoplasmic reticulum,are widely distributed throughout the neuron,others are segregated to either the somatodendritic or axonal compartment.For example,Golgi outposts and acidified lysosomes are predominantly present in the somatodendritic domain and rarely distributed along the axon,whereas newly formed autophagosomes and synaptic vesicles are mainly distributed in the distal axon(Britt et al.,2016). 展开更多
关键词 ORGANELLE regulation DISTRIBUTION
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Multi-Stage Voltage Control Optimization Strategy for Distribution Networks Considering Active-Reactive Co-Regulation of Electric Vehicles
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作者 Shukang Lyu Fei Zeng +3 位作者 Huachun Han Huiyu Miao Yi Pan Xiaodong Yuan 《Energy Engineering》 EI 2025年第1期221-242,共22页
The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the exis... The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution network.Firstly,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are established.Additionally,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the EVcharger.Amultiobjective optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy consumption.Then,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time scales.Themulti-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control optimization.Simulation results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution network.It effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network. 展开更多
关键词 Electric vehicle(EV) distribution network multi-stage optimization active-reactive power regulation voltage control
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Structure Regulation Engineering for Biomass-Derived Carbon Anodes Enabling High-Rate Dual-Ion Batteries
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作者 Rui Zhou Rui Liu +4 位作者 Yun-Nuo Li Si-Jie Jiang Tian-Tian Jing Yan-Song Xu Fei-Fei Cao 《电化学(中英文)》 北大核心 2025年第8期34-43,共10页
Dual-ion batteries(DIBs)usually use carbon-based materials as electrodes,showing advantages in high operating volt-age,potential low cost,and environmental friendliness.Different from conventional“rocking chair”type... Dual-ion batteries(DIBs)usually use carbon-based materials as electrodes,showing advantages in high operating volt-age,potential low cost,and environmental friendliness.Different from conventional“rocking chair”type secondary batter-ies,DIBs perform a unique working mechanism,which employ both cation and anion taking part in capacity contribution at an anode and a cathode,respectively,during electrochemical reactions.Graphite has been identified as a suitable cathode material for anion intercalation at high voltages(>4.8 V)with fast reaction kinetics.However,the development of DIBs is being hindered by dynamic mismatch between a cathode and an anode due to sluggish Li+diffusion at a high rate.Herein,we prepared phyllostachys edulis derived carbon(PEC)through microstructure regulation strategy and investigated the carbonized temperature effect,which effectively tailored the rich short-range ordered graphite microdomains and disor-dered amorphous regions,as well as a unique nano-pore hierarchical structure.The pore size distribution of nano-pores was concentrated in 0.5-5 nm,providing suitable channels for rapid Li+transportation.It was found that PEC-500(carbon-ized at 500℃)achieved a high capacity of 436 mAh·g^(-1)at 300 mA·g^(-1)and excellent rate performance(maintaining a high capacity of 231 mAh·g^(-1)at 3 A·g^(-1)).The assembled dual-carbon PEC-500||graphite full battery delivered 114 mAh·g^(-1)at 10 C with 96%capacity retention after 3000 cycles and outstanding rate capability,providing 74 mAh·g^(-1)at 50 C. 展开更多
关键词 Dual-ion battery Biomass hard carbon Structural regulation High operating voltage High rate
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