再生基因家族成员4 (Regenerating Islet-derived Family Member 4, REG4)是一种分泌性蛋白,属于钙依赖性C型凝集素超家族。其在正常胃肠道组织中局限表达,主要功能涉及黏膜保护、增殖与分化。近年研究发现,REG4在结肠癌中呈现显著的高...再生基因家族成员4 (Regenerating Islet-derived Family Member 4, REG4)是一种分泌性蛋白,属于钙依赖性C型凝集素超家族。其在正常胃肠道组织中局限表达,主要功能涉及黏膜保护、增殖与分化。近年研究发现,REG4在结肠癌中呈现显著的高表达,并通过激活多条关键信号通路,在肿瘤细胞的增殖、凋亡逃逸、侵袭、转移、化疗抵抗以及干细胞特性维持中发挥核心作用。本综述系统阐述了REG4的分子结构与生物学功能,详细分析了其在结肠癌中异常表达的调控机制,并深入探讨了其通过EGFR/Akt、MAPK、STAT3等通路促进肿瘤恶性进展的分子机理。此外,本文重点评述了REG4作为结肠癌诊断、预后判断和疗效预测的新型生物标志物的巨大潜力,以及其作为创新治疗靶点的最新研究进展。最后,我们对当前研究的挑战和未来转化医学的方向进行了展望,旨在为结肠癌的精准医疗提供新的理论依据和策略方向。展开更多
Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using tw...Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using two rotating cascaded transmissive metasurfaces for adaptive aberration correction in focus scanning.The optimized phase profiles enable precise control of the focal position for scanning custom-curved surfaces.This concept was experimentally validated by two allsilicon meta-devices in the terahertz regime,paving the way for high-precision and compact optical devices in various applications.展开更多
文摘再生基因家族成员4 (Regenerating Islet-derived Family Member 4, REG4)是一种分泌性蛋白,属于钙依赖性C型凝集素超家族。其在正常胃肠道组织中局限表达,主要功能涉及黏膜保护、增殖与分化。近年研究发现,REG4在结肠癌中呈现显著的高表达,并通过激活多条关键信号通路,在肿瘤细胞的增殖、凋亡逃逸、侵袭、转移、化疗抵抗以及干细胞特性维持中发挥核心作用。本综述系统阐述了REG4的分子结构与生物学功能,详细分析了其在结肠癌中异常表达的调控机制,并深入探讨了其通过EGFR/Akt、MAPK、STAT3等通路促进肿瘤恶性进展的分子机理。此外,本文重点评述了REG4作为结肠癌诊断、预后判断和疗效预测的新型生物标志物的巨大潜力,以及其作为创新治疗靶点的最新研究进展。最后,我们对当前研究的挑战和未来转化医学的方向进行了展望,旨在为结肠癌的精准医疗提供新的理论依据和策略方向。
文摘Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using two rotating cascaded transmissive metasurfaces for adaptive aberration correction in focus scanning.The optimized phase profiles enable precise control of the focal position for scanning custom-curved surfaces.This concept was experimentally validated by two allsilicon meta-devices in the terahertz regime,paving the way for high-precision and compact optical devices in various applications.
