Pore structure engineering has been acknowledged as suitable approach to creating active sites and en-hancing ion transport capabilities of hard carbon anodes.However,conventional porous carbon materials exhibit high ...Pore structure engineering has been acknowledged as suitable approach to creating active sites and en-hancing ion transport capabilities of hard carbon anodes.However,conventional porous carbon materials exhibit high BET and surface defects.Additionally,the sodium storage mechanism predominantly occurs in the slope region.This contradicts practical application requirements because the capacity of the plateau region is crucial for determining the actual capacity of batteries.In our work,we prepared a novel“core-shell”carbon framework(CNA1200).Introducingclosedporesand carboxylgroupsinto coal-basedcarbon materials to enhance its sodium storage performance.The closed pore structure dominates in the“core”structure,which is attributed to the timely removal of sodium hydroxide(NaOH)to prevent further for-mation of active carbon structure.The presence of closed pores is beneficial for increasing sodium ion storage in the low-voltage plateau region.And the“shell”structure originates from coal tar pitch,it not only uniformly connects hard carbon particles together to improve cycling stability,but is also rich in carboxyl groups to enhance the reversible sodium storage performance in slope region.CNA1200 has ex-cellent electrochemical performance,it exhibits a specific capacity of 335.2 mAh g^(−1)at a current density of 20 mA g^(−1)with ICE=51.53%.In addition,CNA1200 has outstanding cycling stability with a capac-ity retention of 91.8%even when cycling over 200 times.When CNA1200 is used as anode paired with Na_(3)V_(2)(PO_(4))_(3)cathode,it demonstrates a capacity of 109.54 mAh g^(−1)at 0.1 C and capacity retention of 94.64%at 0.5 C.This work provides valuable methods for regulating the structure of sodium-ion battery(SIBs)anode and enhances the potential for commercialization.展开更多
This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expan...This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expansion with environmental protection,a comprehensive evaluation index system is constructed,encompassing two key dimensions:regional economy and ecological environment.Using panel data from 2013 to 2022,the coupling coordination degree model is employed to quantify the interactions and synergy between these dimensions.Additionally,spatial econometric methods are applied to calculate both global and local Moran’s Index,revealing spatial clustering patterns,regional disparities,and heterogeneity.The relative development model further identifies critical factors influencing regional coordination,with a focus on the lagging development of basic infrastructure and public services.The findings demonstrate a positive temporal trend toward improved regional coordination and reduced development gaps,with a spatial pattern characterized by higher coupling degrees in eastern and central regions compared to western areas.Based on these results,this study proposes actionable strategies to enhance coordinated development,emphasizing ecological conservation,the establishment of green production and consumption systems,ecological restoration,and strengthened municipal collaboration.This revised abstract emphasizes the study’s purpose,methods,and key findings more clearly while maintaining a professional and concise tone.Finally,based on the above analysis results,the corresponding coordinated development suggestions of regional economy and ecological environment are given from the aspects of ecological environment protection measures,green production and consumption system construction,ecological environment restoration and municipal coordination.展开更多
Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper th...Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.展开更多
Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycli...Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycling,and reuse in different industries.Currently,a large portion of tailings are managed through the tailing storage facilities(TSF)where these tailings undergo hydro-thermal-mechanical stresses with seasonal cycles which are not comprehensively understood.This study presents an investigative study to evaluate the performance of control and cement-stabilized copper MT under the influence of seasonal cycles,freeze-thaw(F-T)and wet-dry(W-D)conditions,representing the seasonal variability in the cold and arid regions.The control and cement-stabilized MT samples were subjected to a maximum of 12 F-T and 12 W-D cycles and corresponding micro-and-macro behavior was investigated through scanning electron microscope(SEM),volumetric strain(εvT,wet density(r),moisture content loss,and unconfined compressive strength(UCS)tests.The results indicated the vulnerability of Copper MT to 67%and 75%strength loss reaching residual states with 12 F-T and 8 W-D cycles,respectively.Whereas the stabilized MT retained 39%-55%and 16%-34%strength with F-T and W-D cycles,demonstrating increased durability.This research highlights the impact of seasonal cycles and corresponding strength-deformation characteristics of control and stabilized Copper MT in cold and arid regions.展开更多
The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas an...The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas and brought challenges to development policies and revitalization strategies in mountainous rural regions,especially in karst mountainous areas.In light of the difficulty in and as the key to the development of China's mountainous rural areas,the scientific and systematic construction of indicators for evaluating the level of rural revitalization development and clarifying the level of rural revitalization development and influential factors in karst mountainous areas are of great significance to the implementation of the development of the strategy for the revitalization of the rural areas in karst mountainous areas in China.This study constructed an evaluation index system of the rural regional system and rural revitalization development(RTSRD)from the perspective of rural regional system theory,assessed the spatial differentiation patterns and influential factors of RTSRD,and refined a typical territorial model of rural revitalization development in karst mountainous areas by taking Guizhou Province,a typical karst mountainous region,as a case study area.The evaluation and spatial analyses show that the RTSRD indices of karst mountainous areas in the system perspective show a linear growth trend in all single dimensions,with industrial revitalization(IR)showing the most significant increase each year.In time,the RTSRD of karst mountainous regions has developed from low to high,with evident improvement;spatially,the RTSRD shows the characteristics of‘high in the middle and low in the surroundings,and low in the plateau and low in the depression,'with apparent spatial heterogeneity.In addition,this study found that the spatial and temporal differences in RTSRD result from a combination of endogenous push and exogenous pull in the rural system.In particular,this study has refined a typical regional model of rural revitalization development in karst mountainous regions,which provides theoretical support and case practice for rural development in other karst mountainous regions.At the same time,it provides a basis for decision-making for the county level government and rural development planning.展开更多
Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence fac...Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.展开更多
In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional c...In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.展开更多
BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression i...BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression is programmed death ligand 1(PD-L1).Previously,we investigated PD-L1 expression in BC via a new antibody against programmed cell death protein 1 ligand 1(PDCD1 LG1)and reported that high PDCD1 LG1 expression in tumor cells is an independent factor for a high risk of regional metastasis in patients with BC.However,the prognostic significance of PDCD1 LG1 expression in BC stromal cells has not been adequately studied.AIM To study the features of PDCD1 LG1 expression in BC stromal cells and its relationship with BC clinicopathological characteristics.METHODS In a prospective single-center observational study,tumor samples from 148 patients with newly diagnosed BC were examined.The tumor sections were immunohistochemically stained with antibodies against PDCD1 LG1.In the tumor samples,the PDCD1 LG1-positive lymphocyte(PDCD1 LG1+LF)score,presence of nuclear PDCD1 LG1 expression in the LFs,PDCD1 LG1 expression in polymorphic cell infiltrates(PDCD1 LG1+polymorphic cell infiltrates[PCIs]),and cells of the fibroblastic stroma and endothelial cells of the tumor microvessels were assessed.Statistical analyses were performed using Statistica 10.0 software.RESULTS A PDCD1 LG1+LF score≥3 was detected more often at stages N0 and N3 than at N1 and N2(P=0.03).Moderate and pronounced PDCD1 LG1+PCIs and the presence of PDCD1 LG1+fibroblastic stroma were associated with negative estrogen receptor status(P=0.0008 and P=0.03,respectively),human epidermal growth factor receptor 2-positive(HER2+)BC(P<0.00001 and P=0.0005),and luminal B HER2+,non-luminal HER2+and triple-negative BC(P<0.00001 and P=0.004).The risk of metastasis to regional lymph nodes(RLNs)depend on lymphovascular invasion(LVI)and the PDCD1 LG1+LF score.In the absence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were absent in 66.6%and 93.9%of patients with BC,respectively.In the presence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were detected in 82.6%and 92.7%of patients with BC,respectively.CONCLUSION The results indicated that the combined assessment of the PDCD1 LG1+LF score and LVI can improve the accuracy of predicting the risk of metastasis to RLNs in patients with BC.展开更多
The heat content(HC)of water masses on the Ross Sea continental shelf plays an important role in regulating the circulations and the basal melting of the Ross Ice Shelf(RIS).Yet,the evolution of the HC on the Ross Sea...The heat content(HC)of water masses on the Ross Sea continental shelf plays an important role in regulating the circulations and the basal melting of the Ross Ice Shelf(RIS).Yet,the evolution of the HC on the Ross Sea continental shelf is still not clear due to the sparsity of observations.By employing a coupled regional ocean-sea ice-ice shelf model for the Ross Sea,this study analyzes the heat budget of water masses over the continental shelf and in the RIS cavity.According to the topographic features and the HC density,the continental shelf region is divided into 17 subdomains.The heat budget of the middle layer for every subdomain is analyzed.In addition,the heat budget for the RIS cavity is assessed for the first time.Owing to Modified Circumpolar Deep Water intrusion,water masses over the eastern shelf are warmer than over the western shelf,with the coldest water identified in the southwestern inner shelf.The horizontal heat flux mainly provides heat to the continental shelf,while the atmospheric forcing tends to warm up the ocean during the ice-melting period and cool down the ocean during the ice-freezing period.The vertical heat flux is generally upward and transports heat from the deep layer to the upper layer.In the RIS cavity,the seasonal cycle of the HC is dominated by the horizontal flux across the RIS front rather than the basal thermal forcing of the RIS.展开更多
In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future...In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future extreme climate changes in the Asian arid region and Tibetan Plateau,this study applied the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6)to assess the changes in EHP(Rx5d and R95pTOT)and EHT(TX90p and TXx)under different emission scenarios in the 21st century.Findings suggest that both the frequency and the intensity of the extreme indices will increase,exhibiting accelerated growth under higher emission scenarios,particularly under the SSP5-8.5 emission scenario.It is suggested that the growth of EHT and EHP in the early subperiod of the 21st century(2026-2045)will be relatively moderate,with small differences between different emission scenarios.However,by the middle subperiod of the 21st century(2041-2060),the differences between different emission scenarios will become larger than the 2035s and the growth will become more intense.In western central Asia,TX90p,TXx,Rx5d,and R95pTOT increase by 9.7%-14.2%(13.3%-24.7%),1.3℃-1.7℃(1.6℃-2.7℃),6.5%-8.9%(8.2%-8.8%),and 18.1%-27.0%(25.6%-30.0%)by the early(middle)subperiod;in eastern central Asia,TX90p,TXx,Rx5d,and R95pTOT increase 8.1%-12.0%(11.3%-21.1%),1.4℃-1.8℃(1.9℃-2.9℃),7.4%-9.7%(10.4%-13.8%),and 20.2%-29.3%(32.0%-40.8%)by the early(middle)subperiod;and over the Tibetan Plateau,TX90p,TXx,Rx5d,and R95pTOT increase 12.5%-17.4%(17.0%-31.0%),1.2℃-1.5℃(1.6℃-2.5℃),7.2%-10.0%(9.9%-15.0%),and 26.6%-33.1%(36.1%-55.3%)by the early(middle)subperiod.展开更多
Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and ...Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and broader Asia.However,long-term TWSC characterization remains challenging due to limited observational data in this alpine region.Here,we integrate GRACE observations(2002-2020),ERA5-Land reanalysis,and GLDAS data to reconstruct TWSC using two methods:(1)the water balance method(PER)and(2)the component summation method(SS),applied to three input datasets(ERA5-Land,GLDAS,and their average,GLER).Comparative analysis reveals that the SS method applied to GL-ER yields the highest consistency with GRACE-derived TWSC.Using this optimal approach,we extend the analysis to 1951~2020,uncovering spatiotemporal TWSC patterns.Although annual TWSC trends appear negligible due to strong seasonality,we introduce the intra-year TWSC fluctuation(TWSCF)index to quantify cumulative variability.A significant(p<0.05)transition occurred in 1980,with TWSCF shifting from a declining trend(-0.39 mm/yr)to an increasing trend(0.56 mm/yr),primarily driven by soil moisture changes.However,Hurst exponent analysis suggests this upward trend may not persist.Drought and vegetation assessments indicate concurrent wetting and greening in the TRSR.TWSC correlates strongly with meteorological drought,acting as a reliable drought indicator while its linkage with vegetation dynamics suggests a potential contribution to greening.Our findings provide a robust framework for understanding long-term TWSC evolution and its hydrological-ecological interactions under climate change.展开更多
Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many ...Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning.展开更多
Wigner-Ville distribution(WVD)is widely used in the field of signal processing due to its excellent time-frequency(TF)concentration.However,WVD is severely limited by the cross-term when working with multicomponent si...Wigner-Ville distribution(WVD)is widely used in the field of signal processing due to its excellent time-frequency(TF)concentration.However,WVD is severely limited by the cross-term when working with multicomponent signals.In this paper,we analyze the property differences between auto-term and cross-term in the one-dimensional sequence and the two-dimensional plane and approximate entropy and Rényi entropy are employed to describe them,respectively.Based on this information,we propose a new method to achieve adaptive cross-term removal by combining seeded region growing.Compared to other methods,the new method can achieve cross-term removal without decreasing the TF concentration of the auto-term.Simulation and experimental data processing results show that the method is adaptive and is not constrained by the type or distribution of signals.And it performs well in low signal-to-noise ratio environments.展开更多
Acute mountain sickness(AMS) is an illness caused by hypoxia due to rapid ascent to altitudes above 2,500 m. Symptoms include headache,nausea, vomiting, and loss of appetite, all of which usually improve within 1 to 2...Acute mountain sickness(AMS) is an illness caused by hypoxia due to rapid ascent to altitudes above 2,500 m. Symptoms include headache,nausea, vomiting, and loss of appetite, all of which usually improve within 1 to 2 days. However,untreated AMS can progress to life-threatening conditions such as high-altitude cerebral and pulmonary edema(HACE and HAPE, respectively)^([1]).展开更多
The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.Howeve...The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.However,the inversion for the ES model suffers from nonuniqueness and instability,which remain unresolved.To mitigate these issues,we introduce both the minimum and flattest models into the model objective function as an alternative regularization approach in the spherical ES method.We first present the methods,then analyze the accuracy of forward calculation and test the proposed ES method in this study by using synthetic data.The experimental results from simulation data indicate that our proposed regularization effectively suppresses the Backus effect and mitigates inversion instability in the low-latitude region.Finally,we apply the proposed method to magnetic anomaly data from China Seismo-Electromagnetic Satellite-1(CSES-1)and Macao Science Satellite-1(MSS-1)magnetic measurements over Africa by constructing an ES model of the large-scale lithospheric magnetic field.Compared with existing global lithospheric magnetic field models,our ES model demonstrates good consistency at high altitudes and predicts more stable fields at low altitudes.Furthermore,we derive the reduction to the pole(RTP)magnetic anomaly fields and the apparent susceptibility contrast distribution based on the ES model.The latter correlates well with the regional tectonic framework in Africa and surroundings.展开更多
Audio-visual scene classification(AVSC)poses a formidable challenge owing to the intricate spatial-temporal relationships exhibited by audio-visual signals,coupled with the complex spatial patterns of objects and text...Audio-visual scene classification(AVSC)poses a formidable challenge owing to the intricate spatial-temporal relationships exhibited by audio-visual signals,coupled with the complex spatial patterns of objects and textures found in visual images.The focus of recent studies has predominantly revolved around extracting features from diverse neural network structures,inadvertently neglecting the acquisition of semantically meaningful regions and crucial components within audio-visual data.The authors present a feature pyramid attention network(FPANet)for audio-visual scene understanding,which extracts semantically significant characteristics from audio-visual data.The authors’approach builds multi-scale hierarchical features of sound spectrograms and visual images using a feature pyramid representation and localises the semantically relevant regions with a feature pyramid attention module(FPAM).A dimension alignment(DA)strategy is employed to align feature maps from multiple layers,a pyramid spatial attention(PSA)to spatially locate essential regions,and a pyramid channel attention(PCA)to pinpoint significant temporal frames.Experiments on visual scene classification(VSC),audio scene classification(ASC),and AVSC tasks demonstrate that FPANet achieves performance on par with state-of-the-art(SOTA)approaches,with a 95.9 F1-score on the ADVANCE dataset and a relative improvement of 28.8%.Visualisation results show that FPANet can prioritise semantically meaningful areas in audio-visual signals.展开更多
Machine learning(ML)is increasingly applied for medical image processing with appropriate learning paradigms.These applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify sp...Machine learning(ML)is increasingly applied for medical image processing with appropriate learning paradigms.These applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for diagnosis.The primary concern of ML applications is the precise selection of flexible image features for pattern detection and region classification.Most of the extracted image features are irrelevant and lead to an increase in computation time.Therefore,this article uses an analytical learning paradigm to design a Congruent Feature Selection Method to select the most relevant image features.This process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel distributions.The similarity between the pixels over the various distribution patterns with high indexes is recommended for disease diagnosis.Later,the correlation based on intensity and distribution is analyzed to improve the feature selection congruency.Therefore,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the distribution.Now,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of selection.Therefore,the probability of feature selection,regardless of the textures and medical image patterns,is improved.This process enhances the performance of ML applications for different medical image processing.The proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected dataset.The mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.展开更多
The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagn...The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.展开更多
Thermospheric neutral winds(TNWs)refer to the neutral gases in the thermosphere circulating as tides,which play a crucial role in the dynamics of the thermosphere-ionosphere system(TIS).Global geospace neutral winds,p...Thermospheric neutral winds(TNWs)refer to the neutral gases in the thermosphere circulating as tides,which play a crucial role in the dynamics of the thermosphere-ionosphere system(TIS).Global geospace neutral winds,particularly over the magnetic equator,have been a subject of study for several decades.However,despite the known importance of neutral winds,a comprehensive understanding and characterization of the winds is still lacking.Various ground-based and satellite missions have provided valuable information on the contribution of neutral winds to the global atmospheric dynamics.However,efforts in the global monitoring of neutral winds are still lacking,and the drivers behind the behavior of TNWs as well as their influence on the TIS remain incomplete.To address these knowledge gaps in the global circulation of TNWs,it is crucial to develop a deep understanding of the neutral wind characteristics over different regions.The low-latitude equatorial region in particular has been observed to exert complex influences on TNWs because of the unique effects of the Earth’s magnetic field at the dip equator.Studying neutral winds over this region will provide valuable insights into the unique dynamics and processes that occur in this region,thereby enhancing our understanding of their role in the overall dynamics of the TIS.Additionally,through empirical observations,an improved ability to accurately model and predict the behavior of this region can be achieved.This review article addresses challenges in understanding equatorial winds by reviewing historical measurements,current missions,and the interactions of ionospheric and thermospheric phenomena,emphasizing the need for comprehensive measurements to improve global atmospheric dynamics and weather forecasting.展开更多
基金the National Natural Science Foundation of China(No.21978164,22078189 and 22105120)the Outstanding Youth Science Fund of Shaanxi Province(No.2021JC-046)and the Special Support Program for high level talents of Shaanxi Province+3 种基金the Innovation Support Program of Shaanxi Province(2021JZY-001)the Key Research and Development Program of Shaanxi Province(No.2020GY-243)the Special Research Fund of Education Department of Shaanxi(No.20JK0535)the National High-end Foreign Expert Project(No.GDW20186100428).
文摘Pore structure engineering has been acknowledged as suitable approach to creating active sites and en-hancing ion transport capabilities of hard carbon anodes.However,conventional porous carbon materials exhibit high BET and surface defects.Additionally,the sodium storage mechanism predominantly occurs in the slope region.This contradicts practical application requirements because the capacity of the plateau region is crucial for determining the actual capacity of batteries.In our work,we prepared a novel“core-shell”carbon framework(CNA1200).Introducingclosedporesand carboxylgroupsinto coal-basedcarbon materials to enhance its sodium storage performance.The closed pore structure dominates in the“core”structure,which is attributed to the timely removal of sodium hydroxide(NaOH)to prevent further for-mation of active carbon structure.The presence of closed pores is beneficial for increasing sodium ion storage in the low-voltage plateau region.And the“shell”structure originates from coal tar pitch,it not only uniformly connects hard carbon particles together to improve cycling stability,but is also rich in carboxyl groups to enhance the reversible sodium storage performance in slope region.CNA1200 has ex-cellent electrochemical performance,it exhibits a specific capacity of 335.2 mAh g^(−1)at a current density of 20 mA g^(−1)with ICE=51.53%.In addition,CNA1200 has outstanding cycling stability with a capac-ity retention of 91.8%even when cycling over 200 times.When CNA1200 is used as anode paired with Na_(3)V_(2)(PO_(4))_(3)cathode,it demonstrates a capacity of 109.54 mAh g^(−1)at 0.1 C and capacity retention of 94.64%at 0.5 C.This work provides valuable methods for regulating the structure of sodium-ion battery(SIBs)anode and enhances the potential for commercialization.
基金support from Guangdong Science and Technology(20230505)Guangdong Provincial Philosophy and Social Science Planning Project(GD20SQ25)Guangdong Provincial Special Fund for Science and Technology Innovation Strategy in 2024(Cultivation of College Students’Science and Technology Innovation)(pdjh2024a391)during preparation of this manuscript.
文摘This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expansion with environmental protection,a comprehensive evaluation index system is constructed,encompassing two key dimensions:regional economy and ecological environment.Using panel data from 2013 to 2022,the coupling coordination degree model is employed to quantify the interactions and synergy between these dimensions.Additionally,spatial econometric methods are applied to calculate both global and local Moran’s Index,revealing spatial clustering patterns,regional disparities,and heterogeneity.The relative development model further identifies critical factors influencing regional coordination,with a focus on the lagging development of basic infrastructure and public services.The findings demonstrate a positive temporal trend toward improved regional coordination and reduced development gaps,with a spatial pattern characterized by higher coupling degrees in eastern and central regions compared to western areas.Based on these results,this study proposes actionable strategies to enhance coordinated development,emphasizing ecological conservation,the establishment of green production and consumption systems,ecological restoration,and strengthened municipal collaboration.This revised abstract emphasizes the study’s purpose,methods,and key findings more clearly while maintaining a professional and concise tone.Finally,based on the above analysis results,the corresponding coordinated development suggestions of regional economy and ecological environment are given from the aspects of ecological environment protection measures,green production and consumption system construction,ecological environment restoration and municipal coordination.
基金supported by the National Natural Science Foundation of China(82071143,82371000,82270361)Key Research and Development Program of Jiangsu Province(BE2022795)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_1801)the Jiangsu Province Capability Improvement Project through the Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4)Jiangsu Provincial Medical Innovation Center(CXZX202227).
文摘Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.
基金the W.M.Keck Center for Nano-Scale Imaging in the Department of Chemistry and Biochemistry at the University of Arizona(Grant No.RRID:SCR_022884),with funding from the W.M.Keck Foundation Grant.
文摘Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycling,and reuse in different industries.Currently,a large portion of tailings are managed through the tailing storage facilities(TSF)where these tailings undergo hydro-thermal-mechanical stresses with seasonal cycles which are not comprehensively understood.This study presents an investigative study to evaluate the performance of control and cement-stabilized copper MT under the influence of seasonal cycles,freeze-thaw(F-T)and wet-dry(W-D)conditions,representing the seasonal variability in the cold and arid regions.The control and cement-stabilized MT samples were subjected to a maximum of 12 F-T and 12 W-D cycles and corresponding micro-and-macro behavior was investigated through scanning electron microscope(SEM),volumetric strain(εvT,wet density(r),moisture content loss,and unconfined compressive strength(UCS)tests.The results indicated the vulnerability of Copper MT to 67%and 75%strength loss reaching residual states with 12 F-T and 8 W-D cycles,respectively.Whereas the stabilized MT retained 39%-55%and 16%-34%strength with F-T and W-D cycles,demonstrating increased durability.This research highlights the impact of seasonal cycles and corresponding strength-deformation characteristics of control and stabilized Copper MT in cold and arid regions.
基金supported by the National Natural Science Foundation of China(Grant No.42061035)the Guizhou Provincial Program on Commercialization of Scientific and Technological Achievements([2022]010)。
文摘The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas and brought challenges to development policies and revitalization strategies in mountainous rural regions,especially in karst mountainous areas.In light of the difficulty in and as the key to the development of China's mountainous rural areas,the scientific and systematic construction of indicators for evaluating the level of rural revitalization development and clarifying the level of rural revitalization development and influential factors in karst mountainous areas are of great significance to the implementation of the development of the strategy for the revitalization of the rural areas in karst mountainous areas in China.This study constructed an evaluation index system of the rural regional system and rural revitalization development(RTSRD)from the perspective of rural regional system theory,assessed the spatial differentiation patterns and influential factors of RTSRD,and refined a typical territorial model of rural revitalization development in karst mountainous areas by taking Guizhou Province,a typical karst mountainous region,as a case study area.The evaluation and spatial analyses show that the RTSRD indices of karst mountainous areas in the system perspective show a linear growth trend in all single dimensions,with industrial revitalization(IR)showing the most significant increase each year.In time,the RTSRD of karst mountainous regions has developed from low to high,with evident improvement;spatially,the RTSRD shows the characteristics of‘high in the middle and low in the surroundings,and low in the plateau and low in the depression,'with apparent spatial heterogeneity.In addition,this study found that the spatial and temporal differences in RTSRD result from a combination of endogenous push and exogenous pull in the rural system.In particular,this study has refined a typical regional model of rural revitalization development in karst mountainous regions,which provides theoretical support and case practice for rural development in other karst mountainous regions.At the same time,it provides a basis for decision-making for the county level government and rural development planning.
基金supported by the National Key R&D program of China(No.2022YFC3703404)the National Natural Science Foundation of China(No.22188102)the Samsung Advanced Institute of Technology.
文摘Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.
文摘In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.
基金Supported by Russian Science Foundation,No.23-25-00183.
文摘BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression is programmed death ligand 1(PD-L1).Previously,we investigated PD-L1 expression in BC via a new antibody against programmed cell death protein 1 ligand 1(PDCD1 LG1)and reported that high PDCD1 LG1 expression in tumor cells is an independent factor for a high risk of regional metastasis in patients with BC.However,the prognostic significance of PDCD1 LG1 expression in BC stromal cells has not been adequately studied.AIM To study the features of PDCD1 LG1 expression in BC stromal cells and its relationship with BC clinicopathological characteristics.METHODS In a prospective single-center observational study,tumor samples from 148 patients with newly diagnosed BC were examined.The tumor sections were immunohistochemically stained with antibodies against PDCD1 LG1.In the tumor samples,the PDCD1 LG1-positive lymphocyte(PDCD1 LG1+LF)score,presence of nuclear PDCD1 LG1 expression in the LFs,PDCD1 LG1 expression in polymorphic cell infiltrates(PDCD1 LG1+polymorphic cell infiltrates[PCIs]),and cells of the fibroblastic stroma and endothelial cells of the tumor microvessels were assessed.Statistical analyses were performed using Statistica 10.0 software.RESULTS A PDCD1 LG1+LF score≥3 was detected more often at stages N0 and N3 than at N1 and N2(P=0.03).Moderate and pronounced PDCD1 LG1+PCIs and the presence of PDCD1 LG1+fibroblastic stroma were associated with negative estrogen receptor status(P=0.0008 and P=0.03,respectively),human epidermal growth factor receptor 2-positive(HER2+)BC(P<0.00001 and P=0.0005),and luminal B HER2+,non-luminal HER2+and triple-negative BC(P<0.00001 and P=0.004).The risk of metastasis to regional lymph nodes(RLNs)depend on lymphovascular invasion(LVI)and the PDCD1 LG1+LF score.In the absence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were absent in 66.6%and 93.9%of patients with BC,respectively.In the presence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were detected in 82.6%and 92.7%of patients with BC,respectively.CONCLUSION The results indicated that the combined assessment of the PDCD1 LG1+LF score and LVI can improve the accuracy of predicting the risk of metastasis to RLNs in patients with BC.
基金supported by the National Key R&D Program of China (Grant No. 2024YFF0506603)the Independent Research Foundation of the Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (Grant Nos. SML2023SP201 and SML2021SP306)+2 种基金the Natural Science Foundation of Guangdong Province, China (Grant No. 2024A1515012717)the Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (Grant Nos. 313021004, 313022009 and 313022001)the Program of Innovation 2030 on Smart Ocean, Zhejiang University
文摘The heat content(HC)of water masses on the Ross Sea continental shelf plays an important role in regulating the circulations and the basal melting of the Ross Ice Shelf(RIS).Yet,the evolution of the HC on the Ross Sea continental shelf is still not clear due to the sparsity of observations.By employing a coupled regional ocean-sea ice-ice shelf model for the Ross Sea,this study analyzes the heat budget of water masses over the continental shelf and in the RIS cavity.According to the topographic features and the HC density,the continental shelf region is divided into 17 subdomains.The heat budget of the middle layer for every subdomain is analyzed.In addition,the heat budget for the RIS cavity is assessed for the first time.Owing to Modified Circumpolar Deep Water intrusion,water masses over the eastern shelf are warmer than over the western shelf,with the coldest water identified in the southwestern inner shelf.The horizontal heat flux mainly provides heat to the continental shelf,while the atmospheric forcing tends to warm up the ocean during the ice-melting period and cool down the ocean during the ice-freezing period.The vertical heat flux is generally upward and transports heat from the deep layer to the upper layer.In the RIS cavity,the seasonal cycle of the HC is dominated by the horizontal flux across the RIS front rather than the basal thermal forcing of the RIS.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program[grant number 2019QZKK0101]。
文摘In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future extreme climate changes in the Asian arid region and Tibetan Plateau,this study applied the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6)to assess the changes in EHP(Rx5d and R95pTOT)and EHT(TX90p and TXx)under different emission scenarios in the 21st century.Findings suggest that both the frequency and the intensity of the extreme indices will increase,exhibiting accelerated growth under higher emission scenarios,particularly under the SSP5-8.5 emission scenario.It is suggested that the growth of EHT and EHP in the early subperiod of the 21st century(2026-2045)will be relatively moderate,with small differences between different emission scenarios.However,by the middle subperiod of the 21st century(2041-2060),the differences between different emission scenarios will become larger than the 2035s and the growth will become more intense.In western central Asia,TX90p,TXx,Rx5d,and R95pTOT increase by 9.7%-14.2%(13.3%-24.7%),1.3℃-1.7℃(1.6℃-2.7℃),6.5%-8.9%(8.2%-8.8%),and 18.1%-27.0%(25.6%-30.0%)by the early(middle)subperiod;in eastern central Asia,TX90p,TXx,Rx5d,and R95pTOT increase 8.1%-12.0%(11.3%-21.1%),1.4℃-1.8℃(1.9℃-2.9℃),7.4%-9.7%(10.4%-13.8%),and 20.2%-29.3%(32.0%-40.8%)by the early(middle)subperiod;and over the Tibetan Plateau,TX90p,TXx,Rx5d,and R95pTOT increase 12.5%-17.4%(17.0%-31.0%),1.2℃-1.5℃(1.6℃-2.5℃),7.2%-10.0%(9.9%-15.0%),and 26.6%-33.1%(36.1%-55.3%)by the early(middle)subperiod.
基金funded by the Postdoctoral Research Startup Foundation of University of Jinan(Grant No.100389917).
文摘Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and broader Asia.However,long-term TWSC characterization remains challenging due to limited observational data in this alpine region.Here,we integrate GRACE observations(2002-2020),ERA5-Land reanalysis,and GLDAS data to reconstruct TWSC using two methods:(1)the water balance method(PER)and(2)the component summation method(SS),applied to three input datasets(ERA5-Land,GLDAS,and their average,GLER).Comparative analysis reveals that the SS method applied to GL-ER yields the highest consistency with GRACE-derived TWSC.Using this optimal approach,we extend the analysis to 1951~2020,uncovering spatiotemporal TWSC patterns.Although annual TWSC trends appear negligible due to strong seasonality,we introduce the intra-year TWSC fluctuation(TWSCF)index to quantify cumulative variability.A significant(p<0.05)transition occurred in 1980,with TWSCF shifting from a declining trend(-0.39 mm/yr)to an increasing trend(0.56 mm/yr),primarily driven by soil moisture changes.However,Hurst exponent analysis suggests this upward trend may not persist.Drought and vegetation assessments indicate concurrent wetting and greening in the TRSR.TWSC correlates strongly with meteorological drought,acting as a reliable drought indicator while its linkage with vegetation dynamics suggests a potential contribution to greening.Our findings provide a robust framework for understanding long-term TWSC evolution and its hydrological-ecological interactions under climate change.
基金supported by the National Natural Science Foundation of China(Grant No.42076214)Natural Science Foundation of Shandong Province(Grant No.ZR2024QD057).
文摘Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning.
基金Supported by the National Natural Science Foundation of China(62201171).
文摘Wigner-Ville distribution(WVD)is widely used in the field of signal processing due to its excellent time-frequency(TF)concentration.However,WVD is severely limited by the cross-term when working with multicomponent signals.In this paper,we analyze the property differences between auto-term and cross-term in the one-dimensional sequence and the two-dimensional plane and approximate entropy and Rényi entropy are employed to describe them,respectively.Based on this information,we propose a new method to achieve adaptive cross-term removal by combining seeded region growing.Compared to other methods,the new method can achieve cross-term removal without decreasing the TF concentration of the auto-term.Simulation and experimental data processing results show that the method is adaptive and is not constrained by the type or distribution of signals.And it performs well in low signal-to-noise ratio environments.
文摘Acute mountain sickness(AMS) is an illness caused by hypoxia due to rapid ascent to altitudes above 2,500 m. Symptoms include headache,nausea, vomiting, and loss of appetite, all of which usually improve within 1 to 2 days. However,untreated AMS can progress to life-threatening conditions such as high-altitude cerebral and pulmonary edema(HACE and HAPE, respectively)^([1]).
基金supported by the National Natural Science Foundation of China(Grant Nos.42250103 and 42174090)the Opening Fund of Key Laboratory of Geological Survey and Evaluation of Ministry of Education(Grant No.GLAB2023ZR02)the MOST Special Fund from the State Key Laboratory of Geological Processes and Mineral Resources(Grant No.MSFGPMR2022-4).
文摘The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.However,the inversion for the ES model suffers from nonuniqueness and instability,which remain unresolved.To mitigate these issues,we introduce both the minimum and flattest models into the model objective function as an alternative regularization approach in the spherical ES method.We first present the methods,then analyze the accuracy of forward calculation and test the proposed ES method in this study by using synthetic data.The experimental results from simulation data indicate that our proposed regularization effectively suppresses the Backus effect and mitigates inversion instability in the low-latitude region.Finally,we apply the proposed method to magnetic anomaly data from China Seismo-Electromagnetic Satellite-1(CSES-1)and Macao Science Satellite-1(MSS-1)magnetic measurements over Africa by constructing an ES model of the large-scale lithospheric magnetic field.Compared with existing global lithospheric magnetic field models,our ES model demonstrates good consistency at high altitudes and predicts more stable fields at low altitudes.Furthermore,we derive the reduction to the pole(RTP)magnetic anomaly fields and the apparent susceptibility contrast distribution based on the ES model.The latter correlates well with the regional tectonic framework in Africa and surroundings.
基金Shenzhen Institute of Artificial Intelligence and Robotics for Society,Grant/Award Number:AC01202201003-02GuangDong Basic and Applied Basic Research Foundation,Grant/Award Number:2024A1515010252Longgang District Shenzhen's“Ten Action Plan”for Supporting Innovation Projects,Grant/Award Number:LGKCSDPT2024002。
文摘Audio-visual scene classification(AVSC)poses a formidable challenge owing to the intricate spatial-temporal relationships exhibited by audio-visual signals,coupled with the complex spatial patterns of objects and textures found in visual images.The focus of recent studies has predominantly revolved around extracting features from diverse neural network structures,inadvertently neglecting the acquisition of semantically meaningful regions and crucial components within audio-visual data.The authors present a feature pyramid attention network(FPANet)for audio-visual scene understanding,which extracts semantically significant characteristics from audio-visual data.The authors’approach builds multi-scale hierarchical features of sound spectrograms and visual images using a feature pyramid representation and localises the semantically relevant regions with a feature pyramid attention module(FPAM).A dimension alignment(DA)strategy is employed to align feature maps from multiple layers,a pyramid spatial attention(PSA)to spatially locate essential regions,and a pyramid channel attention(PCA)to pinpoint significant temporal frames.Experiments on visual scene classification(VSC),audio scene classification(ASC),and AVSC tasks demonstrate that FPANet achieves performance on par with state-of-the-art(SOTA)approaches,with a 95.9 F1-score on the ADVANCE dataset and a relative improvement of 28.8%.Visualisation results show that FPANet can prioritise semantically meaningful areas in audio-visual signals.
基金the Deanship of Scientifc Research at King Khalid University for funding this work through large group Research Project under grant number RGP2/421/45supported via funding from Prince Sattam bin Abdulaziz University project number(PSAU/2024/R/1446)+1 种基金supported by theResearchers Supporting Project Number(UM-DSR-IG-2023-07)Almaarefa University,Riyadh,Saudi Arabia.supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2021R1F1A1055408).
文摘Machine learning(ML)is increasingly applied for medical image processing with appropriate learning paradigms.These applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for diagnosis.The primary concern of ML applications is the precise selection of flexible image features for pattern detection and region classification.Most of the extracted image features are irrelevant and lead to an increase in computation time.Therefore,this article uses an analytical learning paradigm to design a Congruent Feature Selection Method to select the most relevant image features.This process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel distributions.The similarity between the pixels over the various distribution patterns with high indexes is recommended for disease diagnosis.Later,the correlation based on intensity and distribution is analyzed to improve the feature selection congruency.Therefore,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the distribution.Now,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of selection.Therefore,the probability of feature selection,regardless of the textures and medical image patterns,is improved.This process enhances the performance of ML applications for different medical image processing.The proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected dataset.The mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.81672638 and W2421095)National Natural Science Foundation of Shandong Province(Grant No.ZR2024LMB011)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003)。
文摘The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.
基金the Ministry of Higher Education(KPT)Malaysia for the MyBrainSc program.Idahwati Sarudin was supported by Universiti Sains Malaysia through a Short-Term Grant(Project No.304/PFIZIK/6315730)Nurul Shazana Abdul Hamid received funding from Universiti Kebangsaan Malaysia for funding this work through a University Research Grant(Grant No.GUP-2023-048)。
文摘Thermospheric neutral winds(TNWs)refer to the neutral gases in the thermosphere circulating as tides,which play a crucial role in the dynamics of the thermosphere-ionosphere system(TIS).Global geospace neutral winds,particularly over the magnetic equator,have been a subject of study for several decades.However,despite the known importance of neutral winds,a comprehensive understanding and characterization of the winds is still lacking.Various ground-based and satellite missions have provided valuable information on the contribution of neutral winds to the global atmospheric dynamics.However,efforts in the global monitoring of neutral winds are still lacking,and the drivers behind the behavior of TNWs as well as their influence on the TIS remain incomplete.To address these knowledge gaps in the global circulation of TNWs,it is crucial to develop a deep understanding of the neutral wind characteristics over different regions.The low-latitude equatorial region in particular has been observed to exert complex influences on TNWs because of the unique effects of the Earth’s magnetic field at the dip equator.Studying neutral winds over this region will provide valuable insights into the unique dynamics and processes that occur in this region,thereby enhancing our understanding of their role in the overall dynamics of the TIS.Additionally,through empirical observations,an improved ability to accurately model and predict the behavior of this region can be achieved.This review article addresses challenges in understanding equatorial winds by reviewing historical measurements,current missions,and the interactions of ionospheric and thermospheric phenomena,emphasizing the need for comprehensive measurements to improve global atmospheric dynamics and weather forecasting.
