This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tum...This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration （Ct） of tumor interstitium in two types of dosing regiments （i.e., single-shot and triple-shot ones）. The two regiments were performed via antitumor drug, hydroxycamptothecin （HCPT）, on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.展开更多
Abstract： The study aimed to assess the predictors of performance administered by the Philippine Regulation Commission （PRC） in the licensure examination of Maritime Academy of Asia and the Pacific （MAAP） for Aca...Abstract： The study aimed to assess the predictors of performance administered by the Philippine Regulation Commission （PRC） in the licensure examination of Maritime Academy of Asia and the Pacific （MAAP） for Academic Year 2007-2011. Specifically, this also aimed to answer the following questions： demographic profile of the maritime graduates, the college related factors, administrative related factors, the level of scholastic achievement of the graduates, and the performance of the graduates in the licensure examination. A total of one hundred seventy three （173） graduates of MAAP from Class 2007-2011 were utilized as the respondents for the study. The study found out that the results of pre board examination and scholastic achievement of the graduates had significant effect on the performance of the graduates in O.I.C Navigational Watch Licensure Examination. Other variables found out to have no significant effect on the result of the licensure examination of the graduates. Therefore, the null hypotheses that the demographic profile of the graduates, college related factors, and administrative related factors has no significant effect on scholastic the achievement of the students were accepted. However, the null hypothesis that scholastic achievement of the students has no significant effect on the performance in maritime licensure examination was rejected. The same way, the null hypothesis that the demographic profile of the graduates, college related factors and the administrative related factors has no significant effect on the performance in Officer in Charge--Navigational Watch licensure Examination were accepted.展开更多
基金Project suppoted by the National Natural Science Foundation of China (Grant No10372026)the Shanghai Leading Academic Discipline Project (Grant NoB112)
文摘This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration （Ct） of tumor interstitium in two types of dosing regiments （i.e., single-shot and triple-shot ones）. The two regiments were performed via antitumor drug, hydroxycamptothecin （HCPT）, on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.
文摘Abstract： The study aimed to assess the predictors of performance administered by the Philippine Regulation Commission （PRC） in the licensure examination of Maritime Academy of Asia and the Pacific （MAAP） for Academic Year 2007-2011. Specifically, this also aimed to answer the following questions： demographic profile of the maritime graduates, the college related factors, administrative related factors, the level of scholastic achievement of the graduates, and the performance of the graduates in the licensure examination. A total of one hundred seventy three （173） graduates of MAAP from Class 2007-2011 were utilized as the respondents for the study. The study found out that the results of pre board examination and scholastic achievement of the graduates had significant effect on the performance of the graduates in O.I.C Navigational Watch Licensure Examination. Other variables found out to have no significant effect on the result of the licensure examination of the graduates. Therefore, the null hypotheses that the demographic profile of the graduates, college related factors, and administrative related factors has no significant effect on scholastic the achievement of the students were accepted. However, the null hypothesis that scholastic achievement of the students has no significant effect on the performance in maritime licensure examination was rejected. The same way, the null hypothesis that the demographic profile of the graduates, college related factors and the administrative related factors has no significant effect on the performance in Officer in Charge--Navigational Watch licensure Examination were accepted.
