Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infecte...Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite.In immune-competent individuals,T.展开更多
Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but mos...Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but most output a long list of significantly enriched terms that are often redundant, making it difficult to extract the most meaningful functions. In this paper, we present GOMA, a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules. With this method, we systematically revealed functional GO modules, i.e., groups of functionally similar GO terms, via an optimization model and then ranked them by enrichment scores. Our new method simplifies enrichment analysis results by reducing redundancy, thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results.展开更多
Dual redundant manipulators are extremely useful for tasks in dangerous or space environments, but efficient and real time coordinated control is hard to achieve. Collision avoidance between two cooperative manipulat...Dual redundant manipulators are extremely useful for tasks in dangerous or space environments, but efficient and real time coordinated control is hard to achieve. Collision avoidance between two cooperative manipulators is vital to the successful applications of dual redundant manipulators. Although methods based on the distance function have been demonstrated simple and efficient, different collision avoidance points can usually produce completely different results and even failure. The paper discussed the choices of collision avoidance points and proposed a novel method for the choosing of those points. The method is testified by simulation results of two redundant planar manipulators.展开更多
Reservoirs are an important water source in many densely populated areas in southwest China.Phytoplankton play an essential role in maintaining the structure and function of reservoir ecosystems.Understanding the succ...Reservoirs are an important water source in many densely populated areas in southwest China.Phytoplankton play an essential role in maintaining the structure and function of reservoir ecosystems.Understanding the succession in phytoplankton communities and the factors driving it are essential for eff ective water quality management in drinking water reservoirs.In this study,water samples were collected monthly at the surface layers from March 2016 to December 2019 in Hongfeng Reservoir,southwest China.The relationship between functional group succession was analyzed based on nonmetric multidimensional scaling analysis(NMDS),redundancy analysis(RDA),succession rate,and other analysis methods.The results showed distinct shifts in the community structure of phytoplankton functional groups within study period.The Cyclotella sp.was dominant in 2016 and 2017,and Pseudanabaena limnetica was the dominant group in 2018 and 2019.It appears that the phytoplankton composition and biomass are closely related to the water temperature and nutrient status in this reservoir.The results clearly showed that the permanganate index(COD_(Mn))was the key factor of dramatic phytoplankton functional group succession,and the change in succession rates was closely caused by total nitrogen concentration(TN).Therefore,the succession pattern and key factors of Hongfeng Reservoir revealed in this study were important guidance for the management of drinking water reservoirs in southwest China.A reasonable limit on exogenous nutrient input should be a priority,especially in high water temperature period.展开更多
Synapses are essential structures in the nervous system and normally form between two cells.However,some occur in a single neuron between the axon and its own dendrites and soma.These special synapses are known as aut...Synapses are essential structures in the nervous system and normally form between two cells.However,some occur in a single neuron between the axon and its own dendrites and soma.These special synapses are known as autapses(or autosynapses or self-synapses)[1].Previous studies have shown that autapses were much more abundant in cultured neurons[2–4]than in the intact brain,so there was suspicion that autapses in vivo may be wiring errors or redundant structures[5].展开更多
The study of macroscopic discrete granular materials holds significance in hydraulic engineering,geotechnical engineering,as well as road and bridge engineering.Its foundational scientific exploration bears profound t...The study of macroscopic discrete granular materials holds significance in hydraulic engineering,geotechnical engineering,as well as road and bridge engineering.Its foundational scientific exploration bears profound theoretical implications and is of pivotal practical value to engineering endeavors.Within the realm of engineering construction,issues such as dam breakages,earth-rock dam damage,and geological disasters involving loose particles pose substantial threats to the safety of both national livelihoods and property.Thus,delving into the examination of the structural stability of granular materials at the mesoscopic scale becomes an imperative pursuit.In this study,the topological structure of granular materials is identified and segmented based on image processing techniques,and the relationship between the compressive capacity of polygonal structures and the number of polygonal sides is studied.The redundancy function is defined to evaluate the structural stability of granular materials.In addition,the definition of structure tensor is introduced,and redundancy and structure tensor are applied to the study of biaxial compression of shale materials.The research results contribute to improving engineering safety and have guiding merits for the research and application of granular materials.Future work could focus on extending these methods to other types of granular materials and exploring their behavior under different loading conditions.展开更多
针对传统的K-medoids聚类算法在聚类时需要随机选择初始类中心且指定聚类数目K,及聚类结果不稳定的问题,提出了一种优化初始类中心的自适应K-medoids算法(adaptive K-medoids algorithm for optimizing initial class centers,CH_KD)....针对传统的K-medoids聚类算法在聚类时需要随机选择初始类中心且指定聚类数目K,及聚类结果不稳定的问题,提出了一种优化初始类中心的自适应K-medoids算法(adaptive K-medoids algorithm for optimizing initial class centers,CH_KD).其思想是定义了特征重要度,以此筛选出每一簇中最优的代表特征,组成特征子集,并重点研究了传统划分算法的自适应优化与改进.首先,利用特征标准差定义特征区分度,选择出区分度强的特征.其次,利用皮尔逊相关系数度量特征簇中每个特征的冗余度,选择出冗余度低的特征.最后,将特征区分度与特征冗余度之积作为特征重要度,以此筛选出每一簇中最优的代表特征,组成特征子集.实验将所提算法与其他聚类算法在14个UCI数据集上进行对比,结果验证了CH_KD算法的有效性与优势.展开更多
基金supported by the National Natural Sci ence Foundation of China(No.31672543)the Zhejiang Province“Sannongliufang”Science and Technology Coopera tion Project(No.2020SNLF007),China.
文摘Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals,including humans(Montoya and Liesenfeld,2004).It occurs worldwide and can persist for a lifetime in mammals.Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite.In immune-competent individuals,T.
基金supported by grants from the National Natural Science Foundation of China(No.60970091, 61171007, 11131009)
文摘Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but most output a long list of significantly enriched terms that are often redundant, making it difficult to extract the most meaningful functions. In this paper, we present GOMA, a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules. With this method, we systematically revealed functional GO modules, i.e., groups of functionally similar GO terms, via an optimization model and then ranked them by enrichment scores. Our new method simplifies enrichment analysis results by reducing redundancy, thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results.
文摘Dual redundant manipulators are extremely useful for tasks in dangerous or space environments, but efficient and real time coordinated control is hard to achieve. Collision avoidance between two cooperative manipulators is vital to the successful applications of dual redundant manipulators. Although methods based on the distance function have been demonstrated simple and efficient, different collision avoidance points can usually produce completely different results and even failure. The paper discussed the choices of collision avoidance points and proposed a novel method for the choosing of those points. The method is testified by simulation results of two redundant planar manipulators.
基金Supported by the National Natural Science Foundation of China(No.U1612442)the Science and Technology Foundation of Guizhou Province(Nos.[2020]6009,[2020]4Y009)Anton Brancelj was supported by Slovenian Research Agency(ARRS)(No.P1-0255)。
文摘Reservoirs are an important water source in many densely populated areas in southwest China.Phytoplankton play an essential role in maintaining the structure and function of reservoir ecosystems.Understanding the succession in phytoplankton communities and the factors driving it are essential for eff ective water quality management in drinking water reservoirs.In this study,water samples were collected monthly at the surface layers from March 2016 to December 2019 in Hongfeng Reservoir,southwest China.The relationship between functional group succession was analyzed based on nonmetric multidimensional scaling analysis(NMDS),redundancy analysis(RDA),succession rate,and other analysis methods.The results showed distinct shifts in the community structure of phytoplankton functional groups within study period.The Cyclotella sp.was dominant in 2016 and 2017,and Pseudanabaena limnetica was the dominant group in 2018 and 2019.It appears that the phytoplankton composition and biomass are closely related to the water temperature and nutrient status in this reservoir.The results clearly showed that the permanganate index(COD_(Mn))was the key factor of dramatic phytoplankton functional group succession,and the change in succession rates was closely caused by total nitrogen concentration(TN).Therefore,the succession pattern and key factors of Hongfeng Reservoir revealed in this study were important guidance for the management of drinking water reservoirs in southwest China.A reasonable limit on exogenous nutrient input should be a priority,especially in high water temperature period.
基金supported by the National Natural Science Foundation of China (31430038, 31630029, and 31661143037)
文摘Synapses are essential structures in the nervous system and normally form between two cells.However,some occur in a single neuron between the axon and its own dendrites and soma.These special synapses are known as autapses(or autosynapses or self-synapses)[1].Previous studies have shown that autapses were much more abundant in cultured neurons[2–4]than in the intact brain,so there was suspicion that autapses in vivo may be wiring errors or redundant structures[5].
基金supported by the Postdoctor Project of Hubei Province(2024HBBHCXA028)CRSRI Open Research Program(grant No.CKWV20241179/KY)+1 种基金Postdoctoral Fellowship Program of CPSF(grant No.GZC20230901)China Postdoctoral Science Foundation(grant No.2023M741267).
文摘The study of macroscopic discrete granular materials holds significance in hydraulic engineering,geotechnical engineering,as well as road and bridge engineering.Its foundational scientific exploration bears profound theoretical implications and is of pivotal practical value to engineering endeavors.Within the realm of engineering construction,issues such as dam breakages,earth-rock dam damage,and geological disasters involving loose particles pose substantial threats to the safety of both national livelihoods and property.Thus,delving into the examination of the structural stability of granular materials at the mesoscopic scale becomes an imperative pursuit.In this study,the topological structure of granular materials is identified and segmented based on image processing techniques,and the relationship between the compressive capacity of polygonal structures and the number of polygonal sides is studied.The redundancy function is defined to evaluate the structural stability of granular materials.In addition,the definition of structure tensor is introduced,and redundancy and structure tensor are applied to the study of biaxial compression of shale materials.The research results contribute to improving engineering safety and have guiding merits for the research and application of granular materials.Future work could focus on extending these methods to other types of granular materials and exploring their behavior under different loading conditions.
文摘针对传统的K-medoids聚类算法在聚类时需要随机选择初始类中心且指定聚类数目K,及聚类结果不稳定的问题,提出了一种优化初始类中心的自适应K-medoids算法(adaptive K-medoids algorithm for optimizing initial class centers,CH_KD).其思想是定义了特征重要度,以此筛选出每一簇中最优的代表特征,组成特征子集,并重点研究了传统划分算法的自适应优化与改进.首先,利用特征标准差定义特征区分度,选择出区分度强的特征.其次,利用皮尔逊相关系数度量特征簇中每个特征的冗余度,选择出冗余度低的特征.最后,将特征区分度与特征冗余度之积作为特征重要度,以此筛选出每一簇中最优的代表特征,组成特征子集.实验将所提算法与其他聚类算法在14个UCI数据集上进行对比,结果验证了CH_KD算法的有效性与优势.
