Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with ca...Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.展开更多
Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were ra...Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and展开更多
To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The R...To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The RBM,constructed via eigenvector continuation and trained on both bound and resonant configurations,enables the fast and accurate emulation of resonance properties across the parameter space.To identify the physical resonant states from the emulator’s output,we introduce an overlap-based selection technique that effectively isolates true solutions from background artifacts.By applying this framework to unbound nucleus ^(6)Be,we quantified the model uncertainty in the predicted complex energies.The results demonstrate relative errors of 17.48%in the real part and 8.24%in the imaginary part,while achieving a speedup of four orders of magnitude compared with the full GCC calculations.To further investigate the asymptotic behavior of the resonant-state wavefunctions within the RBM framework,we employed a Lippmann–Schwinger(L–S)-based correction scheme.This approach not only improves the consistency between eigenvalues and wavefunctions but also enables a seamless extension from real-space training data to the complex energy plane.By bridging the gap between bound-state and continuum regimes,the L–S correction significantly enhances the emulator’s capability to accurately capture continuum structures in open quantum systems.展开更多
OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluo...OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.展开更多
In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.T...In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.The reduced differential transforms method(RDTM)is one of the interesting methods for finding the approximate solutions for nonlinear problems.We apply the RDTM to discuss the analytic approximate solutions to the SI1I2R model for the spread of virus HCV-subtype and SIR childhood disease model.We discuss the numerical results at some special values of parameters in the approximate solutions.We use the computer software package such as Mathematical to find more iteration when calculating the approximate solutions.Graphical results and discussed quantitatively are presented to illustrate behavior of the obtained approximate solutions.展开更多
In this paper a new method for solving Goursat problem is introduced using Reduced Differential Transform Method (RDTM). The approximate analytical solution of the problem is calculated in the form of series with easi...In this paper a new method for solving Goursat problem is introduced using Reduced Differential Transform Method (RDTM). The approximate analytical solution of the problem is calculated in the form of series with easily computable components. The comparison of the methodology presented in this paper with some other well known techniques demonstrates the effectiveness and power of the newly proposed methodology.展开更多
The thermokinetic reduced extent equations of reversible inhibitions for Michaiels-Menten enzymatic reaction were deduced, and then the criteria for distingushing inhibition type was given and the methods for calculat...The thermokinetic reduced extent equations of reversible inhibitions for Michaiels-Menten enzymatic reaction were deduced, and then the criteria for distingushing inhibition type was given and the methods for calculating kinetic parameters, KM,Ki and Urn were suggested. This theory was applied to inverstigate the inhibited thermokinetics of laccase-catalyzed oxidation of o-dihydroxybenzene by m-dihydroxybenzene. The experimental results show the inhibition belongs to reversible competitive type, KM=6.224×10-3 mol L-1, Ki=2. 363 × 10-2 mol. L-1.展开更多
The current situation and difficulties of the structural system reliability analysis are mentioned. Then on the basis of Monte Carlo method and computer simulation, a new analysis method reduced expanding load method ...The current situation and difficulties of the structural system reliability analysis are mentioned. Then on the basis of Monte Carlo method and computer simulation, a new analysis method reduced expanding load method (RELM) is presented, which can be used to solve structural reliability problems effectively and conveniently. In this method, the uncertainties of loads, structural material properties and dimensions can be fully considered. If the statistic parameters of stochastic variables are known, by using this method, the probability of failure can be estimated rather accurately. In contrast with traditional approaches,RELM method gives a much better understanding of structural failure frequency and its reliability index β is more meaningful.To illustrate this new idea, a specific example is given.展开更多
This paper presents the generalized reduced gradient method （GRG） and its realization forms. The application example of GRG in the optimization design of a single-stage cylindrical gear reducer is introduced. The al...This paper presents the generalized reduced gradient method （GRG） and its realization forms. The application example of GRG in the optimization design of a single-stage cylindrical gear reducer is introduced. The algo- rithm of the GRG method is realized in Vissim software. Based on the mathematical model of the single-stage cylin- drical gear reducer, the simulation structure of the optimization design was achieved. The experiment results show that the GRG method has fewer iterations and higher precision. The GRG method is very suitable for solving mechanical optimization design.展开更多
Probabilistic assessment of seismic performance(SPPA)is a crucial aspect of evaluating the seismic behavior of structures.For complex bridges with inherent uncertainties,conducting precise and efficient seismic reliab...Probabilistic assessment of seismic performance(SPPA)is a crucial aspect of evaluating the seismic behavior of structures.For complex bridges with inherent uncertainties,conducting precise and efficient seismic reliability analysis remains a significant challenge.To address this issue,the current study introduces a sample-unequal weight fractional moment assessment method,which is based on an improved correlation-reduced Latin hypercube sampling(ICLHS)technique.This method integrates the benefits of important sampling techniques with interpolator quadrature formulas to enhance the accuracy of estimating the extreme value distribution(EVD)for the seismic response of complex nonlinear structures subjected to non-stationary ground motions.Additionally,the core theoretical approaches employed in seismic reliability analysis(SRA)are elaborated,such as dimension reduction for simulating non-stationary random ground motions and a fractional-maximum entropy single-loop solution strategy.The effectiveness of this proposed method is validated through a three-story nonlinear shear frame structure.Furthermore,a comprehensive reliability analysis of a real-world long-span,single-pylon suspension bridge is conducted using the developed theoretical framework within the OpenSees platform,leading to key insights and conclusions.展开更多
Objective： To observe the clinical effect of lower-reinforcing and upper-reducing acupuncture method for hyperplasia of mammary gland （HMG） and its influence on estradiol （E2） and progesterone （P）. Methods： A ...Objective： To observe the clinical effect of lower-reinforcing and upper-reducing acupuncture method for hyperplasia of mammary gland （HMG） and its influence on estradiol （E2） and progesterone （P）. Methods： A randomized, single-blinded and controlled trial was conducted. A total of 124 cases conforming to the inclusion criteria were randomized by random number table into a treatment group and a control group, with 62 cases in each group. Patients in both groups received acupuncture therapy at the same acupoints, while patients in the treatment group received lower-reinforcing and upper-reducing method, and patients in the control group received even reinforcing-reducing manipulation. The treatment started around 10 d before menstruation and was conducted every other day. Patients received 5 treatments in each menstruation cycle for consecutive 3 cycles. The levels of E2, P and E2/P and clinical efficacy were measured before and after treatment. Results： After treatment, the breast lump size, pain intensity and concomitant symptoms score in both groups were substantially lower than those before treatment, showing statistical significances （all P〈0.01）, and the improvement in the treatment group was higher than that in the control group, and the between-group comparisons showed statistical significances （all P〈0.01）. After treatment, the overall effective rate was 91.9% in the treatment group, higher than 72.6% in the control group, and the between-group comparison showed a statistical significance （P〈0.01）. After treatment, levels of E2, P and E2/P value showed no statistical significance when compared with those before treatment in the two groups （all P〉0.05）. Conclusion： Lower-reinforcing and upper-reducing acupuncture method can effectively alleviate clinical symptoms and signs in HMG patients, and produce a better effect than even reinforcing-reducing manipulation. The majority of HMG patients＇ E2, P level and E2/P value were not beyond the normal ranges; therefore, acupuncture showed no substantial influence on E2 and P levels and E2/P value.展开更多
By applying nanotechnology, a new type of silver/graphite (AgC) electricalcontact was fabricated and characterized. The AgC coating powders were obtained through high-energyball milling and reducer liquid spraying-coa...By applying nanotechnology, a new type of silver/graphite (AgC) electricalcontact was fabricated and characterized. The AgC coating powders were obtained through high-energyball milling and reducer liquid spraying-coating method. The as-prepared powders were examined bytransmission electron microscope (TEM), scanning electron microscope (SEM), and X-ray diffraction(XRD). The results show that the thickness of graphite flakes milled for 10 h is about 50-60 nm andthe AgC coating powders exhibit flocculent structure with quite fine and homogeneous internalmicropores. XRD implies that the average crystalline size of silver in coating powders is about 50nm. The mechanical and physical properties of this newly developed AgC contact made from theabove-mentioned nanocrystalline powders by traditional powder metallurgy technique were measured.Compared with its counterparts made from other techniques, the properties of this new AgC contacthave been optimized. High surface energy and high-energy interfaces of the nanocrystalline AgCcoating powders provide powerful driving force for sintering densification. Moreover, the flocculentstructure of the powders is also an important factor to acquire fine density ratio.展开更多
The development of mathematical modeling of infectious diseases is a key research area in various elds including ecology and epidemiology.One aim of these models is to understand the dynamics of behavior in infectious...The development of mathematical modeling of infectious diseases is a key research area in various elds including ecology and epidemiology.One aim of these models is to understand the dynamics of behavior in infectious diseases.For the new strain of coronavirus(COVID-19),there is no vaccine to protect people and to prevent its spread so far.Instead,control strategies associated with health care,such as social distancing,quarantine,travel restrictions,can be adopted to control the pandemic of COVID-19.This article sheds light on the dynamical behaviors of nonlinear COVID-19 models based on two methods:the homotopy perturbation method(HPM)and the modied reduced differential transform method(MRDTM).We invoke a novel signal ow graph that is used to describe the COVID-19 model.Through our mathematical studies,it is revealed that social distancing between potentially infected individuals who are carrying the virus and healthy individuals can decrease or interrupt the spread of the virus.The numerical simulation results are in reasonable agreement with the study predictions.The free equilibrium and stability point for the COVID-19 model are investigated.Also,the existence of a uniformly stable solution is proved.展开更多
AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(gr...AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.展开更多
In this paper, we use the classical Lie group symmetry method to get the Lie point symmetries of the （2＋1）-dimensional hyperbolic nonlinear Schr6dinger （HNLS） equation and reduce the （2＋1）-dimensional HNLS equ...In this paper, we use the classical Lie group symmetry method to get the Lie point symmetries of the （2＋1）-dimensional hyperbolic nonlinear Schr6dinger （HNLS） equation and reduce the （2＋1）-dimensional HNLS equation to some （1 ＋ 1 ）-dimensional partial differential systems. Finally, many exact travelling solutions of the （2＋1）-dimensional HNLS equation are obtained by the classical Lie symmetry reduced method.展开更多
In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usa...In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usage of linear interpolation principle.The original problem is projected onto the reduced basis space by linear interpolation projection,and subsequently an associated interpolation matrix is generated.To ensure the largest nonsingularity,the interpolation matrix needs to go through a timenode choosing process,which is developed by applying the angle of vector spaces.As a part of this technique,error estimation is recommended for achieving the computational error bound.To ensure the successful performance of this technique,the offline-online computational procedures are conducted in practical engineering.Two numerical examples demonstrate the accuracy and efficiency of the presented method.展开更多
From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied comp...From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.展开更多
In the paper,a reduced basis(RB)method for time-dependent nonlocal problems with a special parameterized fractional Laplace kernel function is proposed.Because of the lack of sparsity of discretized nonlocal systems c...In the paper,a reduced basis(RB)method for time-dependent nonlocal problems with a special parameterized fractional Laplace kernel function is proposed.Because of the lack of sparsity of discretized nonlocal systems compared to corresponding local partial differential equation(PDE)systems,model reduction for nonlocal systems becomes more critical.The method of snapshots and greedy(MOS-greedy)algorithm of RB method is developed for nonlocal problems with random inputs,which provides an efficient and reliable approximation of the solution.A major challenge lies in the excessive influence of the time domain on the model reduction process.To address this,the Fourier transform is applied to convert the original time-dependent parabolic equation into a frequency-dependent elliptic equation,where variable frequencies are independent.This enables parallel computation for approximating the solution in the frequency domain.Finally,the proposed MOS-greedy algorithm is applied to the nonlocal diffusion problems.Numerical results demonstrate that it provides an accurate approximation of the full order problems and significantly improves computational efficiency.展开更多
The multibody system transfer matrix method(MSTMM),a novel dynamics approach developed during the past three decades,has several advantages compared to conventional dynamics methods.Some of these advantages include av...The multibody system transfer matrix method(MSTMM),a novel dynamics approach developed during the past three decades,has several advantages compared to conventional dynamics methods.Some of these advantages include avoiding global dynamics equations with a system inertia matrix,utilizing low‐order matrices independent of system degree of freedom,high computational speed,and simplicity of computer implementation.MSTMM has been widely used in computer modeling,simulations,and performance evaluation of approximately 150 different complex mechanical systems.In this paper,the following aspects regarding MSTMM are reviewed:basic theory,algorithms,simulation and design software,and applications.Future research directions and generalization to more applications in various fields of science,technology,and engineering are discussed.展开更多
In this work we consider the Reduced Basis method for the solution of parametrized advection-reaction partial differential equations. For the generation of the basis we adopt a stabilized finite element method and we ...In this work we consider the Reduced Basis method for the solution of parametrized advection-reaction partial differential equations. For the generation of the basis we adopt a stabilized finite element method and we define the Reduced Basis method in the ＂primal- dual＂ formulation for this stabilized problem. We provide a priori Reduced Basis error estimates and we discuss the effects of the finite element approximation on the Reduced Basis error. We propose an adaptive algorithm, based on the a posteriori Reduced Basis error estimate, for the selection of the sample sets upon which the basis are built; the idea leading this algorithm is the minimization of the computational costs associated with the solution of the Reduced Basis problem. Numerical tests demonstrate the efficiency, in terms of computational costs, of the ＂primal-dual＂ Reduced Basis approach with respect to an ＂only primal＂ one. Parametrized advection-reaction partial differential equations, Reduced Basis method, ＂primal-dual＂ reduced basis approach, Stabilized finite element method, a posteriori error estimation.展开更多
文摘Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.
文摘Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and
基金supported by the National Key Research and Development Program(MOST 2023YFA1606404 and MOST 2022YFA1602303)the National Natural Science Foundation of China(Nos.12347106,12147101,and 12447122)the China Postdoctoral Science Foundation(No.2024M760489).
文摘To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The RBM,constructed via eigenvector continuation and trained on both bound and resonant configurations,enables the fast and accurate emulation of resonance properties across the parameter space.To identify the physical resonant states from the emulator’s output,we introduce an overlap-based selection technique that effectively isolates true solutions from background artifacts.By applying this framework to unbound nucleus ^(6)Be,we quantified the model uncertainty in the predicted complex energies.The results demonstrate relative errors of 17.48%in the real part and 8.24%in the imaginary part,while achieving a speedup of four orders of magnitude compared with the full GCC calculations.To further investigate the asymptotic behavior of the resonant-state wavefunctions within the RBM framework,we employed a Lippmann–Schwinger(L–S)-based correction scheme.This approach not only improves the consistency between eigenvalues and wavefunctions but also enables a seamless extension from real-space training data to the complex energy plane.By bridging the gap between bound-state and continuum regimes,the L–S correction significantly enhances the emulator’s capability to accurately capture continuum structures in open quantum systems.
基金Supported by the National Natural Science Foundation of China(Use PET Brain Imaging Technology to Study the Acupuncture Manipulation of Twirling Reinforcing-Reducing Regulation in Spontaneously Hypertensive Rats by Central Integration Signaling Network Construction,No.8157150840)
文摘OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.
文摘In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.The reduced differential transforms method(RDTM)is one of the interesting methods for finding the approximate solutions for nonlinear problems.We apply the RDTM to discuss the analytic approximate solutions to the SI1I2R model for the spread of virus HCV-subtype and SIR childhood disease model.We discuss the numerical results at some special values of parameters in the approximate solutions.We use the computer software package such as Mathematical to find more iteration when calculating the approximate solutions.Graphical results and discussed quantitatively are presented to illustrate behavior of the obtained approximate solutions.
文摘In this paper a new method for solving Goursat problem is introduced using Reduced Differential Transform Method (RDTM). The approximate analytical solution of the problem is calculated in the form of series with easily computable components. The comparison of the methodology presented in this paper with some other well known techniques demonstrates the effectiveness and power of the newly proposed methodology.
文摘The thermokinetic reduced extent equations of reversible inhibitions for Michaiels-Menten enzymatic reaction were deduced, and then the criteria for distingushing inhibition type was given and the methods for calculating kinetic parameters, KM,Ki and Urn were suggested. This theory was applied to inverstigate the inhibited thermokinetics of laccase-catalyzed oxidation of o-dihydroxybenzene by m-dihydroxybenzene. The experimental results show the inhibition belongs to reversible competitive type, KM=6.224×10-3 mol L-1, Ki=2. 363 × 10-2 mol. L-1.
文摘The current situation and difficulties of the structural system reliability analysis are mentioned. Then on the basis of Monte Carlo method and computer simulation, a new analysis method reduced expanding load method (RELM) is presented, which can be used to solve structural reliability problems effectively and conveniently. In this method, the uncertainties of loads, structural material properties and dimensions can be fully considered. If the statistic parameters of stochastic variables are known, by using this method, the probability of failure can be estimated rather accurately. In contrast with traditional approaches,RELM method gives a much better understanding of structural failure frequency and its reliability index β is more meaningful.To illustrate this new idea, a specific example is given.
文摘This paper presents the generalized reduced gradient method （GRG） and its realization forms. The application example of GRG in the optimization design of a single-stage cylindrical gear reducer is introduced. The algo- rithm of the GRG method is realized in Vissim software. Based on the mathematical model of the single-stage cylin- drical gear reducer, the simulation structure of the optimization design was achieved. The experiment results show that the GRG method has fewer iterations and higher precision. The GRG method is very suitable for solving mechanical optimization design.
基金Sichuan Science and Technology Program under Grant No.2024NSFSC0932the National Natural Science Foundation of China under Grant No.52008047。
文摘Probabilistic assessment of seismic performance(SPPA)is a crucial aspect of evaluating the seismic behavior of structures.For complex bridges with inherent uncertainties,conducting precise and efficient seismic reliability analysis remains a significant challenge.To address this issue,the current study introduces a sample-unequal weight fractional moment assessment method,which is based on an improved correlation-reduced Latin hypercube sampling(ICLHS)technique.This method integrates the benefits of important sampling techniques with interpolator quadrature formulas to enhance the accuracy of estimating the extreme value distribution(EVD)for the seismic response of complex nonlinear structures subjected to non-stationary ground motions.Additionally,the core theoretical approaches employed in seismic reliability analysis(SRA)are elaborated,such as dimension reduction for simulating non-stationary random ground motions and a fractional-maximum entropy single-loop solution strategy.The effectiveness of this proposed method is validated through a three-story nonlinear shear frame structure.Furthermore,a comprehensive reliability analysis of a real-world long-span,single-pylon suspension bridge is conducted using the developed theoretical framework within the OpenSees platform,leading to key insights and conclusions.
文摘Objective： To observe the clinical effect of lower-reinforcing and upper-reducing acupuncture method for hyperplasia of mammary gland （HMG） and its influence on estradiol （E2） and progesterone （P）. Methods： A randomized, single-blinded and controlled trial was conducted. A total of 124 cases conforming to the inclusion criteria were randomized by random number table into a treatment group and a control group, with 62 cases in each group. Patients in both groups received acupuncture therapy at the same acupoints, while patients in the treatment group received lower-reinforcing and upper-reducing method, and patients in the control group received even reinforcing-reducing manipulation. The treatment started around 10 d before menstruation and was conducted every other day. Patients received 5 treatments in each menstruation cycle for consecutive 3 cycles. The levels of E2, P and E2/P and clinical efficacy were measured before and after treatment. Results： After treatment, the breast lump size, pain intensity and concomitant symptoms score in both groups were substantially lower than those before treatment, showing statistical significances （all P〈0.01）, and the improvement in the treatment group was higher than that in the control group, and the between-group comparisons showed statistical significances （all P〈0.01）. After treatment, the overall effective rate was 91.9% in the treatment group, higher than 72.6% in the control group, and the between-group comparison showed a statistical significance （P〈0.01）. After treatment, levels of E2, P and E2/P value showed no statistical significance when compared with those before treatment in the two groups （all P〉0.05）. Conclusion： Lower-reinforcing and upper-reducing acupuncture method can effectively alleviate clinical symptoms and signs in HMG patients, and produce a better effect than even reinforcing-reducing manipulation. The majority of HMG patients＇ E2, P level and E2/P value were not beyond the normal ranges; therefore, acupuncture showed no substantial influence on E2 and P levels and E2/P value.
基金This work was financially supported by the National Natural Science Foundation of China (No. 50071029).
文摘By applying nanotechnology, a new type of silver/graphite (AgC) electricalcontact was fabricated and characterized. The AgC coating powders were obtained through high-energyball milling and reducer liquid spraying-coating method. The as-prepared powders were examined bytransmission electron microscope (TEM), scanning electron microscope (SEM), and X-ray diffraction(XRD). The results show that the thickness of graphite flakes milled for 10 h is about 50-60 nm andthe AgC coating powders exhibit flocculent structure with quite fine and homogeneous internalmicropores. XRD implies that the average crystalline size of silver in coating powders is about 50nm. The mechanical and physical properties of this newly developed AgC contact made from theabove-mentioned nanocrystalline powders by traditional powder metallurgy technique were measured.Compared with its counterparts made from other techniques, the properties of this new AgC contacthave been optimized. High surface energy and high-energy interfaces of the nanocrystalline AgCcoating powders provide powerful driving force for sintering densification. Moreover, the flocculentstructure of the powders is also an important factor to acquire fine density ratio.
基金funded by“Taif University Researchers Supporting Project Number(TURSP-2020/16),Taif University,Taif,Saudi Arabia.”。
文摘The development of mathematical modeling of infectious diseases is a key research area in various elds including ecology and epidemiology.One aim of these models is to understand the dynamics of behavior in infectious diseases.For the new strain of coronavirus(COVID-19),there is no vaccine to protect people and to prevent its spread so far.Instead,control strategies associated with health care,such as social distancing,quarantine,travel restrictions,can be adopted to control the pandemic of COVID-19.This article sheds light on the dynamical behaviors of nonlinear COVID-19 models based on two methods:the homotopy perturbation method(HPM)and the modied reduced differential transform method(MRDTM).We invoke a novel signal ow graph that is used to describe the COVID-19 model.Through our mathematical studies,it is revealed that social distancing between potentially infected individuals who are carrying the virus and healthy individuals can decrease or interrupt the spread of the virus.The numerical simulation results are in reasonable agreement with the study predictions.The free equilibrium and stability point for the COVID-19 model are investigated.Also,the existence of a uniformly stable solution is proved.
基金Supported by Foundation for Promotion of Cancer Research by Ministry of Health,Labor and Welfare in Japan
文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.
基金Supported by the National Natural Science Foundation of China under Grant No.10875106
文摘In this paper, we use the classical Lie group symmetry method to get the Lie point symmetries of the （2＋1）-dimensional hyperbolic nonlinear Schr6dinger （HNLS） equation and reduce the （2＋1）-dimensional HNLS equation to some （1 ＋ 1 ）-dimensional partial differential systems. Finally, many exact travelling solutions of the （2＋1）-dimensional HNLS equation are obtained by the classical Lie symmetry reduced method.
基金supported by the National Natural Science Foundation of China (10802028)the Major State Basic Research Development Program of China (2010CB832705)the National Science Fund for Distinguished Young Scholars (10725208)
文摘In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usage of linear interpolation principle.The original problem is projected onto the reduced basis space by linear interpolation projection,and subsequently an associated interpolation matrix is generated.To ensure the largest nonsingularity,the interpolation matrix needs to go through a timenode choosing process,which is developed by applying the angle of vector spaces.As a part of this technique,error estimation is recommended for achieving the computational error bound.To ensure the successful performance of this technique,the offline-online computational procedures are conducted in practical engineering.Two numerical examples demonstrate the accuracy and efficiency of the presented method.
文摘From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,China(Grant 2024A1515012548)supported by the National Natural Science Foundation of China(Grant 12401567)+1 种基金by the 2023 Guangzhou Basic and Applied Basic Research Project(Grant 2023A04J0035)by the Talent Special Projects of School-level Scientific Research Programs under Guangdong Poiytechnic Normal University(Grant 2022SDKYA025).
文摘In the paper,a reduced basis(RB)method for time-dependent nonlocal problems with a special parameterized fractional Laplace kernel function is proposed.Because of the lack of sparsity of discretized nonlocal systems compared to corresponding local partial differential equation(PDE)systems,model reduction for nonlocal systems becomes more critical.The method of snapshots and greedy(MOS-greedy)algorithm of RB method is developed for nonlocal problems with random inputs,which provides an efficient and reliable approximation of the solution.A major challenge lies in the excessive influence of the time domain on the model reduction process.To address this,the Fourier transform is applied to convert the original time-dependent parabolic equation into a frequency-dependent elliptic equation,where variable frequencies are independent.This enables parallel computation for approximating the solution in the frequency domain.Finally,the proposed MOS-greedy algorithm is applied to the nonlocal diffusion problems.Numerical results demonstrate that it provides an accurate approximation of the full order problems and significantly improves computational efficiency.
基金National Program on Key Basic Research Project of China,Grant/Award Number:613308Science Challenge Project,Grant/Award Number:TZ2016006‐0104+3 种基金Natural Science Foundation of China Government,Grant/Award Number:11472135supported by the National Program on Key Basic Research Project of China(973 Program,No.613308)the Science Challenge Project(No.TZ2016006‐0104)the Natural Science Foundation of China Government(No.11472135).
文摘The multibody system transfer matrix method(MSTMM),a novel dynamics approach developed during the past three decades,has several advantages compared to conventional dynamics methods.Some of these advantages include avoiding global dynamics equations with a system inertia matrix,utilizing low‐order matrices independent of system degree of freedom,high computational speed,and simplicity of computer implementation.MSTMM has been widely used in computer modeling,simulations,and performance evaluation of approximately 150 different complex mechanical systems.In this paper,the following aspects regarding MSTMM are reviewed:basic theory,algorithms,simulation and design software,and applications.Future research directions and generalization to more applications in various fields of science,technology,and engineering are discussed.
基金support provided thorough the "Progetto Rocca", MIT-Politecnico di Milano collaboration
文摘In this work we consider the Reduced Basis method for the solution of parametrized advection-reaction partial differential equations. For the generation of the basis we adopt a stabilized finite element method and we define the Reduced Basis method in the ＂primal- dual＂ formulation for this stabilized problem. We provide a priori Reduced Basis error estimates and we discuss the effects of the finite element approximation on the Reduced Basis error. We propose an adaptive algorithm, based on the a posteriori Reduced Basis error estimate, for the selection of the sample sets upon which the basis are built; the idea leading this algorithm is the minimization of the computational costs associated with the solution of the Reduced Basis problem. Numerical tests demonstrate the efficiency, in terms of computational costs, of the ＂primal-dual＂ Reduced Basis approach with respect to an ＂only primal＂ one. Parametrized advection-reaction partial differential equations, Reduced Basis method, ＂primal-dual＂ reduced basis approach, Stabilized finite element method, a posteriori error estimation.
