Photodynamic therapy(PDT)has thrived as a promising cancer treatment modality in recent years.Herein,four trinuclear platinum-triphenylamine isomers were synthesized to investigate their potential as PDT anticancer ag...Photodynamic therapy(PDT)has thrived as a promising cancer treatment modality in recent years.Herein,four trinuclear platinum-triphenylamine isomers were synthesized to investigate their potential as PDT anticancer agents.The results found that when platinum_((II))moieties were conjugated to the paraposition of the pyridyl ring of the triphenylamine core(complexes 1 and 2),they exhibited much better PDT activities than their meta-position coordinated counterparts(complexes 3 and 4),owing to the redder absorption and emission wavelength,higher singlet oxygen quantum yield and cell nucleus-targeted ability.Further studies revealed that complex 2,which was the most potent among the four complexes,effectively induced DNA damage responses,arrested the cell cycle in the G2/M phase and consequently resulted in cancer cell apoptosis upon 425 nm light irradiation(40 mW cm^(-2),15 min).In vivo studies also demonstrated that 2 was an effective photodynamic anticancer agent.展开更多
基金supported by the 973 program(No.2015CB856301)the National Science Foundation of China(No.21837006 and 21572282)+2 种基金the Ministry of Education of China(No.IRT-17R111)the Science and Technology Planning Project of Guangdong Province(No.2013B051000047 and 207999)the Fundamental Research Funds for the Central Universities。
文摘Photodynamic therapy(PDT)has thrived as a promising cancer treatment modality in recent years.Herein,four trinuclear platinum-triphenylamine isomers were synthesized to investigate their potential as PDT anticancer agents.The results found that when platinum_((II))moieties were conjugated to the paraposition of the pyridyl ring of the triphenylamine core(complexes 1 and 2),they exhibited much better PDT activities than their meta-position coordinated counterparts(complexes 3 and 4),owing to the redder absorption and emission wavelength,higher singlet oxygen quantum yield and cell nucleus-targeted ability.Further studies revealed that complex 2,which was the most potent among the four complexes,effectively induced DNA damage responses,arrested the cell cycle in the G2/M phase and consequently resulted in cancer cell apoptosis upon 425 nm light irradiation(40 mW cm^(-2),15 min).In vivo studies also demonstrated that 2 was an effective photodynamic anticancer agent.
