The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve ...The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve the depolarization of cell membrane , speed up the burst ot slow wave and spikepotentials (when the drug concentration was 1 % ,P>0. 05 , 10 % or 20 % ,P<O. 05) , which were dose de-pendent. At the same concentration the effects of Rb were more significant than those of DCQ. These re-sults suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the con-traction of the colon , is one of the mechanisms of the purgative actiort of these drugs at the cellular level.The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranesin a resting state.展开更多
文摘The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve the depolarization of cell membrane , speed up the burst ot slow wave and spikepotentials (when the drug concentration was 1 % ,P>0. 05 , 10 % or 20 % ,P<O. 05) , which were dose de-pendent. At the same concentration the effects of Rb were more significant than those of DCQ. These re-sults suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the con-traction of the colon , is one of the mechanisms of the purgative actiort of these drugs at the cellular level.The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranesin a resting state.
