The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensit...The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensity changes,which can compromise accuracy and repeatability.In this study,we report a novel fluorescent probe(R)-Z1 that achieves effective enantioselective recognition of chiral amino acids in water by altering emission wavelengths(>60 nm).This water-soluble probe(R)-Z1 exhibits cyan or yellow-green luminescence upon interaction with amino acid enantiomers,enabling reliable chiral detection of 14 natural amino acids.It also allows for the determination of enantiomeric excess through monitoring changes in luminescent color.Additionally,a logic operation with two inputs and three outputs was constructed based on these optical properties.Notably,amino acid enantiomers were successfully detected via dual-channel analysis at both the food and cellular levels.This study provides a new dynamic luminescence-based tool for the accurate sensing and detection of amino acid enantiomers.展开更多
An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction...An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.展开更多
Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patient...Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patients.Methods We conducted a single-center,prospective,parallel-group feasibility randomized controlled trial.We recruited 80 participants using convenience sampling from the ICU of a hospital in Ningbo City,Zhejiang Province,between March 2025 and June 2025,and they were randomly assigned to either the control group(routine care)or the intervention group(routine care plus image recognition-based detection system).The system continuously tracked patients’hand positions via bedside cameras and generated real-time alarms when hands entered predefined risk zones,notifying on-duty nurses to enable early intervention.System stability was assessed by continuous system uptime;system performance and clinical feasibility were evaluated by the frequencies of risk actions and accidental dislodgement of medical supplies(ADMS).Results All 80 participants completed the intervention,with 40 patients in each group.The baseline characteristics and median observation time of the two groups were balanced(intervention group:48 h/patient vs.control group:49 h/patient).Compared with the control group,the intervention group showed fewer ADMS(2/40 vs.9/40)and detected more risk actions per 100 h(36 vs.25);all system-detected events had corroborating images with complete concordance on manual review,and all nurse-recorded hand-contact events were accurately captured.Conclusions The study demonstrated that the image recognition-based detection system can function stably in clinical settings,providing accurate and continuous surveillance while supporting the early detection of risk actions.By reducing the observation burden and offering real-time cognitive support,the system complements routine nursing care and serves as an additional safety measure in ICU practice.With further optimization and larger multicenter validation,this approach could have the potential to make a significant contribution to the development of smart ICUs and the broader digital transformation of nursing care.展开更多
In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,...In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.展开更多
目的基于MyD88/NF-κB通路探讨芪黄健脾滋肾颗粒(QJZ)改善MRL/lpr小鼠肾损害的作用机制。方法6只雌性C57BL/6小鼠为正常对照组(Control组),将30只雌性MRL/lpr小鼠随机分为模型组(Model组)、芪黄健脾滋肾颗粒低剂量组(QJZ-L组)、芪黄健...目的基于MyD88/NF-κB通路探讨芪黄健脾滋肾颗粒(QJZ)改善MRL/lpr小鼠肾损害的作用机制。方法6只雌性C57BL/6小鼠为正常对照组(Control组),将30只雌性MRL/lpr小鼠随机分为模型组(Model组)、芪黄健脾滋肾颗粒低剂量组(QJZ-L组)、芪黄健脾滋肾颗粒中剂量组(QJZ-M组)、芪黄健脾滋肾颗粒高剂量组(QJZ-H组)、泼尼松组(Pred组),6只/组。干预8周后取各组小鼠的尿液、全血及肾脏组织,生化试剂盒检测肾损害指标:24 h尿蛋白定量(24 h PRO)、尿总蛋白肌酐比值(UTPCR)、尿蛋白肌酐比(UACR)。ELISA法检测血清中免疫球蛋白G(IgG)、补体3(C3)、补体4(C4)、抗双链DNA抗体(antidsDNA)、干扰素γ(IFN-γ)、白细胞介素17(IL-17)。肾脏组织进行HE染色和透射电镜观察肾小球超微结构。采用RT-qPCR、Western blotting和免疫组化法检测肾组织中MyD88/NF-κB通路相关分子的表达。结果与Model组相比,QJZ-L、QJZ-M、QJZ-H和Pred组24 h PRO、UTPCR、UACR、IgG、anti-dsDNA、IFN-γ、IL-17降低(P<0.01),C3、C4水平升高(P<0.01)。HE染色结果显示,与Model组比较,各组肾小球内皮细胞增生、系膜增厚减轻。透射电镜显示,各组肾小球电子致密物沉积、炎性细胞浸润较Model组减轻。RT-qPCR和免疫组化结果显示,与Model组相比,QJZ-L、QJZ-M、QJZ-H和Pred组肾脏中MyD88、NF-κB表达下降(P<0.05)。Western blotting结果显示,各组肾脏中p65、p52蛋白水平低于Model组(P<0.01)。结论芪黄健脾滋肾颗粒能够改善MRL/lpr小鼠肾损害,其机制可能与抑制MyD88/NF-κB通路过度激活有关。展开更多
Artificial intelligence,such as deep learning technology,has advanced the study of facial expression recognition since facial expression carries rich emotional information and is significant for many naturalistic situ...Artificial intelligence,such as deep learning technology,has advanced the study of facial expression recognition since facial expression carries rich emotional information and is significant for many naturalistic situations.To pursue a high facial expression recognition accuracy,the network model of deep learning is generally designed to be very deep while the model’s real-time performance is typically constrained and limited.With MobileNetV3,a lightweight model with a good accuracy,a further study is conducted by adding a basic ResNet module to each of its existing modules and an SSH(Single Stage Headless Face Detector)context module to expand the model’s perceptual field.In this article,the enhanced model named Res-MobileNetV3,could alleviate the subpar of real-time performance and compress the size of large network models,which can process information at a rate of up to 33 frames per second.Although the improved model has been verified to be slightly inferior to the current state-of-the-art method in aspect of accuracy rate on the publically available face expression datasets,it can bring a good balance on accuracy,real-time performance,model size and model complexity in practical applications.展开更多
In the era of artificial intelligence(AI),healthcare and medical sciences are inseparable from different AI technologies[1].ChatGPT once shocked the medical field,but the latest AI model DeepSeek has recently taken th...In the era of artificial intelligence(AI),healthcare and medical sciences are inseparable from different AI technologies[1].ChatGPT once shocked the medical field,but the latest AI model DeepSeek has recently taken the lead[2].PubMed indexed publications on DeepSeek are evolving[3],but limited to editorials and news articles.In this Letter,we explore the use of DeepSeek in early symptoms recognition for stroke care.To the best of our knowledge,this is the first DeepSeek-related writing on stroke.展开更多
A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can ...A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number recognition.In the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection effect.In terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background noise.In addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production date.The experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line speeds.The Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.展开更多
As an essential field of multimedia and computer vision,3D shape recognition has attracted much research attention in recent years.Multiview-based approaches have demonstrated their superiority in generating effective...As an essential field of multimedia and computer vision,3D shape recognition has attracted much research attention in recent years.Multiview-based approaches have demonstrated their superiority in generating effective 3D shape representations.Typical methods usually extract the multiview global features and aggregate them together to generate 3D shape descriptors.However,there exist two disadvantages:First,the mainstream methods ignore the comprehensive exploration of local information in each view.Second,many approaches roughly aggregate multiview features by adding or concatenating them together.The information loss for some discriminative characteristics limits the representation effectiveness.To address these problems,a novel architecture named region-based joint attention network(RJAN)was proposed.Specifically,the authors first design a hierarchical local information exploration module for view descriptor extraction.The region-to-region and channel-to-channel relationships from different granularities can be comprehensively explored and utilised to provide more discriminative characteristics for view feature learning.Subsequently,a novel relation-aware view aggregation module is designed to aggregate the multiview features for shape descriptor generation,considering the view-to-view relationships.Extensive experiments were conducted on three public databases:ModelNet40,ModelNet10,and ShapeNetCore55.RJAN achieves state-of-the-art performance in the tasks of 3D shape classification and 3D shape retrieval,which demonstrates the effectiveness of RJAN.The code has been released on https://github.com/slurrpp/RJAN.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.22377097,22307036,22074114)Natural Science Foundation of Hubei Province of China(Nos.2020CFB623,2021CFB556)Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education(No.LCX202305)。
文摘The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensity changes,which can compromise accuracy and repeatability.In this study,we report a novel fluorescent probe(R)-Z1 that achieves effective enantioselective recognition of chiral amino acids in water by altering emission wavelengths(>60 nm).This water-soluble probe(R)-Z1 exhibits cyan or yellow-green luminescence upon interaction with amino acid enantiomers,enabling reliable chiral detection of 14 natural amino acids.It also allows for the determination of enantiomeric excess through monitoring changes in luminescent color.Additionally,a logic operation with two inputs and three outputs was constructed based on these optical properties.Notably,amino acid enantiomers were successfully detected via dual-channel analysis at both the food and cellular levels.This study provides a new dynamic luminescence-based tool for the accurate sensing and detection of amino acid enantiomers.
基金financially supported by the National Science and Technology Major Project——Deep Earth Probe and Mineral Resources Exploration(No.2024ZD1003701)the National Key R&D Program of China(No.2022YFC2905004)。
文摘An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.
文摘Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patients.Methods We conducted a single-center,prospective,parallel-group feasibility randomized controlled trial.We recruited 80 participants using convenience sampling from the ICU of a hospital in Ningbo City,Zhejiang Province,between March 2025 and June 2025,and they were randomly assigned to either the control group(routine care)or the intervention group(routine care plus image recognition-based detection system).The system continuously tracked patients’hand positions via bedside cameras and generated real-time alarms when hands entered predefined risk zones,notifying on-duty nurses to enable early intervention.System stability was assessed by continuous system uptime;system performance and clinical feasibility were evaluated by the frequencies of risk actions and accidental dislodgement of medical supplies(ADMS).Results All 80 participants completed the intervention,with 40 patients in each group.The baseline characteristics and median observation time of the two groups were balanced(intervention group:48 h/patient vs.control group:49 h/patient).Compared with the control group,the intervention group showed fewer ADMS(2/40 vs.9/40)and detected more risk actions per 100 h(36 vs.25);all system-detected events had corroborating images with complete concordance on manual review,and all nurse-recorded hand-contact events were accurately captured.Conclusions The study demonstrated that the image recognition-based detection system can function stably in clinical settings,providing accurate and continuous surveillance while supporting the early detection of risk actions.By reducing the observation burden and offering real-time cognitive support,the system complements routine nursing care and serves as an additional safety measure in ICU practice.With further optimization and larger multicenter validation,this approach could have the potential to make a significant contribution to the development of smart ICUs and the broader digital transformation of nursing care.
文摘In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.
文摘目的基于MyD88/NF-κB通路探讨芪黄健脾滋肾颗粒(QJZ)改善MRL/lpr小鼠肾损害的作用机制。方法6只雌性C57BL/6小鼠为正常对照组(Control组),将30只雌性MRL/lpr小鼠随机分为模型组(Model组)、芪黄健脾滋肾颗粒低剂量组(QJZ-L组)、芪黄健脾滋肾颗粒中剂量组(QJZ-M组)、芪黄健脾滋肾颗粒高剂量组(QJZ-H组)、泼尼松组(Pred组),6只/组。干预8周后取各组小鼠的尿液、全血及肾脏组织,生化试剂盒检测肾损害指标:24 h尿蛋白定量(24 h PRO)、尿总蛋白肌酐比值(UTPCR)、尿蛋白肌酐比(UACR)。ELISA法检测血清中免疫球蛋白G(IgG)、补体3(C3)、补体4(C4)、抗双链DNA抗体(antidsDNA)、干扰素γ(IFN-γ)、白细胞介素17(IL-17)。肾脏组织进行HE染色和透射电镜观察肾小球超微结构。采用RT-qPCR、Western blotting和免疫组化法检测肾组织中MyD88/NF-κB通路相关分子的表达。结果与Model组相比,QJZ-L、QJZ-M、QJZ-H和Pred组24 h PRO、UTPCR、UACR、IgG、anti-dsDNA、IFN-γ、IL-17降低(P<0.01),C3、C4水平升高(P<0.01)。HE染色结果显示,与Model组比较,各组肾小球内皮细胞增生、系膜增厚减轻。透射电镜显示,各组肾小球电子致密物沉积、炎性细胞浸润较Model组减轻。RT-qPCR和免疫组化结果显示,与Model组相比,QJZ-L、QJZ-M、QJZ-H和Pred组肾脏中MyD88、NF-κB表达下降(P<0.05)。Western blotting结果显示,各组肾脏中p65、p52蛋白水平低于Model组(P<0.01)。结论芪黄健脾滋肾颗粒能够改善MRL/lpr小鼠肾损害,其机制可能与抑制MyD88/NF-κB通路过度激活有关。
基金supported by China Academy of Railway Sciences Corporation Limited(No.2021YJ127).
文摘Artificial intelligence,such as deep learning technology,has advanced the study of facial expression recognition since facial expression carries rich emotional information and is significant for many naturalistic situations.To pursue a high facial expression recognition accuracy,the network model of deep learning is generally designed to be very deep while the model’s real-time performance is typically constrained and limited.With MobileNetV3,a lightweight model with a good accuracy,a further study is conducted by adding a basic ResNet module to each of its existing modules and an SSH(Single Stage Headless Face Detector)context module to expand the model’s perceptual field.In this article,the enhanced model named Res-MobileNetV3,could alleviate the subpar of real-time performance and compress the size of large network models,which can process information at a rate of up to 33 frames per second.Although the improved model has been verified to be slightly inferior to the current state-of-the-art method in aspect of accuracy rate on the publically available face expression datasets,it can bring a good balance on accuracy,real-time performance,model size and model complexity in practical applications.
文摘In the era of artificial intelligence(AI),healthcare and medical sciences are inseparable from different AI technologies[1].ChatGPT once shocked the medical field,but the latest AI model DeepSeek has recently taken the lead[2].PubMed indexed publications on DeepSeek are evolving[3],but limited to editorials and news articles.In this Letter,we explore the use of DeepSeek in early symptoms recognition for stroke care.To the best of our knowledge,this is the first DeepSeek-related writing on stroke.
文摘A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number recognition.In the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection effect.In terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background noise.In addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production date.The experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line speeds.The Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.
基金the National Key Research and Development Program of China,Grant/Award Number:2020YFB1711704the National Natural Science Foundation of China,Grant/Award Number:62272337。
文摘As an essential field of multimedia and computer vision,3D shape recognition has attracted much research attention in recent years.Multiview-based approaches have demonstrated their superiority in generating effective 3D shape representations.Typical methods usually extract the multiview global features and aggregate them together to generate 3D shape descriptors.However,there exist two disadvantages:First,the mainstream methods ignore the comprehensive exploration of local information in each view.Second,many approaches roughly aggregate multiview features by adding or concatenating them together.The information loss for some discriminative characteristics limits the representation effectiveness.To address these problems,a novel architecture named region-based joint attention network(RJAN)was proposed.Specifically,the authors first design a hierarchical local information exploration module for view descriptor extraction.The region-to-region and channel-to-channel relationships from different granularities can be comprehensively explored and utilised to provide more discriminative characteristics for view feature learning.Subsequently,a novel relation-aware view aggregation module is designed to aggregate the multiview features for shape descriptor generation,considering the view-to-view relationships.Extensive experiments were conducted on three public databases:ModelNet40,ModelNet10,and ShapeNetCore55.RJAN achieves state-of-the-art performance in the tasks of 3D shape classification and 3D shape retrieval,which demonstrates the effectiveness of RJAN.The code has been released on https://github.com/slurrpp/RJAN.
