A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environment...A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environments. At the mobile hosts, all transactions perform local pre-validation. The local pre-validation process is carried out against the committed transactions at the server in the last broadcast cycle. Transactions that survive in local pre-validation must be submitted to the server for local final validation. The new protocol eliminates conflicts between mobile read-only and mobile update transactions, and resolves data conflicts flexibly by using multiversion dynamic adjustment of serialization order to avoid unnecessary restarts of transactions. Mobile read-only transactions can be committed with no-blocking, and respond time of mobile read-only transactions is greatly shortened. The tolerance of mobile transactions of disconnections from the broadcast channel is increased. In global validation mobile distributed transactions have to do check to ensure distributed serializability in all participants. The simulation results show that the new concurrency control protocol proposed offers better performance than other protocols in terms of miss rate, restart rate, commit rate. Under high work load （think time is ls） the miss rate of DMVOCC-MVDA is only 14.6%, is significantly lower than that of other protocols. The restart rate of DMVOCC-MVDA is only 32.3%, showing that DMVOCC-MVDA can effectively reduce the restart rate of mobile transactions. And the commit rate of DMVOCC-MVDA is up to 61.2%, which is obviously higher than that of other protocols.展开更多
Recovery performance in the event of failures is very important for distributed real-time database systems. This paper presents a time-cognizant logging-based crash recovery scheme （TCLCRS） that aims at distributed ...Recovery performance in the event of failures is very important for distributed real-time database systems. This paper presents a time-cognizant logging-based crash recovery scheme （TCLCRS） that aims at distributed real-time databases, which adopts a main memory database as its ground support. In our scheme, each site maintains a real-time log for local transactions and the subtransactions, which execute at the site, and execte local checkpointing independently. Log records are stored in non-volatile high- speed store, which is divided into four different partitions based on transaction classes. During restart recovery after a site crash, partitioned crash recovery strategy is adopted to ensure that the site can be brought up before the entire local secondary database is reloaded in main memory. The partitioned crash recovery strategy not only guarantees the internal consistency to be recovered, but also guarantee the temporal consistency and recovery of the sates of physical world influenced by uncommitted transactions. Combined with two- phase commit protocol, TCLCRS can guarantee failure atomicity of distributed real-time transactions.展开更多
This paper formally defines and analyses the new notion of correctness called quasi serializability, and then outlines corresponding concurrency control protocol QDHP for distributed real-time databases. Finally, thro...This paper formally defines and analyses the new notion of correctness called quasi serializability, and then outlines corresponding concurrency control protocol QDHP for distributed real-time databases. Finally, through a series of simulation studies, it shows that using the new concurrency control protocol the performance of distributed real-time databases can be much improved.展开更多
In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can e...In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.展开更多
Most of the proposed concurrency control protocols for real time database systems are based on serializability theorem. Owing to the unique characteristics of real time database applications and the importance of sa...Most of the proposed concurrency control protocols for real time database systems are based on serializability theorem. Owing to the unique characteristics of real time database applications and the importance of satisfying the timing constraints of transactions, serializability is too strong as a correctness criterion and not suitable for real time databases in most cases. On the other hand, relaxed serializability including epsilon serializability and similarity serializability can allow more real time transactions to satisfy their timing constraints, but database consistency may be sacrificed to some extent. We thus propose the use of weak serializability(WSR) that is more relaxed than conflicting serializability while database consistency is maintained. In this paper, we first formally define the new notion of correctness called weak serializability. After the necessary and sufficient conditions for weak serializability are shown, corresponding concurrency control protocol WDHP(weak serializable distributed high priority protocol) is outlined for distributed real time databases, where a new lock mode called mask lock mode is proposed for simplifying the condition of global consistency. Finally, through a series of simulation studies, it is shown that using the new concurrency control protocol the performance of distributed real time databases can be greatly improved.展开更多
The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for he...The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for healthcare systems,particularly for identifying actions critical to patient well-being.However,challenges such as high computational demands,low accuracy,and limited adaptability persist in Human Motion Recognition(HMR).While some studies have integrated HMR with IoT for real-time healthcare applications,limited research has focused on recognizing MRHA as essential for effective patient monitoring.This study proposes a novel HMR method tailored for MRHA detection,leveraging multi-stage deep learning techniques integrated with IoT.The approach employs EfficientNet to extract optimized spatial features from skeleton frame sequences using seven Mobile Inverted Bottleneck Convolutions(MBConv)blocks,followed by Convolutional Long Short Term Memory(ConvLSTM)to capture spatio-temporal patterns.A classification module with global average pooling,a fully connected layer,and a dropout layer generates the final predictions.The model is evaluated on the NTU RGB+D 120 and HMDB51 datasets,focusing on MRHA such as sneezing,falling,walking,sitting,etc.It achieves 94.85%accuracy for cross-subject evaluations and 96.45%for cross-view evaluations on NTU RGB+D 120,along with 89.22%accuracy on HMDB51.Additionally,the system integrates IoT capabilities using a Raspberry Pi and GSM module,delivering real-time alerts via Twilios SMS service to caregivers and patients.This scalable and efficient solution bridges the gap between HMR and IoT,advancing patient monitoring,improving healthcare outcomes,and reducing costs.展开更多
BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking an...A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking and policies related to human/environmental worlds at local, regional, and global scales. Maps are an important part of these innovative and ongoing research approaches. In this context, we consider urban forests a topic meriting more attention of scholars studying the geographic and environmental intersections of the natural sciences with the social sciences and humanities. We construct two innovative knowledge bases, one a conceptual framework based on major themes and concepts related to mapping urban forests using key words of the first 100 results of a Google Scholar query and a second using the number of Google Scholar hyperlinks about mapping urban forests in 244 capital cities. We discovered that the constructed world maps reveal vast global unevenness in our knowledge about urban forests in hyperlink numbers and ratios, results that merit further attention by disciplinary, international and interdisciplinary scholarly communities.展开更多
Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does no...Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does not represent an important parameter.However,in critical applications,this parameter represents a crucial aspect.One important sensing device used in IoT designs is the accelerometer.In most applications,the response time of the embedded driver software handling this device is generally not analysed and not taken into account.In this paper,we present the design and implementation of a predictable real-time driver stack for a popular accelerometer and gyroscope device family.We provide clear justifications for why this response time is extremely important for critical applications in the acquisition process of such data.We present extensive measurements and experimental results that demonstrate the predictability of our solution,making it suitable for critical real-time systems.展开更多
Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throug...Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throughput and efficient methodologies for the annotation and discovery of NPs are desired to address the complexity and diversity of NP-based systems.Mass spectrometry(MS)has emerged as a powerful platform for the annotation and discovery of NPs.MS databases provide vital support for the structural characterization of NPs by integrating extensive mass spectral data and sample information.Additionally,the released annotation methodologies,based on a variety of informatics tools,continuously improve the ability to annotate the structure and properties of compounds.This review examines the current mainstream databases and annotation methodologies,focusing on their advantages and limitations.Prospects for future technological advancements are then discussed in terms of novel applications and research objectives.Through a systematic overview,this review aims to provide valuable insights and a reference for MS-based NPs annotation,thereby promoting the discovery of novel natural entities.展开更多
The unique long-range disordered atomic arrangement inherent in amorphous materials endows them with a range of superior properties,rendering them highly promising for applications in catalysis,medicine,and battery te...The unique long-range disordered atomic arrangement inherent in amorphous materials endows them with a range of superior properties,rendering them highly promising for applications in catalysis,medicine,and battery technology,among other fields.Since not all materials can be synthesized into an amorphous structure,the composition design of amorphous materials holds significant importance.Machine learning offers a valuable alternative to traditional“trial-anderror”methods by predicting properties through experimental data,thus providing efficient guidance in material design.In this study,we develop a machine learning workflow to predict the critical casting diameter,glass transition temperature,and Young's modulus for 45 ternary reported amorphous alloy systems.The predicted results have been organized into a database,enabling direct retrieval of predicted values based on compositional information.Furthermore,the applications of high glass forming ability region screening for specified system,multi-property target system screening and high glass forming ability region search through iteration are also demonstrated.By utilizing machine learning predictions,researchers can effectively narrow the experimental scope and expedite the exploration of compositions.展开更多
Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tecto...Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tectonic activities.In the big data era,the establishment of new data platforms and the application of big data methods have become a focus for metamorphic rocks.Significant progress has been made in creating specialized databases,compiling comprehensive datasets,and utilizing data analytics to address complex scientific questions.However,many existing databases are inadequate in meeting the specific requirements of metamorphic research,resulting from a substantial amount of valuable data remaining uncollected.Therefore,constructing new databases that can cope with the development of the data era is necessary.This article provides an extensive review of existing databases related to metamorphic rocks and discusses data-driven studies in this.Accordingly,several crucial factors that need to be taken into consideration in the establishment of specialized metamorphic databases are identified,aiming to leverage data-driven applications to achieve broader scientific objectives in metamorphic research.展开更多
AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database...AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database of Solid-State Electrolyte(DDSE)demonstrate how machine learning and predictive modeling can improve catalyst and solid-state electrolyte development.These databases facilitate data standardization,high-throughput screening,and cross-disciplinary collaboration,addressing key challenges in materials informatics.As AI techniques advance,materials databases are expected to play an increasingly vital role in accelerating research and innovation.展开更多
Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for su...Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for subsequent research on HSP70.Methods:The GSE41929 dataset was selected from the GEO database.Screening and analysis were performed to identify differentially expressed genes between bortezomib-treated and non-treated MM cells.Results:After bortezomib treatment,126 genes in MM cells showed the most significant changes in expression(P<0.05,absolute value of logFC≥1.5).Based on the fold change and the most significant gene module,HSPA1B exhibited the most notable upregulation after HMOX1,followed by HSPA6 and DNAJB1.HSPA1B and HSPA6 are members of the HSP70 protein family,while DNAJB1 primarily interacts with HSP70 to stimulate its ATPase activity and negatively regulates the transcriptional activity of HSF1 induced by heat shock.Conclusion:HSP70 was the most significantly upregulated molecule in MM cells following bortezomib stimulation.展开更多
Real-time semantic segmentation tasks place stringent demands on network inference speed,often requiring a reduction in network depth to decrease computational load.However,shallow networks tend to exhibit degradation...Real-time semantic segmentation tasks place stringent demands on network inference speed,often requiring a reduction in network depth to decrease computational load.However,shallow networks tend to exhibit degradation in feature extraction completeness and inference accuracy.Therefore,balancing high performance with real-time requirements has become a critical issue in the study of real-time semantic segmentation.To address these challenges,this paper proposes a lightweight bilateral dual-residual network.By introducing a novel residual structure combined with feature extraction and fusion modules,the proposed network significantly enhances representational capacity while reducing computational costs.Specifically,an improved compound residual structure is designed to optimize the efficiency of information propagation and feature extraction.Furthermore,the proposed feature extraction and fusion module enables the network to better capture multi-scale information in images,improving the ability to detect both detailed and global semantic features.Experimental results on the publicly available Cityscapes dataset demonstrate that the proposed lightweight dual-branch network achieves outstanding performance while maintaining low computational complexity.In particular,the network achieved a mean Intersection over Union(mIoU)of 78.4%on the Cityscapes validation set,surpassing many existing semantic segmentation models.Additionally,in terms of inference speed,the network reached 74.5 frames per second when tested on an NVIDIA GeForce RTX 3090 GPU,significantly improving real-time performance.展开更多
BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a si...BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a similar survival benefit with early-stage gallbladder cancer is limited.This study seeks to evaluate the impact chemotherapy has on survival in patients with early-stage gallbladder cancer using a large,multi-institution database.AIM To investigate the survival benefit of chemotherapy in patients with stage II gallbladder cancer.METHODS We performed a retrospective multivariable analysis of the National Cancer Database from 2010 to 2017 to evaluate the effect that chemotherapy has on the survival of patients with stage II gallbladder cancer.Our objective was to de-termine if there were any statistically significant survival differences between those who received surgery and chemotherapy vs those who only underwent surgery.RESULTS Of the 899 patients with stage II gallbladder cancer,328 patients had undergone chemotherapy and surgery.The average overall survival for those who had surgery and chemotherapy vs only surgery was 52.6 months and 51.1 months,respectively.This difference was not statistically significant(P=0.2).In the secondary analysis,the surgical group who had a liver resection had better overall survival(P<0.0001).CONCLUSION Practitioners should carefully consider chemotherapy for early-stage gallbladder cancer,as risks may outweigh survival benefits,and surgeons should also consider liver resections as part of their surgical management.展开更多
基金Project(20030533011)supported by the National Research Foundation for the Doctoral Program of Higher Education of China
文摘A DMVOCC-MVDA （distributed multiversion optimistic concurrency control with multiversion dynamic adjustment） protocol was presented to process mobile distributed real-time transaction in mobile broadcast environments. At the mobile hosts, all transactions perform local pre-validation. The local pre-validation process is carried out against the committed transactions at the server in the last broadcast cycle. Transactions that survive in local pre-validation must be submitted to the server for local final validation. The new protocol eliminates conflicts between mobile read-only and mobile update transactions, and resolves data conflicts flexibly by using multiversion dynamic adjustment of serialization order to avoid unnecessary restarts of transactions. Mobile read-only transactions can be committed with no-blocking, and respond time of mobile read-only transactions is greatly shortened. The tolerance of mobile transactions of disconnections from the broadcast channel is increased. In global validation mobile distributed transactions have to do check to ensure distributed serializability in all participants. The simulation results show that the new concurrency control protocol proposed offers better performance than other protocols in terms of miss rate, restart rate, commit rate. Under high work load （think time is ls） the miss rate of DMVOCC-MVDA is only 14.6%, is significantly lower than that of other protocols. The restart rate of DMVOCC-MVDA is only 32.3%, showing that DMVOCC-MVDA can effectively reduce the restart rate of mobile transactions. And the commit rate of DMVOCC-MVDA is up to 61.2%, which is obviously higher than that of other protocols.
基金Project supported by National Natural Science Foundation ofChina (Grant No .60203017) Defense Pre-research Projectof the"Tenth Five-Year-Plan"of China (Grant No .413150403)
文摘Recovery performance in the event of failures is very important for distributed real-time database systems. This paper presents a time-cognizant logging-based crash recovery scheme （TCLCRS） that aims at distributed real-time databases, which adopts a main memory database as its ground support. In our scheme, each site maintains a real-time log for local transactions and the subtransactions, which execute at the site, and execte local checkpointing independently. Log records are stored in non-volatile high- speed store, which is divided into four different partitions based on transaction classes. During restart recovery after a site crash, partitioned crash recovery strategy is adopted to ensure that the site can be brought up before the entire local secondary database is reloaded in main memory. The partitioned crash recovery strategy not only guarantees the internal consistency to be recovered, but also guarantee the temporal consistency and recovery of the sates of physical world influenced by uncommitted transactions. Combined with two- phase commit protocol, TCLCRS can guarantee failure atomicity of distributed real-time transactions.
基金the National Natural Science Foundation of China and the Commission of Science,Technokgy and Industry for National Defense
文摘This paper formally defines and analyses the new notion of correctness called quasi serializability, and then outlines corresponding concurrency control protocol QDHP for distributed real-time databases. Finally, through a series of simulation studies, it shows that using the new concurrency control protocol the performance of distributed real-time databases can be much improved.
文摘In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.
文摘Most of the proposed concurrency control protocols for real time database systems are based on serializability theorem. Owing to the unique characteristics of real time database applications and the importance of satisfying the timing constraints of transactions, serializability is too strong as a correctness criterion and not suitable for real time databases in most cases. On the other hand, relaxed serializability including epsilon serializability and similarity serializability can allow more real time transactions to satisfy their timing constraints, but database consistency may be sacrificed to some extent. We thus propose the use of weak serializability(WSR) that is more relaxed than conflicting serializability while database consistency is maintained. In this paper, we first formally define the new notion of correctness called weak serializability. After the necessary and sufficient conditions for weak serializability are shown, corresponding concurrency control protocol WDHP(weak serializable distributed high priority protocol) is outlined for distributed real time databases, where a new lock mode called mask lock mode is proposed for simplifying the condition of global consistency. Finally, through a series of simulation studies, it is shown that using the new concurrency control protocol the performance of distributed real time databases can be greatly improved.
基金funded by the ICT Division of theMinistry of Posts,Telecommunications,and Information Technology of Bangladesh under Grant Number 56.00.0000.052.33.005.21-7(Tracking No.22FS15306)support from the University of Rajshahi.
文摘The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for healthcare systems,particularly for identifying actions critical to patient well-being.However,challenges such as high computational demands,low accuracy,and limited adaptability persist in Human Motion Recognition(HMR).While some studies have integrated HMR with IoT for real-time healthcare applications,limited research has focused on recognizing MRHA as essential for effective patient monitoring.This study proposes a novel HMR method tailored for MRHA detection,leveraging multi-stage deep learning techniques integrated with IoT.The approach employs EfficientNet to extract optimized spatial features from skeleton frame sequences using seven Mobile Inverted Bottleneck Convolutions(MBConv)blocks,followed by Convolutional Long Short Term Memory(ConvLSTM)to capture spatio-temporal patterns.A classification module with global average pooling,a fully connected layer,and a dropout layer generates the final predictions.The model is evaluated on the NTU RGB+D 120 and HMDB51 datasets,focusing on MRHA such as sneezing,falling,walking,sitting,etc.It achieves 94.85%accuracy for cross-subject evaluations and 96.45%for cross-view evaluations on NTU RGB+D 120,along with 89.22%accuracy on HMDB51.Additionally,the system integrates IoT capabilities using a Raspberry Pi and GSM module,delivering real-time alerts via Twilios SMS service to caregivers and patients.This scalable and efficient solution bridges the gap between HMR and IoT,advancing patient monitoring,improving healthcare outcomes,and reducing costs.
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
文摘A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking and policies related to human/environmental worlds at local, regional, and global scales. Maps are an important part of these innovative and ongoing research approaches. In this context, we consider urban forests a topic meriting more attention of scholars studying the geographic and environmental intersections of the natural sciences with the social sciences and humanities. We construct two innovative knowledge bases, one a conceptual framework based on major themes and concepts related to mapping urban forests using key words of the first 100 results of a Google Scholar query and a second using the number of Google Scholar hyperlinks about mapping urban forests in 244 capital cities. We discovered that the constructed world maps reveal vast global unevenness in our knowledge about urban forests in hyperlink numbers and ratios, results that merit further attention by disciplinary, international and interdisciplinary scholarly communities.
文摘Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does not represent an important parameter.However,in critical applications,this parameter represents a crucial aspect.One important sensing device used in IoT designs is the accelerometer.In most applications,the response time of the embedded driver software handling this device is generally not analysed and not taken into account.In this paper,we present the design and implementation of a predictable real-time driver stack for a popular accelerometer and gyroscope device family.We provide clear justifications for why this response time is extremely important for critical applications in the acquisition process of such data.We present extensive measurements and experimental results that demonstrate the predictability of our solution,making it suitable for critical real-time systems.
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
基金supported by the National Natural Science Foundation of China(Nos.82274064,82374026,and 82204591)。
文摘Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throughput and efficient methodologies for the annotation and discovery of NPs are desired to address the complexity and diversity of NP-based systems.Mass spectrometry(MS)has emerged as a powerful platform for the annotation and discovery of NPs.MS databases provide vital support for the structural characterization of NPs by integrating extensive mass spectral data and sample information.Additionally,the released annotation methodologies,based on a variety of informatics tools,continuously improve the ability to annotate the structure and properties of compounds.This review examines the current mainstream databases and annotation methodologies,focusing on their advantages and limitations.Prospects for future technological advancements are then discussed in terms of novel applications and research objectives.Through a systematic overview,this review aims to provide valuable insights and a reference for MS-based NPs annotation,thereby promoting the discovery of novel natural entities.
基金Project supported by funding from the National Natural Science Foundation of China(Grant Nos.52172258,52473227 and 52171150)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB0500200)。
文摘The unique long-range disordered atomic arrangement inherent in amorphous materials endows them with a range of superior properties,rendering them highly promising for applications in catalysis,medicine,and battery technology,among other fields.Since not all materials can be synthesized into an amorphous structure,the composition design of amorphous materials holds significant importance.Machine learning offers a valuable alternative to traditional“trial-anderror”methods by predicting properties through experimental data,thus providing efficient guidance in material design.In this study,we develop a machine learning workflow to predict the critical casting diameter,glass transition temperature,and Young's modulus for 45 ternary reported amorphous alloy systems.The predicted results have been organized into a database,enabling direct retrieval of predicted values based on compositional information.Furthermore,the applications of high glass forming ability region screening for specified system,multi-property target system screening and high glass forming ability region search through iteration are also demonstrated.By utilizing machine learning predictions,researchers can effectively narrow the experimental scope and expedite the exploration of compositions.
基金funded by the National Natural Science Foundation of China(No.42220104008)。
文摘Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tectonic activities.In the big data era,the establishment of new data platforms and the application of big data methods have become a focus for metamorphic rocks.Significant progress has been made in creating specialized databases,compiling comprehensive datasets,and utilizing data analytics to address complex scientific questions.However,many existing databases are inadequate in meeting the specific requirements of metamorphic research,resulting from a substantial amount of valuable data remaining uncollected.Therefore,constructing new databases that can cope with the development of the data era is necessary.This article provides an extensive review of existing databases related to metamorphic rocks and discusses data-driven studies in this.Accordingly,several crucial factors that need to be taken into consideration in the establishment of specialized metamorphic databases are identified,aiming to leverage data-driven applications to achieve broader scientific objectives in metamorphic research.
文摘AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database of Solid-State Electrolyte(DDSE)demonstrate how machine learning and predictive modeling can improve catalyst and solid-state electrolyte development.These databases facilitate data standardization,high-throughput screening,and cross-disciplinary collaboration,addressing key challenges in materials informatics.As AI techniques advance,materials databases are expected to play an increasingly vital role in accelerating research and innovation.
基金The Innovation Capability Support Program for Medical Research Projects of Xi’an Science and Technology Bureau(23YXYJ0123)The Hospital Level Fund of the First Affiliated Hospital of Xi’an Medical University(XYYFY-2023-08)。
文摘Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for subsequent research on HSP70.Methods:The GSE41929 dataset was selected from the GEO database.Screening and analysis were performed to identify differentially expressed genes between bortezomib-treated and non-treated MM cells.Results:After bortezomib treatment,126 genes in MM cells showed the most significant changes in expression(P<0.05,absolute value of logFC≥1.5).Based on the fold change and the most significant gene module,HSPA1B exhibited the most notable upregulation after HMOX1,followed by HSPA6 and DNAJB1.HSPA1B and HSPA6 are members of the HSP70 protein family,while DNAJB1 primarily interacts with HSP70 to stimulate its ATPase activity and negatively regulates the transcriptional activity of HSF1 induced by heat shock.Conclusion:HSP70 was the most significantly upregulated molecule in MM cells following bortezomib stimulation.
文摘Real-time semantic segmentation tasks place stringent demands on network inference speed,often requiring a reduction in network depth to decrease computational load.However,shallow networks tend to exhibit degradation in feature extraction completeness and inference accuracy.Therefore,balancing high performance with real-time requirements has become a critical issue in the study of real-time semantic segmentation.To address these challenges,this paper proposes a lightweight bilateral dual-residual network.By introducing a novel residual structure combined with feature extraction and fusion modules,the proposed network significantly enhances representational capacity while reducing computational costs.Specifically,an improved compound residual structure is designed to optimize the efficiency of information propagation and feature extraction.Furthermore,the proposed feature extraction and fusion module enables the network to better capture multi-scale information in images,improving the ability to detect both detailed and global semantic features.Experimental results on the publicly available Cityscapes dataset demonstrate that the proposed lightweight dual-branch network achieves outstanding performance while maintaining low computational complexity.In particular,the network achieved a mean Intersection over Union(mIoU)of 78.4%on the Cityscapes validation set,surpassing many existing semantic segmentation models.Additionally,in terms of inference speed,the network reached 74.5 frames per second when tested on an NVIDIA GeForce RTX 3090 GPU,significantly improving real-time performance.
文摘BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a similar survival benefit with early-stage gallbladder cancer is limited.This study seeks to evaluate the impact chemotherapy has on survival in patients with early-stage gallbladder cancer using a large,multi-institution database.AIM To investigate the survival benefit of chemotherapy in patients with stage II gallbladder cancer.METHODS We performed a retrospective multivariable analysis of the National Cancer Database from 2010 to 2017 to evaluate the effect that chemotherapy has on the survival of patients with stage II gallbladder cancer.Our objective was to de-termine if there were any statistically significant survival differences between those who received surgery and chemotherapy vs those who only underwent surgery.RESULTS Of the 899 patients with stage II gallbladder cancer,328 patients had undergone chemotherapy and surgery.The average overall survival for those who had surgery and chemotherapy vs only surgery was 52.6 months and 51.1 months,respectively.This difference was not statistically significant(P=0.2).In the secondary analysis,the surgical group who had a liver resection had better overall survival(P<0.0001).CONCLUSION Practitioners should carefully consider chemotherapy for early-stage gallbladder cancer,as risks may outweigh survival benefits,and surgeons should also consider liver resections as part of their surgical management.
