In this study,a high-confining pressure and real-time large-displacement shearing-flow setup was developed.The test setup can be used to analyze the injection pressure conditions that increase the hydro-shearing perme...In this study,a high-confining pressure and real-time large-displacement shearing-flow setup was developed.The test setup can be used to analyze the injection pressure conditions that increase the hydro-shearing permeability and injection-induced seismicity during hot dry rock geothermal extraction.For optimizing injection strategies and improving engineering safety,real-time permeability,deformation,and energy release characteristics of fractured granite samples driven by injected water pressure under different critical sliding conditions were evaluated.The results indicated that:(1)A low injection water pressure induced intermittent small-deformation stick-slip behavior in fractures,and a high injection pressure primarily caused continuous high-speed large-deformation sliding in fractures.The optimal injection water pressure range was defined for enhancing hydraulic shear permeability and preventing large injection-induced earthquakes.(2)Under the same experimental conditions,fracture sliding was deemed as the major factor that enhanced the hydraulic shear-permeability enhancement and the maximum permeability increased by 36.54 and 41.59 times,respectively,in above two slip modes.(3)Based on the real-time transient evolution of water pressure during fracture sliding,the variation coefficients of slip rate,permeability,and water pressure were fitted,and the results were different from those measured under quasi-static conditions.(4)The maximum and minimum shear strength criteria for injection-induced fracture sliding were also determined(μ=0.6665 andμ=0.1645,respectively,μis friction coefficient).Using the 3D(three-dimensional)fracture surface scanning technology,the weakening effect of injection pressure on fracture surface damage characteristics was determined,which provided evidence for the geological markers of fault sliding mode and sliding nature transitions under the fluid influence.展开更多
To fulfill the requirements for hybrid real-time system scheduling, a long-release-interval-first （LRIF） real-time scheduling algorithm is proposed. The algorithm adopts both the fixed priority and the dynamic prior...To fulfill the requirements for hybrid real-time system scheduling, a long-release-interval-first （LRIF） real-time scheduling algorithm is proposed. The algorithm adopts both the fixed priority and the dynamic priority to assign priorities for tasks. By assigning higher priorities to the aperiodic soft real-time jobs with longer release intervals, it guarantees the executions for periodic hard real-time tasks and further probabilistically guarantees the executions for aperiodic soft real-time tasks. The schedulability test approach for the LRIF algorithm is presented. The implementation issues of the LRIF algorithm are also discussed. Simulation result shows that LRIF obtains better schedulable performance than the maximum urgency first （MUF） algorithm, the earliest deadline first （EDF） algorithm and EDF for hybrid tasks. LRIF has great capability to schedule both periodic hard real-time and aperiodic soft real-time tasks.展开更多
Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve thro...Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.展开更多
Real-time performance and reliability are two most important issues in applications of time-triggered controller area network （CAN） bus systems at present. A scheduling matrix of time-triggered CAN-bus system is est...Real-time performance and reliability are two most important issues in applications of time-triggered controller area network （CAN） bus systems at present. A scheduling matrix of time-triggered CAN-bus system is established using average-loading algorithm. Periodic messages are guaranteed to transmit without delay by distributing independent transmission windows within the system matrix. Considering the traditional CAN-bus transmission mechanism and the time-triggered feature, an algorithm is improved to calculate the worst-case delay of event-triggered messages in time-triggered CAN-bus systems. The failure probability is calculated for event-triggered messages whose worst-case delay exceeds their deadlines. Different levels of redundant structures of CAN-bus circuits are analyzed and the maintenance management is proposed to improve the system reliability. Finally, the reliabilities of different structures are calculated and the influences of maintenance on the system reliability are analyzed.展开更多
A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not...A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not have any impact on the product's performance.However,in some cases,the measurement process may exert extra stress on products being measured.To obtain trustful results in such a situation,a new degradation model was derived.Then,by fusing the prior information of product and its own on-line degradation data,the real-time reliability was evaluated on the basis of Bayesian formula.To make the proposed method more practical,a procedure based on expectation maximization (EM) algorithm was presented to estimate the unknown parameters.Finally,the performance of the proposed method was illustrated by a simulation study.The results show that ignoring the influence of the damaged measurement process can lead to biased evaluation results,if the damaged measurement process is involved.展开更多
Landslides have occurred frequently in the Luoshan mining area because of disordered mining.This paper discusses the landforms and physiognomy,hydro-meteorology,formation lithology,and geologic structure of the Luosha...Landslides have occurred frequently in the Luoshan mining area because of disordered mining.This paper discusses the landforms and physiognomy,hydro-meteorology,formation lithology,and geologic structure of the Luoshan mining area.It also describes the factors influencing the slope stability of landslide No.Ⅲ,determines the general parameters and typical section plane,analyzes the stress-strain state of the No.Ⅲ slope,and calculates its safety factors with FLAC3 D under saturated and natural conditions.Based on a stability analysis,a remote real-time monitoring system was applied to the No.Ⅲ slope,and these monitoring data were collected and analyzed.展开更多
Operational reliability evaluation theory reflects real-time reliability level of power system. The component failure rate varies with operating conditions. The impact of real-time operating conditions such as ambient...Operational reliability evaluation theory reflects real-time reliability level of power system. The component failure rate varies with operating conditions. The impact of real-time operating conditions such as ambient temperature and transformer MVA (megavolt-ampere) loading on transformer insulation life is studied in this paper. The formula of transformer failure rate based on the winding hottest-spot temperature (HST) is given. Thus the real-time reliability model of transformer based on oper- ating conditions is presented. The work is illustrated using the 1979 IEEE Reliability Test System. The changes of operating conditions are simulated by using hourly load curve and temperature curve, so the curves of real-time reliability indices are ob- tained by using operational reliability evaluation.展开更多
It is well-recognized that a transfer system response delay that reduces the test stability inevitably exists in real-time dynamic hybrid testing （RTDHT）. This paper focuses on the delay-dependent stability and adde...It is well-recognized that a transfer system response delay that reduces the test stability inevitably exists in real-time dynamic hybrid testing （RTDHT）. This paper focuses on the delay-dependent stability and added damping of SDOF systems in RTDHT. The exponential delay term is transferred into a rational fraction by the Pad6 approximation, and the delay-dependent stability conditions and instability mechanism of SDOF RTDHT systems are investigated by the root locus technique. First, the stability conditions are discussed separately for the cases of stiffness, mass, and damping experimental substructure. The use of root locus plots shows that the added damping effect and instability mechanism for mass are different from those for stiffness. For the stiffness experimental substructure case, the instability results from the inherent mode because of an obvious negative damping effect of the delay. For the mass case, the delay introduces an equivalent positive damping into the inherent mode, and instability occurs at an added high frequency mode. Then, the compound stability condition is investigated for a general case and the results show that the mass ratio may have both upper and lower limits to remain stable. Finally, a high-emulational virtual shaking table model is built to validate the stability conclusions.展开更多
AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl trans...AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat model.METHODS:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic rats.The stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)algorithms.RESULTS:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic retinas.The 18s gene was expressed consistently in both normal control and diabetic rats’retinal tissue.That this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic rats.Furthermore,there was no ideal gene stably expressed for use in all experimental settings.CONCLUSION:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.展开更多
For real-time dynamic substructure testing(RTDST),the influence of the inertia force of fluid specimens on the stability and accuracy of the integration algorithms has never been investigated.Therefore,this study prop...For real-time dynamic substructure testing(RTDST),the influence of the inertia force of fluid specimens on the stability and accuracy of the integration algorithms has never been investigated.Therefore,this study proposes to investigate the stability and accuracy of the central difference method(CDM)for RTDST considering the specimen mass participation coefficient.First,the theory of the CDM for RTDST is presented.Next,the stability and accuracy of the CDM for RTDST considering the specimen mass participation coefficient are investigated.Finally,numerical simulations and experimental tests are conducted for verifying the effectiveness of the method.The study indicates that the stability of the algorithm is affected by the mass participation coefficient of the specimen,and the stability limit first increases and then decreases as the mass participation coefficient increases.In most cases,the mass participation coefficient will increase the stability limit of the algorithm,but in specific circumstances,the algorithm may lose its stability.The stability and accuracy of the CDM considering the mass participation coefficient are verified by numerical simulations and experimental tests on a three-story frame structure with a tuned liquid damper.展开更多
The low egg production of goose greatly limits the development of the industry.China possesses the most abundant goose breeds resources.In this study,genome resequencing data of swan goose(Anser cygnoides)and domestic...The low egg production of goose greatly limits the development of the industry.China possesses the most abundant goose breeds resources.In this study,genome resequencing data of swan goose(Anser cygnoides)and domesticated high and low laying goose breeds(Anser cygnoides domestiation)were used to identify key genes related to egg laying ability in geese and verify their functions.Selective sweep analyses revealed 416 genes that were specifically selected during the domestication process from swan geese to high laying geese.Furthermore,SNPs and Indels markers were used in GWAS analyses between high and low laying breed geese.The results showed that RTCB,BPIFC,SYN3,SYNE1,VIP,and ESR1 may be related to the differences in laying ability of geese.Notably,only ESR1 was identified simultaneously by GWAS and selective sweep analysis.The genotype of Indelchr3:54429172,located downstream of ESR1,was confirmed to affect the expression of ESR1 in the ovarian stroma and showed significant correlation with body weight at first egg and laying frequency of geese.CCK-8,EdU,and flow cytometry confirmed that ESR1 can promote the apoptosis of goose pre-hierarchical follicles ganulosa cells(phGCs)and inhibit their proliferation.Combined with transcriptome data,it was found ESR1 involved in the function of goose phGCs may be related to MAPK and TGF-beta signaling pathways.Overall,our study used genomic information from different goose breeds to identify an indel located in the downstream of ESR1 associated with goose laying ability.The main pathways and biological processes of ESR1 involved in the regulation of goose laying ability were identified by cell biology and transcriptomics methods.These results are helpful to further understand the laying ability characteristics of goose and improve the egg production of geese.展开更多
This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with ...This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.展开更多
With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the c...With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the college English audio-visual oral course not only imparts language knowledge and skills,but also shoulders the important task of cultivating students’critical thinking.As one of the essential core qualities of modern talents,critical thinking ability plays an irreplaceable role in students’in-depth understanding of English knowledge,improving intercultural communication ability and cultivating innovative thinking.This paper expounds the significance of cultivating students’critical thinking ability in college English audio-visual and oral teaching,and puts forward a series of innovative teaching strategies to cultivate students’critical thinking ability combined with practical teaching experience and cutting-edge education theory,in order to provide new ideas and practical guidance for the improvement of college English teaching quality and the development of students’comprehensive quality.展开更多
The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for he...The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for healthcare systems,particularly for identifying actions critical to patient well-being.However,challenges such as high computational demands,low accuracy,and limited adaptability persist in Human Motion Recognition(HMR).While some studies have integrated HMR with IoT for real-time healthcare applications,limited research has focused on recognizing MRHA as essential for effective patient monitoring.This study proposes a novel HMR method tailored for MRHA detection,leveraging multi-stage deep learning techniques integrated with IoT.The approach employs EfficientNet to extract optimized spatial features from skeleton frame sequences using seven Mobile Inverted Bottleneck Convolutions(MBConv)blocks,followed by Convolutional Long Short Term Memory(ConvLSTM)to capture spatio-temporal patterns.A classification module with global average pooling,a fully connected layer,and a dropout layer generates the final predictions.The model is evaluated on the NTU RGB+D 120 and HMDB51 datasets,focusing on MRHA such as sneezing,falling,walking,sitting,etc.It achieves 94.85%accuracy for cross-subject evaluations and 96.45%for cross-view evaluations on NTU RGB+D 120,along with 89.22%accuracy on HMDB51.Additionally,the system integrates IoT capabilities using a Raspberry Pi and GSM module,delivering real-time alerts via Twilios SMS service to caregivers and patients.This scalable and efficient solution bridges the gap between HMR and IoT,advancing patient monitoring,improving healthcare outcomes,and reducing costs.展开更多
Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from N...Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from November 2020 to April 2021 in three different agroecological regions such as BARI, Gazipur, RARS Barisal and RARS Rangpur. Seven inbred lines were selected on the basis of genetic diversity and per se performance and they were crossed separately in a 7 × 7 half diallel fashion, producing 21F1 hybrids in 2019 which were evaluated at three locations. However, variances due to GCA were much higher in magnitude than SCA for all the characters indicating preponderance of additive gene effects on the inheritance of these characters. Two parents viz., P3 (CML33) and P4 (CML41) were good general combiners and two crosses viz., P4 × P5 (CML41 × CML31) and P5 × P7 (CML31 × CML124) expressed significant positive SCA effects coupled with significant positive heterosis for grain yield and for most of the yield contributing characters over the two commercial check varieties BHM 9 and NK40. Four crosses: P1 × P5 (CML116 × CML31), P1 × P6 (CML116 × CML32), P2 × P6 (CML72 × CML32) and P3 × P4 (CML33 × CML41), exhibited significant and negative SCA effects for both plant and ear height which were desirable for short stature. Genotypes x location interaction was also significant for maximum characters, suggesting that genotypes interacted significantly in different environments.展开更多
Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does no...Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does not represent an important parameter.However,in critical applications,this parameter represents a crucial aspect.One important sensing device used in IoT designs is the accelerometer.In most applications,the response time of the embedded driver software handling this device is generally not analysed and not taken into account.In this paper,we present the design and implementation of a predictable real-time driver stack for a popular accelerometer and gyroscope device family.We provide clear justifications for why this response time is extremely important for critical applications in the acquisition process of such data.We present extensive measurements and experimental results that demonstrate the predictability of our solution,making it suitable for critical real-time systems.展开更多
This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China ...This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China Family Panel Studies(CFPS)data,1491 children(girls ratio=53.78%;average grade=6.023 years,school grade standard deviation=1.825 years).Results following multiple regression model(OLS)show that the higher the parental cognitive ability,the higher the children’s logical reasoning ability.Secondly,parental academic expectation serves as a mediator between their cognitive ability and children’s logical reasoning ability for higher logical reasoning by children.Third,a possible family environment acts as a mediator in the relationship between parents’cognitive ability and children’s logical reasoning ability to be higher.We conclude from thesefindings that parents with high cognitive abilities can enhance their children’s logical reasoning skills not only by setting higher academic expectations,but also by cultivating a supportive family environment.Thesefindings imply a need for intervention to improve family quality of life to enhance children’s thinking abilities to optimize their academic learning.展开更多
To meet the demands of higher education reform and innovative talent cultivation,the teaching team of Tarim University,with ability cultivation as the core,has established a new“331”university mathematics teaching s...To meet the demands of higher education reform and innovative talent cultivation,the teaching team of Tarim University,with ability cultivation as the core,has established a new“331”university mathematics teaching system.Through the multi-dimensional linkage of master teachers’guidance,course optimization,stratified teaching,practical reinforcement,and competition-driven,it has significantly improved students’mathematical application ability and innovative quality.展开更多
AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ab...AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized glasses.Recording with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion.Additionally,the correlation of stereopsis were also analyzed.RESULTS:A total of 48 patients(age range:4-33y;54.17%male)participated in the study.When viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at near.These scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment capabilities.This expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.52122405)Science and Technology Major Project of Shanxi Province,China (Grant No.202101060301024)Science and Technology Major Project of Xizang Autonomous Region,China (Grant No.XZ202201ZD0004G0204).
文摘In this study,a high-confining pressure and real-time large-displacement shearing-flow setup was developed.The test setup can be used to analyze the injection pressure conditions that increase the hydro-shearing permeability and injection-induced seismicity during hot dry rock geothermal extraction.For optimizing injection strategies and improving engineering safety,real-time permeability,deformation,and energy release characteristics of fractured granite samples driven by injected water pressure under different critical sliding conditions were evaluated.The results indicated that:(1)A low injection water pressure induced intermittent small-deformation stick-slip behavior in fractures,and a high injection pressure primarily caused continuous high-speed large-deformation sliding in fractures.The optimal injection water pressure range was defined for enhancing hydraulic shear permeability and preventing large injection-induced earthquakes.(2)Under the same experimental conditions,fracture sliding was deemed as the major factor that enhanced the hydraulic shear-permeability enhancement and the maximum permeability increased by 36.54 and 41.59 times,respectively,in above two slip modes.(3)Based on the real-time transient evolution of water pressure during fracture sliding,the variation coefficients of slip rate,permeability,and water pressure were fitted,and the results were different from those measured under quasi-static conditions.(4)The maximum and minimum shear strength criteria for injection-induced fracture sliding were also determined(μ=0.6665 andμ=0.1645,respectively,μis friction coefficient).Using the 3D(three-dimensional)fracture surface scanning technology,the weakening effect of injection pressure on fracture surface damage characteristics was determined,which provided evidence for the geological markers of fault sliding mode and sliding nature transitions under the fluid influence.
基金The Natural Science Foundation of Jiangsu Province(NoBK2005408)
文摘To fulfill the requirements for hybrid real-time system scheduling, a long-release-interval-first （LRIF） real-time scheduling algorithm is proposed. The algorithm adopts both the fixed priority and the dynamic priority to assign priorities for tasks. By assigning higher priorities to the aperiodic soft real-time jobs with longer release intervals, it guarantees the executions for periodic hard real-time tasks and further probabilistically guarantees the executions for aperiodic soft real-time tasks. The schedulability test approach for the LRIF algorithm is presented. The implementation issues of the LRIF algorithm are also discussed. Simulation result shows that LRIF obtains better schedulable performance than the maximum urgency first （MUF） algorithm, the earliest deadline first （EDF） algorithm and EDF for hybrid tasks. LRIF has great capability to schedule both periodic hard real-time and aperiodic soft real-time tasks.
基金Supported by Chongqing Health Commission and Chongqing Science and Technology Bureau,No.2023MSXM182。
文摘Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.
基金supported by Fundamental Research Funds for the Central Universities and National Science and Technology Major Project (No. 2010ZX04014-017)
文摘Real-time performance and reliability are two most important issues in applications of time-triggered controller area network （CAN） bus systems at present. A scheduling matrix of time-triggered CAN-bus system is established using average-loading algorithm. Periodic messages are guaranteed to transmit without delay by distributing independent transmission windows within the system matrix. Considering the traditional CAN-bus transmission mechanism and the time-triggered feature, an algorithm is improved to calculate the worst-case delay of event-triggered messages in time-triggered CAN-bus systems. The failure probability is calculated for event-triggered messages whose worst-case delay exceeds their deadlines. Different levels of redundant structures of CAN-bus circuits are analyzed and the maintenance management is proposed to improve the system reliability. Finally, the reliabilities of different structures are calculated and the influences of maintenance on the system reliability are analyzed.
基金Project(60904002)supported by the National Natural Science Foundation of China
文摘A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not have any impact on the product's performance.However,in some cases,the measurement process may exert extra stress on products being measured.To obtain trustful results in such a situation,a new degradation model was derived.Then,by fusing the prior information of product and its own on-line degradation data,the real-time reliability was evaluated on the basis of Bayesian formula.To make the proposed method more practical,a procedure based on expectation maximization (EM) algorithm was presented to estimate the unknown parameters.Finally,the performance of the proposed method was illustrated by a simulation study.The results show that ignoring the influence of the damaged measurement process can lead to biased evaluation results,if the damaged measurement process is involved.
文摘Landslides have occurred frequently in the Luoshan mining area because of disordered mining.This paper discusses the landforms and physiognomy,hydro-meteorology,formation lithology,and geologic structure of the Luoshan mining area.It also describes the factors influencing the slope stability of landslide No.Ⅲ,determines the general parameters and typical section plane,analyzes the stress-strain state of the No.Ⅲ slope,and calculates its safety factors with FLAC3 D under saturated and natural conditions.Based on a stability analysis,a remote real-time monitoring system was applied to the No.Ⅲ slope,and these monitoring data were collected and analyzed.
基金Project (No. 2004CB217901) supported by the National Basic Re-search Program (973) of China
文摘Operational reliability evaluation theory reflects real-time reliability level of power system. The component failure rate varies with operating conditions. The impact of real-time operating conditions such as ambient temperature and transformer MVA (megavolt-ampere) loading on transformer insulation life is studied in this paper. The formula of transformer failure rate based on the winding hottest-spot temperature (HST) is given. Thus the real-time reliability model of transformer based on oper- ating conditions is presented. The work is illustrated using the 1979 IEEE Reliability Test System. The changes of operating conditions are simulated by using hourly load curve and temperature curve, so the curves of real-time reliability indices are ob- tained by using operational reliability evaluation.
基金State Key Laboratory of Hydroscience and Engineering Under Grant No.2008-TC-2National Natural Science Foundation of China Under Grant No.90510018,50779021 and 90715041
文摘It is well-recognized that a transfer system response delay that reduces the test stability inevitably exists in real-time dynamic hybrid testing （RTDHT）. This paper focuses on the delay-dependent stability and added damping of SDOF systems in RTDHT. The exponential delay term is transferred into a rational fraction by the Pad6 approximation, and the delay-dependent stability conditions and instability mechanism of SDOF RTDHT systems are investigated by the root locus technique. First, the stability conditions are discussed separately for the cases of stiffness, mass, and damping experimental substructure. The use of root locus plots shows that the added damping effect and instability mechanism for mass are different from those for stiffness. For the stiffness experimental substructure case, the instability results from the inherent mode because of an obvious negative damping effect of the delay. For the mass case, the delay introduces an equivalent positive damping into the inherent mode, and instability occurs at an added high frequency mode. Then, the compound stability condition is investigated for a general case and the results show that the mass ratio may have both upper and lower limits to remain stable. Finally, a high-emulational virtual shaking table model is built to validate the stability conclusions.
基金Supported by grant from Fundamental Research Grant Scheme by Ministry of Higher Education(MoHE)600-IRMI/FRGS 5/3(101/2019).
文摘AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat model.METHODS:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic rats.The stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)algorithms.RESULTS:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic retinas.The 18s gene was expressed consistently in both normal control and diabetic rats’retinal tissue.That this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic rats.Furthermore,there was no ideal gene stably expressed for use in all experimental settings.CONCLUSION:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.
基金National Natural Science Foundation of China under Grant Nos.51978213 and 51778190the National Key Research and Development Program of China under Grant Nos.2017YFC0703605 and 2016YFC0701106。
文摘For real-time dynamic substructure testing(RTDST),the influence of the inertia force of fluid specimens on the stability and accuracy of the integration algorithms has never been investigated.Therefore,this study proposes to investigate the stability and accuracy of the central difference method(CDM)for RTDST considering the specimen mass participation coefficient.First,the theory of the CDM for RTDST is presented.Next,the stability and accuracy of the CDM for RTDST considering the specimen mass participation coefficient are investigated.Finally,numerical simulations and experimental tests are conducted for verifying the effectiveness of the method.The study indicates that the stability of the algorithm is affected by the mass participation coefficient of the specimen,and the stability limit first increases and then decreases as the mass participation coefficient increases.In most cases,the mass participation coefficient will increase the stability limit of the algorithm,but in specific circumstances,the algorithm may lose its stability.The stability and accuracy of the CDM considering the mass participation coefficient are verified by numerical simulations and experimental tests on a three-story frame structure with a tuned liquid damper.
基金supported by the China Agriculture Research System of MOF and MARA(CARS-42-4)School Cooperation Project of Ya’an(21SXHZ0028)the Key Technology Support Program of Sichuan Province,China(2021YFYZ0014),for the financial support。
文摘The low egg production of goose greatly limits the development of the industry.China possesses the most abundant goose breeds resources.In this study,genome resequencing data of swan goose(Anser cygnoides)and domesticated high and low laying goose breeds(Anser cygnoides domestiation)were used to identify key genes related to egg laying ability in geese and verify their functions.Selective sweep analyses revealed 416 genes that were specifically selected during the domestication process from swan geese to high laying geese.Furthermore,SNPs and Indels markers were used in GWAS analyses between high and low laying breed geese.The results showed that RTCB,BPIFC,SYN3,SYNE1,VIP,and ESR1 may be related to the differences in laying ability of geese.Notably,only ESR1 was identified simultaneously by GWAS and selective sweep analysis.The genotype of Indelchr3:54429172,located downstream of ESR1,was confirmed to affect the expression of ESR1 in the ovarian stroma and showed significant correlation with body weight at first egg and laying frequency of geese.CCK-8,EdU,and flow cytometry confirmed that ESR1 can promote the apoptosis of goose pre-hierarchical follicles ganulosa cells(phGCs)and inhibit their proliferation.Combined with transcriptome data,it was found ESR1 involved in the function of goose phGCs may be related to MAPK and TGF-beta signaling pathways.Overall,our study used genomic information from different goose breeds to identify an indel located in the downstream of ESR1 associated with goose laying ability.The main pathways and biological processes of ESR1 involved in the regulation of goose laying ability were identified by cell biology and transcriptomics methods.These results are helpful to further understand the laying ability characteristics of goose and improve the egg production of geese.
基金023 Zhejiang Provincial Department of Education General Project:Research on an interdisciplinary teaching model to promote the development of computational thinking in the context of the new curriculum standards[Grant NO:Y202351596]Key Project of Zhejiang Provincial Education Science Planning:Research on an interdisciplinary teaching model to promote students’computational thinking from multiple analytical perspectives[Grant NO:2025SB103].
文摘This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.
基金A Study on the Teaching Reform of College English Audio-Visual Oral Course Oriented towards the Cultivation of Critical Thinking Ability(2501032339)。
文摘With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the college English audio-visual oral course not only imparts language knowledge and skills,but also shoulders the important task of cultivating students’critical thinking.As one of the essential core qualities of modern talents,critical thinking ability plays an irreplaceable role in students’in-depth understanding of English knowledge,improving intercultural communication ability and cultivating innovative thinking.This paper expounds the significance of cultivating students’critical thinking ability in college English audio-visual and oral teaching,and puts forward a series of innovative teaching strategies to cultivate students’critical thinking ability combined with practical teaching experience and cutting-edge education theory,in order to provide new ideas and practical guidance for the improvement of college English teaching quality and the development of students’comprehensive quality.
基金funded by the ICT Division of theMinistry of Posts,Telecommunications,and Information Technology of Bangladesh under Grant Number 56.00.0000.052.33.005.21-7(Tracking No.22FS15306)support from the University of Rajshahi.
文摘The Internet of Things(IoT)and mobile technology have significantly transformed healthcare by enabling real-time monitoring and diagnosis of patients.Recognizing Medical-Related Human Activities(MRHA)is pivotal for healthcare systems,particularly for identifying actions critical to patient well-being.However,challenges such as high computational demands,low accuracy,and limited adaptability persist in Human Motion Recognition(HMR).While some studies have integrated HMR with IoT for real-time healthcare applications,limited research has focused on recognizing MRHA as essential for effective patient monitoring.This study proposes a novel HMR method tailored for MRHA detection,leveraging multi-stage deep learning techniques integrated with IoT.The approach employs EfficientNet to extract optimized spatial features from skeleton frame sequences using seven Mobile Inverted Bottleneck Convolutions(MBConv)blocks,followed by Convolutional Long Short Term Memory(ConvLSTM)to capture spatio-temporal patterns.A classification module with global average pooling,a fully connected layer,and a dropout layer generates the final predictions.The model is evaluated on the NTU RGB+D 120 and HMDB51 datasets,focusing on MRHA such as sneezing,falling,walking,sitting,etc.It achieves 94.85%accuracy for cross-subject evaluations and 96.45%for cross-view evaluations on NTU RGB+D 120,along with 89.22%accuracy on HMDB51.Additionally,the system integrates IoT capabilities using a Raspberry Pi and GSM module,delivering real-time alerts via Twilios SMS service to caregivers and patients.This scalable and efficient solution bridges the gap between HMR and IoT,advancing patient monitoring,improving healthcare outcomes,and reducing costs.
文摘Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from November 2020 to April 2021 in three different agroecological regions such as BARI, Gazipur, RARS Barisal and RARS Rangpur. Seven inbred lines were selected on the basis of genetic diversity and per se performance and they were crossed separately in a 7 × 7 half diallel fashion, producing 21F1 hybrids in 2019 which were evaluated at three locations. However, variances due to GCA were much higher in magnitude than SCA for all the characters indicating preponderance of additive gene effects on the inheritance of these characters. Two parents viz., P3 (CML33) and P4 (CML41) were good general combiners and two crosses viz., P4 × P5 (CML41 × CML31) and P5 × P7 (CML31 × CML124) expressed significant positive SCA effects coupled with significant positive heterosis for grain yield and for most of the yield contributing characters over the two commercial check varieties BHM 9 and NK40. Four crosses: P1 × P5 (CML116 × CML31), P1 × P6 (CML116 × CML32), P2 × P6 (CML72 × CML32) and P3 × P4 (CML33 × CML41), exhibited significant and negative SCA effects for both plant and ear height which were desirable for short stature. Genotypes x location interaction was also significant for maximum characters, suggesting that genotypes interacted significantly in different environments.
文摘Along with process control,perception represents the main function performed by the Edge Layer of an Internet of Things(IoT)network.Many of these networks implement various applications where the response time does not represent an important parameter.However,in critical applications,this parameter represents a crucial aspect.One important sensing device used in IoT designs is the accelerometer.In most applications,the response time of the embedded driver software handling this device is generally not analysed and not taken into account.In this paper,we present the design and implementation of a predictable real-time driver stack for a popular accelerometer and gyroscope device family.We provide clear justifications for why this response time is extremely important for critical applications in the acquisition process of such data.We present extensive measurements and experimental results that demonstrate the predictability of our solution,making it suitable for critical real-time systems.
基金supported by scientific research fund of Jiangxi Provincial Social Sciences“14th Five-Year Plan”(No.23SH05).
文摘This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China Family Panel Studies(CFPS)data,1491 children(girls ratio=53.78%;average grade=6.023 years,school grade standard deviation=1.825 years).Results following multiple regression model(OLS)show that the higher the parental cognitive ability,the higher the children’s logical reasoning ability.Secondly,parental academic expectation serves as a mediator between their cognitive ability and children’s logical reasoning ability for higher logical reasoning by children.Third,a possible family environment acts as a mediator in the relationship between parents’cognitive ability and children’s logical reasoning ability to be higher.We conclude from thesefindings that parents with high cognitive abilities can enhance their children’s logical reasoning skills not only by setting higher academic expectations,but also by cultivating a supportive family environment.Thesefindings imply a need for intervention to improve family quality of life to enhance children’s thinking abilities to optimize their academic learning.
基金Advanced Mathematics A1 First-Class Course of Tarim University(TDYLKC202428)Educational Reform Project of Xinjiang Production and Construction Corps(BTBKXM-2024-Y41)。
文摘To meet the demands of higher education reform and innovative talent cultivation,the teaching team of Tarim University,with ability cultivation as the core,has established a new“331”university mathematics teaching system.Through the multi-dimensional linkage of master teachers’guidance,course optimization,stratified teaching,practical reinforcement,and competition-driven,it has significantly improved students’mathematical application ability and innovative quality.
基金Supported by the National Natural Science Foundation of China(No.82070995,No.82301256)Youth S&T Talent Support Programme of Guangdong Provincial Association for Science and Technology.
文摘AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized glasses.Recording with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion.Additionally,the correlation of stereopsis were also analyzed.RESULTS:A total of 48 patients(age range:4-33y;54.17%male)participated in the study.When viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at near.These scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment capabilities.This expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.
