This study proposes the development of a system to classify phytomedicine projects by applying the technology readiness level (TRL). This strategy is gaining relevance in the field of health innovation because it prom...This study proposes the development of a system to classify phytomedicine projects by applying the technology readiness level (TRL). This strategy is gaining relevance in the field of health innovation because it promotes synergism between researchers and R&D managers working in this area. Nine TRLs were created for the development of herbal medicines by the authors, which is a group of experts in natural products, supported by pre-existing records on project management in the institutions to which they belong. The levels were determined by mirroring the bench-to-bedside development of synthetic drug pathways, in accordance with concepts of translational research. Each level was sectioned by disciplinary areas ruling pools of multiple activities, the achievements of which represent independent technologies. Short content deliveries (SCD) were empirically established at the end of each level as a requirement to enter the next technological stage. A TRL scale was constructed to classify the stages of phytomedicines development to reflect project maturity. Detailed descriptions of the first five nonclinical levels and their sublevels were provided. At the end of each level, the SCD served as an indicator of sufficiency to move on to the next stage. The TRL framework for developing phytomedicines provided an organized panel to clarify the independent technology generated in each stage. The integration of these technologies constitutes a valuable tool for institutions that foster pharmaceutical product development. The five initial levels of TRL considered here can contribute to accelerating innovation in R&D organizations dedicated to the development of plant-based products.展开更多
Contemporary system maturity assessment approaches have failed to provide robust quantitative system evaluations resulting in increased program costs and developmental risks.Standard assessment metrics,such as Technol...Contemporary system maturity assessment approaches have failed to provide robust quantitative system evaluations resulting in increased program costs and developmental risks.Standard assessment metrics,such as Technology Readiness Levels（TRL）,do not sufficiently evaluate increasingly complex systems.The System Readiness Level（SRL）is a newly developed system development metric that is a mathematical function of TRL and Integration Readiness Level（IRL） values for the components and connections of a particular system.SRL acceptance has been hindered because of concerns over SRL mathematical operations that may lead to inaccurate system readiness assessments.These inaccurate system readiness assessments are called readiness reversals.A new SRL calculation method using incidence matrices is proposed to alleviate these mathematical concerns.The presence of SRL readiness reversal is modeled for four SRL calculation methods across several system configurations.Logistic regression analysis demonstrates that the proposed Incidence Matrix SRL（IMSRL）method has a decreased presence of readiness reversal than other approaches suggested in the literature.Viable SRL methods will foster greater SRL adoption by systems engineering professionals and will support system development risk reduction goals.展开更多
An integration-centric approach is proposed to handle inadequate information in the system readiness level(SRL)assessment using the evidential reasoning(ER)algorithm.Current SRL assessment approaches cannot be applied...An integration-centric approach is proposed to handle inadequate information in the system readiness level(SRL)assessment using the evidential reasoning(ER)algorithm.Current SRL assessment approaches cannot be applied to handle inadequate information as the input.The ER-based approach is proposed to synthesize inadequate input information and an integration-centric perspective is applied to reduce the computational complexity.Two case studies are performed to validate the efficiency of the proposed approach.And these studies are also performed to study how the inadequate information will affect the assessment result.And the differences caused by the system's structure.The importance of the system's structure in the SRL assessment is demonstrated and the contributions made in this study are summarized as conclusions.展开更多
Considering current space debris situation in outer space environment,different methods for debris removal missions are proposed.In addition,advanced technologies are needed to be demonstrated for future human space e...Considering current space debris situation in outer space environment,different methods for debris removal missions are proposed.In addition,advanced technologies are needed to be demonstrated for future human space exploration programs.The main issue regarding to these missions is high mission cost for both debris removal missions and space environmental tests to achieve high maturity level for new space-usable technologies.Since,these missions are unavoidable for future of human space activities,a solution which can tackle these challenges is necessary.This paper will address to an idea which has the possibility to give a solution for facilitating technology readiness level(TRL)maturity tests by debris removal mission platform consideration.展开更多
Two problems were found in recent applications of TRLs in aerospace projects.One is how to accurately evaluate the readiness level of a given technology in a project using the TRL scale.The other is how to deal with t...Two problems were found in recent applications of TRLs in aerospace projects.One is how to accurately evaluate the readiness level of a given technology in a project using the TRL scale.The other is how to deal with the diversity(different types) of technologies involved in an aerospace project.To solve these problems,a technology readiness assessment(TRA) method based on three maturity characteristics is established,and this method is adapted according to the features of different types of technologies.The proposed method has been successfully applied to aerospace projects and enables great effectiveness and accuracy in assessing new technologies.展开更多
Integrating the photovoltaic/thermal(PV/T)system in green hydrogen production is an improvement in sustainable energy technologies.In PV/T systems,solar energy is converted into electricity and thermal energy simultan...Integrating the photovoltaic/thermal(PV/T)system in green hydrogen production is an improvement in sustainable energy technologies.In PV/T systems,solar energy is converted into electricity and thermal energy simultaneously using hot water or air together with electricity.This dual use saves a significant amount of energy and officially fights greenhouse gases.Different cooling techniques have been proposed in the literature for improving the overall performance of the PV/T systems;employing different types of agents including nanofluids and phase change materials.Hydrogen is the lightest and most abundant element in the universe and has later turned into a flexible energy carrier for transportation and other industrial applications.Issues,including the processes of Hydrogen manufacturing,preservation as well as some risks act as barriers.This paper provides an analysis of several recent publications on the efficiency of using PV/T technology in the process of green hydrogen production and indicates the potential for its increased efficiency as compared to conventional systems that rely on fossil fuels.Due to the effective integration of solar energy,the PV/T system can play an important role in the reduction of the levelized cost of hydrogen(LCOH)and hence play an important part in reducing the economic calculations of the decarbonized energy system.展开更多
This paper builds on exploring the applications of biomediated pathways to solve geotechnical challenges.First,the state of the art of biological remediation strategies including microbial remediation and phytoremedia...This paper builds on exploring the applications of biomediated pathways to solve geotechnical challenges.First,the state of the art of biological remediation strategies including microbial remediation and phytoremediation have been introduced and critically reviewed in the context of decontaminating the soils.Next,biopolymerisation,biomineralisation and bioneutralisation processes have been depicted with a special emphasis on the applications including but not limited to soil stabilisation,soil erosion prevention,anti-desertification and pH neutralisation.Each of these methods have their own limitations and bottlenecks while scaling up,and these challenges have been summarised and some possible paths to overcome the challenges have also been discussed.The state of the art of electromagnetic(EM)monitoring methods to capture the effects of biomediation on spatio-temporal soil properties are then highlighted as a non-invasive and rapid pathway to track the progress of biomediated soil processes.Finally,each of the technologies discussed have been evaluated for their maturity level using the principles of technology readiness level(TRL).A majority of the technologies amounting to around 77%are still in the TRL 4e7,i.e.in the valley of death.It is thus evident that development of these technologies needs to be supported with appropriate funding for improving their maturity to a level of industrial deployment.展开更多
The world is rapidly adopting renewable energy alternatives at a remarkable rate to address the ever-increasing environmental crisis of CO_(2) emissions.Renewable energy system offers enormous potential to decarbonize...The world is rapidly adopting renewable energy alternatives at a remarkable rate to address the ever-increasing environmental crisis of CO_(2) emissions.Renewable energy system offers enormous potential to decarbonize the environment because they produce no greenhouse gases or other polluting emissions.However,the RES relies on natural resources for energy generation,such as sunlight,wind,water,geothermal,which are generally un-predictable and reliant on weather,season,and year.To account for these intermittencies,renewable energy can be stored using various techniques and then used in a consistent and controlled manner as needed.Several researchers from around the world have made substantial contributions over the last century to developing novel methods of energy storage that are efficient enough to meet increasing energy demand and technological break-throughs.This review attempts to provide a critical review of the advancements in the energy storage system from 1850-2022,including its evolution,classification,operating principles and comparison.展开更多
The construction industry is a major contributor to environmental pollution.The effect of the construction industry on the environment may be mitigated using eco-friendly construction materials,such as biocomposites.O...The construction industry is a major contributor to environmental pollution.The effect of the construction industry on the environment may be mitigated using eco-friendly construction materials,such as biocomposites.Once developed,biocomposites may offer a viable alternative to the current materials in use.However,biocomposites are lagging in terms of adoption and eventual use in the construction industry.This article provides insights into the steps for biocomposites to become a product that is ready to use by the construction industry in a structural role.The development and the adoption of such a material is tackled with the use of two concepts,i.e.,technology readiness level and roadmapping,and explored in a case study on the“liquid wood”.Furthermore,interviews in the construction industry are carried out to identify the industry’s take on biocomposites.A customized roadmap,which underlines a mostly nontechnical perspective concerning this material,has emerged.Additionally,the adoption and diffusion issues that the“liquid wood”may encounter are outlined and complemented with further recommendations.展开更多
文摘This study proposes the development of a system to classify phytomedicine projects by applying the technology readiness level (TRL). This strategy is gaining relevance in the field of health innovation because it promotes synergism between researchers and R&D managers working in this area. Nine TRLs were created for the development of herbal medicines by the authors, which is a group of experts in natural products, supported by pre-existing records on project management in the institutions to which they belong. The levels were determined by mirroring the bench-to-bedside development of synthetic drug pathways, in accordance with concepts of translational research. Each level was sectioned by disciplinary areas ruling pools of multiple activities, the achievements of which represent independent technologies. Short content deliveries (SCD) were empirically established at the end of each level as a requirement to enter the next technological stage. A TRL scale was constructed to classify the stages of phytomedicines development to reflect project maturity. Detailed descriptions of the first five nonclinical levels and their sublevels were provided. At the end of each level, the SCD served as an indicator of sufficiency to move on to the next stage. The TRL framework for developing phytomedicines provided an organized panel to clarify the independent technology generated in each stage. The integration of these technologies constitutes a valuable tool for institutions that foster pharmaceutical product development. The five initial levels of TRL considered here can contribute to accelerating innovation in R&D organizations dedicated to the development of plant-based products.
文摘Contemporary system maturity assessment approaches have failed to provide robust quantitative system evaluations resulting in increased program costs and developmental risks.Standard assessment metrics,such as Technology Readiness Levels（TRL）,do not sufficiently evaluate increasingly complex systems.The System Readiness Level（SRL）is a newly developed system development metric that is a mathematical function of TRL and Integration Readiness Level（IRL） values for the components and connections of a particular system.SRL acceptance has been hindered because of concerns over SRL mathematical operations that may lead to inaccurate system readiness assessments.These inaccurate system readiness assessments are called readiness reversals.A new SRL calculation method using incidence matrices is proposed to alleviate these mathematical concerns.The presence of SRL readiness reversal is modeled for four SRL calculation methods across several system configurations.Logistic regression analysis demonstrates that the proposed Incidence Matrix SRL（IMSRL）method has a decreased presence of readiness reversal than other approaches suggested in the literature.Viable SRL methods will foster greater SRL adoption by systems engineering professionals and will support system development risk reduction goals.
基金supported by the National Natural Science Foundation of China(7090107471001104)
文摘An integration-centric approach is proposed to handle inadequate information in the system readiness level(SRL)assessment using the evidential reasoning(ER)algorithm.Current SRL assessment approaches cannot be applied to handle inadequate information as the input.The ER-based approach is proposed to synthesize inadequate input information and an integration-centric perspective is applied to reduce the computational complexity.Two case studies are performed to validate the efficiency of the proposed approach.And these studies are also performed to study how the inadequate information will affect the assessment result.And the differences caused by the system's structure.The importance of the system's structure in the SRL assessment is demonstrated and the contributions made in this study are summarized as conclusions.
基金Supported by the National Natural Science Foundation of China(11572037)
文摘Considering current space debris situation in outer space environment,different methods for debris removal missions are proposed.In addition,advanced technologies are needed to be demonstrated for future human space exploration programs.The main issue regarding to these missions is high mission cost for both debris removal missions and space environmental tests to achieve high maturity level for new space-usable technologies.Since,these missions are unavoidable for future of human space activities,a solution which can tackle these challenges is necessary.This paper will address to an idea which has the possibility to give a solution for facilitating technology readiness level(TRL)maturity tests by debris removal mission platform consideration.
文摘Two problems were found in recent applications of TRLs in aerospace projects.One is how to accurately evaluate the readiness level of a given technology in a project using the TRL scale.The other is how to deal with the diversity(different types) of technologies involved in an aerospace project.To solve these problems,a technology readiness assessment(TRA) method based on three maturity characteristics is established,and this method is adapted according to the features of different types of technologies.The proposed method has been successfully applied to aerospace projects and enables great effectiveness and accuracy in assessing new technologies.
基金funding support from Arabian Gulf University to cover any necessary publication fees.
文摘Integrating the photovoltaic/thermal(PV/T)system in green hydrogen production is an improvement in sustainable energy technologies.In PV/T systems,solar energy is converted into electricity and thermal energy simultaneously using hot water or air together with electricity.This dual use saves a significant amount of energy and officially fights greenhouse gases.Different cooling techniques have been proposed in the literature for improving the overall performance of the PV/T systems;employing different types of agents including nanofluids and phase change materials.Hydrogen is the lightest and most abundant element in the universe and has later turned into a flexible energy carrier for transportation and other industrial applications.Issues,including the processes of Hydrogen manufacturing,preservation as well as some risks act as barriers.This paper provides an analysis of several recent publications on the efficiency of using PV/T technology in the process of green hydrogen production and indicates the potential for its increased efficiency as compared to conventional systems that rely on fossil fuels.Due to the effective integration of solar energy,the PV/T system can play an important role in the reduction of the levelized cost of hydrogen(LCOH)and hence play an important part in reducing the economic calculations of the decarbonized energy system.
文摘This paper builds on exploring the applications of biomediated pathways to solve geotechnical challenges.First,the state of the art of biological remediation strategies including microbial remediation and phytoremediation have been introduced and critically reviewed in the context of decontaminating the soils.Next,biopolymerisation,biomineralisation and bioneutralisation processes have been depicted with a special emphasis on the applications including but not limited to soil stabilisation,soil erosion prevention,anti-desertification and pH neutralisation.Each of these methods have their own limitations and bottlenecks while scaling up,and these challenges have been summarised and some possible paths to overcome the challenges have also been discussed.The state of the art of electromagnetic(EM)monitoring methods to capture the effects of biomediation on spatio-temporal soil properties are then highlighted as a non-invasive and rapid pathway to track the progress of biomediated soil processes.Finally,each of the technologies discussed have been evaluated for their maturity level using the principles of technology readiness level(TRL).A majority of the technologies amounting to around 77%are still in the TRL 4e7,i.e.in the valley of death.It is thus evident that development of these technologies needs to be supported with appropriate funding for improving their maturity to a level of industrial deployment.
文摘The world is rapidly adopting renewable energy alternatives at a remarkable rate to address the ever-increasing environmental crisis of CO_(2) emissions.Renewable energy system offers enormous potential to decarbonize the environment because they produce no greenhouse gases or other polluting emissions.However,the RES relies on natural resources for energy generation,such as sunlight,wind,water,geothermal,which are generally un-predictable and reliant on weather,season,and year.To account for these intermittencies,renewable energy can be stored using various techniques and then used in a consistent and controlled manner as needed.Several researchers from around the world have made substantial contributions over the last century to developing novel methods of energy storage that are efficient enough to meet increasing energy demand and technological break-throughs.This review attempts to provide a critical review of the advancements in the energy storage system from 1850-2022,including its evolution,classification,operating principles and comparison.
文摘The construction industry is a major contributor to environmental pollution.The effect of the construction industry on the environment may be mitigated using eco-friendly construction materials,such as biocomposites.Once developed,biocomposites may offer a viable alternative to the current materials in use.However,biocomposites are lagging in terms of adoption and eventual use in the construction industry.This article provides insights into the steps for biocomposites to become a product that is ready to use by the construction industry in a structural role.The development and the adoption of such a material is tackled with the use of two concepts,i.e.,technology readiness level and roadmapping,and explored in a case study on the“liquid wood”.Furthermore,interviews in the construction industry are carried out to identify the industry’s take on biocomposites.A customized roadmap,which underlines a mostly nontechnical perspective concerning this material,has emerged.Additionally,the adoption and diffusion issues that the“liquid wood”may encounter are outlined and complemented with further recommendations.
