Metal cluster(MC)sites confined within discrete porous molecular cages have been extensively utilized in heterogeneous catalysis.However,studies on how encapsulated MCs influence the catalytic performance of their con...Metal cluster(MC)sites confined within discrete porous molecular cages have been extensively utilized in heterogeneous catalysis.However,studies on how encapsulated MCs influence the catalytic performance of their containers are scarce.Herein,by leveraging an eco-friendly alcohol reduction method,we fabricated an organic cage-encapsulated MC complex,abbreviated as Au■TPPCage·Cl.Notably,the charge transfer between the Au clusters and the porphyrin cage skeleton significantly modifies the electronic structure of the porphyrin units,thereby enhancing cages'photophysical properties.This results in a distinct O_(2)activation ability,switching from^(1)O_(2)to O_(2)·-.Consequently,this hybrid exhibits superior performance in the catalytic degradation of the blister agent simulant CEES,with a half-life of 2.0 min under visible light.The Lindqvist-type POM anions introduced by ion exchange endow this hybrid with additional hydrolysis sites,enabling the efficient detoxification of nerve agent simulant DECP,with a half-life of 4.2 min.Furthermore,a facile and universal method is advanced to tightly load the cageencapsulated MC complex onto different types of fibers,leading to fiber composites that enhance practical applicability compared to untreated parent fibers,including extended protection duration and increased degradation efficiency.This work pioneers a new perspective involving MC-regulated switching reactive oxygen species within cage-type containers,while offering exciting opportunities for developing advanced catalysts for chemical warfare agent detoxification.展开更多
Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials ...Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position.However,they suffer from inherent issues such as complicated synthesis,batch-to-batch variability,high cost,and potential biological toxicity caused by metal elements.Here,we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalenestructured small-molecule enzyme imitator(DHKNase)exhibited 2-edged ROS regulation,catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems.Based on this,DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models,including the pathogen-infected wound-healing model and the dextran sulfate sodium(DSS)-caused inflammatory bowel disease(IBD).This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.展开更多
The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors...The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors such as bacterial infections,hyperglycemia,and oxidative stress disrupt cellular functions and impair angiogenesis,substantially delaying wound repair.Nanozymes,which are engineered nanoscale materials with enzyme-like activities,offer distinct advantages over conventional enzymes and traditional nanomaterials,making them promising candidates for chronic wound treatment.To enhance their clinical potential,nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility,anti-oxidant activity,antibacterial efficacy,and tissue repair capabilities,ensuring their safety and clinical applicability.When integrated into multifunctional wound dressings,nanozymes modulate reactive oxygen species levels,promote tissue regeneration,and simultaneously combat infections and oxidative damage,extending beyond conventional enzyme-like catalysis in chronic wound treatment.The customizable architectures of nanozymes enable precise therapeutic applications,enhancing their effectiveness in managing complex wound conditions.This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings,detailing fabrication methods and emphasizing their transformative potential in chronic wound management.By identifying and addressing key limitations,we introduce strategic advancements to drive the development of nanozyme-driven dressings,paving the way for next-generation chronic wound treatments.展开更多
It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped ca...It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped carbon quantum dots(Te-CDs)were developed by a simple and efficient hydrothermal method,which can scavenge H2O2 to protect cells under ambient condition,but generateáOH under 808 nm irradiation as photodynamic application.This contribution presented a kind of novel CDs with dual-functions,which can potentially regulate ROS under different conditions.展开更多
Due to the limited self-repair ability of the annulus fibrosus (AF), current tissue engineering strategies tend to use structurally biomimetic scaffolds for AF defect repair. However, the poor integration between impl...Due to the limited self-repair ability of the annulus fibrosus (AF), current tissue engineering strategies tend to use structurally biomimetic scaffolds for AF defect repair. However, the poor integration between implanted scaffolds and tissue severely affects their therapeutic effects. To solve this issue, we prepared a multifunctional scaffold containing loaded lysyl oxidase (LOX) plasmid DNA exosomes and manganese dioxide nanoparticles (MnO2 NPs). LOX facilitates extracellular matrix (ECM) cross-linking, while MnO2 NPs inhibit excessive reactive oxygen species (ROS)-induced ECM degradation at the injury site, enhancing the crosslinking effect of LOX. Our results revealed that this multifunctional scaffold significantly facilitated the integration between the scaffold and AF tissue. Cells were able to migrate into the scaffold, indicating that the scaffold was not encapsulated as a foreign body by fibrous tissue. The functional scaffold was closely integrated with the tissue, effectively enhancing the mechanical properties, and preventing vascular invasion, which emphasized the importance of scaffold-tissue integration in AF repair.展开更多
基金supported by the National Natural Science Foundation of China(22071008 and 22471018)the High-level Overseas Talents Program of China+1 种基金the Excellent Young Scholars Research Fund from the Beijing Institute of Technologythe Fund of State Key Laboratory of Structural Chemistry。
文摘Metal cluster(MC)sites confined within discrete porous molecular cages have been extensively utilized in heterogeneous catalysis.However,studies on how encapsulated MCs influence the catalytic performance of their containers are scarce.Herein,by leveraging an eco-friendly alcohol reduction method,we fabricated an organic cage-encapsulated MC complex,abbreviated as Au■TPPCage·Cl.Notably,the charge transfer between the Au clusters and the porphyrin cage skeleton significantly modifies the electronic structure of the porphyrin units,thereby enhancing cages'photophysical properties.This results in a distinct O_(2)activation ability,switching from^(1)O_(2)to O_(2)·-.Consequently,this hybrid exhibits superior performance in the catalytic degradation of the blister agent simulant CEES,with a half-life of 2.0 min under visible light.The Lindqvist-type POM anions introduced by ion exchange endow this hybrid with additional hydrolysis sites,enabling the efficient detoxification of nerve agent simulant DECP,with a half-life of 4.2 min.Furthermore,a facile and universal method is advanced to tightly load the cageencapsulated MC complex onto different types of fibers,leading to fiber composites that enhance practical applicability compared to untreated parent fibers,including extended protection duration and increased degradation efficiency.This work pioneers a new perspective involving MC-regulated switching reactive oxygen species within cage-type containers,while offering exciting opportunities for developing advanced catalysts for chemical warfare agent detoxification.
基金supported by the Science and Technology Innovation Program of Hunan Province(2023RC3148)the Scientific Research Foundation of Hunan Provincial Education Department(22B0221)+3 种基金the Opening Foundation of the State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University(20230754)the National Natural Science Foundation of China(22004035 and 31672457)the Double first-class construction project of Hunan Agricultural University(CX20190497)the National Key Research and Development Program(2021YFD1300205-2)。
文摘Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position.However,they suffer from inherent issues such as complicated synthesis,batch-to-batch variability,high cost,and potential biological toxicity caused by metal elements.Here,we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalenestructured small-molecule enzyme imitator(DHKNase)exhibited 2-edged ROS regulation,catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems.Based on this,DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models,including the pathogen-infected wound-healing model and the dextran sulfate sodium(DSS)-caused inflammatory bowel disease(IBD).This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.
基金supported by the Key Project of the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China(U23A20686)the National Natural Science Foundation of China(81901979)+2 种基金the Peking University People’s Hospital Scientific Research Development Funds(RDJP2022-07)the Joint Funds for the Innovation of Science and Technology,Fujian Province(2023Y9226)the Introduced High-Level Talent Team Project of Quanzhou City(2023CT008).
文摘The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.Factors such as bacterial infections,hyperglycemia,and oxidative stress disrupt cellular functions and impair angiogenesis,substantially delaying wound repair.Nanozymes,which are engineered nanoscale materials with enzyme-like activities,offer distinct advantages over conventional enzymes and traditional nanomaterials,making them promising candidates for chronic wound treatment.To enhance their clinical potential,nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility,anti-oxidant activity,antibacterial efficacy,and tissue repair capabilities,ensuring their safety and clinical applicability.When integrated into multifunctional wound dressings,nanozymes modulate reactive oxygen species levels,promote tissue regeneration,and simultaneously combat infections and oxidative damage,extending beyond conventional enzyme-like catalysis in chronic wound treatment.The customizable architectures of nanozymes enable precise therapeutic applications,enhancing their effectiveness in managing complex wound conditions.This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings,detailing fabrication methods and emphasizing their transformative potential in chronic wound management.By identifying and addressing key limitations,we introduce strategic advancements to drive the development of nanozyme-driven dressings,paving the way for next-generation chronic wound treatments.
基金the National Natural Foundation of China(21774130 and 51925306)National Key R&D Program of China(2018FYA0305800)+4 种基金the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046)Key Research Program of the Chinese Academy of Sciences(XDPB08-2)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)the International Partnership Program of Chinese Academy of Sciences(211211KYSB20170014)University of Chinese Academy of Sciences。
文摘It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped carbon quantum dots(Te-CDs)were developed by a simple and efficient hydrothermal method,which can scavenge H2O2 to protect cells under ambient condition,but generateáOH under 808 nm irradiation as photodynamic application.This contribution presented a kind of novel CDs with dual-functions,which can potentially regulate ROS under different conditions.
基金National Natural Science Foundation of China(32201115,32130059,81925027)Suzhou Science and Technology Development Plan Project(SKY2022100)+2 种基金Gusu Health Talents Program of Suzhou Municipal Health Commission(GSWS2021070)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_3269)Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Due to the limited self-repair ability of the annulus fibrosus (AF), current tissue engineering strategies tend to use structurally biomimetic scaffolds for AF defect repair. However, the poor integration between implanted scaffolds and tissue severely affects their therapeutic effects. To solve this issue, we prepared a multifunctional scaffold containing loaded lysyl oxidase (LOX) plasmid DNA exosomes and manganese dioxide nanoparticles (MnO2 NPs). LOX facilitates extracellular matrix (ECM) cross-linking, while MnO2 NPs inhibit excessive reactive oxygen species (ROS)-induced ECM degradation at the injury site, enhancing the crosslinking effect of LOX. Our results revealed that this multifunctional scaffold significantly facilitated the integration between the scaffold and AF tissue. Cells were able to migrate into the scaffold, indicating that the scaffold was not encapsulated as a foreign body by fibrous tissue. The functional scaffold was closely integrated with the tissue, effectively enhancing the mechanical properties, and preventing vascular invasion, which emphasized the importance of scaffold-tissue integration in AF repair.
