A new type of localized oscillatory pattern is presented in a two-layer coupled reaction-diffusion system under conditions in which no Hopf instability can be discerned in either layer.The transitions from stationary ...A new type of localized oscillatory pattern is presented in a two-layer coupled reaction-diffusion system under conditions in which no Hopf instability can be discerned in either layer.The transitions from stationary patterns to asynchronous and synchronous oscillatory patterns are obtained.A novel method based on decomposing coupled systems into two associated subsystems has been proposed to elucidate the mechanism of formation of oscillating patterns.Linear stability analysis of the associated subsystems reveals that the Turing pattern in one layer induces the other layer locally,undergoes a supercritical Hopf bifurcation and gives rise to localized oscillations.It is found that the sizes and positions of oscillations are determined by the spatial distribution of the Turing patterns.When the size is large,localized traveling waves such as spirals and targets emerge.These results may be useful for deeper understanding of pattern formation in complex systems,particularly multilayered systems.展开更多
In this paper, we consider the existence of pullback random exponential attractor for non-autonomous random reaction-diffusion equation driven by nonlinear colored noise defined onR^(N) . The key steps of the proof ar...In this paper, we consider the existence of pullback random exponential attractor for non-autonomous random reaction-diffusion equation driven by nonlinear colored noise defined onR^(N) . The key steps of the proof are the tails estimate and to demonstrate the Lipschitz continuity and random squeezing property of the solution for the equation defined on R^(N) .展开更多
An evolution inequality of Sobolev type involving a nonlinear convolution term is considered.By using the nonlinear capacity method and the contradiction argument,the non-existence of the nontrivial local weak solutio...An evolution inequality of Sobolev type involving a nonlinear convolution term is considered.By using the nonlinear capacity method and the contradiction argument,the non-existence of the nontrivial local weak solution is proved.展开更多
The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the ...The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the flow of these problems and the vacuum isolation of solutions are obtained by introducing a family of potential wells. Then the threshold result of global existence and nonexistence of solutions are given. Finally, the problem with critical initial conditions are discussed.展开更多
Qigong is an important part of traditional Chinese health preservation culture,and the accurate translation of its terms is of great significance for international communication.Currently,there are many deficiencies i...Qigong is an important part of traditional Chinese health preservation culture,and the accurate translation of its terms is of great significance for international communication.Currently,there are many deficiencies in the translation of Qigong terms,such as a lack of systematicity and inconsistent translations.Based on hermeneutics theory,this study analyzes the factors influencing the acceptance of Qigong term translations,and constructs an evaluation model for translation acceptance,covering three dimensions:culture,language,and readers.Accordingly,translation strategies are proposed,including culturally adaptive translation,optimization of language structure,reader stratification strategies,horizon fusion,and the hermeneutic circle,etc.The aim is to balance the cultural connotations and readers’acceptance,and to promote the international communication of Qigong culture.展开更多
This article aims to analyze the repercussions of food trade between China and various regions of the world to understand the dynamics of food flows and offer a novel perspective on the contemporary globalization proc...This article aims to analyze the repercussions of food trade between China and various regions of the world to understand the dynamics of food flows and offer a novel perspective on the contemporary globalization process.Understanding these flows involves analyzing the global production and commercialization of food and the effects of these movements on exporting and importing countries in economic terms and food security.The concept of unequal caloric exchange is applied to the case of China,which allows for an understanding of how its economic growth and participation in international trade have transformed its global and internal commercial dynamics by establishing links with self-sufficiency and the composition of its population’s diet.The results show that China is increasingly dependent on international markets for its food supply.From 1961 to 2021,food consumption in China has tripled in calories and experienced qualitative changes,with a reduction in high-quality carbohydrates and vegetable proteins and an increase in cereals,vegetable oils,alcohol,and vegetables.This dietary transformation is related to economic growth and greater dependence on international trade.From 1987 to 2022,China has shown a growing deficit in the food trade balance,with imports exceeding exports in volume,value,and calories,although it maintains favorable terms of trade.Food self-sufficiency has decreased from 95%in 1961 to 76%in 2022,and the diet has diversified,replacing traditional foods with products demanded in international trade.展开更多
This study investigates translation strategies for Chinese cultural terms in academic texts through a case study of Chapter 7 from“Jade Myth Belief and Chinese Spirit”.Using a qualitative research approach based on ...This study investigates translation strategies for Chinese cultural terms in academic texts through a case study of Chapter 7 from“Jade Myth Belief and Chinese Spirit”.Using a qualitative research approach based on cultural context framework and cognitive model,the study analyzes translation challenges and solutions in rendering cultural terms related to jade mythology and archaeological concepts.The research identifies three primary translation strategies:transliteration with annotation,domestication with explanation,and cognitive-based translation.The findings reveal that effective translation requires a balanced approach between maintaining academic precision and preserving cultural authenticity.The study demonstrates that successful translation of cultural terms in academic contexts demands a sophisticated understanding of both source and target cultural contexts,along with careful consideration of the academic audience’s needs.This research contributes to the field by providing practical insights for translators working with Chinese cultural texts in academic settings and proposing an approach to handling complex cultural terminology.展开更多
Large-scale deep-seated landslides pose a significant threat to human life and infrastructure.Therefore,closely monitoring these landslides is crucial for assessing and mitigating their associated risks.In this paper,...Large-scale deep-seated landslides pose a significant threat to human life and infrastructure.Therefore,closely monitoring these landslides is crucial for assessing and mitigating their associated risks.In this paper,the authors introduce the So Lo Mon framework,a comprehensive monitoring system developed for three large-scale landslides in the Autonomous Province of Bolzano,Italy.A web-based platform integrates various monitoring data(GNSS,topographic data,in-place inclinometer),providing a user-friendly interface for visualizing and analyzing the collected data.This facilitates the identification of trends and patterns in landslide behaviour,enabling the triggering of warnings and the implementation of appropriate mitigation measures.The So Lo Mon platform has proven to be an invaluable tool for managing the risks associated with large-scale landslides through non-structural measures and driving countermeasure works design.It serves as a centralized data repository,offering visualization and analysis tools.This information empowers decisionmakers to make informed choices regarding risk mitigation,ultimately ensuring the safety of communities and infrastructures.展开更多
It is well known that the A-square term must be considered in both cavity and circuit quantum electrodynamics systems,because it arises in the derivation from the minimal coupling Hamiltonian at any finite coupling st...It is well known that the A-square term must be considered in both cavity and circuit quantum electrodynamics systems,because it arises in the derivation from the minimal coupling Hamiltonian at any finite coupling strength.In this paper,we study the quantum Rabi model with A-square terms using the Bogoliubov operator approach.After a unitary transformation,the A-square terms can be eliminated,resulting in a modified quantum Rabi model with renormalized parameters.A transcendental function responsible for the exact solution is then derived.The presence of the A-square terms is found to significantly alter the energy spectrum.The dynamics are also studied using the obtained exact wave function,which is sensitive to the strength of the A-square terms at strong coupling.We believe that these results could be observed in future light–matter interaction systems in the ultra-strong and deep strong coupling regimes.展开更多
In this paper,we investigate the blow-up phenomenon for a class of logarithmic viscoelastic equations with delay and nonlocal terms under acoustic boundary conditions.Using the energy method,we prove that nontrivial s...In this paper,we investigate the blow-up phenomenon for a class of logarithmic viscoelastic equations with delay and nonlocal terms under acoustic boundary conditions.Using the energy method,we prove that nontrivial solutions with negative initial energy will blow up in finite time,and provide an upper bound estimate for the blow-up time.Additionally,we also derive a lower bound estimate for the blow-up time.展开更多
In this study,the climatology and long-term trends of middle atmospheric temperatures at mid-latitudes are investigated using Rayleigh/Sodium lidar observations collected from January 2010 to December 2021 over Hefei,...In this study,the climatology and long-term trends of middle atmospheric temperatures at mid-latitudes are investigated using Rayleigh/Sodium lidar observations collected from January 2010 to December 2021 over Hefei,China(32°N,117°E).The seasonal variations and vertical profiles of lidar-derived temperatures demonstrate strong agreement with temperature measurements from the Microwave Limb Sounder(MLS)instrument on the Earth Observing System(EOS)Aura satellite.In terms of seasonal variation,middle atmospheric temperatures primarily exhibit annual oscillations(AO)and semi-annual oscillations(SAO).Harmonic analysis of the lidar and MLS temperature data reveals close phase alignment for both AO and SAO,with AO amplitudes ranging from 2 to 6 K,and SAO amplitudes from 1 to 4 K.The dependence of temperature on solar forcing was analyzed using the F10.7 index as a proxy,showing positive solar response coefficients at all altitudes,with a maximum of 15±1.1 K/100 SFU observed near 42–44 km.After removing the temperature response to solar cycle variations,a cooling trend in mid-latitude temperatures is evident across all altitudes,ranging from 3 to 6 K/decade.展开更多
Through its unique five-year planning system,China demonstrates how long-term,strategic policy continuity can effectively address both domestic and global challenges.
BACKGROUND Necrotizing enterocolitis(NEC)remains a prominent gastrointestinal emergency among infants,particularly term infants with congenital heart defects(CHD)being at high risk.The molecular processes that contrib...BACKGROUND Necrotizing enterocolitis(NEC)remains a prominent gastrointestinal emergency among infants,particularly term infants with congenital heart defects(CHD)being at high risk.The molecular processes that contribute to NEC have yet to be completely understood.The high mortality rates necessitate an active search for noninvasive biomarkers that can aid in the preclinical diagnosis and prognosis of NEC.MicroRNAs(miRs),which are involved in many biological processes in both health and disease,have been discovered to play an important role in regulating inflammation and immune responses via various signaling pathways.AIM To determine the plasma levels of miR-155,miR-221,miR-223,miR-320a,miR-451a as potential NEC biomarkers in term newborns with CHD.METHODS This prospective cohort study included twenty-tree term newborns with CHD who underwent cardiac surgery on the median day of life(DOL)=7.Nine of them developed NEC(Bell’s stage IIA and IIIA)within 1 week of cardiac surgery(NEC newborns).Blood samples were collected before(median DOL=5)and following(median DOL=13)cardiac surgery.Levels of plasma miR-155-5p,miR-221-3p,miR-223-3p,miR-320a-3p,and miR-451a were determined using real-time polymerase chain reaction.The functional analysis was executed using the DIANA-miRPath v4.0.RESULTS Preoperatively,NEC newborns had significantly lower plasma levels of miR-155(2.70-fold,P=0.020),miR-223(2.42-fold,P=0.030),and miR-320a(3.62-fold,P=0.006)than newborns without NEC.Postoperatively,miR-451a levels differed significantly between the newborn groups,showing a 4.70-fold decrease(P=0.014)in expression when clinical NEC symptoms appeared.According to receiver operating characteristic analysis,miR-320a was found to be the most effective predictive biomarker for NEC[area under the curve(AUC)=0.835,63%sensitivity,100%specificity],while miR-451a was identified as a NEC biomarker(AUC=0.835,85.7%sensitivity,76.9%specificity).Preoperatively,miR-155-5p,miR-223-3p,and miR-320a-3p were differentially expressed and targeted the forkhead box O and Hippo pathways(P<0.01).CONCLUSION Our study demonstrates,for the first time,that plasma miR-320a-3p levels can be used as a preclinical biomarker for NEC in term newborns with CHD.展开更多
Sarcomerogenesis,the addition of serial sarcomeres in skeletal muscle myofibrils and fibres,is a natural occurrence during growth and maturation of animals,including humans.However,the detailed mechanisms that allow f...Sarcomerogenesis,the addition of serial sarcomeres in skeletal muscle myofibrils and fibres,is a natural occurrence during growth and maturation of animals,including humans.However,the detailed mechanisms that allow for sarcomerogenesis are not fully understood.In some diseases,such as cerebral palsy in children,sarcomerogenesis appears to be inhibited or at least reduced,1,2 often causing severe restrictions in muscle and joint function.展开更多
China’s stability and long-term planning make it a sheet anchor amid global storm China is stepping up e!orts to fulfil the targets set in the 14th Five-Year Plan(FYP)in its final year of implementation and to formul...China’s stability and long-term planning make it a sheet anchor amid global storm China is stepping up e!orts to fulfil the targets set in the 14th Five-Year Plan(FYP)in its final year of implementation and to formulate the next FYP.Chinese President Xi Jinping called for adapting to changing situations,identifying strategic priorities,and making sound plans for the compilation of the 15th FYP(2026-2030)on April 30.展开更多
Spanish scholars decode China’s five-year planning as a strategic governance model that ensures long-term national development through continuity,popular participation,and adaptability,offering valuable insights for ...Spanish scholars decode China’s five-year planning as a strategic governance model that ensures long-term national development through continuity,popular participation,and adaptability,offering valuable insights for global governance.展开更多
China’s five-year plans crystallize a governance model that merges long-term strategic vision with adaptive execution.AS China prepares to unveil its 15th Five-Year Plan in 2026,policymakers,investors,and scholars ar...China’s five-year plans crystallize a governance model that merges long-term strategic vision with adaptive execution.AS China prepares to unveil its 15th Five-Year Plan in 2026,policymakers,investors,and scholars around the world are watching closely.For over 70 years,these plans have guided the country’s economic and social development.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12275065,12275064,12475203)the Natural Science Foundation of Hebei Province(Grant Nos.A2021201010 and A2024201020)+3 种基金Interdisciplinary Research Program of Natural Science of Hebei University(Grant No.DXK202108)Hebei Provincial Central Government Guiding Local Science and Technology Development Funds(Grant No.236Z1501G)Scientific Research and Innovation Team Foundation of Hebei University(Grant No.IT2023B03)the Excellent Youth Research Innovation Team of Hebei University(Grant No.QNTD202402)。
文摘A new type of localized oscillatory pattern is presented in a two-layer coupled reaction-diffusion system under conditions in which no Hopf instability can be discerned in either layer.The transitions from stationary patterns to asynchronous and synchronous oscillatory patterns are obtained.A novel method based on decomposing coupled systems into two associated subsystems has been proposed to elucidate the mechanism of formation of oscillating patterns.Linear stability analysis of the associated subsystems reveals that the Turing pattern in one layer induces the other layer locally,undergoes a supercritical Hopf bifurcation and gives rise to localized oscillations.It is found that the sizes and positions of oscillations are determined by the spatial distribution of the Turing patterns.When the size is large,localized traveling waves such as spirals and targets emerge.These results may be useful for deeper understanding of pattern formation in complex systems,particularly multilayered systems.
基金supported by the NSFC(12271141)supported by the Fundamental Research Funds for the Central Universities(B240205026)the Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX24_0821).
文摘In this paper, we consider the existence of pullback random exponential attractor for non-autonomous random reaction-diffusion equation driven by nonlinear colored noise defined onR^(N) . The key steps of the proof are the tails estimate and to demonstrate the Lipschitz continuity and random squeezing property of the solution for the equation defined on R^(N) .
基金Supported by Scientific Research Fund of Hunan Provincial Education Departmen(t23A0361)。
文摘An evolution inequality of Sobolev type involving a nonlinear convolution term is considered.By using the nonlinear capacity method and the contradiction argument,the non-existence of the nontrivial local weak solution is proved.
基金the National Natural Science Foundation of China(No.10271034)the Basic Research Foundation of Harbin Engineering University(No.HEUF04012)
文摘The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the flow of these problems and the vacuum isolation of solutions are obtained by introducing a family of potential wells. Then the threshold result of global existence and nonexistence of solutions are given. Finally, the problem with critical initial conditions are discussed.
基金Hunan Province Social Science Achievements Evaluation Committee Project(XSP2023WXC039)Scientific Research Fund of Hunan Provincial Education Department(22B1037)。
文摘Qigong is an important part of traditional Chinese health preservation culture,and the accurate translation of its terms is of great significance for international communication.Currently,there are many deficiencies in the translation of Qigong terms,such as a lack of systematicity and inconsistent translations.Based on hermeneutics theory,this study analyzes the factors influencing the acceptance of Qigong term translations,and constructs an evaluation model for translation acceptance,covering three dimensions:culture,language,and readers.Accordingly,translation strategies are proposed,including culturally adaptive translation,optimization of language structure,reader stratification strategies,horizon fusion,and the hermeneutic circle,etc.The aim is to balance the cultural connotations and readers’acceptance,and to promote the international communication of Qigong culture.
基金supported by the Government of Catalonia,and the ETOS project(TED2021-132032A-I00)supported by the Spanish Ministry of Science and Innovation.
文摘This article aims to analyze the repercussions of food trade between China and various regions of the world to understand the dynamics of food flows and offer a novel perspective on the contemporary globalization process.Understanding these flows involves analyzing the global production and commercialization of food and the effects of these movements on exporting and importing countries in economic terms and food security.The concept of unequal caloric exchange is applied to the case of China,which allows for an understanding of how its economic growth and participation in international trade have transformed its global and internal commercial dynamics by establishing links with self-sufficiency and the composition of its population’s diet.The results show that China is increasingly dependent on international markets for its food supply.From 1961 to 2021,food consumption in China has tripled in calories and experienced qualitative changes,with a reduction in high-quality carbohydrates and vegetable proteins and an increase in cereals,vegetable oils,alcohol,and vegetables.This dietary transformation is related to economic growth and greater dependence on international trade.From 1987 to 2022,China has shown a growing deficit in the food trade balance,with imports exceeding exports in volume,value,and calories,although it maintains favorable terms of trade.Food self-sufficiency has decreased from 95%in 1961 to 76%in 2022,and the diet has diversified,replacing traditional foods with products demanded in international trade.
基金sponsored by the Humanities and Social Sciences Project of the Ministry of Education under Grant No.24YJCZH443Shanghai Philosophy and Social Science Planning Project under Grant No.2024EYY015Shanghai Municipal Philosophy and Social Sciences Planning Project under Grant No.2024EYY011.
文摘This study investigates translation strategies for Chinese cultural terms in academic texts through a case study of Chapter 7 from“Jade Myth Belief and Chinese Spirit”.Using a qualitative research approach based on cultural context framework and cognitive model,the study analyzes translation challenges and solutions in rendering cultural terms related to jade mythology and archaeological concepts.The research identifies three primary translation strategies:transliteration with annotation,domestication with explanation,and cognitive-based translation.The findings reveal that effective translation requires a balanced approach between maintaining academic precision and preserving cultural authenticity.The study demonstrates that successful translation of cultural terms in academic contexts demands a sophisticated understanding of both source and target cultural contexts,along with careful consideration of the academic audience’s needs.This research contributes to the field by providing practical insights for translators working with Chinese cultural texts in academic settings and proposing an approach to handling complex cultural terminology.
基金funded by the So Lo Mon project“Monitoraggio a Lungo Termine di Grandi Frane basato su Sistemi Integrati di Sensori e Reti”(Longterm monitoring of large-scale landslides based on integrated systems of sensors and networks),Program EFRE-FESR 2014–2020,Project EFRE-FESR4008 South Tyrol–Person in charge:V.Mair。
文摘Large-scale deep-seated landslides pose a significant threat to human life and infrastructure.Therefore,closely monitoring these landslides is crucial for assessing and mitigating their associated risks.In this paper,the authors introduce the So Lo Mon framework,a comprehensive monitoring system developed for three large-scale landslides in the Autonomous Province of Bolzano,Italy.A web-based platform integrates various monitoring data(GNSS,topographic data,in-place inclinometer),providing a user-friendly interface for visualizing and analyzing the collected data.This facilitates the identification of trends and patterns in landslide behaviour,enabling the triggering of warnings and the implementation of appropriate mitigation measures.The So Lo Mon platform has proven to be an invaluable tool for managing the risks associated with large-scale landslides through non-structural measures and driving countermeasure works design.It serves as a centralized data repository,offering visualization and analysis tools.This information empowers decisionmakers to make informed choices regarding risk mitigation,ultimately ensuring the safety of communities and infrastructures.
基金supported by the National Science Foundation of China under Grant Nos.12305009(XYC)and 11834005(QHC)the China Postdoctoral Science Foundation under Grant No.2022M720387(XYC).
文摘It is well known that the A-square term must be considered in both cavity and circuit quantum electrodynamics systems,because it arises in the derivation from the minimal coupling Hamiltonian at any finite coupling strength.In this paper,we study the quantum Rabi model with A-square terms using the Bogoliubov operator approach.After a unitary transformation,the A-square terms can be eliminated,resulting in a modified quantum Rabi model with renormalized parameters.A transcendental function responsible for the exact solution is then derived.The presence of the A-square terms is found to significantly alter the energy spectrum.The dynamics are also studied using the obtained exact wave function,which is sensitive to the strength of the A-square terms at strong coupling.We believe that these results could be observed in future light–matter interaction systems in the ultra-strong and deep strong coupling regimes.
基金supported by the National Natural Sciences Foundation of China(No.62363005)。
文摘In this paper,we investigate the blow-up phenomenon for a class of logarithmic viscoelastic equations with delay and nonlocal terms under acoustic boundary conditions.Using the energy method,we prove that nontrivial solutions with negative initial energy will blow up in finite time,and provide an upper bound estimate for the blow-up time.Additionally,we also derive a lower bound estimate for the blow-up time.
基金supported by the National Natural Science Foundation of China(Grant 42125402,42174183 and 42304165)the National Key Technologies R&D Program of China(Grant 2022YFF0503703)+7 种基金the B-type Strategic Priority Program of CAS(Grant XDB0780000)the Chinese Meridian Projectthe Fundamental Research Funds for the Central Universitiesthe Joint Open Fund of Mengcheng National Geophysical Observatory(MENGO-202406,MENGO-202407)the National Natural Science Foundation of China(NSFC)Distinguished Overseas Young Talents ProgramBasic Research Project of the National Key Laboratory of Deep Space Exploration(NKLDSE2023A002)the Pre-research project on Civil Aerospace Technologies No.D010305 and D010301 funded by China National Space Administration(CNSA)Supported by the Specialized Research Fund for State Key Laboratory of Solar Activity and Space Weathe.
文摘In this study,the climatology and long-term trends of middle atmospheric temperatures at mid-latitudes are investigated using Rayleigh/Sodium lidar observations collected from January 2010 to December 2021 over Hefei,China(32°N,117°E).The seasonal variations and vertical profiles of lidar-derived temperatures demonstrate strong agreement with temperature measurements from the Microwave Limb Sounder(MLS)instrument on the Earth Observing System(EOS)Aura satellite.In terms of seasonal variation,middle atmospheric temperatures primarily exhibit annual oscillations(AO)and semi-annual oscillations(SAO).Harmonic analysis of the lidar and MLS temperature data reveals close phase alignment for both AO and SAO,with AO amplitudes ranging from 2 to 6 K,and SAO amplitudes from 1 to 4 K.The dependence of temperature on solar forcing was analyzed using the F10.7 index as a proxy,showing positive solar response coefficients at all altitudes,with a maximum of 15±1.1 K/100 SFU observed near 42–44 km.After removing the temperature response to solar cycle variations,a cooling trend in mid-latitude temperatures is evident across all altitudes,ranging from 3 to 6 K/decade.
文摘Through its unique five-year planning system,China demonstrates how long-term,strategic policy continuity can effectively address both domestic and global challenges.
基金Supported by The Russian Science Foundation,No.19-75-20076.
文摘BACKGROUND Necrotizing enterocolitis(NEC)remains a prominent gastrointestinal emergency among infants,particularly term infants with congenital heart defects(CHD)being at high risk.The molecular processes that contribute to NEC have yet to be completely understood.The high mortality rates necessitate an active search for noninvasive biomarkers that can aid in the preclinical diagnosis and prognosis of NEC.MicroRNAs(miRs),which are involved in many biological processes in both health and disease,have been discovered to play an important role in regulating inflammation and immune responses via various signaling pathways.AIM To determine the plasma levels of miR-155,miR-221,miR-223,miR-320a,miR-451a as potential NEC biomarkers in term newborns with CHD.METHODS This prospective cohort study included twenty-tree term newborns with CHD who underwent cardiac surgery on the median day of life(DOL)=7.Nine of them developed NEC(Bell’s stage IIA and IIIA)within 1 week of cardiac surgery(NEC newborns).Blood samples were collected before(median DOL=5)and following(median DOL=13)cardiac surgery.Levels of plasma miR-155-5p,miR-221-3p,miR-223-3p,miR-320a-3p,and miR-451a were determined using real-time polymerase chain reaction.The functional analysis was executed using the DIANA-miRPath v4.0.RESULTS Preoperatively,NEC newborns had significantly lower plasma levels of miR-155(2.70-fold,P=0.020),miR-223(2.42-fold,P=0.030),and miR-320a(3.62-fold,P=0.006)than newborns without NEC.Postoperatively,miR-451a levels differed significantly between the newborn groups,showing a 4.70-fold decrease(P=0.014)in expression when clinical NEC symptoms appeared.According to receiver operating characteristic analysis,miR-320a was found to be the most effective predictive biomarker for NEC[area under the curve(AUC)=0.835,63%sensitivity,100%specificity],while miR-451a was identified as a NEC biomarker(AUC=0.835,85.7%sensitivity,76.9%specificity).Preoperatively,miR-155-5p,miR-223-3p,and miR-320a-3p were differentially expressed and targeted the forkhead box O and Hippo pathways(P<0.01).CONCLUSION Our study demonstrates,for the first time,that plasma miR-320a-3p levels can be used as a preclinical biomarker for NEC in term newborns with CHD.
文摘Sarcomerogenesis,the addition of serial sarcomeres in skeletal muscle myofibrils and fibres,is a natural occurrence during growth and maturation of animals,including humans.However,the detailed mechanisms that allow for sarcomerogenesis are not fully understood.In some diseases,such as cerebral palsy in children,sarcomerogenesis appears to be inhibited or at least reduced,1,2 often causing severe restrictions in muscle and joint function.
文摘China’s stability and long-term planning make it a sheet anchor amid global storm China is stepping up e!orts to fulfil the targets set in the 14th Five-Year Plan(FYP)in its final year of implementation and to formulate the next FYP.Chinese President Xi Jinping called for adapting to changing situations,identifying strategic priorities,and making sound plans for the compilation of the 15th FYP(2026-2030)on April 30.
文摘Spanish scholars decode China’s five-year planning as a strategic governance model that ensures long-term national development through continuity,popular participation,and adaptability,offering valuable insights for global governance.
文摘China’s five-year plans crystallize a governance model that merges long-term strategic vision with adaptive execution.AS China prepares to unveil its 15th Five-Year Plan in 2026,policymakers,investors,and scholars around the world are watching closely.For over 70 years,these plans have guided the country’s economic and social development.
