In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by which high glucose triggers oxidative stress and contributes to kidney injury in diabetes.The high level of unmetabolized glucose reaching the kidney triggers glucose reabsorption by renal tubules,which elevates the cellular glucose level of renal cells.High glucose induces lactate dehydrogenase overexpression and thus shifts glucose metabolism,which causes mitochondrial dysfunction.Mitochondria generate approximately 90%of the reactive oxygen species in cells,whose dysfunction further alters glucose metabolism and enhances reactive oxygen species generation.Oxidative stress stimulates proinflammatory factor production and kidney inflammatory injury.Mizagliflozin decreases glucose reabsorption and thus ameliorates diabetes-induced kidney injury.展开更多
Background:Very low-protein(VLP)diets negatively impact calcium(Ca)metabolism and absorption.The objective of this study was to investigate the effect of supplemental branched-chain amino acids(BCAA)and limiting amino...Background:Very low-protein(VLP)diets negatively impact calcium(Ca)metabolism and absorption.The objective of this study was to investigate the effect of supplemental branched-chain amino acids(BCAA)and limiting amino acids(LAA)on Ca digestibility,absorption and reabsorption in pigs fed with VLP diets.Forty-eight piglets were assigned to six treatments:positive control(PC),negative control(NC),and NC containing LAA 25%,LAA 50%,LAA+BCAA 25%(LB25)and LAA+BCAA 50%(LB50)more than recommendations.Results:Relative to PC or NC,LB25 and LB50 had higher digestibility of Ca and plasma Ca and phosphorus(P),but lower plasma vitamin D3.LB50 tended to increase vitamin D receptor transcript and protein in the gut,but decreased mRNA or protein abundance of parathyroid hormone 1 receptor(PTH1R),calbindin 1(CALB1),cytochrome P450 family 27 subfamily B member 1 and occludin in small intestine.LB50 increased the transcript of cytochrome P450 family 24 subfamily A member 1 and PTH1R but decreased the transcript of transient receptor potential cation channel subfamily V member 5,CALB1 and solute carrier family 17 member 4 in kidney.Conclusion:Overall,BCAA increased Ca digestibility through regulating the transcellular and paracellular Ca absorption in the gut and reabsorption in kidney during protein restriction.展开更多
BACKGROUND Conservative treatments have been reported to diminish or resolve clinical symptoms of lumbar intervertebral disc herniation(LIDH)within a few weeks.CASE SUMMARY Computed tomography and magnetic resonance i...BACKGROUND Conservative treatments have been reported to diminish or resolve clinical symptoms of lumbar intervertebral disc herniation(LIDH)within a few weeks.CASE SUMMARY Computed tomography and magnetic resonance imaging(MRI)of the lumbar region of a 25-yearold male diagnosed with LIDH showed prolapse of the L5/S2 disc.The disc extended 1.0 cm beyond the vertebral edge and hung along the posterior vertebral edge.The patient elected a conservative treatment regimen that included traditional Chinese medicine(TCM),acupuncture,and massage.During a follow-up period of more than 12 mo,good improvement in pain was reported without complications.MRI of the lumbar region after 12 mo showed obvious reabsorption of the herniation.CONCLUSION A conservative treatment regimen of TCM,acupuncture,and massage promoted reabsorption of a prolapsed disc.展开更多
基金Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
文摘In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by which high glucose triggers oxidative stress and contributes to kidney injury in diabetes.The high level of unmetabolized glucose reaching the kidney triggers glucose reabsorption by renal tubules,which elevates the cellular glucose level of renal cells.High glucose induces lactate dehydrogenase overexpression and thus shifts glucose metabolism,which causes mitochondrial dysfunction.Mitochondria generate approximately 90%of the reactive oxygen species in cells,whose dysfunction further alters glucose metabolism and enhances reactive oxygen species generation.Oxidative stress stimulates proinflammatory factor production and kidney inflammatory injury.Mizagliflozin decreases glucose reabsorption and thus ameliorates diabetes-induced kidney injury.
基金funded by Animal Health and Production and Animal Products:Improved Nutritional Performance,Growth,and Lactation of Animals,grant no. 2021–67016-33399/project accession no. 1024334Hatch project accession no. 1012889 from the USDA National Institute of Food and Agriculture (NIFA)
文摘Background:Very low-protein(VLP)diets negatively impact calcium(Ca)metabolism and absorption.The objective of this study was to investigate the effect of supplemental branched-chain amino acids(BCAA)and limiting amino acids(LAA)on Ca digestibility,absorption and reabsorption in pigs fed with VLP diets.Forty-eight piglets were assigned to six treatments:positive control(PC),negative control(NC),and NC containing LAA 25%,LAA 50%,LAA+BCAA 25%(LB25)and LAA+BCAA 50%(LB50)more than recommendations.Results:Relative to PC or NC,LB25 and LB50 had higher digestibility of Ca and plasma Ca and phosphorus(P),but lower plasma vitamin D3.LB50 tended to increase vitamin D receptor transcript and protein in the gut,but decreased mRNA or protein abundance of parathyroid hormone 1 receptor(PTH1R),calbindin 1(CALB1),cytochrome P450 family 27 subfamily B member 1 and occludin in small intestine.LB50 increased the transcript of cytochrome P450 family 24 subfamily A member 1 and PTH1R but decreased the transcript of transient receptor potential cation channel subfamily V member 5,CALB1 and solute carrier family 17 member 4 in kidney.Conclusion:Overall,BCAA increased Ca digestibility through regulating the transcellular and paracellular Ca absorption in the gut and reabsorption in kidney during protein restriction.
基金Supported by National Nature Science Foundation of China,No.82004495Natural Science Foundation of Shandong Province,China,No.ZR2020QH318+1 种基金The 69th batch of a grant from China Postdoctoral Foundation,No.2021M691985Taishan Scholars Young Experts Program,China,No.tsqn202211349.
文摘BACKGROUND Conservative treatments have been reported to diminish or resolve clinical symptoms of lumbar intervertebral disc herniation(LIDH)within a few weeks.CASE SUMMARY Computed tomography and magnetic resonance imaging(MRI)of the lumbar region of a 25-yearold male diagnosed with LIDH showed prolapse of the L5/S2 disc.The disc extended 1.0 cm beyond the vertebral edge and hung along the posterior vertebral edge.The patient elected a conservative treatment regimen that included traditional Chinese medicine(TCM),acupuncture,and massage.During a follow-up period of more than 12 mo,good improvement in pain was reported without complications.MRI of the lumbar region after 12 mo showed obvious reabsorption of the herniation.CONCLUSION A conservative treatment regimen of TCM,acupuncture,and massage promoted reabsorption of a prolapsed disc.
文摘目的观察分析三维平衡正脊疗法联合麦肯基疗法治疗腰椎间盘突出症(lumbar disc herniation,LDH)的临床疗效及对突出物重吸收的影响。方法收集2022年1月—2023年6月在山东第一医科大学附属颈肩腰腿痛医院接受三维平衡正脊手法、推拿、针刺、麦肯基疗法的LDH患者的临床资料。所有患者均在治疗前和随访时接受MRI检查,两次MRI检查时间间隔≥6个月,比较3组临床疗效评价、腰腿痛视觉模拟量表(visual analog scale,VAS)、焦虑自评量表(self-rating anxiety scale,SAS)分数,以及日本骨科协会评估治疗分数(Japanese orthopaedic association Scores,JOA)和腰椎间盘突出重吸收情况。结果(1)综合治疗组的总有效率、VAS评分、JOA评分、SAS评分结果优于麦肯基疗法组,差异均有统计学意义(P<0.05);(2)综合治疗组JOA评分、SAS评分结果优于三维平衡正脊疗法组,差异均有统计学意义(P<0.05);(3)综合治疗组腰椎间盘突出物重吸收概率高于三维平衡正脊疗法组与麦肯基疗法组,但差异无统计学意义(P>0.05)。结论三维平衡正脊疗法联合麦肯基疗法对腰椎间盘突出症治疗疗效较好,且在治疗后突出物重吸收概率以及完全吸收概率高于三维平衡正脊疗法组和麦肯基疗法组。
