This study employs data-driven approaches to analyze single-cell transcriptomic differences between male and female subjects in subpopulations of peripheral blood mononuclear cells(PBMCs).Applying a RandomForestRegres...This study employs data-driven approaches to analyze single-cell transcriptomic differences between male and female subjects in subpopulations of peripheral blood mononuclear cells(PBMCs).Applying a RandomForestRegressor,we observed consistent model performance across different samples.We reveal significant sex differences in PBMC subpopulations,most notably in four cell types:CD4^(+)Th2,CD8^(+)naïve T,CD4^(+)memory Treg,and CD4^(+)Th1/17 cells.展开更多
基金supported by the Institutional Development Funds from the Children's Hospital of Philadelphia to the Center for Applied Genomics(USA)The Children's Hospital of Philadelphia Endowed Chair in Genomic Research(USA)to Hakon Hakonarson.
文摘This study employs data-driven approaches to analyze single-cell transcriptomic differences between male and female subjects in subpopulations of peripheral blood mononuclear cells(PBMCs).Applying a RandomForestRegressor,we observed consistent model performance across different samples.We reveal significant sex differences in PBMC subpopulations,most notably in four cell types:CD4^(+)Th2,CD8^(+)naïve T,CD4^(+)memory Treg,and CD4^(+)Th1/17 cells.
