Based on time difference of arrive （TDOA）, the regularized constrained total least square （RCTLS） algorithm for passive location is presented in this paper. RCLTS is used to solve the location equations by transfo...Based on time difference of arrive （TDOA）, the regularized constrained total least square （RCTLS） algorithm for passive location is presented in this paper. RCLTS is used to solve the location equations by transforming the nonlinear equations about TDOA into linear equations about parameters of the position and range and expanding the true TDOA in a first-order Taylor series about measurement TDOA. A proper weight is chosen by the least mean square error （MSE） rule to obtain the location solution through analyzing the location error, whose feasibility and effectiveness are well proved by computer simulations. The CRB and GDOP for TDOA-based location are given.展开更多
Novel biologics that redirect cytotoxic T lymphocytes （CTLs） to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL tow...Novel biologics that redirect cytotoxic T lymphocytes （CTLs） to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens （TAA） expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.展开更多
基金Supported by the Program for New Century Excellent Talents in University, Ministry of Education, China (Grant No. NCET-05-0803)
文摘Based on time difference of arrive （TDOA）, the regularized constrained total least square （RCTLS） algorithm for passive location is presented in this paper. RCLTS is used to solve the location equations by transforming the nonlinear equations about TDOA into linear equations about parameters of the position and range and expanding the true TDOA in a first-order Taylor series about measurement TDOA. A proper weight is chosen by the least mean square error （MSE） rule to obtain the location solution through analyzing the location error, whose feasibility and effectiveness are well proved by computer simulations. The CRB and GDOP for TDOA-based location are given.
文摘Novel biologics that redirect cytotoxic T lymphocytes （CTLs） to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens （TAA） expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
