Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related...Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.展开更多
The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and an...The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and annual output of 100 kg or more fissile 239Pu (FBR > 0.238) as objective parameters, and based on the three-dimensional Monte Carlo neutron-photon transport code MCNP/4A, a neutronics-optimizated calculation of different cases was carried out and the concept is proved feasible. In addition, the total breeding ratio ( BR = TBR + FBR ) is listed corresponding to different cases.展开更多
In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ...In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.展开更多
本文从文摘文本认知模式与语篇结构角度出发,研制开发了一种电脑辅助文摘文本生成软件系统,Electronic Abstrac Made Easy(EAME)。与同类研究相比,本项研究旨在强调计算机辅助文本生成系统开发中认知与结构问题的重要性。以下,我们打算...本文从文摘文本认知模式与语篇结构角度出发,研制开发了一种电脑辅助文摘文本生成软件系统,Electronic Abstrac Made Easy(EAME)。与同类研究相比,本项研究旨在强调计算机辅助文本生成系统开发中认知与结构问题的重要性。以下,我们打算就本套写作软件系统的基本理念、认知模式、语篇分析,以及操作程序进行讨论与描述。本文共由五个部分组成。我们首先简单介绍了本套电子文摘文本生成系统,然后提出了问句驱动和镜像模拟两种理论模式。此外,我们还通过七组主题/论元问题组群的讨论,揭示出文本生成过程中认知模式和语篇结构的关系;通过实际操作步骤的描述,展示了本套写作软件系统的具体使用方法。最后,我们通过小结与前瞻,以此结束了全文的讨论。本项研究表明,EAME具有较强的实用性,可资进一步推广。本项研究结果可望对相关研究产生积极影响。这些影响主要体现在:1)计算机辅助文本生成系统的开发研制工作中,应处理好人机对话接口层面的技术问题;2)元认知研究在电子文本生成系统的研制与开发中,具有不可取代的重要作用。展开更多
文摘Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.
基金This work was supported by the Chinese Academy of Sciences and the National Natural Science Foundation of China No.10175068.
文摘The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and annual output of 100 kg or more fissile 239Pu (FBR > 0.238) as objective parameters, and based on the three-dimensional Monte Carlo neutron-photon transport code MCNP/4A, a neutronics-optimizated calculation of different cases was carried out and the concept is proved feasible. In addition, the total breeding ratio ( BR = TBR + FBR ) is listed corresponding to different cases.
文摘In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.
文摘本文从文摘文本认知模式与语篇结构角度出发,研制开发了一种电脑辅助文摘文本生成软件系统,Electronic Abstrac Made Easy(EAME)。与同类研究相比,本项研究旨在强调计算机辅助文本生成系统开发中认知与结构问题的重要性。以下,我们打算就本套写作软件系统的基本理念、认知模式、语篇分析,以及操作程序进行讨论与描述。本文共由五个部分组成。我们首先简单介绍了本套电子文摘文本生成系统,然后提出了问句驱动和镜像模拟两种理论模式。此外,我们还通过七组主题/论元问题组群的讨论,揭示出文本生成过程中认知模式和语篇结构的关系;通过实际操作步骤的描述,展示了本套写作软件系统的具体使用方法。最后,我们通过小结与前瞻,以此结束了全文的讨论。本项研究表明,EAME具有较强的实用性,可资进一步推广。本项研究结果可望对相关研究产生积极影响。这些影响主要体现在:1)计算机辅助文本生成系统的开发研制工作中,应处理好人机对话接口层面的技术问题;2)元认知研究在电子文本生成系统的研制与开发中,具有不可取代的重要作用。
