BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emoti...BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.展开更多
BACKGROUND People living with human immunodeficiency virus(HIV)are aging as a result the benefits of combination antiretroviral therapy.AIM To provide descriptions of eligible existing studies on demographics,methodol...BACKGROUND People living with human immunodeficiency virus(HIV)are aging as a result the benefits of combination antiretroviral therapy.AIM To provide descriptions of eligible existing studies on demographics,methodologies,and outcome measures related to health-related quality of life(HRQoL)in the context of HIV and aging.METHODS The MEDLINE,CINAHL,Scopus,and PsycINFO databases were systematically searched using the terms HIV,age,and HRQoL to find studies published between January 1995 and June 2022.Key variables of the eligible studies were identified and categorized into demographics(e.g.,study sites,study year),methodologies(e.g.,use of conceptual frameworks,measures used),and outcome measures[e.g.,HRQoL,quality of life(QoL)].The PRISMA 2009 checklist was followed.RESULTS A total of 68 published studies involving 53504 participants were included.The majority of the studies(55.88%)were conducted in North America,with relatively few studies conducted in Africa.The median age of participants was 51.0 years(IQR=11.0).Over one-third(32.56%)of all participants were older people living with HIV aged 50 years and older Four studies included only older female participants,and six studies included only men who have sex with men.Outcome mea-sures were assessed as HRQoL(26.47%)or QoL(36.76%).Overall,data from African studies,older women living with HIV,socioeconomic status(e.g.,employment,income,education),sexual behavioral risks,theoretical frameworks used,and follow-up studies were limited.CONCLUSION This narrative review highlights imbalances and gaps in research on HRQoL in the context of HIV and aging,providing direction for future studies in this area.展开更多
BACKGROUND Prostate cancer is common among men,and radical surgery is the primary treatment.Surgery,however,can affect both physical and mental health,including anxiety,depression,and quality of life(QoL).AIM To asses...BACKGROUND Prostate cancer is common among men,and radical surgery is the primary treatment.Surgery,however,can affect both physical and mental health,including anxiety,depression,and quality of life(QoL).AIM To assess the effect of radical prostatectomy on psychological status and QoL in patients with prostate cancer.METHODS This observational study included 102 patients undergoing radical prostatectomy between June 2024 and April 2025.Pain(numerical rating scale),Hamilton Anxiety Scale,Hamilton Depression Scale,and QoL(European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and short-form 36)were evaluated before and after surgery.RESULTS At one month postoperatively,the mean European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 score increased significantly from 60.72±5.37 preoperatively to 86.48±7.52(P<0.001),indicating marked improvement in overall QoL.Psychological assessments revealed significant reductions in anxiety and depression:The mean Hamilton Anxiety Scale score decreased from 23.36±5.15 preoperatively to 12.15±4.36(P<0.001),and the mean Hamilton Depression Scale score declined from 22.61±5.02 to 13.83±4.54(P<0.001).Pain levels,as measured by the numerical rating scale,decreased significantly from 7.68±2.17 preoperatively to 2.67±0.72(P<0.001).Additionally,the urinary incontinence rate dropped from 20.59%(21/102)preoperatively to 11.76%(12/102)(P<0.05),showing a statistically significant reduction.CONCLUSION Radical prostatectomy improves psychological health and the QoL of patients with prostate cancer.These results may help to inform future therapies.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has had profound physical,psychological,and social consequences,with lasting effects on health-related quality of life(HRQoL)among people with a history of COV...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has had profound physical,psychological,and social consequences,with lasting effects on health-related quality of life(HRQoL)among people with a history of COVID-19.AIM To synthesize the current evidence on HRQoL and long-term health outcomes among people with a history of COVID-19 in India.METHODS We incorporated studies from India reporting post-COVID HRQoL outcomes using validated instruments,including the 5-level EuroQol 5-Dimensional questionnaire,the EuroQol Visual Analogue Scale,the Short Form-36 Health Survey,the World Health Organization Quality of Life-Brief Version,and the European Health Interview Survey-Quality of Life.Pooled mean 5-level EuroQol 5-Dimensional questionnaire scores with 95%CIs were calculated for HRQoL.Adjusted odds ratios were pooled for comorbidity,disease severity,intensive care unit admission,age,sex,and vaccination status using random-effects models.RESULTS Three studies(n=1526)reported EuroQol instruments,with the 5-level EuroQol 5-Dimensional questionnaire utility scores suitable for quantitative pooling.The pooled mean utility was 0.83(95%CI:0.75-0.92),although heterogeneity was high because the included studies represented clinically distinct populations.Across all studies,several determinants were consistently associated with impaired HRQoL.Older adults(≥60 years)had higher odds of poor HRQoL[pooled odds ratio(OR)=1.83,95%CI:1.43-2.35],and females were more likely to experience impaired HRQoL(pooled OR=1.74,95%CI:1.44-2.10),whereas males had a lower risk(pooled OR=0.58,95%CI:0.48-0.70).Being unvaccinated increased the likelihood of persistent symptoms or reduced HRQoL(pooled OR=1.60,95%CI:1.21-2.14).Comorbidity(pooled OR=1.94,95%CI:1.43-2.63)and severe acute COVID-19 or intensive care unit admission(pooled OR=2.77,95%CI:2.13-3.59)were also strongly associated with poorer HRQoL Six additional studies utilizing disparate instruments(EuroQol Visual Analogue Scale,Short Form-36 Health Survey,World Health Organization Quality of Life-Brief Version,European Health Interview Survey-Quality of Life)were excluded from quantitative synthesis due to measurement heterogeneity.CONCLUSION Post-COVID HRQoL in people with a history of COVID-19 in India is suboptimal,with greater impairment observed among older adults,females,patients with comorbidities or severe disease,and unvaccinated individuals.These findings highlight the need for targeted rehabilitation and preventive strategies.展开更多
Objective:To evaluate and compare the quality of life(QoL)in patients with multidrug-resistant(MDR-TB)and drug-sensitive(DS-TB)as well as to investigate factors associated with QoL among MDR-TB patients in real-world ...Objective:To evaluate and compare the quality of life(QoL)in patients with multidrug-resistant(MDR-TB)and drug-sensitive(DS-TB)as well as to investigate factors associated with QoL among MDR-TB patients in real-world scenarios at the Haji Hospital,Surabaya.Methods:We conducted a case-control study from June to December 2024.MDR-TB and DS-TB patients were classified into case and control groups,respectively.We used the World Health Organization’s Quality of Life Brief(WHOQOL-BREF)instrument and Patient Health Questionnaire-9(PHQ-9)to assess QoL and depression levels,respectively.Multivariate analysis was used to analyze factors associated with QoL of patients with MDR-TB.Results:Forty-one patients with MDR-TB and 43 with DS-TB were enrolled in the study.A mean score for all domains(physical,psychological,social relationship,environmental)and total mean score of WHOQOL-BREF was significantly lower in MDR-TB than those with DS-TB(P<0.05).The prevalence of depression and the mean score of PHQ-9 were significantly higher in MDR-TB than in DS-TB(P<0.05).PHQ-9 negatively correlates with the WHOQOL-BREF score(r=-0.502,P<0.05)among MDR-TB patients.MDR-TB patients with depression were significantly associated with low QoL in the physical(OR 3.611;95%CI 2.393-6.951;P=0.029),psychological(OR 1.672;95%CI 1.179-5.941;P=0.021),social relationship(OR 2.586;95%CI 1.611-2.909;P=0.014),and environmental domains(OR 1.926;95%CI 1.047-2.147;P=0.048).Conclusions:MDR-TB patients had worse QoL than DS-TB.Those with depression were associated with low QoL.Strategies that identify and tackle alterations in the QoL for MDR-TB patients are necessary during TB treatment.展开更多
BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine t...BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine the association of resilience with coping styles and quality of life in patients with malignancies.METHODS This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.The Connor-Davidson Resilience Scale,Medical Coping Modes Questionnaire,Social Support Rating Scale,and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were utilized to assess patients’resilience,coping styles,social support,and quality of life,respectively.Pearson correlation analysis was conducted to assess the correlations.RESULTS A total of 175 patients with malignant tumors demonstrated no marked difference in terms of age,education level,employment status,monthly household income,and disease staging(P<0.05).Further,patients with malignancies demonstrated scores of 17.49±1.20,17.27±1.46,and 11.19±1.29 points in terms of coping styles in confrontation,avoidance,and resignation dimensions,respectively.Subjective support,objective support,and support utilization scores in terms of social support were 10.67±1.80,11.26±2.08,and 9.24±1.14 points,respectively.The total resilience score and tenacity,self-improvement,and optimism dimension scores were positively correlatedwith the confrontation coping style score,whereas the total resilience score and tenacity and self-improvementscores were negatively associated with avoidance and resignation coping style scores(P<0.05).The total resiliencescore and the tenacity dimension score were positively associated with physical,role,cognitive,emotional,andsocial functions,as well as global health status(P<0.05),and were inversely related to fatigue,insomnia,andeconomic difficulties(P<0.05).CONCLUSIONThe resilience of patients with malignancies is positively associated with the confrontation dimension in the copingstyle,the total and various social support domain scores,and the overall quality of life.Clinical medical staff needto pay attention to the effect of medical coping styles and social support on the resilience level of patients withmalignancies to further improve their quality of life.展开更多
The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for lit...The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for literature that brought the observed aspects to the structuring of the technical sheets, i.e., literature that contains data related to composition, active ingredients, interaction (when described in the consulted literature), health condition in which they may be useful in helath care by various health professionals and anyone who may be of interest. The data obtained shows that there is a need for a careful evaluation of the foods (that contain roots, rhizomes, or tubers) used by polymedicated people due to possible interactions and incompatibilities that may exist.展开更多
OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December ...OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December 2021.Seventy-eight patients received standards of care(control group)and 76 patients received Yunpiqiangshen gel[Traditional Chinese Medicine,(TCM)group]for 6 months in statistical analysis.The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3(KDQOL-SFTM 1.3),including Short Form Health Survey(SF-36)and Kidney Disease Targeted Areas(KDTA)scores.The second outcomes included the TCM syndrome score,Fatigue Assessment Instrument(FAI)score,Modified Quantitative Subjective Global Assessment(MQSGA)score,anthropometric indicators,and blood chemical testing.Adverse events,including decompensated gastrointestinal symptoms,were evaluated.RESULTS:The results showed that the mean change of SF-36(75±13 vs 64±16,F=6.070,P=0.015)and KDTA(76±7 vs 70±9,F=4.118,P=0.044)scores in the TCM group had an improvement(increase)from baseline,as compared with the control group.Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL.At the end of follow-up,the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group(76.32%vs 20.51%,χ^(2)=48.02,P=0.000).The fatigue,soreness of waist,anorexia,abdominal distension,loose stool,and constipation were alleviated after Yunpiqiangshen gel therapy.The FAI(98.58±25.08 vs 131.21±31.85,F=8.745,P=0.004)and MQSGA(10.13±2.84 vs 12.83±3.85,F=11.396,P=0.001)scores in the TCM group had an improvement(reduce)from baseline compared with the control group.A higher level of albumin of patients in the TCM group compared with the control group.Diarrhea,vomit,and loose stool were more common in the TCM group,but generally mild in severity.CONCLUSION:Compared with the standards of care,added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.展开更多
Haemochromatosis is the most common genetic condition among people of European descent,resulting in iron overload and multi-organ dysfunction.Despite early detection and treatment advances,affected individuals experie...Haemochromatosis is the most common genetic condition among people of European descent,resulting in iron overload and multi-organ dysfunction.Despite early detection and treatment advances,affected individuals experience significant morbidity impacting their quality of life(QoL).To scope the literature for QoL issues and rank them in order of relevance by professional bodies.A literature search was conducted using PubMed,EMBASE,and MEDLINE in addition to a grey literature search against the eligibility criteria up to July 2023.Inclusion cri-teria included original articles with data concerning symptoms and QoL in patients with haemochromatosis.Nineteen issues were identified from 47 articles and scored by a haemochromatosis special interest group using a scale of 1 to 10(10=highest importance).Mean scores were then calculated for each issue.Fatigue,joint pain and sexual issues were key factors associated with impaired QoL.The least relevant were weight changes and abdominal pain.Other issues raised were anxiety,the development of diabetes,and concerns about genetics and family.This is the first scoping review examining common symptoms affecting QoL of patients with hereditary haemochromatosis.Further studies,including patient interviews and a randomised controlled trial,will inform a validated QoL questionnaire.展开更多
BACKGROUND Endoscopic bariatric therapies(EBT)have been developed as an adjunctive therapy to treat persistent obesity and recurrent weight gain and dumping symptoms after metabolic and bariatric surgery(MBS).While th...BACKGROUND Endoscopic bariatric therapies(EBT)have been developed as an adjunctive therapy to treat persistent obesity and recurrent weight gain and dumping symptoms after metabolic and bariatric surgery(MBS).While the efficacy of revisional EBTs has been documented,no studies to date have examined how these procedures impact quality of life(QOL)and internalized weight bias(IWB).AIM To understand how endoscopic revisional therapies impact QOL,IWB,and dumping syndrome.METHODS Analysis included 19 participants treated for post-MBS recurrent weight gain and/or dumping syndrome.The short-form 36 survey,weight bias internalization scale,and the Sigstad scoring system were used to measure QOL,IWB,and dumping syndrome pre-and≥4 weeks post-EBT.RESULTS At 6-months,total body weight loss was 8.6%±7.15%(n=16),at 12-months was 13.4%±7.46%(n=16).Short-form 36 scores for all 8 scales significantly increased from pre-to post-procedure with the greatest improvement in the scales related to emotional(mean improvement=59.6,P<0.05)and physical health(mean improvement=31.1,P<0.05).Both total Sigstad score(mean difference=4.947,P<0.05)and total weight bias internalization score(mean difference=0.761,P<0.05)significantly decreased from pre-to post-procedure.CONCLUSION Findings suggest that revisional EBT may improve post-MBS QOL across a broad spectrum of outcomes beyond optimizing body weight.As early EBT results indicate positive mental and physical health outcomes,further research is needed to evaluate the relationship between these improvements,body weight and interdisciplinary post-MBS care.展开更多
Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable bet...Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable better person-centered health care.Methods:The study described is a qualitative meta-synthesis literature review.The search was performed in databases such as CINAHL,Scopus,PubMed,Web of Science,the Cochrane Library,and Cuiden Plus through Medical Subject Headings and free terms.Qualitative and mixed studies were included on individuals undergoing hemodialysis or peritoneal dialysis,18 years of age or older,published in English or Spanish,between January 2013 and January 2024.The Mixed Methods Appraisal Tool was used to assess the methodological quality.The information was analyzed and coded through a socioecological model and the social determinants of health.Results:Fourteen qualitative and two mixed articles were selected.A total of 256 individuals participated in the study.Seventeen themes and 25 sub-themes were identifiedand grouped into two blocks(difficulties and resources).The difficultiesthat stood out were a low tolerance for activities of daily living and physical activity,loss of self-control over life and social roles,and lack of community and public resources.As for the resources,the following was found:the positive meaning of dialysis,the safety offered by close individuals and the healthcare team,the activation of specificprograms,and person-centered policies.Conclusions:The analysis and interpretation of the identifieddifficultiesand resources revealed key elements to consider when designing and implementing health programs for individuals undergoing dialysis.Future research should explore these dimensions in diverse cultural and geographical contexts to enhance generalizability and support health equity.展开更多
BACKGROUND First-generation antipsychotics demonstrate certain therapeutic benefits in schizophrenia;however,they often fail to significantly address negative symptoms.Thus,continued exploration is essential to refine...BACKGROUND First-generation antipsychotics demonstrate certain therapeutic benefits in schizophrenia;however,they often fail to significantly address negative symptoms.Thus,continued exploration is essential to refine these treatments.AIM To examine lurasidone plus sulpiride influence on treatment efficacy,psychiatric symptoms,and quality of life in patients with schizophrenia.METHODS A total of 110 patients with schizophrenia,admitted between October 2021 and October 2024,were recruited for this study.The control group(n=50)received sulpiride alone.Conversely,the observation group(n=60)was treated with a combination of lurasidone and sulpiride.A series of assessments were conducted to compare the two groups.These included evaluating treatment efficacy;recording the incidence of adverse events such as fatigue,xerostomia,insomnia,anorexia,and headache;assessing psychiatric symptoms using the positive and negative syndrome scale(PANSS);evaluating cognitive and social functions using the repeatable battery for the assessment of neuropsychological status(RBANS),and the personal and social performance scale(PSP);measuring quality of life using the schizophrenia quality of life scale(SQLS);and analyzing serum markers including interleukin 6(IL-6),IL-17,and prolactin(PRL).RESULTS Overall treatment efficacy was significantly higher in the observation group than in the control group.The total incidence of adverse events was comparable between the two groups.After treatment,the scores for positive symptoms,negative symptoms,and general psychopathological symptoms on the PANSS in the observation group were significantly reduced compared to pretreatment levels,and were also lower than those in the control group.Additionally,RBANS and PSP scores in the observation group significantly increased post-treatment and were notably higher than in the control group.Regarding the quality of life,SQLS scores in the psychosocial,symptoms,and side effects and motivation and energy dimensions in the observation group were significantly lower after treatment than both baseline levels and those in the control group.Furthermore,post-treatment levels of IL-6 and IL-17 in the observation group were significantly reduced and lower than those in the control group,whereas the PRL level was significantly elevated.CONCLUSION The combination of lurasidone and sulpiride can effectively enhance treatment efficacy,alleviate psychiatric symptoms,and improve quality of life in patients with schizophrenia,supporting its broader clinical use.展开更多
BACKGROUND Chronic kidney disease(CKD)is an incapacitating illness associated with distressing symptoms(DS)that have negative impact on patients’health-related quality of life(HRQOL).AIM To assess the severity of DS ...BACKGROUND Chronic kidney disease(CKD)is an incapacitating illness associated with distressing symptoms(DS)that have negative impact on patients’health-related quality of life(HRQOL).AIM To assess the severity of DS and their relationships with HRQOL among patients with CKD in Jordan.METHODS A descriptive cross-sectional design was used.A convenience sampling approach was used to recruit the participants.Patients with CKD(n=140)who visited the outpatient clinics in four hospitals in Amman between November 2021 and December 2021 were included.RESULTS The Edmonton Symptom Assessment System was used to measure the severity of the DS while the Short Form-36 tool was used to measure the HRQOL.Participants’mean age was 50.9(SD=15.14).Most of them were males(n=92,65.7%),married(n=95,67.9%),and unemployed(n=93,66.4%).The highest DS were tiredness(mean=4.68,SD=2.98)and worse well-being(mean=3.69,SD=2.43).The highest HRQOL mean score was for the bodily pain scale with a mean score of 68.50 out of 100(SD=32.02)followed by the emotional well-being scale with mean score of 67.60(SD=18.57).CONCLUSION Patients with CKD had suboptimal HRQOL,physically and mentally.They suffer from multiple DS that have a strong association with diminished HRQOL such as tiredness and depression.Therefore,healthcare providers should be equipped with the essential knowledge and skills to promote individualized strategies that focusing on symptom management.展开更多
BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality...BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.展开更多
AIM:To evaluate the effects of refractive errors and binocular vision anomalies on the quality of life(QOL)of university students.METHODS:This cross-sectional analytical study was conducted on university students usin...AIM:To evaluate the effects of refractive errors and binocular vision anomalies on the quality of life(QOL)of university students.METHODS:This cross-sectional analytical study was conducted on university students using simple random sampling.Objective refraction,ocular alignment,vergence and accommodative performance were measured and assessed in all participants.Data on QOL were collected using the College of Optometrists in Vision Development-Quality of Life(COVD-QOL)Questionnaire.The effect of mentioned parameters on the QOL were evaluated.RESULTS:Totally 726 students with mean age of 21.35±1.88y were evaluated in this study,51.5%of whom were female.Esophoria was caused significantly lower QOL in the domains of somatic symptoms and occupationalphysical symptoms(P<0.05);Besides,esotropia decreased QOL in domains of somatic symptoms P=0.002 and psychological factors(P=0.023).Students with accommodation insufficiency experienced more symptoms in all domains(P<0.05)except for psychological factors(P=0.07).Increasing in the near point of convergence and accommodation and decreases QOL and increasing accommodative facility increases QOL(all P<0.05).Myopia and astigmatism cause decrease in QOL(both P<0.05),but hyperopic students had better QOL in comparison with others(P<0.05).CONCLUSION:Screening programs and treatment of refractive errors and binocular vision anomalies,especially phoria and accommodative insufficiency,positively impact the QOL and academic achievements of university students.展开更多
Objective:To analyze the effect of interventional nursing on the therapeutic effect,negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy.Methods:Eighty-...Objective:To analyze the effect of interventional nursing on the therapeutic effect,negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy.Methods:Eighty-four patients who received cardio-cerebral vascular interventional therapy in a hospital during January 2024–December 2024 were selected,and were divided into the control group and the observation group by the mean score method,each with 42 cases.The control group was given standardized perioperative care,and the observation group was given interventional nursing intervention on this basis.The two groups were compared in terms of clinical efficacy,negative emotion score,incidence of related complications,quality of life score and nursing satisfaction.Results:The total effective rate of treatment of patients in the observation group(95.24%)was significantly higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05);before nursing care,the difference between SDS and SAS scores of patients in the two groups was insignificant(P>0.05);after nursing care,the scores of various indexes of the two groups were significantly reduced and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);the patients in the observation group had more negative moods than those in the control group;the complication rate of patients in the observation group(2.38%)was significantly lower than that of the control group(19.04%),and the difference was statistically significant(P<0.05);the quality of life scores of patients in the observation group were higher than that of the control group,and the difference was statistically significant(P<0.05);the satisfaction rate of patients’nursing care in the observation group was 97.62%,which was higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05).The difference is statistically significant(P<0.05).Conclusion:The implementation of interventional nursing intervention for patients with cardiovascular and cerebrovascular interventional therapy can further enhance the clinical therapeutic effect,improve the negative emotions of patients’anxiety and depression,reduce the risk of related complications,improve the quality of life of patients,and obtain higher satisfaction.展开更多
BACKGROUND Breast cancer is one of the most common cancers among women worldwide,often leading to significant emotional and psychological stress.This stress is compounded by concerns about parenting roles and the pote...BACKGROUND Breast cancer is one of the most common cancers among women worldwide,often leading to significant emotional and psychological stress.This stress is compounded by concerns about parenting roles and the potential impact on children.Mindfulness-based cognitive therapy(MBCT)has shown promise in addressing anxiety and depressive symptoms.However,its effects on parenting anxiety and self-efficacy in patients with breast cancer are underexplored.AIM To evaluate the effects of MBCT on parenting anxiety,negative emotions,quality of life(QoL),and self-efficacy in patients with breast cancer.METHODS This retrospective study involved 249 patients with breast cancer admitted between January 2024 and December 2024.Participants were divided into two groups:The conventional treatment group(n=123)and the MBCT group(n=126),based on chosen treatment methods.Interventions lasted 8 weeks,with one session per week.Outcomes were measured using standardized questionnaires,including parenting anxiety[parenting concerns questionnaire(PCQ)],parenting sense of competence[parenting sense of competence scale(PSOCS)],negative emotions(self-rating anxiety scale and self-rating depression scale),hospital anxiety and depression[hospital anxiety and depression scale(HADS)],traumarelated distress[impact of event scale-revised(IES-R)],mindfulness(five-facet mindfulness questionnaire),QoL[functional assessment of cancer therapy-breast(FACT-B)],symptom severity(numeric rating scales),and self-efficacy[general self-efficacy scale(GSES)].RESULTS Post-treatment,the MBCT group showed a marked reduction in parenting anxiety scores(PCQ:MBCT 50.54±4.65 vs conventional 52.12±5.53,P=0.016)and notable improvement in parenting competence(PSOCS total:MBCT 61.56±4.65 vs conventional 59.75±4.96,P=0.003).The MBCT group also exhibited significant reductions in anxiety(HADS anxiety:MBCT 6.78±1.65 vs conventional 7.31±2.08,P=0.027)and trauma-related distress(IES-R intrusion:P=0.030;avoidance:P=0.004;hyperarousal:P=0.035).QoL scores significantly improved in the MBCT group in terms of physiological condition(FACT-B:MBCT 13.85±3.93 vs conventional 12.55±2.75,P=0.003)and functional status(P=0.010).Enhanced self-efficacy was observed in strategic effectiveness(GSES:MBCT 9.87±0.75 vs conventional 9.72±0.13,P=0.029).CONCLUSION MBCT significantly reduces parenting anxiety and enhances self-efficacy,QoL,and emotional regulation in patients with breast cancer.展开更多
Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical ...Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical records of patients with lumbar vertebral fractures in Suzhou Municipal Hospital(North District),60 patients underwent percutaneous vertebroplasty(PVP/PKP),they were divided into control and experimental groups according to a random number table,30 people per group;In addition to traditional care method,Also intervened with behavioural awareness training and exercise therapy,By comparing the Oswestry dysfunction index score(ODI),visual simulation score(VAS),ability of daily living score(ADL),quality of life score(SF-36),To evaluate the eff ectiveness of the intervention.Results:Before the intervention,the ODI,VAS,ADL,and SF-36 scores were basically the same,with no significant diff erence(P>0.05).After treatment,the ODI and VAS scores of the experimental group and the control group were signifi cantly lower,and the experimental group was significantly lower than the control group(P<0.05);the ADL scores of the experimental group were signifi cantly higher than those of the control group(P<0.05);their SF-36 quality of life scores in all dimensions were signifi cantly higher(P<0.05).Conclusion:Through the rehabilitation treatment method combining mindfulness behavior training and exercise intervention,it can eff ectively promote the functional recovery of osteoporotic lumbar fractures in the elderly,thus reducing their pain and improving their quality of life.展开更多
BACKGROUND The correlation conclusions between self-management,frailty,and quality of life(QoL)of chronic obstructive pulmonary disease(COPD)patients are inconsistent.AIM To comprehensively assess the current status o...BACKGROUND The correlation conclusions between self-management,frailty,and quality of life(QoL)of chronic obstructive pulmonary disease(COPD)patients are inconsistent.AIM To comprehensively assess the current status of self-management,psychological cognitive impairment,and QoL in elderly patients with COPD.METHODS Convenient sampling was employed to select 312 elderly patients with COPD who were receiving treatment in the respiratory and critical care medicine department of a tertiary grade A hospital from November 2023 to February 2024.The study utilized demographic information and clinical characteristics,selfmanagement behavior,occurrence of psychological cognitive impairment,and QoL as evaluated through general information questionnaires,the COPD patient self-management scale,simple frailty scale,simple mental status scale,clinical dementia assessment scale,and the clinical COPD assessment test questionnaire.This research aims to describe the current status and correlations among selfmanagement behavior,cognitive impairment occurrence,and QoL.RESULTS The average score for self-management behavior in elderly COPD patients was 136.00(119.00,164.50),indicating a moderate level overall.There were 98 cases of cognitive impairment,accounting for 31.4%,with a mental status score of 3(2,3.75).The average QoL score was 24(19,28),indicating a low level.Additionally,there was a negative correlation between total self-management behavior score and cognitive impairment occurrence(r=-0.589,P<0.001),and QoL total score(r=-0.409,P<0.001).Cognitive impairment occurrence was positively correlated with QoL total score(r=0.345,P<0.001).Disease course and self-management behavior score were independent factors affecting the total QoL score in elderly COPD patients(P<0.05).CONCLUSION The self-management behavior of elderly patients with COPD is at a moderate level.However,the occurrence of cognitive impairment is high and significantly influenced by disease course,level of self-management,and mental status.The QoL is low,emphasizing the urgent need to intervene in the self-management behaviors of elderly COPD patients,actively reduce the occurrence of cognitive impairment,and mitigate the impact of the disease on QoL.展开更多
Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 wer...Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.展开更多
文摘BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.
文摘BACKGROUND People living with human immunodeficiency virus(HIV)are aging as a result the benefits of combination antiretroviral therapy.AIM To provide descriptions of eligible existing studies on demographics,methodologies,and outcome measures related to health-related quality of life(HRQoL)in the context of HIV and aging.METHODS The MEDLINE,CINAHL,Scopus,and PsycINFO databases were systematically searched using the terms HIV,age,and HRQoL to find studies published between January 1995 and June 2022.Key variables of the eligible studies were identified and categorized into demographics(e.g.,study sites,study year),methodologies(e.g.,use of conceptual frameworks,measures used),and outcome measures[e.g.,HRQoL,quality of life(QoL)].The PRISMA 2009 checklist was followed.RESULTS A total of 68 published studies involving 53504 participants were included.The majority of the studies(55.88%)were conducted in North America,with relatively few studies conducted in Africa.The median age of participants was 51.0 years(IQR=11.0).Over one-third(32.56%)of all participants were older people living with HIV aged 50 years and older Four studies included only older female participants,and six studies included only men who have sex with men.Outcome mea-sures were assessed as HRQoL(26.47%)or QoL(36.76%).Overall,data from African studies,older women living with HIV,socioeconomic status(e.g.,employment,income,education),sexual behavioral risks,theoretical frameworks used,and follow-up studies were limited.CONCLUSION This narrative review highlights imbalances and gaps in research on HRQoL in the context of HIV and aging,providing direction for future studies in this area.
基金Supported by Shanxi Provincial Higher Education Institutions Scientific and Technological Innovation Program,No.2024083Science and Technology Achievements Promotion Program of Shanxi Provincial Health Commission,No.2024069Academy General Program of First Hospital of Shanxi Medical University,No.YY2209。
文摘BACKGROUND Prostate cancer is common among men,and radical surgery is the primary treatment.Surgery,however,can affect both physical and mental health,including anxiety,depression,and quality of life(QoL).AIM To assess the effect of radical prostatectomy on psychological status and QoL in patients with prostate cancer.METHODS This observational study included 102 patients undergoing radical prostatectomy between June 2024 and April 2025.Pain(numerical rating scale),Hamilton Anxiety Scale,Hamilton Depression Scale,and QoL(European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and short-form 36)were evaluated before and after surgery.RESULTS At one month postoperatively,the mean European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 score increased significantly from 60.72±5.37 preoperatively to 86.48±7.52(P<0.001),indicating marked improvement in overall QoL.Psychological assessments revealed significant reductions in anxiety and depression:The mean Hamilton Anxiety Scale score decreased from 23.36±5.15 preoperatively to 12.15±4.36(P<0.001),and the mean Hamilton Depression Scale score declined from 22.61±5.02 to 13.83±4.54(P<0.001).Pain levels,as measured by the numerical rating scale,decreased significantly from 7.68±2.17 preoperatively to 2.67±0.72(P<0.001).Additionally,the urinary incontinence rate dropped from 20.59%(21/102)preoperatively to 11.76%(12/102)(P<0.05),showing a statistically significant reduction.CONCLUSION Radical prostatectomy improves psychological health and the QoL of patients with prostate cancer.These results may help to inform future therapies.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has had profound physical,psychological,and social consequences,with lasting effects on health-related quality of life(HRQoL)among people with a history of COVID-19.AIM To synthesize the current evidence on HRQoL and long-term health outcomes among people with a history of COVID-19 in India.METHODS We incorporated studies from India reporting post-COVID HRQoL outcomes using validated instruments,including the 5-level EuroQol 5-Dimensional questionnaire,the EuroQol Visual Analogue Scale,the Short Form-36 Health Survey,the World Health Organization Quality of Life-Brief Version,and the European Health Interview Survey-Quality of Life.Pooled mean 5-level EuroQol 5-Dimensional questionnaire scores with 95%CIs were calculated for HRQoL.Adjusted odds ratios were pooled for comorbidity,disease severity,intensive care unit admission,age,sex,and vaccination status using random-effects models.RESULTS Three studies(n=1526)reported EuroQol instruments,with the 5-level EuroQol 5-Dimensional questionnaire utility scores suitable for quantitative pooling.The pooled mean utility was 0.83(95%CI:0.75-0.92),although heterogeneity was high because the included studies represented clinically distinct populations.Across all studies,several determinants were consistently associated with impaired HRQoL.Older adults(≥60 years)had higher odds of poor HRQoL[pooled odds ratio(OR)=1.83,95%CI:1.43-2.35],and females were more likely to experience impaired HRQoL(pooled OR=1.74,95%CI:1.44-2.10),whereas males had a lower risk(pooled OR=0.58,95%CI:0.48-0.70).Being unvaccinated increased the likelihood of persistent symptoms or reduced HRQoL(pooled OR=1.60,95%CI:1.21-2.14).Comorbidity(pooled OR=1.94,95%CI:1.43-2.63)and severe acute COVID-19 or intensive care unit admission(pooled OR=2.77,95%CI:2.13-3.59)were also strongly associated with poorer HRQoL Six additional studies utilizing disparate instruments(EuroQol Visual Analogue Scale,Short Form-36 Health Survey,World Health Organization Quality of Life-Brief Version,European Health Interview Survey-Quality of Life)were excluded from quantitative synthesis due to measurement heterogeneity.CONCLUSION Post-COVID HRQoL in people with a history of COVID-19 in India is suboptimal,with greater impairment observed among older adults,females,patients with comorbidities or severe disease,and unvaccinated individuals.These findings highlight the need for targeted rehabilitation and preventive strategies.
文摘Objective:To evaluate and compare the quality of life(QoL)in patients with multidrug-resistant(MDR-TB)and drug-sensitive(DS-TB)as well as to investigate factors associated with QoL among MDR-TB patients in real-world scenarios at the Haji Hospital,Surabaya.Methods:We conducted a case-control study from June to December 2024.MDR-TB and DS-TB patients were classified into case and control groups,respectively.We used the World Health Organization’s Quality of Life Brief(WHOQOL-BREF)instrument and Patient Health Questionnaire-9(PHQ-9)to assess QoL and depression levels,respectively.Multivariate analysis was used to analyze factors associated with QoL of patients with MDR-TB.Results:Forty-one patients with MDR-TB and 43 with DS-TB were enrolled in the study.A mean score for all domains(physical,psychological,social relationship,environmental)and total mean score of WHOQOL-BREF was significantly lower in MDR-TB than those with DS-TB(P<0.05).The prevalence of depression and the mean score of PHQ-9 were significantly higher in MDR-TB than in DS-TB(P<0.05).PHQ-9 negatively correlates with the WHOQOL-BREF score(r=-0.502,P<0.05)among MDR-TB patients.MDR-TB patients with depression were significantly associated with low QoL in the physical(OR 3.611;95%CI 2.393-6.951;P=0.029),psychological(OR 1.672;95%CI 1.179-5.941;P=0.021),social relationship(OR 2.586;95%CI 1.611-2.909;P=0.014),and environmental domains(OR 1.926;95%CI 1.047-2.147;P=0.048).Conclusions:MDR-TB patients had worse QoL than DS-TB.Those with depression were associated with low QoL.Strategies that identify and tackle alterations in the QoL for MDR-TB patients are necessary during TB treatment.
文摘BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine the association of resilience with coping styles and quality of life in patients with malignancies.METHODS This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.The Connor-Davidson Resilience Scale,Medical Coping Modes Questionnaire,Social Support Rating Scale,and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were utilized to assess patients’resilience,coping styles,social support,and quality of life,respectively.Pearson correlation analysis was conducted to assess the correlations.RESULTS A total of 175 patients with malignant tumors demonstrated no marked difference in terms of age,education level,employment status,monthly household income,and disease staging(P<0.05).Further,patients with malignancies demonstrated scores of 17.49±1.20,17.27±1.46,and 11.19±1.29 points in terms of coping styles in confrontation,avoidance,and resignation dimensions,respectively.Subjective support,objective support,and support utilization scores in terms of social support were 10.67±1.80,11.26±2.08,and 9.24±1.14 points,respectively.The total resilience score and tenacity,self-improvement,and optimism dimension scores were positively correlatedwith the confrontation coping style score,whereas the total resilience score and tenacity and self-improvementscores were negatively associated with avoidance and resignation coping style scores(P<0.05).The total resiliencescore and the tenacity dimension score were positively associated with physical,role,cognitive,emotional,andsocial functions,as well as global health status(P<0.05),and were inversely related to fatigue,insomnia,andeconomic difficulties(P<0.05).CONCLUSIONThe resilience of patients with malignancies is positively associated with the confrontation dimension in the copingstyle,the total and various social support domain scores,and the overall quality of life.Clinical medical staff needto pay attention to the effect of medical coping styles and social support on the resilience level of patients withmalignancies to further improve their quality of life.
文摘The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for literature that brought the observed aspects to the structuring of the technical sheets, i.e., literature that contains data related to composition, active ingredients, interaction (when described in the consulted literature), health condition in which they may be useful in helath care by various health professionals and anyone who may be of interest. The data obtained shows that there is a need for a careful evaluation of the foods (that contain roots, rhizomes, or tubers) used by polymedicated people due to possible interactions and incompatibilities that may exist.
基金Jiangsu Science and Technology Development Project of Chinese Medicine:Yunpiqiangshen Improves Quality of Life in Dialysis Patients in Basis of Zou's Theory of Kidney Disease(ZD201904)Jiangsu Province Hospital of Chinese Medicine Peak Talent Program:Study on Promotion of Rehabilitation of Dialysis Patients by Traditional Chinese Medicine(Y2021RC10)+2 种基金National Natural Science Foundation of China:Study of Astragalus on Peritoneum Function by Myostatin-mediated Protein Turnover of Skeletal Muscle Cells(82004295)Science and Technology Planning Project of Jiangsu Province:Mechanism Study of Astragalus on Peritoneal Fibrosis by Pyroptosis of Peritoneal Mesothelial Cell via Peritoneal Mesothelial Cell(BK20211393)Outstanding Young Doctor's Fund of Jiangsu Province Hospital of Chinese Medicine:Traditional Chinese Medicine Improves Quality of Life in Chronic Renal Disease(2023QB0133)。
文摘OBJECTIVE:To evaluate the efficacy and safety of Yunpiqiangshen gel(运脾强肾浸膏)which composed of eleven herbs on quality of life(QOL)improvement.METHODS:We enrolled 180 patients lasted from January 2020 to December 2021.Seventy-eight patients received standards of care(control group)and 76 patients received Yunpiqiangshen gel[Traditional Chinese Medicine,(TCM)group]for 6 months in statistical analysis.The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3(KDQOL-SFTM 1.3),including Short Form Health Survey(SF-36)and Kidney Disease Targeted Areas(KDTA)scores.The second outcomes included the TCM syndrome score,Fatigue Assessment Instrument(FAI)score,Modified Quantitative Subjective Global Assessment(MQSGA)score,anthropometric indicators,and blood chemical testing.Adverse events,including decompensated gastrointestinal symptoms,were evaluated.RESULTS:The results showed that the mean change of SF-36(75±13 vs 64±16,F=6.070,P=0.015)and KDTA(76±7 vs 70±9,F=4.118,P=0.044)scores in the TCM group had an improvement(increase)from baseline,as compared with the control group.Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL.At the end of follow-up,the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group(76.32%vs 20.51%,χ^(2)=48.02,P=0.000).The fatigue,soreness of waist,anorexia,abdominal distension,loose stool,and constipation were alleviated after Yunpiqiangshen gel therapy.The FAI(98.58±25.08 vs 131.21±31.85,F=8.745,P=0.004)and MQSGA(10.13±2.84 vs 12.83±3.85,F=11.396,P=0.001)scores in the TCM group had an improvement(reduce)from baseline compared with the control group.A higher level of albumin of patients in the TCM group compared with the control group.Diarrhea,vomit,and loose stool were more common in the TCM group,but generally mild in severity.CONCLUSION:Compared with the standards of care,added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.
文摘Haemochromatosis is the most common genetic condition among people of European descent,resulting in iron overload and multi-organ dysfunction.Despite early detection and treatment advances,affected individuals experience significant morbidity impacting their quality of life(QoL).To scope the literature for QoL issues and rank them in order of relevance by professional bodies.A literature search was conducted using PubMed,EMBASE,and MEDLINE in addition to a grey literature search against the eligibility criteria up to July 2023.Inclusion cri-teria included original articles with data concerning symptoms and QoL in patients with haemochromatosis.Nineteen issues were identified from 47 articles and scored by a haemochromatosis special interest group using a scale of 1 to 10(10=highest importance).Mean scores were then calculated for each issue.Fatigue,joint pain and sexual issues were key factors associated with impaired QoL.The least relevant were weight changes and abdominal pain.Other issues raised were anxiety,the development of diabetes,and concerns about genetics and family.This is the first scoping review examining common symptoms affecting QoL of patients with hereditary haemochromatosis.Further studies,including patient interviews and a randomised controlled trial,will inform a validated QoL questionnaire.
文摘BACKGROUND Endoscopic bariatric therapies(EBT)have been developed as an adjunctive therapy to treat persistent obesity and recurrent weight gain and dumping symptoms after metabolic and bariatric surgery(MBS).While the efficacy of revisional EBTs has been documented,no studies to date have examined how these procedures impact quality of life(QOL)and internalized weight bias(IWB).AIM To understand how endoscopic revisional therapies impact QOL,IWB,and dumping syndrome.METHODS Analysis included 19 participants treated for post-MBS recurrent weight gain and/or dumping syndrome.The short-form 36 survey,weight bias internalization scale,and the Sigstad scoring system were used to measure QOL,IWB,and dumping syndrome pre-and≥4 weeks post-EBT.RESULTS At 6-months,total body weight loss was 8.6%±7.15%(n=16),at 12-months was 13.4%±7.46%(n=16).Short-form 36 scores for all 8 scales significantly increased from pre-to post-procedure with the greatest improvement in the scales related to emotional(mean improvement=59.6,P<0.05)and physical health(mean improvement=31.1,P<0.05).Both total Sigstad score(mean difference=4.947,P<0.05)and total weight bias internalization score(mean difference=0.761,P<0.05)significantly decreased from pre-to post-procedure.CONCLUSION Findings suggest that revisional EBT may improve post-MBS QOL across a broad spectrum of outcomes beyond optimizing body weight.As early EBT results indicate positive mental and physical health outcomes,further research is needed to evaluate the relationship between these improvements,body weight and interdisciplinary post-MBS care.
文摘Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable better person-centered health care.Methods:The study described is a qualitative meta-synthesis literature review.The search was performed in databases such as CINAHL,Scopus,PubMed,Web of Science,the Cochrane Library,and Cuiden Plus through Medical Subject Headings and free terms.Qualitative and mixed studies were included on individuals undergoing hemodialysis or peritoneal dialysis,18 years of age or older,published in English or Spanish,between January 2013 and January 2024.The Mixed Methods Appraisal Tool was used to assess the methodological quality.The information was analyzed and coded through a socioecological model and the social determinants of health.Results:Fourteen qualitative and two mixed articles were selected.A total of 256 individuals participated in the study.Seventeen themes and 25 sub-themes were identifiedand grouped into two blocks(difficulties and resources).The difficultiesthat stood out were a low tolerance for activities of daily living and physical activity,loss of self-control over life and social roles,and lack of community and public resources.As for the resources,the following was found:the positive meaning of dialysis,the safety offered by close individuals and the healthcare team,the activation of specificprograms,and person-centered policies.Conclusions:The analysis and interpretation of the identifieddifficultiesand resources revealed key elements to consider when designing and implementing health programs for individuals undergoing dialysis.Future research should explore these dimensions in diverse cultural and geographical contexts to enhance generalizability and support health equity.
文摘BACKGROUND First-generation antipsychotics demonstrate certain therapeutic benefits in schizophrenia;however,they often fail to significantly address negative symptoms.Thus,continued exploration is essential to refine these treatments.AIM To examine lurasidone plus sulpiride influence on treatment efficacy,psychiatric symptoms,and quality of life in patients with schizophrenia.METHODS A total of 110 patients with schizophrenia,admitted between October 2021 and October 2024,were recruited for this study.The control group(n=50)received sulpiride alone.Conversely,the observation group(n=60)was treated with a combination of lurasidone and sulpiride.A series of assessments were conducted to compare the two groups.These included evaluating treatment efficacy;recording the incidence of adverse events such as fatigue,xerostomia,insomnia,anorexia,and headache;assessing psychiatric symptoms using the positive and negative syndrome scale(PANSS);evaluating cognitive and social functions using the repeatable battery for the assessment of neuropsychological status(RBANS),and the personal and social performance scale(PSP);measuring quality of life using the schizophrenia quality of life scale(SQLS);and analyzing serum markers including interleukin 6(IL-6),IL-17,and prolactin(PRL).RESULTS Overall treatment efficacy was significantly higher in the observation group than in the control group.The total incidence of adverse events was comparable between the two groups.After treatment,the scores for positive symptoms,negative symptoms,and general psychopathological symptoms on the PANSS in the observation group were significantly reduced compared to pretreatment levels,and were also lower than those in the control group.Additionally,RBANS and PSP scores in the observation group significantly increased post-treatment and were notably higher than in the control group.Regarding the quality of life,SQLS scores in the psychosocial,symptoms,and side effects and motivation and energy dimensions in the observation group were significantly lower after treatment than both baseline levels and those in the control group.Furthermore,post-treatment levels of IL-6 and IL-17 in the observation group were significantly reduced and lower than those in the control group,whereas the PRL level was significantly elevated.CONCLUSION The combination of lurasidone and sulpiride can effectively enhance treatment efficacy,alleviate psychiatric symptoms,and improve quality of life in patients with schizophrenia,supporting its broader clinical use.
文摘BACKGROUND Chronic kidney disease(CKD)is an incapacitating illness associated with distressing symptoms(DS)that have negative impact on patients’health-related quality of life(HRQOL).AIM To assess the severity of DS and their relationships with HRQOL among patients with CKD in Jordan.METHODS A descriptive cross-sectional design was used.A convenience sampling approach was used to recruit the participants.Patients with CKD(n=140)who visited the outpatient clinics in four hospitals in Amman between November 2021 and December 2021 were included.RESULTS The Edmonton Symptom Assessment System was used to measure the severity of the DS while the Short Form-36 tool was used to measure the HRQOL.Participants’mean age was 50.9(SD=15.14).Most of them were males(n=92,65.7%),married(n=95,67.9%),and unemployed(n=93,66.4%).The highest DS were tiredness(mean=4.68,SD=2.98)and worse well-being(mean=3.69,SD=2.43).The highest HRQOL mean score was for the bodily pain scale with a mean score of 68.50 out of 100(SD=32.02)followed by the emotional well-being scale with mean score of 67.60(SD=18.57).CONCLUSION Patients with CKD had suboptimal HRQOL,physically and mentally.They suffer from multiple DS that have a strong association with diminished HRQOL such as tiredness and depression.Therefore,healthcare providers should be equipped with the essential knowledge and skills to promote individualized strategies that focusing on symptom management.
基金Supported by Biotropics Malaysia Berhad,Malaysia,NN-2021-016.
文摘BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.
文摘AIM:To evaluate the effects of refractive errors and binocular vision anomalies on the quality of life(QOL)of university students.METHODS:This cross-sectional analytical study was conducted on university students using simple random sampling.Objective refraction,ocular alignment,vergence and accommodative performance were measured and assessed in all participants.Data on QOL were collected using the College of Optometrists in Vision Development-Quality of Life(COVD-QOL)Questionnaire.The effect of mentioned parameters on the QOL were evaluated.RESULTS:Totally 726 students with mean age of 21.35±1.88y were evaluated in this study,51.5%of whom were female.Esophoria was caused significantly lower QOL in the domains of somatic symptoms and occupationalphysical symptoms(P<0.05);Besides,esotropia decreased QOL in domains of somatic symptoms P=0.002 and psychological factors(P=0.023).Students with accommodation insufficiency experienced more symptoms in all domains(P<0.05)except for psychological factors(P=0.07).Increasing in the near point of convergence and accommodation and decreases QOL and increasing accommodative facility increases QOL(all P<0.05).Myopia and astigmatism cause decrease in QOL(both P<0.05),but hyperopic students had better QOL in comparison with others(P<0.05).CONCLUSION:Screening programs and treatment of refractive errors and binocular vision anomalies,especially phoria and accommodative insufficiency,positively impact the QOL and academic achievements of university students.
文摘Objective:To analyze the effect of interventional nursing on the therapeutic effect,negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy.Methods:Eighty-four patients who received cardio-cerebral vascular interventional therapy in a hospital during January 2024–December 2024 were selected,and were divided into the control group and the observation group by the mean score method,each with 42 cases.The control group was given standardized perioperative care,and the observation group was given interventional nursing intervention on this basis.The two groups were compared in terms of clinical efficacy,negative emotion score,incidence of related complications,quality of life score and nursing satisfaction.Results:The total effective rate of treatment of patients in the observation group(95.24%)was significantly higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05);before nursing care,the difference between SDS and SAS scores of patients in the two groups was insignificant(P>0.05);after nursing care,the scores of various indexes of the two groups were significantly reduced and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);the patients in the observation group had more negative moods than those in the control group;the complication rate of patients in the observation group(2.38%)was significantly lower than that of the control group(19.04%),and the difference was statistically significant(P<0.05);the quality of life scores of patients in the observation group were higher than that of the control group,and the difference was statistically significant(P<0.05);the satisfaction rate of patients’nursing care in the observation group was 97.62%,which was higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05).The difference is statistically significant(P<0.05).Conclusion:The implementation of interventional nursing intervention for patients with cardiovascular and cerebrovascular interventional therapy can further enhance the clinical therapeutic effect,improve the negative emotions of patients’anxiety and depression,reduce the risk of related complications,improve the quality of life of patients,and obtain higher satisfaction.
基金Supported by Hebei Provincial Health Commission Research Fund,No.20241695.
文摘BACKGROUND Breast cancer is one of the most common cancers among women worldwide,often leading to significant emotional and psychological stress.This stress is compounded by concerns about parenting roles and the potential impact on children.Mindfulness-based cognitive therapy(MBCT)has shown promise in addressing anxiety and depressive symptoms.However,its effects on parenting anxiety and self-efficacy in patients with breast cancer are underexplored.AIM To evaluate the effects of MBCT on parenting anxiety,negative emotions,quality of life(QoL),and self-efficacy in patients with breast cancer.METHODS This retrospective study involved 249 patients with breast cancer admitted between January 2024 and December 2024.Participants were divided into two groups:The conventional treatment group(n=123)and the MBCT group(n=126),based on chosen treatment methods.Interventions lasted 8 weeks,with one session per week.Outcomes were measured using standardized questionnaires,including parenting anxiety[parenting concerns questionnaire(PCQ)],parenting sense of competence[parenting sense of competence scale(PSOCS)],negative emotions(self-rating anxiety scale and self-rating depression scale),hospital anxiety and depression[hospital anxiety and depression scale(HADS)],traumarelated distress[impact of event scale-revised(IES-R)],mindfulness(five-facet mindfulness questionnaire),QoL[functional assessment of cancer therapy-breast(FACT-B)],symptom severity(numeric rating scales),and self-efficacy[general self-efficacy scale(GSES)].RESULTS Post-treatment,the MBCT group showed a marked reduction in parenting anxiety scores(PCQ:MBCT 50.54±4.65 vs conventional 52.12±5.53,P=0.016)and notable improvement in parenting competence(PSOCS total:MBCT 61.56±4.65 vs conventional 59.75±4.96,P=0.003).The MBCT group also exhibited significant reductions in anxiety(HADS anxiety:MBCT 6.78±1.65 vs conventional 7.31±2.08,P=0.027)and trauma-related distress(IES-R intrusion:P=0.030;avoidance:P=0.004;hyperarousal:P=0.035).QoL scores significantly improved in the MBCT group in terms of physiological condition(FACT-B:MBCT 13.85±3.93 vs conventional 12.55±2.75,P=0.003)and functional status(P=0.010).Enhanced self-efficacy was observed in strategic effectiveness(GSES:MBCT 9.87±0.75 vs conventional 9.72±0.13,P=0.029).CONCLUSION MBCT significantly reduces parenting anxiety and enhances self-efficacy,QoL,and emotional regulation in patients with breast cancer.
文摘Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical records of patients with lumbar vertebral fractures in Suzhou Municipal Hospital(North District),60 patients underwent percutaneous vertebroplasty(PVP/PKP),they were divided into control and experimental groups according to a random number table,30 people per group;In addition to traditional care method,Also intervened with behavioural awareness training and exercise therapy,By comparing the Oswestry dysfunction index score(ODI),visual simulation score(VAS),ability of daily living score(ADL),quality of life score(SF-36),To evaluate the eff ectiveness of the intervention.Results:Before the intervention,the ODI,VAS,ADL,and SF-36 scores were basically the same,with no significant diff erence(P>0.05).After treatment,the ODI and VAS scores of the experimental group and the control group were signifi cantly lower,and the experimental group was significantly lower than the control group(P<0.05);the ADL scores of the experimental group were signifi cantly higher than those of the control group(P<0.05);their SF-36 quality of life scores in all dimensions were signifi cantly higher(P<0.05).Conclusion:Through the rehabilitation treatment method combining mindfulness behavior training and exercise intervention,it can eff ectively promote the functional recovery of osteoporotic lumbar fractures in the elderly,thus reducing their pain and improving their quality of life.
文摘BACKGROUND The correlation conclusions between self-management,frailty,and quality of life(QoL)of chronic obstructive pulmonary disease(COPD)patients are inconsistent.AIM To comprehensively assess the current status of self-management,psychological cognitive impairment,and QoL in elderly patients with COPD.METHODS Convenient sampling was employed to select 312 elderly patients with COPD who were receiving treatment in the respiratory and critical care medicine department of a tertiary grade A hospital from November 2023 to February 2024.The study utilized demographic information and clinical characteristics,selfmanagement behavior,occurrence of psychological cognitive impairment,and QoL as evaluated through general information questionnaires,the COPD patient self-management scale,simple frailty scale,simple mental status scale,clinical dementia assessment scale,and the clinical COPD assessment test questionnaire.This research aims to describe the current status and correlations among selfmanagement behavior,cognitive impairment occurrence,and QoL.RESULTS The average score for self-management behavior in elderly COPD patients was 136.00(119.00,164.50),indicating a moderate level overall.There were 98 cases of cognitive impairment,accounting for 31.4%,with a mental status score of 3(2,3.75).The average QoL score was 24(19,28),indicating a low level.Additionally,there was a negative correlation between total self-management behavior score and cognitive impairment occurrence(r=-0.589,P<0.001),and QoL total score(r=-0.409,P<0.001).Cognitive impairment occurrence was positively correlated with QoL total score(r=0.345,P<0.001).Disease course and self-management behavior score were independent factors affecting the total QoL score in elderly COPD patients(P<0.05).CONCLUSION The self-management behavior of elderly patients with COPD is at a moderate level.However,the occurrence of cognitive impairment is high and significantly influenced by disease course,level of self-management,and mental status.The QoL is low,emphasizing the urgent need to intervene in the self-management behaviors of elderly COPD patients,actively reduce the occurrence of cognitive impairment,and mitigate the impact of the disease on QoL.
文摘Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.
