CDRI compound no. 99/411 is a potent 1,2,4-trioxane antimalarial candidate drug under development at our Institute. An HPLC method for determination of CDRI 99/411 with its starting material and intermediates has been...CDRI compound no. 99/411 is a potent 1,2,4-trioxane antimalarial candidate drug under development at our Institute. An HPLC method for determination of CDRI 99/411 with its starting material and intermediates has been developed and validated for in process quality control and stability studies. The analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection （LOD） and lower limit of quantification （LLOQ） were determined according to International Conference on Harmonization ICH Q2（R1） guidelines. HPLC separation was achieved on a RP-select B Lichrosphere~ column （250 mm x 4 ram, 5 lam, Merck） using water containing 0.1% glacial acetic acid and acetonitrile as the mobile phase in a gradient elution. The eluents were monitored by a photo diode array detector at 245 and 275 nm. Based on signal to noise ratio of 3 and 10 the LOD of CDRI 99/411 was 0.55 μg/mL, while the LLOQ was 1.05 μg/mL. The calibration curves were linear in the range of 1.05- 68 μg/mL. Precision of the method was determined by inter- and intra-assay variations within the acceptable range.展开更多
AIM:To investigate the effects of binocular fusional C-optotypes(positive/negative)and 2D planar C-optotypes on the amplitude and stability of transient accommodation(TAC)in adults,and to provide a basis for non-conta...AIM:To investigate the effects of binocular fusional C-optotypes(positive/negative)and 2D planar C-optotypes on the amplitude and stability of transient accommodation(TAC)in adults,and to provide a basis for non-contact myopia intervention.METHODS:This was a self-controlled study.Using redblue 3D technology,four experimental stages were set up:Test A[fixating on the 1 m negative fusional C-optotypes,8△base-in(BI)],Test B(fixating on the 5 m planar C-optotypes),Test C(fixating on the 1 m planar C-optotypes),and Test D[fixating on the 1 m positive fusional C-optotypes,20△base-out(BO)].A WAM-5500 open-field autorefractor was used to measure TAC and accommodative microfluctuations[evaluated via interquartile range(IQR)and median-based coefficient of variation(CVmed)].Additionally,the convergence accommodation to convergence(CA/C)ratio was calculated,and a visual fatigue questionnaire was administered to assess participants’subjective visual comfort.RESULTS:A total of 21 subjects(7 males,14 females;aged 23-41y)with normal binocular visual function were enrolled.The results showed that the TAC increased gradually across the four stages,and these values were Test A(-0.35±0.26 D)<Test B(-0.46±0.24 D)<Test C(-0.77±0.32 D)<Test D(-1.38±0.31 D).There were significant overall differences(F=56.136,P<0.001).Compared with Test C,Test A reduced TAC by 0.42 D(P<0.05),while Test D increased it by 0.61 D(P<0.001).There was no significant intergroup difference in accommodative fluctuation amplitude(all P>0.05),but the fluctuation stability of Test D showed a significant difference between the first 20s and the second 20s(P=0.017).The CA/C ratio was significantly higher in Test D(0.05±0.02 D/△)than in Test A(0.03±0.02 D/△,P=0.007),indicating stronger accommodation-convergence linkage during positive fusional fixation.The visual fatigue scores of all stages were low(median 0-1),with Test D slightly higher than Test B and Test C(P<0.05).No linear correlation was found between TAC and age(all r<0.1,P>0.05).CONCLUSION:Negative fusional C-optotypes induce ciliary muscle relaxation to reduce TAC,while positive fusional C-optotypes enhance accommodation-convergence coordination to increase TAC.The red-blue 3D-based noncontact training mode exhibits good safety(median visual fatigue scores:0-1 across all tests)and provides a novel dual-directional(relaxation-activation)strategy for myopia prevention and control.展开更多
Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reti...Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reticulum that contributes toward its unique adaptability.It is now recognized that mitochondrial perturbations can activate various innate immune pathways,such as the nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome complex by propagating inflammatory signaling in response to damage-associated molecular patterns(DAMPs).The NLRP3 inflammasome is a multimeric protein complex and is a prominent regulator of innate immunity and cell death by mediating the activation of caspase-1,pro-inflammatory cytokines interleukin-1βand interleukin-18 and pro-pyroptotic protein gasdermin-D.While several studies have begun to demonstrate the relationship between various mitochondrial DAMPs(mtDAMPs)and NLRP3 inflammasome activation,the influence of various metabolic states on the production of these DAMPs and subsequent inflammatory profile remains poorly understood.This narrative review aimed to address this by highlighting the effects of skeletal muscle use and disuse on mitochondrial quality mechanisms including mitochondrial biogenesis,fusion,fission and mitophagy.Secondly,this review summarized the impact of alterations in mitochondrial quality control mechanisms following muscle denervation,aging,and exercise training in relation to NLRP3 inflammasome activation.By consolidating the current body of literature,this work aimed to further the understanding of innate immune signaling within skeletal muscle,which can highlight areas for future research and therapeutic strategies to regulate NLRP3 inflammasome activation during divergent metabolic conditions.展开更多
Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao)...Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.展开更多
Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries ...Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.展开更多
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture....Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.展开更多
The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed To...Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.展开更多
This study aims to analyze and discuss the current situation of quality control and quality management in medical imaging.Firstly,it defines the concepts of quality management and image quality,emphasizing the crucial...This study aims to analyze and discuss the current situation of quality control and quality management in medical imaging.Firstly,it defines the concepts of quality management and image quality,emphasizing the crucial role of the department's Quality and Safety Team in imaging quality management[1].Subsequently,it details the composition and responsibilities of the Quality and Safety Management Group,as well as the specific divisions of labor and tasks of the Quality Management Team.The effective implementation of comprehensive quality control in the imaging department is ensured through the"Seven-Star Sword"method,which encompasses total process control,organization-wide participation,and total quality control[2].Furthermore,the application of the PDCA(Plan-Do-Check-Act)cycle in quality management is explored,along with strategies to improve patient satisfaction by reducing the waiting time for imaging reports[3].Finally,the management of a key departmental medical quality control indicator—critical values—is analyzed,and improvement measures are proposed[4].This study underscores the importance of quality management in enhancing medical service quality and ensuring patient safety,and puts forward specific implementation strategies and improvement methods.展开更多
Walnuts are rich in a variety of nutritional components.However,due to their high content of unsaturated fatty acids(UFAs),the quality of walnuts tends to decline during storage,which adversely affects the development...Walnuts are rich in a variety of nutritional components.However,due to their high content of unsaturated fatty acids(UFAs),the quality of walnuts tends to decline during storage,which adversely affects the development of the walnut industry.This study was aimed to investigate the impacts of temperature and packaging methods on the storage quality and oxidative stability of walnuts.The Wen 185 walnut variety was selected,and the physical-chemical and nutritional indexes of walnuts stored for 42 weeks under different temperatures(18℃,4℃,and room temperature)and packaging methods(vacuum light-exposed,vacuum light-proof,vacuum-ra-diation light-exposed,vacuum-radiation light-proof,nitrogen-filled light-exposed,nitrogen-filled light-proof)were measured.The results showed that low temperatures,especially18℃,in combination with vacuum lightproof packaging,could effectively suppress the increase in oxidative stability indicators such as acid value(AV)and peroxide value(PV),and maintain high retention rates of nutritional indicators like tocopherol and phytosterol.This study has elucidated that low temperatures and appropriate packaging methods play the crucial roles in maintaining the quality and oxidative stability of walnuts during storage.It has provided comprehensive and valuable data support and theoretical basis for the scientific storage of walnuts,contributing to the devel-opment of the walnut industry and the guarantee of product quality.展开更多
Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net ...Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net shapes.This technology is gathering increasing attention from industries such as biomedical,automotive,and aerospace.However,achieving consistent part quality and desired material properties is challenging due to intricate processing parameters and potential process defects such as dynamic melt-pool behavior and localized heat accumulation.This paper reviews recent advances in on-line quality control,focusing on in-situ measurement and closed-loop control for efficient assurance of LDED-fabricated parts.The quality principles,encompassing accuracy and material performance,are summarized to lay a foundation for understanding the mechanisms of quality defects and influencing factors.This review explores and thoroughly compares advancements in indirect process measurements,such as optical,thermal,and acoustic monitoring with direct quality measurements,including laser-line scanning and operando synchrotron X-ray imaging.Depending on the sensing techniques,this paper highlights a hierarchical control strategy for adaptive parameter regulation on intra-layer and inter-layer scales.The requirements and performance of various state-of-the-art controllers are critically compared to indicate their suitable applications.The importance of machine learning in detecting process anomalies and predicting build quality based on sensory signals is also outlined.Future directions are proposed towards adaptive,automated,and intelligent quality control,with a focus on multi-modal monitoring,physics-informed neural networks for interpretable analysis,and multi-objective control applications.展开更多
Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of...Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.展开更多
The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder con...The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.展开更多
[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data...[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.展开更多
Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical e...Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.展开更多
The Argo program measures temperature and salinity in the upper ocean(0–2000 m).These observations are critical for weather/climate studies,ocean circulation analysis,and sea-level monitoring.To address the limitatio...The Argo program measures temperature and salinity in the upper ocean(0–2000 m).These observations are critical for weather/climate studies,ocean circulation analysis,and sea-level monitoring.To address the limitations of traditional thresholds in Argo data quality control(QC),this study proposes a novel probability distribution-based inference method(PDIM)for temperature-salinity threshold inference.By integrating historical observations with climatological data,the method utilizes historical data corresponding to latitude and longitude grids,calculates temperature/salinity frequency distributions for each depth,and determines“zero probability”boundaries through combined frequency distribution and climatology data.Then a probability distribution model is established to detect outliers automatically based on the features in the probability density function,which eliminates the traditional dependence on the normal distribution hypothesis.When applied to global Argo datasets from China Argo Real-time Data Center(CARDC),PDIM successfully identifies suspicious profiles and sensor drifts with high reliability,achieving a low false positive rate(0.55%for temperature,0.18%for salinity)while maintaining competitive true positive rate(28.29%for temperature,55.15%for salinity).This method is expected to improve the reliability of Argo data QC and has important significance for Argo QC.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Pro...Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Process variability often leads to defects,insufficient geometric accuracy and inadequate material properties,which are difficult to effectively manage due to limitations of traditional quality control methods in modeling highdimensional nonlinear relationships and enabling adaptive control.Machine learning(ML)offers a transformative approach to model intricate process-structure-property relationships by leveraging the rich data environment of AM.The study presents a comprehensive examination of ML-driven quality assurance implementations in metallic AM.First,it uniquely examines the innovative exploration of ML in predicting and understanding the fundamental multi-physics fields that influence the quality of a fabricated component,including temperature fields,fluid dynamics and stress/strain evolution.Subsequently,the application of ML in optimizing key quality attributes,including defect detection and mitigation(porosity,cracks,etc.),geometric fidelity enhancement(dimensional accuracy,surface roughness,etc.)and material property tailoring(mechanical strength,fatigue life,corrosion resistance,etc.),are discussed in detail.Finally,the development of ML-driven real-time closed-loop control systems for intelligent quality assurance,the strategies for addressing the data scarcity and cross-scenario transferability in metal AM are discussed.This article provides a novel perspective on the profound potential of ML technology for metal AM quality control applications,highlights the challenges faced during research,and outlines future development directions.展开更多
基金Financial support to Shakti Deep Pachauri and Kiran Khandelwal from the Council of Scientifc and Industrial Research (CSIR)New DelhiIndiais gratefully acknowledged
文摘CDRI compound no. 99/411 is a potent 1,2,4-trioxane antimalarial candidate drug under development at our Institute. An HPLC method for determination of CDRI 99/411 with its starting material and intermediates has been developed and validated for in process quality control and stability studies. The analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection （LOD） and lower limit of quantification （LLOQ） were determined according to International Conference on Harmonization ICH Q2（R1） guidelines. HPLC separation was achieved on a RP-select B Lichrosphere~ column （250 mm x 4 ram, 5 lam, Merck） using water containing 0.1% glacial acetic acid and acetonitrile as the mobile phase in a gradient elution. The eluents were monitored by a photo diode array detector at 245 and 275 nm. Based on signal to noise ratio of 3 and 10 the LOD of CDRI 99/411 was 0.55 μg/mL, while the LLOQ was 1.05 μg/mL. The calibration curves were linear in the range of 1.05- 68 μg/mL. Precision of the method was determined by inter- and intra-assay variations within the acceptable range.
文摘AIM:To investigate the effects of binocular fusional C-optotypes(positive/negative)and 2D planar C-optotypes on the amplitude and stability of transient accommodation(TAC)in adults,and to provide a basis for non-contact myopia intervention.METHODS:This was a self-controlled study.Using redblue 3D technology,four experimental stages were set up:Test A[fixating on the 1 m negative fusional C-optotypes,8△base-in(BI)],Test B(fixating on the 5 m planar C-optotypes),Test C(fixating on the 1 m planar C-optotypes),and Test D[fixating on the 1 m positive fusional C-optotypes,20△base-out(BO)].A WAM-5500 open-field autorefractor was used to measure TAC and accommodative microfluctuations[evaluated via interquartile range(IQR)and median-based coefficient of variation(CVmed)].Additionally,the convergence accommodation to convergence(CA/C)ratio was calculated,and a visual fatigue questionnaire was administered to assess participants’subjective visual comfort.RESULTS:A total of 21 subjects(7 males,14 females;aged 23-41y)with normal binocular visual function were enrolled.The results showed that the TAC increased gradually across the four stages,and these values were Test A(-0.35±0.26 D)<Test B(-0.46±0.24 D)<Test C(-0.77±0.32 D)<Test D(-1.38±0.31 D).There were significant overall differences(F=56.136,P<0.001).Compared with Test C,Test A reduced TAC by 0.42 D(P<0.05),while Test D increased it by 0.61 D(P<0.001).There was no significant intergroup difference in accommodative fluctuation amplitude(all P>0.05),but the fluctuation stability of Test D showed a significant difference between the first 20s and the second 20s(P=0.017).The CA/C ratio was significantly higher in Test D(0.05±0.02 D/△)than in Test A(0.03±0.02 D/△,P=0.007),indicating stronger accommodation-convergence linkage during positive fusional fixation.The visual fatigue scores of all stages were low(median 0-1),with Test D slightly higher than Test B and Test C(P<0.05).No linear correlation was found between TAC and age(all r<0.1,P>0.05).CONCLUSION:Negative fusional C-optotypes induce ciliary muscle relaxation to reduce TAC,while positive fusional C-optotypes enhance accommodation-convergence coordination to increase TAC.The red-blue 3D-based noncontact training mode exhibits good safety(median visual fatigue scores:0-1 across all tests)and provides a novel dual-directional(relaxation-activation)strategy for myopia prevention and control.
文摘Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reticulum that contributes toward its unique adaptability.It is now recognized that mitochondrial perturbations can activate various innate immune pathways,such as the nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome complex by propagating inflammatory signaling in response to damage-associated molecular patterns(DAMPs).The NLRP3 inflammasome is a multimeric protein complex and is a prominent regulator of innate immunity and cell death by mediating the activation of caspase-1,pro-inflammatory cytokines interleukin-1βand interleukin-18 and pro-pyroptotic protein gasdermin-D.While several studies have begun to demonstrate the relationship between various mitochondrial DAMPs(mtDAMPs)and NLRP3 inflammasome activation,the influence of various metabolic states on the production of these DAMPs and subsequent inflammatory profile remains poorly understood.This narrative review aimed to address this by highlighting the effects of skeletal muscle use and disuse on mitochondrial quality mechanisms including mitochondrial biogenesis,fusion,fission and mitophagy.Secondly,this review summarized the impact of alterations in mitochondrial quality control mechanisms following muscle denervation,aging,and exercise training in relation to NLRP3 inflammasome activation.By consolidating the current body of literature,this work aimed to further the understanding of innate immune signaling within skeletal muscle,which can highlight areas for future research and therapeutic strategies to regulate NLRP3 inflammasome activation during divergent metabolic conditions.
文摘Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.
基金fully appreciate financial support from NingXia Natural Science Foundation for Outstanding Young Scholar(No.2024AAC04002)CAS“Light of West China”Program,National Natural Science Foundation of China(Key Program,No.12232013)Natural Science Foundation of Ningxia(Key Program,No.2022AAC2003)。
文摘Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.
基金supported by the National Key Research and Development Project (2021YFA1201404)National Natural Science Foundation of China Major Project (81991514)+6 种基金General Project (82272530, 82372459)Jiangsu Province Medical Innovation Center of Orthopedic Surgery (CXZX202214)Jiangsu Provincial Key Medical Center FoundationJiangsu Provincial Medical Outstanding Talent FoundationJiangsu Provincial Medical Youth Talent FoundationJiangsu Provincial Key Medical Talent Foundationthe Fundamental Research Funds for the Central Universities (14380493, 14380494)
文摘Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.
基金supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP)the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117)the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。
文摘The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
文摘Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.
文摘This study aims to analyze and discuss the current situation of quality control and quality management in medical imaging.Firstly,it defines the concepts of quality management and image quality,emphasizing the crucial role of the department's Quality and Safety Team in imaging quality management[1].Subsequently,it details the composition and responsibilities of the Quality and Safety Management Group,as well as the specific divisions of labor and tasks of the Quality Management Team.The effective implementation of comprehensive quality control in the imaging department is ensured through the"Seven-Star Sword"method,which encompasses total process control,organization-wide participation,and total quality control[2].Furthermore,the application of the PDCA(Plan-Do-Check-Act)cycle in quality management is explored,along with strategies to improve patient satisfaction by reducing the waiting time for imaging reports[3].Finally,the management of a key departmental medical quality control indicator—critical values—is analyzed,and improvement measures are proposed[4].This study underscores the importance of quality management in enhancing medical service quality and ensuring patient safety,and puts forward specific implementation strategies and improvement methods.
基金Key Technology Research and Development Program in Autonomous Region(2022A02009)Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2021-OCRI).
文摘Walnuts are rich in a variety of nutritional components.However,due to their high content of unsaturated fatty acids(UFAs),the quality of walnuts tends to decline during storage,which adversely affects the development of the walnut industry.This study was aimed to investigate the impacts of temperature and packaging methods on the storage quality and oxidative stability of walnuts.The Wen 185 walnut variety was selected,and the physical-chemical and nutritional indexes of walnuts stored for 42 weeks under different temperatures(18℃,4℃,and room temperature)and packaging methods(vacuum light-exposed,vacuum light-proof,vacuum-ra-diation light-exposed,vacuum-radiation light-proof,nitrogen-filled light-exposed,nitrogen-filled light-proof)were measured.The results showed that low temperatures,especially18℃,in combination with vacuum lightproof packaging,could effectively suppress the increase in oxidative stability indicators such as acid value(AV)and peroxide value(PV),and maintain high retention rates of nutritional indicators like tocopherol and phytosterol.This study has elucidated that low temperatures and appropriate packaging methods play the crucial roles in maintaining the quality and oxidative stability of walnuts during storage.It has provided comprehensive and valuable data support and theoretical basis for the scientific storage of walnuts,contributing to the devel-opment of the walnut industry and the guarantee of product quality.
基金supported by Royal Academy of Engineering(IF2223B-125)Royal Society(IECR3213107)。
文摘Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net shapes.This technology is gathering increasing attention from industries such as biomedical,automotive,and aerospace.However,achieving consistent part quality and desired material properties is challenging due to intricate processing parameters and potential process defects such as dynamic melt-pool behavior and localized heat accumulation.This paper reviews recent advances in on-line quality control,focusing on in-situ measurement and closed-loop control for efficient assurance of LDED-fabricated parts.The quality principles,encompassing accuracy and material performance,are summarized to lay a foundation for understanding the mechanisms of quality defects and influencing factors.This review explores and thoroughly compares advancements in indirect process measurements,such as optical,thermal,and acoustic monitoring with direct quality measurements,including laser-line scanning and operando synchrotron X-ray imaging.Depending on the sensing techniques,this paper highlights a hierarchical control strategy for adaptive parameter regulation on intra-layer and inter-layer scales.The requirements and performance of various state-of-the-art controllers are critically compared to indicate their suitable applications.The importance of machine learning in detecting process anomalies and predicting build quality based on sensory signals is also outlined.Future directions are proposed towards adaptive,automated,and intelligent quality control,with a focus on multi-modal monitoring,physics-informed neural networks for interpretable analysis,and multi-objective control applications.
基金Supported by Guangdong Basic and Applied Basic Research Foundation(No.2025A1515011627)San Ming Project of Medicine in Shenzhen(No.SZSM202311012).
文摘Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.
基金Supported by the Inner Mongolia Autonomous Region's Key Research and Achievement Transformation plan (2023YFHH0093).
文摘The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.
基金the Fifth Batch of Innovation Teams of Wuzhou Meteorological Bureau"Wuzhou Innovation Team for Enhancing the Comprehensive Meteorological Observation Ability through Digitization and Intelligence"Wuzhou Science and Technology Planning Project(202402122,202402119).
文摘[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.
基金Urumqi Health Committee Science and Technology Plan Project(202343)。
文摘Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.
基金The National Key Research and Development Program of China under contract No.2021YFC3101503the Hunan Provincial Natural Science Foundation of China under contract No.2023JJ10053+1 种基金the National Natural Science Foundation of China under contract Nos 42276205 and 42406195the Youth Independent Innovation Science Foundation under contract No.ZK24-54.
文摘The Argo program measures temperature and salinity in the upper ocean(0–2000 m).These observations are critical for weather/climate studies,ocean circulation analysis,and sea-level monitoring.To address the limitations of traditional thresholds in Argo data quality control(QC),this study proposes a novel probability distribution-based inference method(PDIM)for temperature-salinity threshold inference.By integrating historical observations with climatological data,the method utilizes historical data corresponding to latitude and longitude grids,calculates temperature/salinity frequency distributions for each depth,and determines“zero probability”boundaries through combined frequency distribution and climatology data.Then a probability distribution model is established to detect outliers automatically based on the features in the probability density function,which eliminates the traditional dependence on the normal distribution hypothesis.When applied to global Argo datasets from China Argo Real-time Data Center(CARDC),PDIM successfully identifies suspicious profiles and sensor drifts with high reliability,achieving a low false positive rate(0.55%for temperature,0.18%for salinity)while maintaining competitive true positive rate(28.29%for temperature,55.15%for salinity).This method is expected to improve the reliability of Argo data QC and has important significance for Argo QC.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
基金supported by the National Key R&D Program of China(No.2024YFB4609700)Major Research Plan of the National Natural Science Foundation of China(No.92266102)+4 种基金National Natural Science Foundation of China(No.52271135,No.52433016)Open project of Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials,China(No.GFST2024KF05)Innovative Research Group Project of Hubei Provincial Natural Science Foundation,China(No.2025AFA014)ECU DVC Strategic Research Support Fund,Australia(No.23965)Natural Science Foundation of Hubei Province,China(No.2025AFD399).
文摘Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Process variability often leads to defects,insufficient geometric accuracy and inadequate material properties,which are difficult to effectively manage due to limitations of traditional quality control methods in modeling highdimensional nonlinear relationships and enabling adaptive control.Machine learning(ML)offers a transformative approach to model intricate process-structure-property relationships by leveraging the rich data environment of AM.The study presents a comprehensive examination of ML-driven quality assurance implementations in metallic AM.First,it uniquely examines the innovative exploration of ML in predicting and understanding the fundamental multi-physics fields that influence the quality of a fabricated component,including temperature fields,fluid dynamics and stress/strain evolution.Subsequently,the application of ML in optimizing key quality attributes,including defect detection and mitigation(porosity,cracks,etc.),geometric fidelity enhancement(dimensional accuracy,surface roughness,etc.)and material property tailoring(mechanical strength,fatigue life,corrosion resistance,etc.),are discussed in detail.Finally,the development of ML-driven real-time closed-loop control systems for intelligent quality assurance,the strategies for addressing the data scarcity and cross-scenario transferability in metal AM are discussed.This article provides a novel perspective on the profound potential of ML technology for metal AM quality control applications,highlights the challenges faced during research,and outlines future development directions.
