The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries ...Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.展开更多
Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of...Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.展开更多
Age-related macular degeneration(AMD)is a disease that affects the vision of elderly individuals worldwide.Although current therapeutics have shown effectiveness against AMD,some patients may remain unresponsive and c...Age-related macular degeneration(AMD)is a disease that affects the vision of elderly individuals worldwide.Although current therapeutics have shown effectiveness against AMD,some patients may remain unresponsive and continue to experience disease progression.Therefore,in-depth knowledge of the mechanism underlying AMD pathogenesis is urgently required to identify potential drug targets for AMD treatment.Recently,studies have suggested that dysfunction of mitochondria can lead to the aggregation of reactive oxygen species(ROS)and activation of the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon genes(STING)innate immunity pathways,ultimately resulting in sterile inflammation and cell death in various cells,such as cardiomyocytes and macrophages.Therefore,combining strategies targeting mitochondrial dysfunction and inflammatory mediators may hold great potential in facilitating AMD management.Notably,emerging evidence indicates that natural products targeting mitochondrial quality control(MQC)and the cGAS/STING innate immunity pathways exhibit promise in treating AMD.Here,we summarize phytochemicals that could directly or indirectly influence the MQC and the cGAS/STING innate immunity pathways,as well as their interconnected mediators,which have the potential to mitigate oxidative stress and suppress excessive inflammatory responses,thereby hoping to offer new insights into therapeutic interventions for AMD treatment.展开更多
Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma...Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.展开更多
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.展开更多
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture....Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.展开更多
Crotalaria ferruginea Graham ex Benth.is a commonly used herb among ethnic minorities.Its whole plant is used as medicine for conditions such as heatstroke,tinnitus,hearing loss,phlegm heat cough,gum swelling and pain...Crotalaria ferruginea Graham ex Benth.is a commonly used herb among ethnic minorities.Its whole plant is used as medicine for conditions such as heatstroke,tinnitus,hearing loss,phlegm heat cough,gum swelling and pain,lower back and knee pain,vaginal discharge and infantile malnutrition.Modern pharmaceutical research has found that Crotalaria ferruginea Graham ex Benth.mainly contains flavonoids,steroids,organic acids and terpenes,which have antibacterial,free radical scavenging,antiinflammatory and other effects.Quality control mainly focuses on characteristics,identification,content determination,etc.This article summarizes the recent research progress on the chemical composition,pharmacological effects,quality control and extraction process of Crotalaria ferruginea Graham ex Benth.on the basis of existing Crotalaria ferruginea Graham ex Benth.research reports.展开更多
[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data...[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
In the current social environment,the importance of energy conservation and emission reduction is increasing day by day for both the country and its people.Electronic and electrical products,as important items for peo...In the current social environment,the importance of energy conservation and emission reduction is increasing day by day for both the country and its people.Electronic and electrical products,as important items for people’s production and life,require high attention from industry insiders in terms of their energy efficiency testing.Relying on energy efficiency testing can achieve the goal of energy conservation and emission reduction,and related quality control technologies will also inject new momentum into the green development of the industry.This article will discuss the practical strategies of quality control technology for energy efficiency testing of electronic and electrical products based on the significance of such testing,hoping to provide some help.展开更多
Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed To...Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.展开更多
The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder con...The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.展开更多
Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical e...Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.展开更多
This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditi...This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditional control system.It introduces the quality control strategies based on BIM,such as constructing the framework,combining with technologies to control deviations,etc.It also mentions the PDCA mechanism,application terminals,etc.,and points out the application obstacles and future development directions.展开更多
In order to further enhance the numerical application of weather radar radial velocity,this paper proposes a quality control scheme for weather radar radial velocity from the perspective of data assimilation.The propo...In order to further enhance the numerical application of weather radar radial velocity,this paper proposes a quality control scheme for weather radar radial velocity from the perspective of data assimilation.The proposed scheme is based on the WRFDA(Weather Research and Forecasting Data Assimilation)system and utilizes the biweight algorithm to perform quality control on weather radar radial velocity data.A series of quality control tests conducted over the course of one month demonstrate that the scheme can be seamlessly integrated into the data assimilation process.The scheme is characterized by its simplicity,fast implementation,and ease of maintenance.By determining an appropri-ate threshold for quality control,the percentage of outliers identified by the scheme remains highly stable over time.Moreover,the mean errors and standard deviations of the O-B(observation-minus-background)values are significantly reduced,improving the overall data quality.The main information and spatial distribution features of the data are pre-served effectively.After quality control,the distribution of the O-B Probability Density Function is adjusted in a manner that brings it closer to a Gaussian distribution.This adjustment is beneficial for the subsequent data assimilation process,contributing to more accurate numerical weather predictions.Thus,the proposed quality control scheme provides a valuable tool for improving weather radar data quality and enhancing numerical forecasting performance.展开更多
Neurodegenerative disorders(NDDs)are prevalent chronic conditions characterized by progressive synaptic loss and pathological protein alterations.Increasing evidence suggested that mitochondrial quality control(MQC)se...Neurodegenerative disorders(NDDs)are prevalent chronic conditions characterized by progressive synaptic loss and pathological protein alterations.Increasing evidence suggested that mitochondrial quality control(MQC)serves as the key cellular process responsible for clearing misfolded proteins and impaired mitochondria.Herein,we provided a comprehensive analysis of the mechanisms through which MQC mediates the onset and progression of NDDs,emphasizing mitochondrial dynamic stability,the clearance of damaged mitochondria,and the generation of new mitochondria.In addition,traditional Chinese medicines(TCMs)and their active monomers targeting MQC in NDD treatment have been demonstrated.Consequently,we compiled the TCMs that show great potential in the treatment of NDDs by targeting MQC,aiming to offer novel insights and a scientific foundation for the use of MQC stabilizers in NDD prevention and treatment.展开更多
Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews...Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews on this topic have however been inconsistencies and lack of systematic organization.Therefore,this review aims to provide a comprehensive and systematic overview of mitochondrial quality control and explore the possibility of targeting the same for the treatment of major diseases.This review systematically summarizes three fundamental characteristics of mitochondrial quality control,including mitochondrial morphology and dynamics,function and metabolism,and protein expression and regulation.It also extensively examines how imbalances in mitochondrial quality are linked to major diseases,such as ischemia-hypoxia,inflammatory disorders,viral infections,metabolic dysregulations,degenerative conditions,and tumors.Additionally,the review explores innovative approaches to target mitochondrial quality control,including using small molecule drugs that regulate critical steps in maintaining mitochondrial quality,nanomolecular materials designed for precise targeting of mitochondria,and novel cellular therapies,such as vesicle therapy and mitochondrial transplantation.This review offers a novel perspective on comprehending the shared mechanisms underlying the occurrence and progression of major diseases and provides theoretical support and practical guidance for the clinical implementation of innovative therapeutic strategies that target mitochondrial quality control for treating major diseases.展开更多
With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction ...With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction quality control are of great significance to enhance the competitiveness of construction enterprises and realize sustainable development.In this paper,the effective strategy of construction management and the effective strategy of construction quality control will be discussed in depth,aiming at providing useful management and quality control strategies for construction enterprises.展开更多
基金supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP)the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117)the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。
文摘The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
基金fully appreciate financial support from NingXia Natural Science Foundation for Outstanding Young Scholar(No.2024AAC04002)CAS“Light of West China”Program,National Natural Science Foundation of China(Key Program,No.12232013)Natural Science Foundation of Ningxia(Key Program,No.2022AAC2003)。
文摘Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.
基金Supported by Guangdong Basic and Applied Basic Research Foundation(No.2025A1515011627)San Ming Project of Medicine in Shenzhen(No.SZSM202311012).
文摘Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.
基金funded by Chinese NSFC(Grant Nos.:82373336,82303238,and U22A20311,Sichuan Science and Technology Department,China(GrantNos.:2024NSFSC1945,,and 2023NSFSC0667)the Third People's Hospital of Chengdu Clinical Research Program,China(Grant Nos.:CSY-YN-01-2023-013,CSYYN-01-2023-005,and CSY-YN-03-2024-003)+1 种基金Sichuan University“From O to 1”Innovative Research Project,China(Project No.:2023SCUH0024)Health Commission of Chengdu,China(Grant No.:2024291).
文摘Age-related macular degeneration(AMD)is a disease that affects the vision of elderly individuals worldwide.Although current therapeutics have shown effectiveness against AMD,some patients may remain unresponsive and continue to experience disease progression.Therefore,in-depth knowledge of the mechanism underlying AMD pathogenesis is urgently required to identify potential drug targets for AMD treatment.Recently,studies have suggested that dysfunction of mitochondria can lead to the aggregation of reactive oxygen species(ROS)and activation of the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon genes(STING)innate immunity pathways,ultimately resulting in sterile inflammation and cell death in various cells,such as cardiomyocytes and macrophages.Therefore,combining strategies targeting mitochondrial dysfunction and inflammatory mediators may hold great potential in facilitating AMD management.Notably,emerging evidence indicates that natural products targeting mitochondrial quality control(MQC)and the cGAS/STING innate immunity pathways exhibit promise in treating AMD.Here,we summarize phytochemicals that could directly or indirectly influence the MQC and the cGAS/STING innate immunity pathways,as well as their interconnected mediators,which have the potential to mitigate oxidative stress and suppress excessive inflammatory responses,thereby hoping to offer new insights into therapeutic interventions for AMD treatment.
基金National Natural ScienceFoundation of China (grant number: 81973696).
文摘Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.
基金supported by the National Natural Science Foundation of China(8210082163,81800343)the Fundamental Research Fund for the Central Universities(2042021kf0081)+1 种基金the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027)the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
文摘Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.
基金supported by the National Key Research and Development Project (2021YFA1201404)National Natural Science Foundation of China Major Project (81991514)+6 种基金General Project (82272530, 82372459)Jiangsu Province Medical Innovation Center of Orthopedic Surgery (CXZX202214)Jiangsu Provincial Key Medical Center FoundationJiangsu Provincial Medical Outstanding Talent FoundationJiangsu Provincial Medical Youth Talent FoundationJiangsu Provincial Key Medical Talent Foundationthe Fundamental Research Funds for the Central Universities (14380493, 14380494)
文摘Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.
文摘Crotalaria ferruginea Graham ex Benth.is a commonly used herb among ethnic minorities.Its whole plant is used as medicine for conditions such as heatstroke,tinnitus,hearing loss,phlegm heat cough,gum swelling and pain,lower back and knee pain,vaginal discharge and infantile malnutrition.Modern pharmaceutical research has found that Crotalaria ferruginea Graham ex Benth.mainly contains flavonoids,steroids,organic acids and terpenes,which have antibacterial,free radical scavenging,antiinflammatory and other effects.Quality control mainly focuses on characteristics,identification,content determination,etc.This article summarizes the recent research progress on the chemical composition,pharmacological effects,quality control and extraction process of Crotalaria ferruginea Graham ex Benth.on the basis of existing Crotalaria ferruginea Graham ex Benth.research reports.
基金the Fifth Batch of Innovation Teams of Wuzhou Meteorological Bureau"Wuzhou Innovation Team for Enhancing the Comprehensive Meteorological Observation Ability through Digitization and Intelligence"Wuzhou Science and Technology Planning Project(202402122,202402119).
文摘[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
文摘In the current social environment,the importance of energy conservation and emission reduction is increasing day by day for both the country and its people.Electronic and electrical products,as important items for people’s production and life,require high attention from industry insiders in terms of their energy efficiency testing.Relying on energy efficiency testing can achieve the goal of energy conservation and emission reduction,and related quality control technologies will also inject new momentum into the green development of the industry.This article will discuss the practical strategies of quality control technology for energy efficiency testing of electronic and electrical products based on the significance of such testing,hoping to provide some help.
文摘Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.
基金Supported by the Inner Mongolia Autonomous Region's Key Research and Achievement Transformation plan (2023YFHH0093).
文摘The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.
基金Urumqi Health Committee Science and Technology Plan Project(202343)。
文摘Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.
文摘This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditional control system.It introduces the quality control strategies based on BIM,such as constructing the framework,combining with technologies to control deviations,etc.It also mentions the PDCA mechanism,application terminals,etc.,and points out the application obstacles and future development directions.
基金funded by Beijige Fund of Nanjing Joint Institute for Atmospheric Sciences(BJG202501)the Joint Research Project for Meteorological Capacity Improvement(22NLTSY009)+2 种基金Key Scientific Research Projects of Jiangsu Provincial Meteorological Bureau(KZ202203)China Meteorological Administration projects(CMAJBGS202316)the Guiding Research Projects of Jiangsu Provincial Meteorological Bureau(ZD202404,ZD202419).
文摘In order to further enhance the numerical application of weather radar radial velocity,this paper proposes a quality control scheme for weather radar radial velocity from the perspective of data assimilation.The proposed scheme is based on the WRFDA(Weather Research and Forecasting Data Assimilation)system and utilizes the biweight algorithm to perform quality control on weather radar radial velocity data.A series of quality control tests conducted over the course of one month demonstrate that the scheme can be seamlessly integrated into the data assimilation process.The scheme is characterized by its simplicity,fast implementation,and ease of maintenance.By determining an appropri-ate threshold for quality control,the percentage of outliers identified by the scheme remains highly stable over time.Moreover,the mean errors and standard deviations of the O-B(observation-minus-background)values are significantly reduced,improving the overall data quality.The main information and spatial distribution features of the data are pre-served effectively.After quality control,the distribution of the O-B Probability Density Function is adjusted in a manner that brings it closer to a Gaussian distribution.This adjustment is beneficial for the subsequent data assimilation process,contributing to more accurate numerical weather predictions.Thus,the proposed quality control scheme provides a valuable tool for improving weather radar data quality and enhancing numerical forecasting performance.
基金supported by the Natural Science Foundation of China(Grant No.:82130113)the“Xinglin Scholars”Research Promotion Program of Chengdu University of Traditional Chinese Medicine,China(Program No.:ZDZX2022005)+1 种基金the China Postdoctoral Science Foundation(Grant No.:2021MD703800)the Science Foundation for Youths of Science&Technology Department of Sichuan Province,China(Grant No.:2022NSFSC1449).
文摘Neurodegenerative disorders(NDDs)are prevalent chronic conditions characterized by progressive synaptic loss and pathological protein alterations.Increasing evidence suggested that mitochondrial quality control(MQC)serves as the key cellular process responsible for clearing misfolded proteins and impaired mitochondria.Herein,we provided a comprehensive analysis of the mechanisms through which MQC mediates the onset and progression of NDDs,emphasizing mitochondrial dynamic stability,the clearance of damaged mitochondria,and the generation of new mitochondria.In addition,traditional Chinese medicines(TCMs)and their active monomers targeting MQC in NDD treatment have been demonstrated.Consequently,we compiled the TCMs that show great potential in the treatment of NDDs by targeting MQC,aiming to offer novel insights and a scientific foundation for the use of MQC stabilizers in NDD prevention and treatment.
基金supported by the National Natural Science Foundation of China (82272252 and 82372192)the Senior Medical Talents Program of Chongqing for Young and Middle-AgedKuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University
文摘Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews on this topic have however been inconsistencies and lack of systematic organization.Therefore,this review aims to provide a comprehensive and systematic overview of mitochondrial quality control and explore the possibility of targeting the same for the treatment of major diseases.This review systematically summarizes three fundamental characteristics of mitochondrial quality control,including mitochondrial morphology and dynamics,function and metabolism,and protein expression and regulation.It also extensively examines how imbalances in mitochondrial quality are linked to major diseases,such as ischemia-hypoxia,inflammatory disorders,viral infections,metabolic dysregulations,degenerative conditions,and tumors.Additionally,the review explores innovative approaches to target mitochondrial quality control,including using small molecule drugs that regulate critical steps in maintaining mitochondrial quality,nanomolecular materials designed for precise targeting of mitochondria,and novel cellular therapies,such as vesicle therapy and mitochondrial transplantation.This review offers a novel perspective on comprehending the shared mechanisms underlying the occurrence and progression of major diseases and provides theoretical support and practical guidance for the clinical implementation of innovative therapeutic strategies that target mitochondrial quality control for treating major diseases.
文摘With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction quality control are of great significance to enhance the competitiveness of construction enterprises and realize sustainable development.In this paper,the effective strategy of construction management and the effective strategy of construction quality control will be discussed in depth,aiming at providing useful management and quality control strategies for construction enterprises.
