We report a detailed investigation on the use of chelators PYTAM,H4PYTAMGly,CHX-PYTAM and H4CHXPYTAMGly for the complexation of Pb(Ⅱ)-radioisotopes with potential use in the preparation of radiopharmaceuticals.The ma...We report a detailed investigation on the use of chelators PYTAM,H4PYTAMGly,CHX-PYTAM and H4CHXPYTAMGly for the complexation of Pb(Ⅱ)-radioisotopes with potential use in the preparation of radiopharmaceuticals.The macrocyclic backbones from which the chelators are prepared,PYAN(3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane)or CHX-PYAN((4^(1)R,4^(2)R,10^(1)R,10^(2)R)-3,5,9,11-tetraaza-1,7(2,6)-dipyridina-4,10(1,2)-dicyclohexanacyclododecaphane).展开更多
基金D.E.-G.and C.P.-I.thank Ministerio de Ciencia e Innovación(Grants PID2019-104626GB-I00 and PID2022-138335NB-I00)Xunta de Galicia(ED431C 2023/33)for generous financial support.C.Hthanks Ministerio de Ciencia e Innovación(Grant PRE2020-092888)for funding her PhD contract and a short-term research visit to SFU and TRIUMF.
文摘We report a detailed investigation on the use of chelators PYTAM,H4PYTAMGly,CHX-PYTAM and H4CHXPYTAMGly for the complexation of Pb(Ⅱ)-radioisotopes with potential use in the preparation of radiopharmaceuticals.The macrocyclic backbones from which the chelators are prepared,PYAN(3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane)or CHX-PYAN((4^(1)R,4^(2)R,10^(1)R,10^(2)R)-3,5,9,11-tetraaza-1,7(2,6)-dipyridina-4,10(1,2)-dicyclohexanacyclododecaphane).
