The development of stretchable conductors with high deformation,conductivity,and thermal conductivity using liquid metal(LM)has sparked widespread interest in the fields of flexible electronics,electromagnetic interfe...The development of stretchable conductors with high deformation,conductivity,and thermal conductivity using liquid metal(LM)has sparked widespread interest in the fields of flexible electronics,electromagnetic interference(EMI),and multifunctional materi-als.However,fabricating desirable shielding materials by directly coating LMs on soft polymer substrates remains a challenge because of the huge surface tension and weak wettability of LMs.In this study,Ga-based composite paste is prepared from a mixture of Ga and dia-mond nonmetallic particles through ultrasonic fragmentation.At various temperatures,the resulting LM composite putty(LMP)exhibits soft and hard properties and can thus be molded into specific shapes according to application needs.In addition,the composite can be eas-ily coated onto polymer substrates,such as thermoplastic polyurethane(TPU)elastomer.The fabricated LMP–TPU exhibits an impress-ive shape deformation capacity of 1100%,demonstrating exceptional tensile properties and achieving electromagnetic interference–shielding effectiveness of up to 52 dB.Furthermore,it retains an ultrahigh conductivity of 20000 S/m,even under a strain of 600%.This feature further makes it a highly competitive multifunctional material.展开更多
<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increas...<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increases causing pain, and complications of fractures can severely compromise the patient.<strong> Aim:</strong> The results in a series of cases treated minimally invasive using a new device for the application of allogenic bone material appear highly promising and shall be presented. <strong>Patients and Methods:</strong> Eight consecutive patients with symptomatic Unicameral Bone Cysts (UBC) were treated by percutaneous instillation of Grafton<span style="white-space:nowrap;">?</span> DBF Putty (demineralised allogenic bone containing fibers) mixed with autologous bone marrow using the Kyphon<span style="white-space:nowrap;">?</span> Cement Delivery System (Medtronic), which allows the injection of this high viscosity paste by controlled high pressure. Five patients with Aneurysmal Bone Cysts (ABC) were treated accordingly after inactivation by Aethoxysclerol 3% and lacking bone formation. Using this approach a high rate of bone regeneration was observed in these patients at 8 months to 5 years follow-up (f/u). <strong>Conclusion:</strong> The presented technique of a minimally invasive biologic treatment led to highly satisfying results using the Grafton<span style="white-space:nowrap;">?</span> DBF Putty with its higher potential for bone regeneration than demineralized bone matrix not containing fibres (DBM).展开更多
In this study,injectable bone graft putty samples were developed using fine and coarse melt-quenched 45S5 bioactive glass(BG)incorporated into a carrier system composed of glycerol and polyethylene glycol(PEG)with dif...In this study,injectable bone graft putty samples were developed using fine and coarse melt-quenched 45S5 bioactive glass(BG)incorporated into a carrier system composed of glycerol and polyethylene glycol(PEG)with different average molecular weights.Selected putty samples were further incorporated with varying amounts of Denosumab(5wt%-10wt%)to investigate its influence on rhe-ological behavior and flow properties using mathematical modeling.All PEG/glycerol/45S5-based putty samples exhibited viscoelastic behavior(storage modulus>loss modulus)and pseudoplastic behavior(n<1),with viscosity values required for optimal flow remaining below 1000 Pa∙s.Both viscosity and thixotropic area increased proportionally with higher BG content and smaller-sized BG particles.All putty samples showed more than 98%injectability through a 12G cannula,suggesting potential clinical suitability.However,injectability decreased with smaller cannulas,dropping to 34.7%-58.3%with a 19G cannula and further decreasing with a 23G cannula at higher BG contents.Incorporation of Denosumab preserved viscoelasticity and injectability but modified the flow behavior,shifting it from pseudo-plastic to more Newtonian with higher Denosumab content,while also reducing viscosity and thixotropic area values.Among all tested samples,putty containing a lower amount of Denosumab and smaller-sized BG exhibited the most suitable combination of injectability and rheological features.All putty samples were well described by both the Power law and Herschel-Bulkley rheological models(coeffi-cient of determination>0.95).This study highlights the influence of Denosumab on flowability and rheological relationships and sug-gests potential improvements in bioactivity through a dual synergistic effect of BG and Denosumab in minimally invasive bone graft sys-tems.展开更多
Background Nanobone putty is an injectable and bioresorbable bone substitute. The neutral-pH putty resembles hard bone tissue, does not contain polymers or plasticizers, and is self-setting and nearly isothermic, prop...Background Nanobone putty is an injectable and bioresorbable bone substitute. The neutral-pH putty resembles hard bone tissue, does not contain polymers or plasticizers, and is self-setting and nearly isothermic, properties which are helpful for the adhesion, proliferation, and function of bone cells. The aim of this study was to investigate the osteogenic potential of human bone morphogenetic protein 2 （hBMP2） gene activated nanobone putty in inducing ectopic bone formation, and the effects of the hBMP2 gene activated nanobone putty on repairing bone defects. Methods Twenty four Kunming mice were randomly divided into two groups. The nanobone putty ＋ hBMP2 plasmid was injected into the right thigh muscle pouches of the mice （experiment side）. The nanobone putty ＋ blank plasmid or nanobone putty was injected into the left thigh muscle pouches of the group 1 （control side 1） or group 2 （control side 2）, respectively. The effects of ectopic bone formation were evaluated by radiography, histology, and molecular biology analysis at 2 and 4 weeks after operation. Bilateral 15 mm radial defects were made in forty-eight rabbits. These rabbits were randomly divided into three groups： Group A, nanobone putty ＋ hBMP2 plasmid; Group B, putty ＋ blank plasmid; Group C, nanobone putty only. Six rabbits with left radial defects served as blank controls. The effect of bone repairing was evaluated by radiography, histology, molecular biology, and biomechanical analysis at 4, 8, and 12 weeks after operation. Results The tissue from the experimental side of the mice expressed hBMP2. Obvious cartilage and island-distributed immature bone formation in implants of the experiment side were observed at 2 weeks after operation, and massive mature bone observed at 4 weeks. No bone formation was observed in the control side of the mice. The ALP activity in the experiment side of the mice was higher than that in the control side. The tissue of Group A rabbits expressed hBMP2 protein and higher ALP level. The new bone formation rate and antibending strength of group A was significantly higher than those of group B and C. The defects in blank control were not healed. Conclusions The hBMP2 gene activated nanobone putty exhibited osteoinductive ability, and had a better bone defect repair capabilitv than that of nanobone putty only.展开更多
This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture.Sixty cases of calcaneal fractures surgically treated w...This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture.Sixty cases of calcaneal fractures surgically treated with open reduction and internal fixation in our hospital from June 2014–2015 were chosen and randomly divided into two groups,including 30 cases treated with biomimetic mineralized collagen artificial bone putty as treatment group,and 30 cases treated with autogenous ilia as control group.The average follow-up time was 17.263.0 months.The results showed that the surgery duration and postoperative drainage volume of treatment group were significantly lower than control group;there were no statistically significant differences in the fracture healing time,American Orthopaedic Foot and Ankle Society scores at 3 and 12 months after surgery,Bo¨hler’s angle,Gissane’s angle and height of calcaneus between the two groups.There were no significant differences in wound complication and reject reaction between the two groups,while significant difference in donor site complication.As a conclusion,the implantation of biomimetic mineralized collagen artificial bone putty in the open reduction of calcaneal fracture resulted in reliable effect and less complications,which is suitable for clinical applications in the treatment of bone defect in calcaneal fractures.展开更多
The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures.From January 2012 to December ...The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures.From January 2012 to December 2015,80 cases of senile patients with osteoporotic proximal humeral fractures were randomly divided into an observation group and a control group,each group with a total of 40 cases.The control group was simply treated with locking plate.The observation group was treated with locking plate in combination with biomimetic mineralized collagen putty.The therapeutic effect thereby was observed.The excellent and satisfactory rate was 90%in observation group and was 72.5%in control group.The difference between the two groups was statistically significant(χ^(2)=5.3312,P<0.05).The fracture healing time was 11.8263.62 weeks in observation group and 19.7865.46 weeks in control group.The shoulder joint function score was 89.6368.12 in observation group and 76.9268.18 in control group.There was significant difference between the two groups(t=7.1272;12.7834,P<0.05).The complication rate was 10%in the observation group and 32.5%in the control group(χ^(2)=7.3786,P<0.05).Locking system strengthened by biomimetic mineralized collagen putty has advantages such as accelerating healing of senile proximal humeral fracture,improving the therapeutic effect,reducing the complications.As one of the optimal internal fixation method,it provides a new option for better treatment of senile osteoporotic fracture.展开更多
This work was undertaken to research organic wood-flour putty as wooden surface undercoat. Four types of wood-flour (300, 500, 800 and 1 000 mesh) were prepared through the technological processes of shattering, coars...This work was undertaken to research organic wood-flour putty as wooden surface undercoat. Four types of wood-flour (300, 500, 800 and 1 000 mesh) were prepared through the technological processes of shattering, coarse grinding and fine grinding. And latex (16% of solid content) and two kinds of agents (A and B) were added into the putty. In this experiment, effects of agent and particle size of wood-flour on properties of organic wood-flour putty, such as painting properties, water resistance, and abrasive resistance and so on, were discussed. The results showed that considering all of performance indexes, wood-flour putty contained with 8.0% agent A or 2.0% agent B has a better performance than the others. In addition, wood-flour putty with 500 mesh of wood-flour is the best.展开更多
Objectives: The aim of this study was to compare the efficacy of using the synthetic β-TCP bone grafting material in two different manufacturing forms (putty and granular) in grafting the jumping zone around immediat...Objectives: The aim of this study was to compare the efficacy of using the synthetic β-TCP bone grafting material in two different manufacturing forms (putty and granular) in grafting the jumping zone around immediate implant. Patients and Method: A randomized controlled clinical and radiographic trial was conducted on 24 male patients aged from 45 - 55 with badly decayed non-restorable teeth in the posterior mandibular area and seeking for receiving immediate dental implant directly after extraction. Vertical bone height and bone density were taken at time of implant placement and 6 months postoperatively. Results: The Putty form group and the Granular form group did not differ statistically in terms of age, post-operative complications, or implant outcome six months postoperatively. Additionally, there was a statistically significant increase in Putty form group compared to the Granular form group regarding Marginal bone loss 6 months postoperatively, but there was no statistically significant difference between the Putty form group and the Granular form group regarding Bone density by CBCT. Conclusion: The β-TCP Putty material, compared to β-TCP granular, displayed better surgical handling properties, and both forms had no adverse effect on bone formation, bone tissue maturation or graft volume stability, The β-TCP granular material, compared to β-TCP putty, displayed less marginal bone loss 6 months post-operatively.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52271167 and U21A2064)the Key Program of Natural Science Foundation of Henan Province,China(No.242300421188)+1 种基金ZUA Innovation Fund for Graduate Education,China(No.2024CX134)Henan Key Laboratory of Aeronautical Material and Technology Open Foundation,China(No.ZHKF-240103).
文摘The development of stretchable conductors with high deformation,conductivity,and thermal conductivity using liquid metal(LM)has sparked widespread interest in the fields of flexible electronics,electromagnetic interference(EMI),and multifunctional materi-als.However,fabricating desirable shielding materials by directly coating LMs on soft polymer substrates remains a challenge because of the huge surface tension and weak wettability of LMs.In this study,Ga-based composite paste is prepared from a mixture of Ga and dia-mond nonmetallic particles through ultrasonic fragmentation.At various temperatures,the resulting LM composite putty(LMP)exhibits soft and hard properties and can thus be molded into specific shapes according to application needs.In addition,the composite can be eas-ily coated onto polymer substrates,such as thermoplastic polyurethane(TPU)elastomer.The fabricated LMP–TPU exhibits an impress-ive shape deformation capacity of 1100%,demonstrating exceptional tensile properties and achieving electromagnetic interference–shielding effectiveness of up to 52 dB.Furthermore,it retains an ultrahigh conductivity of 20000 S/m,even under a strain of 600%.This feature further makes it a highly competitive multifunctional material.
文摘<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increases causing pain, and complications of fractures can severely compromise the patient.<strong> Aim:</strong> The results in a series of cases treated minimally invasive using a new device for the application of allogenic bone material appear highly promising and shall be presented. <strong>Patients and Methods:</strong> Eight consecutive patients with symptomatic Unicameral Bone Cysts (UBC) were treated by percutaneous instillation of Grafton<span style="white-space:nowrap;">?</span> DBF Putty (demineralised allogenic bone containing fibers) mixed with autologous bone marrow using the Kyphon<span style="white-space:nowrap;">?</span> Cement Delivery System (Medtronic), which allows the injection of this high viscosity paste by controlled high pressure. Five patients with Aneurysmal Bone Cysts (ABC) were treated accordingly after inactivation by Aethoxysclerol 3% and lacking bone formation. Using this approach a high rate of bone regeneration was observed in these patients at 8 months to 5 years follow-up (f/u). <strong>Conclusion:</strong> The presented technique of a minimally invasive biologic treatment led to highly satisfying results using the Grafton<span style="white-space:nowrap;">?</span> DBF Putty with its higher potential for bone regeneration than demineralized bone matrix not containing fibres (DBM).
基金supported by Yildiz Technical University Scientific Research Projects Coordination Unit under project number FBA-2023-5377support from the Scientific and Technological Research Council of Turkey(TUBITAK)under the BIDEB/2211-A National PhD Scholarship Program and 2250-Performance-Based Scholarships Program for PhD.
文摘In this study,injectable bone graft putty samples were developed using fine and coarse melt-quenched 45S5 bioactive glass(BG)incorporated into a carrier system composed of glycerol and polyethylene glycol(PEG)with different average molecular weights.Selected putty samples were further incorporated with varying amounts of Denosumab(5wt%-10wt%)to investigate its influence on rhe-ological behavior and flow properties using mathematical modeling.All PEG/glycerol/45S5-based putty samples exhibited viscoelastic behavior(storage modulus>loss modulus)and pseudoplastic behavior(n<1),with viscosity values required for optimal flow remaining below 1000 Pa∙s.Both viscosity and thixotropic area increased proportionally with higher BG content and smaller-sized BG particles.All putty samples showed more than 98%injectability through a 12G cannula,suggesting potential clinical suitability.However,injectability decreased with smaller cannulas,dropping to 34.7%-58.3%with a 19G cannula and further decreasing with a 23G cannula at higher BG contents.Incorporation of Denosumab preserved viscoelasticity and injectability but modified the flow behavior,shifting it from pseudo-plastic to more Newtonian with higher Denosumab content,while also reducing viscosity and thixotropic area values.Among all tested samples,putty containing a lower amount of Denosumab and smaller-sized BG exhibited the most suitable combination of injectability and rheological features.All putty samples were well described by both the Power law and Herschel-Bulkley rheological models(coeffi-cient of determination>0.95).This study highlights the influence of Denosumab on flowability and rheological relationships and sug-gests potential improvements in bioactivity through a dual synergistic effect of BG and Denosumab in minimally invasive bone graft sys-tems.
文摘Background Nanobone putty is an injectable and bioresorbable bone substitute. The neutral-pH putty resembles hard bone tissue, does not contain polymers or plasticizers, and is self-setting and nearly isothermic, properties which are helpful for the adhesion, proliferation, and function of bone cells. The aim of this study was to investigate the osteogenic potential of human bone morphogenetic protein 2 （hBMP2） gene activated nanobone putty in inducing ectopic bone formation, and the effects of the hBMP2 gene activated nanobone putty on repairing bone defects. Methods Twenty four Kunming mice were randomly divided into two groups. The nanobone putty ＋ hBMP2 plasmid was injected into the right thigh muscle pouches of the mice （experiment side）. The nanobone putty ＋ blank plasmid or nanobone putty was injected into the left thigh muscle pouches of the group 1 （control side 1） or group 2 （control side 2）, respectively. The effects of ectopic bone formation were evaluated by radiography, histology, and molecular biology analysis at 2 and 4 weeks after operation. Bilateral 15 mm radial defects were made in forty-eight rabbits. These rabbits were randomly divided into three groups： Group A, nanobone putty ＋ hBMP2 plasmid; Group B, putty ＋ blank plasmid; Group C, nanobone putty only. Six rabbits with left radial defects served as blank controls. The effect of bone repairing was evaluated by radiography, histology, molecular biology, and biomechanical analysis at 4, 8, and 12 weeks after operation. Results The tissue from the experimental side of the mice expressed hBMP2. Obvious cartilage and island-distributed immature bone formation in implants of the experiment side were observed at 2 weeks after operation, and massive mature bone observed at 4 weeks. No bone formation was observed in the control side of the mice. The ALP activity in the experiment side of the mice was higher than that in the control side. The tissue of Group A rabbits expressed hBMP2 protein and higher ALP level. The new bone formation rate and antibending strength of group A was significantly higher than those of group B and C. The defects in blank control were not healed. Conclusions The hBMP2 gene activated nanobone putty exhibited osteoinductive ability, and had a better bone defect repair capabilitv than that of nanobone putty only.
文摘This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture.Sixty cases of calcaneal fractures surgically treated with open reduction and internal fixation in our hospital from June 2014–2015 were chosen and randomly divided into two groups,including 30 cases treated with biomimetic mineralized collagen artificial bone putty as treatment group,and 30 cases treated with autogenous ilia as control group.The average follow-up time was 17.263.0 months.The results showed that the surgery duration and postoperative drainage volume of treatment group were significantly lower than control group;there were no statistically significant differences in the fracture healing time,American Orthopaedic Foot and Ankle Society scores at 3 and 12 months after surgery,Bo¨hler’s angle,Gissane’s angle and height of calcaneus between the two groups.There were no significant differences in wound complication and reject reaction between the two groups,while significant difference in donor site complication.As a conclusion,the implantation of biomimetic mineralized collagen artificial bone putty in the open reduction of calcaneal fracture resulted in reliable effect and less complications,which is suitable for clinical applications in the treatment of bone defect in calcaneal fractures.
基金This work was partially supported by Shanghai Municipal Health Bureau(No.2011239)the National Science and Technology Supporting Program of China(No.2012BAI17B02).
文摘The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures.From January 2012 to December 2015,80 cases of senile patients with osteoporotic proximal humeral fractures were randomly divided into an observation group and a control group,each group with a total of 40 cases.The control group was simply treated with locking plate.The observation group was treated with locking plate in combination with biomimetic mineralized collagen putty.The therapeutic effect thereby was observed.The excellent and satisfactory rate was 90%in observation group and was 72.5%in control group.The difference between the two groups was statistically significant(χ^(2)=5.3312,P<0.05).The fracture healing time was 11.8263.62 weeks in observation group and 19.7865.46 weeks in control group.The shoulder joint function score was 89.6368.12 in observation group and 76.9268.18 in control group.There was significant difference between the two groups(t=7.1272;12.7834,P<0.05).The complication rate was 10%in the observation group and 32.5%in the control group(χ^(2)=7.3786,P<0.05).Locking system strengthened by biomimetic mineralized collagen putty has advantages such as accelerating healing of senile proximal humeral fracture,improving the therapeutic effect,reducing the complications.As one of the optimal internal fixation method,it provides a new option for better treatment of senile osteoporotic fracture.
基金supported by The 15th National Scientific & Technological Support Project "The Process Technology of Framing Timber of Furniture and Fixture (2006BAD18B0602)".
文摘This work was undertaken to research organic wood-flour putty as wooden surface undercoat. Four types of wood-flour (300, 500, 800 and 1 000 mesh) were prepared through the technological processes of shattering, coarse grinding and fine grinding. And latex (16% of solid content) and two kinds of agents (A and B) were added into the putty. In this experiment, effects of agent and particle size of wood-flour on properties of organic wood-flour putty, such as painting properties, water resistance, and abrasive resistance and so on, were discussed. The results showed that considering all of performance indexes, wood-flour putty contained with 8.0% agent A or 2.0% agent B has a better performance than the others. In addition, wood-flour putty with 500 mesh of wood-flour is the best.
文摘Objectives: The aim of this study was to compare the efficacy of using the synthetic β-TCP bone grafting material in two different manufacturing forms (putty and granular) in grafting the jumping zone around immediate implant. Patients and Method: A randomized controlled clinical and radiographic trial was conducted on 24 male patients aged from 45 - 55 with badly decayed non-restorable teeth in the posterior mandibular area and seeking for receiving immediate dental implant directly after extraction. Vertical bone height and bone density were taken at time of implant placement and 6 months postoperatively. Results: The Putty form group and the Granular form group did not differ statistically in terms of age, post-operative complications, or implant outcome six months postoperatively. Additionally, there was a statistically significant increase in Putty form group compared to the Granular form group regarding Marginal bone loss 6 months postoperatively, but there was no statistically significant difference between the Putty form group and the Granular form group regarding Bone density by CBCT. Conclusion: The β-TCP Putty material, compared to β-TCP granular, displayed better surgical handling properties, and both forms had no adverse effect on bone formation, bone tissue maturation or graft volume stability, The β-TCP granular material, compared to β-TCP putty, displayed less marginal bone loss 6 months post-operatively.
