In the present study, we described a novel, simple, and scalable method for isolating and purifying natural mangiferin from fresh mango leaves. An ultrasonic-assisted method was used to extract mangiferin from mango l...In the present study, we described a novel, simple, and scalable method for isolating and purifying natural mangiferin from fresh mango leaves. An ultrasonic-assisted method was used to extract mangiferin from mango leaves using methanol as the solvent. The yields of the mangiferin crude extract and purified mangiferin recrystallized from a mixture of methanol and trichloromethane(10:1, v/v) were 1.41%(purity 86.5%) and 0.75%(purity > 99.6%), respectively. The purity of mangiferin was assessed by UV spectroscopy and HPLC. The structure of the purified compound was confirmed spectroscopically by UV, IR, Q-TOF/MS,;H NMR, and;C NMR. The method described herein to isolate mangiferin was simple, inexpensive, rapid, and efficient. Moreover, we, for the first time, obtained mangiferin with a purity of more than 99.6% using this method.展开更多
The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based ...The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting radiopharmaceu-ticals.The production yield and activity of typical medical isotopes were estimated using the FLUKA simulation.The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical radioisotopes.In particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/week.Based on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.展开更多
基金The Key R&D projects in Hainan Province (Grant No. ZDYF2020160)the National Key Research and Development Project of China (Grant No. 2017YFF0207800)Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (Grant No. 1630082017001)。
文摘In the present study, we described a novel, simple, and scalable method for isolating and purifying natural mangiferin from fresh mango leaves. An ultrasonic-assisted method was used to extract mangiferin from mango leaves using methanol as the solvent. The yields of the mangiferin crude extract and purified mangiferin recrystallized from a mixture of methanol and trichloromethane(10:1, v/v) were 1.41%(purity 86.5%) and 0.75%(purity > 99.6%), respectively. The purity of mangiferin was assessed by UV spectroscopy and HPLC. The structure of the purified compound was confirmed spectroscopically by UV, IR, Q-TOF/MS,;H NMR, and;C NMR. The method described herein to isolate mangiferin was simple, inexpensive, rapid, and efficient. Moreover, we, for the first time, obtained mangiferin with a purity of more than 99.6% using this method.
基金the National Natural Science Foundation of China(No.12075135)the China Postdoctoral Science Foundation(No.2022M721908).
文摘The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting radiopharmaceu-ticals.The production yield and activity of typical medical isotopes were estimated using the FLUKA simulation.The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical radioisotopes.In particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/week.Based on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.
