Deep brain stimulation(DBS)has emerged as a primary therapeutic approach for neurological disorders,including stroke,Alzheimer's disease,and Parkinson's disease.Conventional DBS procedures involve the insertio...Deep brain stimulation(DBS)has emerged as a primary therapeutic approach for neurological disorders,including stroke,Alzheimer's disease,and Parkinson's disease.Conventional DBS procedures involve the insertion of rigid cylindrical electrodes from the cerebral cortex to the subthalamic nucleus(STN).Researchers have successfully developed a new microelectrode with excellent performance by co-doping multi-walled carbon nanotubes(MWCNTs)with ZnO nanoparticles in a polycarbonate matrix to address this limitation.The microelectrode structure was inspired by the bio-mimetic structure of the mosquito maxilla,aiming to minimize insertion-induced tissue damage.Using a custom indentation device for porcine brain tissue puncture tests,the novel electrode showed significant improvements over conventional electrodes:>50%lower insertion force,82%smaller puncture cross-sectional area,and 40%narrower longitudinal width at the same depth.A systematic biocompatibility evaluation demonstrated the microelectrode's outstanding cytocompatibility(cell viability>75%)and longterm stability as an implant.This study established a critical theoretical foundation and advanced technical solutions for developing next-generation microelectrodes that integrate optimal mechanical properties and biosafety.展开更多
基金supported by the National Science Fund of Distinguished Young Scholars(Grant No.51925504)the National Major Scientific Research Instrument Development Project(Grant No.52227810)+2 种基金the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(Grant No.52021003)the Jilin Province Science and Technology Development Plan(Grant No.20220201027GX)the Graduate Innovation Fund of Jilin University(Grant No.2024CX073)。
文摘Deep brain stimulation(DBS)has emerged as a primary therapeutic approach for neurological disorders,including stroke,Alzheimer's disease,and Parkinson's disease.Conventional DBS procedures involve the insertion of rigid cylindrical electrodes from the cerebral cortex to the subthalamic nucleus(STN).Researchers have successfully developed a new microelectrode with excellent performance by co-doping multi-walled carbon nanotubes(MWCNTs)with ZnO nanoparticles in a polycarbonate matrix to address this limitation.The microelectrode structure was inspired by the bio-mimetic structure of the mosquito maxilla,aiming to minimize insertion-induced tissue damage.Using a custom indentation device for porcine brain tissue puncture tests,the novel electrode showed significant improvements over conventional electrodes:>50%lower insertion force,82%smaller puncture cross-sectional area,and 40%narrower longitudinal width at the same depth.A systematic biocompatibility evaluation demonstrated the microelectrode's outstanding cytocompatibility(cell viability>75%)and longterm stability as an implant.This study established a critical theoretical foundation and advanced technical solutions for developing next-generation microelectrodes that integrate optimal mechanical properties and biosafety.
