The performance degradation and even damage of the e-textiles caused by sweat,water,or submersion during all-weather health monitoring are the main reasons that e-textiles have not been commercialized and routinized s...The performance degradation and even damage of the e-textiles caused by sweat,water,or submersion during all-weather health monitoring are the main reasons that e-textiles have not been commercialized and routinized so far.Herein,we developed an amphibious,high-performance,air-permeable,and comfortable all-textile triboelectric sensor for continuous and precise measurement of epidermal pulse waves during full-day activities.Based on the principle of preparing gas by acid-base neutralization reaction,a one-piece preparation process of amphibious conductive yarn(ACY)with densely porous structures is proposed.An innovative three-dimensional(3D)interlocking fabric knitted from ACYs(0.6 mm in diameter)and polytetrafluoroethylene yarns exhibit high sensitivity(0.433 V·kPa^(-1)),wide bandwidth(up to 10 Hz),and stability(>30,000 cycles).With these benefits,98.8%agreement was achieved between wrist pulse waves acquired by the sensor and a high-precision laser vibrometer.Furthermore,the polytetrafluoroethylene yarn with good compression resilience provides sufficient mechanical support for the contact separation of the ACYs.Meanwhile,the unique skeletonized design of the 3D interlocking structure can effectively relieve the water pressure on the sensor surface to obtain stable and accurate pulse waves(underwater depth of 5 cm).This achievement represents an important step in improving the practicality of e-textiles and early diagnosis of cardiovascular diseases.展开更多
Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to...Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to December 2024 were selected and randomly divided into two groups using a random number table.The experimental group(38 patients)received cardiac rehabilitation therapy,while the reference group(38 patients)received conventional drug therapy.The total effective rate,cardiac function indicators,lung function indicators,and pulse wave velocity(PWV)were compared between the two groups.Results:The total effective rate was higher in the experimental group than in the reference group.After treatment,the cardiac and lung function indicators were better in the experimental group than in the reference group,and the PWV was lower in the experimental group(P<0.05).Conclusion:Cardiac rehabilitation therapy for patients with CHF can improve treatment efficacy,enhance cardiopulmonary function,and regulate PWV levels,with high professionalism and feasibility.展开更多
Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the c...Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.展开更多
In certain extracellular environments, there would appear a kind of solitary pulse calcium waves in Rana pipiens sympathetic neurons, propagating inwards along the radial direction from the plasma membrane. To gain a ...In certain extracellular environments, there would appear a kind of solitary pulse calcium waves in Rana pipiens sympathetic neurons, propagating inwards along the radial direction from the plasma membrane. To gain a deeper insight into the waves, a model describing intracellular calcium waves in frog sympathetic neurons was established. In the piecewise linear approximation, the present model is identical to the Sneyd model. Thus, with (Sneyd's) method, analytical expressions for the wave speed and profiles of 1-D solitary pulse wave were obtained. A wave speed of (21.5 μm/s) was deduced, which agrees rather well with experimental data.展开更多
In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking in...In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking into consideration blood's dynamic viscosity and compressibility.Pressure and velocity pulse-wave propagation were investigated through the application of a full-coupling analysis algorithm.The effect of atherosclerosis degree on the propagation characteristics of pulse waves in the bifurcated abdominal aorta was quantitatively analyzed.Arterial bifurcation can cause substantial attenuation on the peak of pressure pulse waveform and an increase in wave velocity during the cardiac cycle.The elastic modulus and bifurcation properties of the arterial wall directly affected the peak value and wave propagation velocity of the pressure pulse wave.The preliminary results of this work will be crucial in guiding the evolution of the pressure pulse wave and the initial diagnosis of atherosclerotic disease through the waveform.展开更多
In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces nove...In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces novel realization of a sensor that us-es a polymer optical multi-mode fiber to sense pulse wave bio-signal from a wrist by analyzing the specklegram mea-sured at the output of the fiber.Applying machine learning techniques over the pulse wave signal allowed medical diag-nostics and recognizing different gestures with accuracy rate of 95%.展开更多
BACKGROUND Cardiorespiratory fitness(CRF)is inversely associated with the risk of cardiovascular disease,which is related to impaired vascular function.However,its relationship with vascular function remains unknown i...BACKGROUND Cardiorespiratory fitness(CRF)is inversely associated with the risk of cardiovascular disease,which is related to impaired vascular function.However,its relationship with vascular function remains unknown in patients with type 2 diabetes.AIM To assess the relationship of CRF with vascular function in type 2 diabetes.METHODS Patients with type 2 diabetes who were aged≥18 years and underwent an incremental and symptom-limited exercise test were included.Vascular function was assessed by the construction of the vascular health index(VHI),which is defined as a composite score of ankle-brachial index,transcutaneous oxygen pressure,pulse wave velocity,and carotid intima-media thickness.Impaired vascular function is defined as a VHI of<8 points.Linear and logistic regression analyses were used to assess the associations.RESULTS We included 343 patients with type 2 diabetes.CRF was positively correlated with VHI(β=0.10,P=0.047),particularly with ankle-brachial index and pulse wave velocity.The odds ratio(OR)of impaired vascular function was 0.44[95%confidence interval(CI):0.20-0.96]for the highest vs the lowest CRF category.For each one metabolic equivalent increase in CRF,the OR of impaired vascular function was 0.73(95%CI:0.57-0.93).CONCLUSION Higher CRF was associated with better vascular function and lower odds of impaired vascular function in patients with type 2 diabetes.展开更多
High-performance flexible pressure sensors have garnered significant attention in fields such as wearable electronics and human-machine interfaces.However,the development of flexible pressure sensors that simultaneous...High-performance flexible pressure sensors have garnered significant attention in fields such as wearable electronics and human-machine interfaces.However,the development of flexible pressure sensors that simultaneously achieve high sensitivity,a wide detection range,and good mechanical stability remains a challenge.In this paper,we propose a flexible piezoresistive pressure sensor based on a Ti_(3)C_(2)Tx(MXene)/polyethylene oxide(PEO)composite nanofiber membrane(CNM).The sensor,utilizing MXene(0.4 wt%)/PEO(5 wt%),exhibits high sensitivity(44.34 kPa^(−1)at 0−50 kPa,12.99 kPa^(−1)at 50−500 kPa)and can reliably monitor physiological signals and other subtle cues.Moreover,the sensor features a wide detection range(0−500 kPa),fast response and recovery time(~150/45 ms),and excellent mechanical stability(over 10000 pressure cycles at maximum load).Through an MXene/PEO sensor array,we demonstrate its applications in human physiological signal monitoring,providing a reliable way to expand the application of MXene-based flexible pressure sensors.展开更多
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular a...The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.展开更多
Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist（QMS） rocks in a cost-effective manner by establishing correla...Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist（QMS） rocks in a cost-effective manner by establishing correlations between non-destructive and destructive tests. Using simple regression analysis, good correlations were obtained between the pulse wave velocities and the properties of QMS rocks. The results were further improved by using multiple regression analysis as compared to those obtained by the simple linear regression analysis. The results were also compared to the ones obtained by other empirical equations available. The general equations encompassing all types of rocks did not give reliable results of rock properties and showed large relative errors, ranging from 23% to 1146%. It is suggested that empirical correlations must be investigated separately for different types of rocks. The general empirical equations should not be used for the design and planning purposes before they are verified at least on one rock sample from the project site, as they may contain large unacceptable errors.展开更多
Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China...Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)from 2011-2018.The ePWV was calculated using an equation that included age and mean blood pressure(MBP).The ΔePWV was assessed as the difference in ePWV between the first two waves.Cox proportional hazard models were used to determine the association between ePWV and ΔePWV with all-cause mortality after adjustment for potential confounders.Results Of 13,116 participants during a median follow-up of 7.0 years,1,356 deaths occurred.An increased ePWV was independently associated with all-cause mortality.The hazard ratio[95% confidence interval(CI)]for participants from the 1^(st)-4^(th) quartile groups was 1.00,1.69(1.31-2.18),3.09(2.44-3.91),and 8.54(6.78-10.75),respectively.Each standard deviation(SD)increment of ePWV increased the risk of all-cause mortality by 132%.Furthermore,theΔePWV was significantly associated with a 1.28-fold(95%CI,1.18-1.38)risk of all-cause mortality per SD increment.Conclusion This cohort study provided novel evidence from a Chinese population that an increased ePWV or progression of the ePWV was independently associated with all-cause mortality,which highlighted the importance of mitigating ePWV progression in clinical practice.展开更多
Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the r...Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were enrolled.The plasma fibulin-1 levels were measured by immunochemistry.Patients with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential confounders.In healthy subjects,no correlation was observed between fibulin-1 levels and CVD risk.This study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.展开更多
Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of...Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.展开更多
Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden dia...Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P<0. 01; 9. 02±1.71 vs 7. 52±1.50, P<0. 01; 8. 69±1. 37 vs 8. 00±1. 27, P<0. 01; 8.52±1. 03 vs 8. 03±1. 2, P<0. 01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC = 0. 818), at the peak point of its ROC curve, the PWV was 8. 32 m/s. PWV>8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.展开更多
Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid a...Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly展开更多
The research presented here is focused on the vibration condition of a small volume solder solder ball,which is placed on the surface of a soldering pad and is exerted a pulse modulated continuous wave laser heat sour...The research presented here is focused on the vibration condition of a small volume solder solder ball,which is placed on the surface of a soldering pad and is exerted a pulse modulated continuous wave laser heat source. Finite element method is applied to analyzed the temperature field in the solder ball, and experi- ment is conducted to test the vibration. the results show that,that, the temperature field flucturates with the same frequency as that of the laser pulse, which in turn causes a forced vibration of the same frequency in the liquid solder ball.展开更多
Based on Womersley' s theory, the frequency equation satisfied by a complex wave velocity of a pulse wave in arteries war generalized to viscoelastic blood, a general formula of the complex wave velocity with rega...Based on Womersley' s theory, the frequency equation satisfied by a complex wave velocity of a pulse wave in arteries war generalized to viscoelastic blood, a general formula of the complex wave velocity with regard to both linearly viscoelastic arteries and linearly viscolelastic blood was obtained, and the effects of the viscoelastic property of blood on the phase velocity and the wave attenuation of the pulse wave using the formula systematically was discussed. It is concluded that the influence of the blood elasticity on the wave propagation of a pulse wave in arteries is weaker than that of the arterial viscosity and may be neglected in larger arteries.展开更多
Based upon the blood vessel of being regarded as the elasticity tube, and that the tissue restricts the blood vessel wall, the rule of pulse wave propagation in blood vessel was studied. The viscosity of blood, the el...Based upon the blood vessel of being regarded as the elasticity tube, and that the tissue restricts the blood vessel wall, the rule of pulse wave propagation in blood vessel was studied. The viscosity of blood, the elastic modulus of blood vessel, the radius of tube that influenced the pulse wave propagation were analyzed. Comparing the result that considered the viscosity of blood with another result that did not consider the viscosity of blood, we finally discover that the viscosity of blood that influences the pulse wave propagation can not be neglected; and with the accretion of the elastic modulus the speed of propagation augments and the press value of blood stream heightens; when diameter of blood vessel reduces, the press of blood stream also heightens and the speed of pulse wave also augments. These results will contribute to making use of the information of pulse wave to analyse and auxiliarily diagnose some causes of human disease.展开更多
BACKGROUND Heart rate variability(HRV) and pulse-wave velocity(PWV),indicators of cardiac function,are altered in patients with spinal cord injury(SCI),suggesting that autonomic cardiac function and arterial stiffness...BACKGROUND Heart rate variability(HRV) and pulse-wave velocity(PWV),indicators of cardiac function,are altered in patients with spinal cord injury(SCI),suggesting that autonomic cardiac function and arterial stiffness may underlie the high risk of cardiovascular complications in these patients.No study has simultaneously investigated HRV and PWV in the same patients.AIM To evaluate cardiovascular complications in SCI patients by comparing HRV and PWV between patients with and without SCI.METHODS In this cross-sectional pilot study,patients with(n = 60) and without SCI(n = 60) were recruited from December 7,2019 to January 21,2020.Each participant received a five-minute assessment of HRV and the cardiovascular system using the Medicore HRV Analyzer SA-3000 P.Differences in HRV and PWV parameters between participants with and without SCI were statistically examined.RESULTS We observed a significant difference between participants with and without SCI with respect to the standard deviation of all normal-to-normal intervals,square root of the mean sum of squared successive risk ratio interval differences,physical stress index,total power,very-low frequency,low frequency,high frequency,and arterial elasticity.CONCLUSION Patients with SCI have weaker sympathetic and parasympathetic activity as well as lower arterial elasticity compared to those without,suggesting that SCI may increase cardiac function loading.展开更多
The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity （baPWV）, and the presence of the metabolic syndrome （MS） in a Chinese populati...The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity （baPWV）, and the presence of the metabolic syndrome （MS） in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in for the general population, males and females, respectively. our study population was 21.7%, 17.2% and 25.6% With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein （LDL） cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure （P 〈 0.001）, diastolic blood pressure （P 〈 0.001）, glucose （P 〈 0.001）, highdensity lipoprotein （HDL） cholesterol （P = 0.04）, and triglycerides （P 〈 0.001）, but no relationship with waist circumference （P = 0.25）. With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.展开更多
基金supported by the National Key Research and Development Program of China(No.2021YFA1201600)the Natural Science Foundation Projects of Chongqing(No.cstc2022ycjh-bgzxm0206)the Natural Science Foundation of Innovative Research Groups(No.cstc2020jcyj-cxttX0005).
文摘The performance degradation and even damage of the e-textiles caused by sweat,water,or submersion during all-weather health monitoring are the main reasons that e-textiles have not been commercialized and routinized so far.Herein,we developed an amphibious,high-performance,air-permeable,and comfortable all-textile triboelectric sensor for continuous and precise measurement of epidermal pulse waves during full-day activities.Based on the principle of preparing gas by acid-base neutralization reaction,a one-piece preparation process of amphibious conductive yarn(ACY)with densely porous structures is proposed.An innovative three-dimensional(3D)interlocking fabric knitted from ACYs(0.6 mm in diameter)and polytetrafluoroethylene yarns exhibit high sensitivity(0.433 V·kPa^(-1)),wide bandwidth(up to 10 Hz),and stability(>30,000 cycles).With these benefits,98.8%agreement was achieved between wrist pulse waves acquired by the sensor and a high-precision laser vibrometer.Furthermore,the polytetrafluoroethylene yarn with good compression resilience provides sufficient mechanical support for the contact separation of the ACYs.Meanwhile,the unique skeletonized design of the 3D interlocking structure can effectively relieve the water pressure on the sensor surface to obtain stable and accurate pulse waves(underwater depth of 5 cm).This achievement represents an important step in improving the practicality of e-textiles and early diagnosis of cardiovascular diseases.
基金Study on the Efficacy and Safety of Hyperbaric Oxygen Therapy Combined with Exercise in Improving Heart Rate Variability in Patients with Stable Chronic Cardiac Insufficiency(Project No.:2023-E-49)。
文摘Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to December 2024 were selected and randomly divided into two groups using a random number table.The experimental group(38 patients)received cardiac rehabilitation therapy,while the reference group(38 patients)received conventional drug therapy.The total effective rate,cardiac function indicators,lung function indicators,and pulse wave velocity(PWV)were compared between the two groups.Results:The total effective rate was higher in the experimental group than in the reference group.After treatment,the cardiac and lung function indicators were better in the experimental group than in the reference group,and the PWV was lower in the experimental group(P<0.05).Conclusion:Cardiac rehabilitation therapy for patients with CHF can improve treatment efficacy,enhance cardiopulmonary function,and regulate PWV levels,with high professionalism and feasibility.
基金the EU RTN Haemodel Project(contract number HPRN-CT-2002-00270)and by an EPSRC Advanced Research Fellowship.
文摘Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.
文摘In certain extracellular environments, there would appear a kind of solitary pulse calcium waves in Rana pipiens sympathetic neurons, propagating inwards along the radial direction from the plasma membrane. To gain a deeper insight into the waves, a model describing intracellular calcium waves in frog sympathetic neurons was established. In the piecewise linear approximation, the present model is identical to the Sneyd model. Thus, with (Sneyd's) method, analytical expressions for the wave speed and profiles of 1-D solitary pulse wave were obtained. A wave speed of (21.5 μm/s) was deduced, which agrees rather well with experimental data.
基金supported by the National Natural Science Foundation of China(Grant No.11872218)Zhejiang Provincial Natural Science Foundation Key Projects(Grant No.LZ23A020001)+2 种基金the National Natural Science Foundation of China Regional Innovation Key Project(Grant No.U21A20502)Zhejiang Province Traditional Chinese Medicine Science and Technology Foundation(Grant No.2022ZB317)the first batch of Medical and Health Brand Discipline Foundation in Ningbo(Grant No.PPXK2018-07)。
文摘In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking into consideration blood's dynamic viscosity and compressibility.Pressure and velocity pulse-wave propagation were investigated through the application of a full-coupling analysis algorithm.The effect of atherosclerosis degree on the propagation characteristics of pulse waves in the bifurcated abdominal aorta was quantitatively analyzed.Arterial bifurcation can cause substantial attenuation on the peak of pressure pulse waveform and an increase in wave velocity during the cardiac cycle.The elastic modulus and bifurcation properties of the arterial wall directly affected the peak value and wave propagation velocity of the pressure pulse wave.The preliminary results of this work will be crucial in guiding the evolution of the pressure pulse wave and the initial diagnosis of atherosclerotic disease through the waveform.
文摘In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces novel realization of a sensor that us-es a polymer optical multi-mode fiber to sense pulse wave bio-signal from a wrist by analyzing the specklegram mea-sured at the output of the fiber.Applying machine learning techniques over the pulse wave signal allowed medical diag-nostics and recognizing different gestures with accuracy rate of 95%.
基金Supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2024ZD0523303the Funding for Pairing Support to Jiangsu High-Level Hospitals-Zhongda Hospital,No.ZDLYG19the Key Research and Development Program in Jiangsu Province,No.BE2022828.
文摘BACKGROUND Cardiorespiratory fitness(CRF)is inversely associated with the risk of cardiovascular disease,which is related to impaired vascular function.However,its relationship with vascular function remains unknown in patients with type 2 diabetes.AIM To assess the relationship of CRF with vascular function in type 2 diabetes.METHODS Patients with type 2 diabetes who were aged≥18 years and underwent an incremental and symptom-limited exercise test were included.Vascular function was assessed by the construction of the vascular health index(VHI),which is defined as a composite score of ankle-brachial index,transcutaneous oxygen pressure,pulse wave velocity,and carotid intima-media thickness.Impaired vascular function is defined as a VHI of<8 points.Linear and logistic regression analyses were used to assess the associations.RESULTS We included 343 patients with type 2 diabetes.CRF was positively correlated with VHI(β=0.10,P=0.047),particularly with ankle-brachial index and pulse wave velocity.The odds ratio(OR)of impaired vascular function was 0.44[95%confidence interval(CI):0.20-0.96]for the highest vs the lowest CRF category.For each one metabolic equivalent increase in CRF,the OR of impaired vascular function was 0.73(95%CI:0.57-0.93).CONCLUSION Higher CRF was associated with better vascular function and lower odds of impaired vascular function in patients with type 2 diabetes.
基金support from Beijing Natural Science Foundation−Xiaomi Innovation Joint Fund(Grant No.L233009)the National Natural Science Foundation of China(NSFC Grant Nos.62422409,62174152 and 62374159)from the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2020115).
文摘High-performance flexible pressure sensors have garnered significant attention in fields such as wearable electronics and human-machine interfaces.However,the development of flexible pressure sensors that simultaneously achieve high sensitivity,a wide detection range,and good mechanical stability remains a challenge.In this paper,we propose a flexible piezoresistive pressure sensor based on a Ti_(3)C_(2)Tx(MXene)/polyethylene oxide(PEO)composite nanofiber membrane(CNM).The sensor,utilizing MXene(0.4 wt%)/PEO(5 wt%),exhibits high sensitivity(44.34 kPa^(−1)at 0−50 kPa,12.99 kPa^(−1)at 50−500 kPa)and can reliably monitor physiological signals and other subtle cues.Moreover,the sensor features a wide detection range(0−500 kPa),fast response and recovery time(~150/45 ms),and excellent mechanical stability(over 10000 pressure cycles at maximum load).Through an MXene/PEO sensor array,we demonstrate its applications in human physiological signal monitoring,providing a reliable way to expand the application of MXene-based flexible pressure sensors.
文摘The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.
文摘Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist（QMS） rocks in a cost-effective manner by establishing correlations between non-destructive and destructive tests. Using simple regression analysis, good correlations were obtained between the pulse wave velocities and the properties of QMS rocks. The results were further improved by using multiple regression analysis as compared to those obtained by the simple linear regression analysis. The results were also compared to the ones obtained by other empirical equations available. The general equations encompassing all types of rocks did not give reliable results of rock properties and showed large relative errors, ranging from 23% to 1146%. It is suggested that empirical correlations must be investigated separately for different types of rocks. The general empirical equations should not be used for the design and planning purposes before they are verified at least on one rock sample from the project site, as they may contain large unacceptable errors.
基金supported by the National Key R&D Program of China[2021YFC2500500]Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences[2021-I2M-1-010]+2 种基金the National Natural Science Foundation of China[82073658]the Taikang Yicai Public Health and Epidemic Control Fund[TKYC-GW-2020]the Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers of the Chinese Academy of Medical Sciences[2019RU038]。
文摘Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)from 2011-2018.The ePWV was calculated using an equation that included age and mean blood pressure(MBP).The ΔePWV was assessed as the difference in ePWV between the first two waves.Cox proportional hazard models were used to determine the association between ePWV and ΔePWV with all-cause mortality after adjustment for potential confounders.Results Of 13,116 participants during a median follow-up of 7.0 years,1,356 deaths occurred.An increased ePWV was independently associated with all-cause mortality.The hazard ratio[95% confidence interval(CI)]for participants from the 1^(st)-4^(th) quartile groups was 1.00,1.69(1.31-2.18),3.09(2.44-3.91),and 8.54(6.78-10.75),respectively.Each standard deviation(SD)increment of ePWV increased the risk of all-cause mortality by 132%.Furthermore,theΔePWV was significantly associated with a 1.28-fold(95%CI,1.18-1.38)risk of all-cause mortality per SD increment.Conclusion This cohort study provided novel evidence from a Chinese population that an increased ePWV or progression of the ePWV was independently associated with all-cause mortality,which highlighted the importance of mitigating ePWV progression in clinical practice.
文摘Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were enrolled.The plasma fibulin-1 levels were measured by immunochemistry.Patients with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential confounders.In healthy subjects,no correlation was observed between fibulin-1 levels and CVD risk.This study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.
基金supported by the Key Laboratory for Endocrine and Metabolic Diseases,Ministry of Health(1994DP131044)National Nature Science Foundation of China(81170739,81170719,81222008,81370960)+3 种基金Shanghai New Excellent Youth Program(XYQ2011009)Shanghai Health Bureau(2011293)EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)Shanghai Shen Kang Hospital Development Center(SHDC12012301)
文摘Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
文摘Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P<0. 01; 9. 02±1.71 vs 7. 52±1.50, P<0. 01; 8. 69±1. 37 vs 8. 00±1. 27, P<0. 01; 8.52±1. 03 vs 8. 03±1. 2, P<0. 01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC = 0. 818), at the peak point of its ROC curve, the PWV was 8. 32 m/s. PWV>8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.
文摘Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly
文摘The research presented here is focused on the vibration condition of a small volume solder solder ball,which is placed on the surface of a soldering pad and is exerted a pulse modulated continuous wave laser heat source. Finite element method is applied to analyzed the temperature field in the solder ball, and experi- ment is conducted to test the vibration. the results show that,that, the temperature field flucturates with the same frequency as that of the laser pulse, which in turn causes a forced vibration of the same frequency in the liquid solder ball.
文摘Based on Womersley' s theory, the frequency equation satisfied by a complex wave velocity of a pulse wave in arteries war generalized to viscoelastic blood, a general formula of the complex wave velocity with regard to both linearly viscoelastic arteries and linearly viscolelastic blood was obtained, and the effects of the viscoelastic property of blood on the phase velocity and the wave attenuation of the pulse wave using the formula systematically was discussed. It is concluded that the influence of the blood elasticity on the wave propagation of a pulse wave in arteries is weaker than that of the arterial viscosity and may be neglected in larger arteries.
文摘Based upon the blood vessel of being regarded as the elasticity tube, and that the tissue restricts the blood vessel wall, the rule of pulse wave propagation in blood vessel was studied. The viscosity of blood, the elastic modulus of blood vessel, the radius of tube that influenced the pulse wave propagation were analyzed. Comparing the result that considered the viscosity of blood with another result that did not consider the viscosity of blood, we finally discover that the viscosity of blood that influences the pulse wave propagation can not be neglected; and with the accretion of the elastic modulus the speed of propagation augments and the press value of blood stream heightens; when diameter of blood vessel reduces, the press of blood stream also heightens and the speed of pulse wave also augments. These results will contribute to making use of the information of pulse wave to analyse and auxiliarily diagnose some causes of human disease.
文摘BACKGROUND Heart rate variability(HRV) and pulse-wave velocity(PWV),indicators of cardiac function,are altered in patients with spinal cord injury(SCI),suggesting that autonomic cardiac function and arterial stiffness may underlie the high risk of cardiovascular complications in these patients.No study has simultaneously investigated HRV and PWV in the same patients.AIM To evaluate cardiovascular complications in SCI patients by comparing HRV and PWV between patients with and without SCI.METHODS In this cross-sectional pilot study,patients with(n = 60) and without SCI(n = 60) were recruited from December 7,2019 to January 21,2020.Each participant received a five-minute assessment of HRV and the cardiovascular system using the Medicore HRV Analyzer SA-3000 P.Differences in HRV and PWV parameters between participants with and without SCI were statistically examined.RESULTS We observed a significant difference between participants with and without SCI with respect to the standard deviation of all normal-to-normal intervals,square root of the mean sum of squared successive risk ratio interval differences,physical stress index,total power,very-low frequency,low frequency,high frequency,and arterial elasticity.CONCLUSION Patients with SCI have weaker sympathetic and parasympathetic activity as well as lower arterial elasticity compared to those without,suggesting that SCI may increase cardiac function loading.
基金support by grants from the National Key TechnologiesR&D Program of China during the 11th Five-Year Plan Period(2007BAI07A10)the Jiangsu Province Science and TechnologySupport Program(BE2009613)the 9th Six Talents Peak Project ofJiangsu Province(WS-022),and the Qing Lan Project
文摘The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity （baPWV）, and the presence of the metabolic syndrome （MS） in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in for the general population, males and females, respectively. our study population was 21.7%, 17.2% and 25.6% With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein （LDL） cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure （P 〈 0.001）, diastolic blood pressure （P 〈 0.001）, glucose （P 〈 0.001）, highdensity lipoprotein （HDL） cholesterol （P = 0.04）, and triglycerides （P 〈 0.001）, but no relationship with waist circumference （P = 0.25）. With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.
