Objective: to analyze the improvement effect of seretide on pulmonary ventilation function in patients with chronic obstructive pulmonary disease and respiratory failure. Methods: 94 patients with chronic obstructive ...Objective: to analyze the improvement effect of seretide on pulmonary ventilation function in patients with chronic obstructive pulmonary disease and respiratory failure. Methods: 94 patients with chronic obstructive pulmonary disease combined with respiratory failure were selected from December 2017 to December 2019. All cases were randomly divided into equal numbers. The experimental group (47 cases) was treated with seretide, while the control group (47 cases) was treated with conventional therapy. The improvement effect of pulmonary ventilation function in the two groups was analyzed. Results: after treatment, the scores of V1, FVC and V1/FVC in the experimental group were significantly better than those in the control group (P < 0.05). Conclusion: seretide improves the pulmonary ventilation function of patients with chronic obstructive pulmonary disease and respiratory failure through the mechanism of drug action.展开更多
Background The assessment of regional pulmonary ventilation and perfusion is essential for the evaluation of a variety of lung disorders. Pulmonary ventilation MRI using inhaled oxygen as a contrast medium can be obt...Background The assessment of regional pulmonary ventilation and perfusion is essential for the evaluation of a variety of lung disorders. Pulmonary ventilation MRI using inhaled oxygen as a contrast medium can be obtained with a clinical MR scanner, without additional equipment, and has been demonstrated to be a feasible means of assessing ventilation in animal models and some clinical patients. However, few studies have reported on MR ventilation-perfusion imaging. In this study, we evaluated the usefulness of oxygen-enhanced ventilation in combination with first-pass Gd-DTPA-enhanced perfusion MRI in a canine model of pulmonary embolism and airway obstruction.Methods Peripheral pulmonary embolisms were produced in eight dogs by intravenous injection of gelfoam strips at the pulmonary segmental arterial level, and airway obstructions were created in five of the dogs by inserting a self-designed balloon catheter into a secondary bronchus. Oxygen-enhanced MR ventilation images were produced by subtracting images from before and after inhalation of pure oxygen. Pulmonary perfusion MR images were acquired with a dynamic three-dimensional fast gradient-echo sequence. MR ventilation and perfusion images were read and contrasted with results from general examinations of pathological anatomy, ventilation-perfusion scintigraphy, and pulmonary angiography. Results Regions identified as having airway obstructions matched using both MR ventilation and perfusion imaging, but regions of pulmonary embolisms were mismatched. The area of airway obstruction defects was smaller using MR ventilation imagery than that using ventilation scintigraphy. Abnormal perfusion regions due to pulmonary embolisms were divided into defective regions and reduced regions based on the time course of signal intensity changes. In the diagnosis of pulmonary embolisms with the technique of ventilation and perfusion MRI, sensitivity and specificity were 75.0% and 98.1%, respectively, and the diagnostic results of this MRI technique were in agreement with the results of ventilation-perfusion scintigraphy and pulmonary angiography (K: 0.899, 0.743).Conclusions Oxygen-enhanced ventilation in combination with pulmonary perfusion MRI can be used to diagnose abnormalities of airways and blood vessels in the lungs, and can provide regional functional information with high spatial and temporal resolution. This method possesses great potential value for clinical applications. F展开更多
文摘Objective: to analyze the improvement effect of seretide on pulmonary ventilation function in patients with chronic obstructive pulmonary disease and respiratory failure. Methods: 94 patients with chronic obstructive pulmonary disease combined with respiratory failure were selected from December 2017 to December 2019. All cases were randomly divided into equal numbers. The experimental group (47 cases) was treated with seretide, while the control group (47 cases) was treated with conventional therapy. The improvement effect of pulmonary ventilation function in the two groups was analyzed. Results: after treatment, the scores of V1, FVC and V1/FVC in the experimental group were significantly better than those in the control group (P < 0.05). Conclusion: seretide improves the pulmonary ventilation function of patients with chronic obstructive pulmonary disease and respiratory failure through the mechanism of drug action.
基金ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (No 3 0 2 0 0 0 66)andtheKeyClinicalSubjectFoundationoftheMinistryofHealthofChina (No .2 0 0 12 0 2 8)
文摘Background The assessment of regional pulmonary ventilation and perfusion is essential for the evaluation of a variety of lung disorders. Pulmonary ventilation MRI using inhaled oxygen as a contrast medium can be obtained with a clinical MR scanner, without additional equipment, and has been demonstrated to be a feasible means of assessing ventilation in animal models and some clinical patients. However, few studies have reported on MR ventilation-perfusion imaging. In this study, we evaluated the usefulness of oxygen-enhanced ventilation in combination with first-pass Gd-DTPA-enhanced perfusion MRI in a canine model of pulmonary embolism and airway obstruction.Methods Peripheral pulmonary embolisms were produced in eight dogs by intravenous injection of gelfoam strips at the pulmonary segmental arterial level, and airway obstructions were created in five of the dogs by inserting a self-designed balloon catheter into a secondary bronchus. Oxygen-enhanced MR ventilation images were produced by subtracting images from before and after inhalation of pure oxygen. Pulmonary perfusion MR images were acquired with a dynamic three-dimensional fast gradient-echo sequence. MR ventilation and perfusion images were read and contrasted with results from general examinations of pathological anatomy, ventilation-perfusion scintigraphy, and pulmonary angiography. Results Regions identified as having airway obstructions matched using both MR ventilation and perfusion imaging, but regions of pulmonary embolisms were mismatched. The area of airway obstruction defects was smaller using MR ventilation imagery than that using ventilation scintigraphy. Abnormal perfusion regions due to pulmonary embolisms were divided into defective regions and reduced regions based on the time course of signal intensity changes. In the diagnosis of pulmonary embolisms with the technique of ventilation and perfusion MRI, sensitivity and specificity were 75.0% and 98.1%, respectively, and the diagnostic results of this MRI technique were in agreement with the results of ventilation-perfusion scintigraphy and pulmonary angiography (K: 0.899, 0.743).Conclusions Oxygen-enhanced ventilation in combination with pulmonary perfusion MRI can be used to diagnose abnormalities of airways and blood vessels in the lungs, and can provide regional functional information with high spatial and temporal resolution. This method possesses great potential value for clinical applications. F
