为提高4K广电素材云传输过程的安全性和效率,文章提出一种融合私有安全传输协议(Private Secure Media Communication,PSMC)和网络切片的4K广电素材云传输多层级深度安全隔离方法。该方法设计PSMC协议格式,利用其中的身份认证机制,建立...为提高4K广电素材云传输过程的安全性和效率,文章提出一种融合私有安全传输协议(Private Secure Media Communication,PSMC)和网络切片的4K广电素材云传输多层级深度安全隔离方法。该方法设计PSMC协议格式,利用其中的身份认证机制,建立客户端(Client)与接收端(Recipient)之间传输链路,然后通过加密算法生成会话密钥,继而生成双方的加/解密密钥和认/验证密钥,实现4K广电素材加密传输。该方法将加密后的4K广电素材通过网络切片,建立多层级传输通道,将不同类型的4K广电素材通过不同的网络切片进行传输,同时通过人工蜂群算法实时优化网络切片资源分配,提高资源利用率。结果表明:文章所研究方法的安全隔离强度在20 h内始终保持在0.960以上,且50路并发流的传输仅需要1.8 s,显著高于传统方法,由此证明了文章所研究方法的安全性和数据效率。展开更多
Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common ...Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common type of gene alteration,gene fusion plays an important role in the pathogenesis and progression of tumors.In this study,we report a novel osteosarcoma-associated fusion gene,EWSR1-PSMC5,found in patients insensitive to chemotherapy.This gene is a novel fusion mode and has been found to play an important role in autophagy activation.The fusion gene may lead to the activation of autophagy through various signaling pathways,thus leading to the development of osteosarcoma resistance.We report this new fusion mode for the first time,and it should be noted that there is a less common report of EWSR1-related fusion gene in osteosarcoma.展开更多
基金supported by the National Natural Science Foundation of China(No.82072979).
文摘Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common type of gene alteration,gene fusion plays an important role in the pathogenesis and progression of tumors.In this study,we report a novel osteosarcoma-associated fusion gene,EWSR1-PSMC5,found in patients insensitive to chemotherapy.This gene is a novel fusion mode and has been found to play an important role in autophagy activation.The fusion gene may lead to the activation of autophagy through various signaling pathways,thus leading to the development of osteosarcoma resistance.We report this new fusion mode for the first time,and it should be noted that there is a less common report of EWSR1-related fusion gene in osteosarcoma.
