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Electropolymerized dopamine-based memristors using threshold switching behaviors for artificial current-activated spiking neurons 被引量:1
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作者 Bowen Zhong Xiaokun Qin +4 位作者 Zhexin Li Yiqiang Zheng Lingchen Liu Zheng Lou Lili Wang 《Journal of Semiconductors》 2025年第2期98-103,共6页
Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely us... Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems. 展开更多
关键词 ELECTROPOLYMERIZATION POLYDOPAMINE MEMRISTOR threshold switching spiking voltage artificial neuron
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A Trusted Distributed Oracle Scheme Based on Share Recovery Threshold Signature 被引量:1
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作者 Shihao Wang Xuehui Du +4 位作者 Xiangyu Wu Qiantao Yang Wenjuan Wang Yu Cao Aodi Liu 《Computers, Materials & Continua》 2025年第2期3355-3379,共25页
With the increasing popularity of blockchain applications, the security of data sources on the blockchain is gradually receiving attention. Providing reliable data for the blockchain safely and efficiently has become ... With the increasing popularity of blockchain applications, the security of data sources on the blockchain is gradually receiving attention. Providing reliable data for the blockchain safely and efficiently has become a research hotspot, and the security of the oracle responsible for providing reliable data has attracted much attention. The most widely used centralized oracles in blockchain, such as Provable and Town Crier, all rely on a single oracle to obtain data, which suffers from a single point of failure and limits the large-scale development of blockchain. To this end, the distributed oracle scheme is put forward, but the existing distributed oracle schemes such as Chainlink and Augur generally have low execution efficiency and high communication overhead, which leads to their poor applicability. To solve the above problems, this paper proposes a trusted distributed oracle scheme based on a share recovery threshold signature. First, a data verification method of distributed oracles is designed based on threshold signature. By aggregating the signatures of oracles, data from different data sources can be mutually verified, leading to a more efficient data verification and aggregation process. Then, a credibility-based cluster head election algorithm is designed, which reduces the communication overhead by clarifying the function distribution and building a hierarchical structure. Considering the good performance of the BLS threshold signature in large-scale applications, this paper combines it with distributed oracle technology and proposes a BLS threshold signature algorithm that supports share recovery in distributed oracles. The share recovery mechanism enables the proposed scheme to solve the key loss issue, and the setting of the threshold value enables the proposed scheme to complete signature aggregation with only a threshold number of oracles, making the scheme more robust. Finally, experimental results indicate that, by using the threshold signature technology and the cluster head election algorithm, our scheme effectively improves the execution efficiency of oracles and solves the problem of a single point of failure, leading to higher scalability and robustness. 展开更多
关键词 Blockchain threshold signature distributed oracle data submission share recovery
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Relationship between Cortical Auditory Evoked Potential (CAEP) Responses and Behavioral Thresholds in Children with Sensorineural Hearing Loss
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作者 Hee Yen Tan Wendi Shi Yonghua Wang 《Journal of Biosciences and Medicines》 2025年第2期480-490,共11页
Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (m... Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations. 展开更多
关键词 Cortical Auditory Evoked Potentials Behavioral thresholds Sensorineural Hearing Loss Hearing threshold Estimation
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Synaptic pruning mechanisms and application of emerging imaging techniques in neurological disorders
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作者 Yakang Xing Yi Mo +1 位作者 Qihui Chen Xiao Li 《Neural Regeneration Research》 2026年第5期1698-1714,共17页
Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience... Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders. 展开更多
关键词 CHEMOKINE COMPLEMENT experience-dependent driven synaptic pruning imaging techniques NEUROGLIA signaling pathways synapse elimination synaptic pruning
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SFPBL:Soft Filter Pruning Based on Logistic Growth Differential Equation for Neural Network
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作者 Can Hu Shanqing Zhang +2 位作者 Kewei Tao Gaoming Yang Li Li 《Computers, Materials & Continua》 2025年第3期4913-4930,共18页
The surge of large-scale models in recent years has led to breakthroughs in numerous fields,but it has also introduced higher computational costs and more complex network architectures.These increasingly large and int... The surge of large-scale models in recent years has led to breakthroughs in numerous fields,but it has also introduced higher computational costs and more complex network architectures.These increasingly large and intricate networks pose challenges for deployment and execution while also exacerbating the issue of network over-parameterization.To address this issue,various network compression techniques have been developed,such as network pruning.A typical pruning algorithm follows a three-step pipeline involving training,pruning,and retraining.Existing methods often directly set the pruned filters to zero during retraining,significantly reducing the parameter space.However,this direct pruning strategy frequently results in irreversible information loss.In the early stages of training,a network still contains much uncertainty,and evaluating filter importance may not be sufficiently rigorous.To manage the pruning process effectively,this paper proposes a flexible neural network pruning algorithm based on the logistic growth differential equation,considering the characteristics of network training.Unlike other pruning algorithms that directly reduce filter weights,this algorithm introduces a three-stage adaptive weight decay strategy inspired by the logistic growth differential equation.It employs a gentle decay rate in the initial training stage,a rapid decay rate during the intermediate stage,and a slower decay rate in the network convergence stage.Additionally,the decay rate is adjusted adaptively based on the filter weights at each stage.By controlling the adaptive decay rate at each stage,the pruning of neural network filters can be effectively managed.In experiments conducted on the CIFAR-10 and ILSVRC-2012 datasets,the pruning of neural networks significantly reduces the floating-point operations while maintaining the same pruning rate.Specifically,when implementing a 30%pruning rate on the ResNet-110 network,the pruned neural network not only decreases floating-point operations by 40.8%but also enhances the classification accuracy by 0.49%compared to the original network. 展开更多
关键词 Filter pruning channel pruning CNN complexity deep neural networks filtering theory logistic model
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A hybrid approach for estimating hydro-geomorphological rainfall thresholds to shallow landslides
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作者 Francesco FUSCO 《Journal of Mountain Science》 2025年第11期4072-4092,共21页
The societal risk related to rainfalltriggered rapid debris flows is commonly managed in urbanized areas by means of early warning systems based on monitoring of hydrological parameters(such as rainfall or soil moistu... The societal risk related to rainfalltriggered rapid debris flows is commonly managed in urbanized areas by means of early warning systems based on monitoring of hydrological parameters(such as rainfall or soil moisture) and thresholds values.In Alpine catchments,this type of landslides is recurrent and represent one of the major geohazards.Debris flows are typically initiated by high-intensity rainstorms,prolonged rainfall with moderate intensity or snow melting.They frequently happen in situations of temporary infiltration into soils that are initially unsaturated.During significant rainfall events,the rise in pore water pressure can become crucial for the stability of slopes in particular areas.This phenomenon relies on hydraulic and geotechnical characteristics,along with the thickness of the involved soils.This procedure can result in a local drop in shear strength,as both apparent cohesion and effective stress decline,while driving forces rise because of the increase in unit weight.Accordingly,this study estimates Intensity-Duration(I-D) rainfall thresholds at the site-specific and distributed scales by combining empirical and physics-based approaches and modeling of soil coverings involved in soil slips or debris slides inducing debris flows.The approach was tested for mountain slopes of the Valtellina valley(Lombardia region,northern Italy),which suffered several catastrophic landslide events in the last decades.The empirical approach was adopted to reconstruct physics-based slope models of representative source areas of past debris flows events.To such a scope,nonpunctual but distributed data of hydro-mechanical soil properties and thicknesses were considered.Thus,to reconstruct the unsaturated/saturated critical conditions leading the slope instability,a combined hydrological modeling and infinite-slope stability analysis was adopted.This combined hydromechanical numerical model was used to attempt to determine a three-dimensional Intensity-Duration threshold for landslide initiation considering plausible rainfall for the Valtellina valley.Due to the lack of reliable records of past landslide hindering a thorough empirical analysis,the presented approach can be considered as a feasible approach for establishing a warning standard in urbanized areas at risk of shallow landslides triggered by rainfall.Moreover,findings highlight the importance of having access to spatially distributed soil characteristics to define and enhance input data for physics-based modelling.Finally,the proposed approach can aid an early warning system for the onset of shallow landslides by utilizing real-time rainfall monitoring or now-casting through a meteorological radar technique. 展开更多
关键词 Shallow landslides Debris flow Physics-based approach Rainfall thresholds Three-dimensional thresholds
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Hierarchical Shape Pruning for 3D Sparse Convolution Networks
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作者 Haiyan Long Chonghao Zhang +2 位作者 Xudong Qiu Hai Chen Gang Chen 《Computers, Materials & Continua》 2025年第8期2975-2988,共14页
3D sparse convolution has emerged as a pivotal technique for efficient voxel-based perception in autonomous systems,enabling selective feature extraction from non-empty voxels while suppressing computational waste.Des... 3D sparse convolution has emerged as a pivotal technique for efficient voxel-based perception in autonomous systems,enabling selective feature extraction from non-empty voxels while suppressing computational waste.Despite its theoretical efficiency advantages,practical implementations face under-explored limitations:the fixed geometric patterns of conventional sparse convolutional kernels inevitably process non-contributory positions during sliding-window operations,particularly in regions with uneven point cloud density.To address this,we propose Hierarchical Shape Pruning for 3D Sparse Convolution(HSP-S),which dynamically eliminates redundant kernel stripes through layer-adaptive thresholding.Unlike static soft pruning methods,HSP-S maintains trainable sparsity patterns by progressively adjusting pruning thresholds during optimization,enlarging original parameter search space while removing redundant operations.Extensive experiments validate effectiveness of HSP-S acrossmajor autonomous driving benchmarks.On KITTI’s 3D object detection task,our method reduces 93.47%redundant kernel computations whilemaintaining comparable accuracy(1.56%mAP drop).Remarkably,on themore complexNuScenes benchmark,HSP-S achieves simultaneous computation reduction(21.94%sparsity)and accuracy gains(1.02%mAP(mean Average Precision)and 0.47%NDS(nuScenes detection score)improvement),demonstrating its scalability to diverse perception scenarios.This work establishes the first learnable shape pruning framework that simultaneously enhances computational efficiency and preserves detection accuracy in 3D perception systems. 展开更多
关键词 Shape pruning model compressing 3D sparse convolution
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Optimizing BERT for Bengali Emotion Classification: Evaluating Knowledge Distillation, Pruning, and Quantization
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作者 Md Hasibur Rahman Mohammed Arif Uddin +1 位作者 Zinnat Fowzia Ria Rashedur M.Rahman 《Computer Modeling in Engineering & Sciences》 2025年第2期1637-1666,共30页
The rapid growth of digital data necessitates advanced natural language processing(NLP)models like BERT(Bidi-rectional Encoder Representations from Transformers),known for its superior performance in text classificati... The rapid growth of digital data necessitates advanced natural language processing(NLP)models like BERT(Bidi-rectional Encoder Representations from Transformers),known for its superior performance in text classification.However,BERT’s size and computational demands limit its practicality,especially in resource-constrained settings.This research compresses the BERT base model for Bengali emotion classification through knowledge distillation(KD),pruning,and quantization techniques.Despite Bengali being the sixth most spoken language globally,NLP research in this area is limited.Our approach addresses this gap by creating an efficient BERT-based model for Bengali text.We have explored 20 combinations for KD,quantization,and pruning,resulting in improved speedup,fewer parameters,and reduced memory size.Our best results demonstrate significant improvements in both speed and efficiency.For instance,in the case of mBERT,we achieved a 3.87×speedup and 4×compression ratio with a combination of Distil+Prune+Quant that reduced parameters from 178 to 46 M,while the memory size decreased from 711 to 178 MB.These results offer scalable solutions for NLP tasks in various languages and advance the field of model compression,making these models suitable for real-world applications in resource-limited environments. 展开更多
关键词 Bengali NLP black-box distillation emotion classification model compression post-training quantization unstructured pruning
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Greedy Pruning Algorithm for DETR Architecture Networks Based on Global Optimization
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作者 HUANG Qiubo XU Jingsai +2 位作者 ZHANG Yakui WANG Mei CHEN Dehua 《Journal of Donghua University(English Edition)》 2025年第1期96-105,共10页
End-to-end object detection Transformer(DETR)successfully established the paradigm of the Transformer architecture in the field of object detection.Its end-to-end detection process and the idea of set prediction have ... End-to-end object detection Transformer(DETR)successfully established the paradigm of the Transformer architecture in the field of object detection.Its end-to-end detection process and the idea of set prediction have become one of the hottest network architectures in recent years.There has been an abundance of work improving upon DETR.However,DETR and its variants require a substantial amount of memory resources and computational costs,and the vast number of parameters in these networks is unfavorable for model deployment.To address this issue,a greedy pruning(GP)algorithm is proposed,applied to a variant denoising-DETR(DN-DETR),which can eliminate redundant parameters in the Transformer architecture of DN-DETR.Considering the different roles of the multi-head attention(MHA)module and the feed-forward network(FFN)module in the Transformer architecture,a modular greedy pruning(MGP)algorithm is proposed.This algorithm separates the two modules and applies their respective optimal strategies and parameters.The effectiveness of the proposed algorithm is validated on the COCO 2017 dataset.The model obtained through the MGP algorithm reduces the parameters by 49%and the number of floating point operations(FLOPs)by 44%compared to the Transformer architecture of DN-DETR.At the same time,the mean average precision(mAP)of the model increases from 44.1%to 45.3%. 展开更多
关键词 model pruning object detection Transformer(DETR) Transformer architecture object detection
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Cloud EMRs auditing with decentralized (t, n)-threshold ownership transfer
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作者 Yamei Wang Weijing You +2 位作者 Yuexin Zhang Ayong Ye Li Xu 《Cybersecurity》 2025年第4期142-158,共17页
In certain cloud Electronic Medical Records (EMRs) applications, the data ownership may need to be transferred. In practice, not only the data but also the auditing ability should be transferred securely and efciently... In certain cloud Electronic Medical Records (EMRs) applications, the data ownership may need to be transferred. In practice, not only the data but also the auditing ability should be transferred securely and efciently. However, we investigate and fnd that most of the existing data ownership transfer protocols only work well between two indi-viduals,and they become inefcient when dealing between two communities. The proposals for transferring tags between communities are problematic as well since, they require all members get involved or a fully trusted aggrega-torfacilitates ownership transfer, which are unrealistic in certain scenarios. To alleviate these problems, in this paper we develop a secure auditing protocol with decentralized (t, n)-threshold ownership transfer for cloud EMRs. This protocol is designed to operate efciently without requiring the mandatory participation of every user or the involve-mentof any trusted third-party. It is achieved by employing the threshold signature. Rigorous security analyses and comprehensive performance evaluations illustrate the security and practicality of our protocol. Specifcally, according to the evaluations and comparisons, the communication and computational consumption is independent of the fle size, i.e., it is constant in our protocol for both communities. 展开更多
关键词 Integrity auditing Ownership transfer threshold signature Cloud EMRs
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Assessment of radio observatory sites using a multi-threshold algorithm
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作者 Hang Yang Liang Dong Lesheng He 《Astronomical Techniques and Instruments》 2025年第4期255-264,共10页
Radio environment plays an important role in radio astronomy observations.Further analysis is needed on the time and intensity distributions of interference signals for long-term radio environment monitoring.Sample va... Radio environment plays an important role in radio astronomy observations.Further analysis is needed on the time and intensity distributions of interference signals for long-term radio environment monitoring.Sample variance is an important estimate of the interference signal decision threshold.Here,we propose an improved algorithm for calculating data sample variance relying on four established statistical methods:the variance of the trimmed data,winsorized sample variance,median absolute deviation,and median of the trimmed data pairwise averaged squares method.The variance and decision threshold in the protected section of the radio astronomy L-band are calculated.Among the four methods,the improved median of the trimmed data pairwise averaged squares algorithm has higher accuracy,but in a comparison of overall experimental results,the cleanliness rate of all algorithms is above 96%.In a comparison between the improved algorithm and the four methods,the cleanliness rate of the improved algorithm is above 98%,verifying its feasibility.The time-intensity interference distribution in the radio protection band is also obtained.Finally,we use comprehensive monitoring data of radio astronomy protection bands,radio interference bands,and interfered frequency bands to establish a comprehensive evaluation system for radio observatory sites,including the observable time proportion in the radio astronomy protection band,the occasional time-intensity distribution in the radio interference frequency band,and the intensity distribution of the interfered frequency band. 展开更多
关键词 Radio astronomy Electromagnetic environment threshold algorithm Cleanliness rate
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Rabbit corneal damage threshold induced by a tunable laser system at 254 nm
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作者 Litong Zhu Zukang Nie +6 位作者 Mengqi Qiu Ying Wang Congling Zhou Lifei Guo Jiarui Wang Zaifu Yang Luguang Jiao 《Journal of Innovative Optical Health Sciences》 2025年第6期99-106,共8页
Low-pressure mercury lamps,with a main emission of about 254 nm,have been used for disinfecting air,water and surfaces for nearly a century.However,only a few studies on the corneal damage threshold at the wavelength ... Low-pressure mercury lamps,with a main emission of about 254 nm,have been used for disinfecting air,water and surfaces for nearly a century.However,only a few studies on the corneal damage threshold at the wavelength of 254nm exist.In this paper,the in vivo corneal damage threshold was determined inchinchilla rabbit model using a laser system at 254 nm.The irradiance of the laser spot was nearly flat-top distributed and the beam diameter on the animal corneal surface was about 3.44mm and 3.28 mm along the horizontal and vertical directions.Damage lesion determinations were performed at 12 h post-exposure using fluorescein sodium staining.TheED50 was17.7 mJ/cm^(2)with a 95%confidence interval of 15.3-20.1 mJ/cm^(2).The obtained results may contribute to the knowledge base for the refinement of the UV hazard function. 展开更多
关键词 Corneal damage threshold ultraviolet-C UV hazard function
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An adaptive continuous threshold wavelet denoising method for LiDAR echo signal
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作者 Dezhi Zheng Tianchi Qu +4 位作者 Chun Hu Shijia Lu Zhongxiang Li Guanyu Yang Xiaojun Yang 《Nanotechnology and Precision Engineering》 2025年第2期51-62,共12页
Atmospheric aerosols are the primary contributors to environmental pollution.As such aerosols are micro-to nanosized particles invisible to the naked eye,it is necessary to utilize LiDAR technology for their detection... Atmospheric aerosols are the primary contributors to environmental pollution.As such aerosols are micro-to nanosized particles invisible to the naked eye,it is necessary to utilize LiDAR technology for their detection.The laser radar echo signal is vulnerable to background light and electronic thermal noise.While single-photon LiDAR can effectively reduce background light interference,electronic thermal noise remains a significant challenge,especially at long distances and in environments with a low signal-to-noise ratio(SNR).However,conventional denoising methods cannot achieve satisfactory results in this case.In this paper,a novel adaptive continuous threshold wavelet denoising algorithm is proposed to filter out the noise.The algorithm features an adaptive threshold and a continuous threshold function.The adaptive threshold is dynamically adjusted according to the wavelet decomposition level,and the continuous threshold function ensures continuity with lower constant error,thus optimizing the denoising process.Simulation results show that the proposed algorithm has excellent performance in improving SNR and reducing root mean square error(RMSE)compared with other algorithms.Experimental results show that denoising of an actual LiDAR echo signal results in a 4.37 dB improvement in SNR and a 39.5%reduction in RMSE.The proposed method significantly enhances the ability of single-photon LiDAR to detect weak signals. 展开更多
关键词 Single-photon LiDAR Echo signal Adaptive thresholding Wavelet transform
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Wavelet Thresholding Denoising Method for Satellite Clock Bias Data Processing Based on Interval Correlation Coefficient
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作者 WANG Xu 《Journal of Geodesy and Geoinformation Science》 2025年第3期53-69,共17页
A clock bias data processing method based on interval correlation coefficient wavelet threshold denoising is suggested for minor mistakes in clock bias data in order to increase the efficacy of satellite clock bias pr... A clock bias data processing method based on interval correlation coefficient wavelet threshold denoising is suggested for minor mistakes in clock bias data in order to increase the efficacy of satellite clock bias prediction.Wavelet analysis was first used to break down the satellite clock frequency data into several levels,producing high and low frequency coefficients for each layer.The correlation coefficients of the high and low frequency coefficients in each of the three sub-intervals created by splitting these coefficients were then determined.The major noise region—the sub-interval with the lowest correlation coefficient—was chosen for thresholding treatment and noise threshold computation.The clock frequency data was then processed using wavelet reconstruction and reconverted to clock data.Lastly,three different kinds of satellite clock data—RTS,whu-o,and IGS-F—were used to confirm the produced data.Our method enhanced the stability of the Quadratic Polynomial(QP)model’s predictions for the C16 satellite by about 40%,according to the results.The accuracy and stability of the Auto Regression Integrated Moving Average(ARIMA)model improved up to 41.8%and 14.2%,respectively,whilst the Wavelet Neural Network(WNN)model improved by roughly 27.8%and 63.6%,respectively.Although our method has little effect on forecasting IGS-F series satellites,the experimental findings show that it can improve the accuracy and stability of QP,ARIMA,and WNN model forecasts for RTS and whu-o satellite clock bias. 展开更多
关键词 satellite clock bias correlation coefficient wavelet threshold method FORECAST
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Subgroup Analysis of a Single-Index Threshold Penalty Quantile Regression Model Based on Variable Selection
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作者 QI Hui XUE Yaxin 《Wuhan University Journal of Natural Sciences》 2025年第2期169-183,共15页
In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This... In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper. 展开更多
关键词 longitudinal data subgroup analysis threshold model quantile regression variable selection
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Effect of minimum and maximum electrical stimulation levels on sound field thresholds,and speech perception in children using the Advanced Bionics Cochlear Implant
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作者 Muthuselvi Thangaraj Ravikumar Arunachalam +1 位作者 Madhuri Gore Ajith Kumar Uppunda 《Journal of Otology》 2025年第3期170-175,共6页
BackgroundIt's crucial to study the effect of changes in thresholds(T)and most comfortable levels(M)on behavioral measurements in young children using cochlear implants.This would help the clinician with the optim... BackgroundIt's crucial to study the effect of changes in thresholds(T)and most comfortable levels(M)on behavioral measurements in young children using cochlear implants.This would help the clinician with the optimization and validation of programming parameters.ObjectiveThe study has attempted to describe the changes in behavioral responses with modification of T and M levels.MethodsTwenty-five participants in the age range 5 to 12 years using HR90K/HiFocus1J or HR90KAdvantage/HiFocus1J with Harmony speech processors participated in the study.A decrease in T levels,a rise in T levels,or a decrease in M levels in the everyday program were used to create experimental programs.Sound field thresholds and speech perception were measured at 50 dBHL for three experimental and everyday programs.ConclusionThe results indicated that only reductions of M levels resulted in significantly(p<0.01)poor aided thresholds and speech perception.On the other hand,variation in T levels did not have significant changes in either sound field thresholds or speech perception.The results highlight that M levels must be correctly established in order to prevent decreased speech perception and audibility. 展开更多
关键词 T levels M levels sound field threshold speech perception
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Effect of the phytohormone salicylic acid on the salinity thresholds to seed germination and seedling growth in the oilseed Camelina sativa
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作者 Esmaeil Bakhshandeh Fatemeh Hosseini Sanehkoori +2 位作者 Najmeh Mirzaaghpour Charlotte E.Seal Mozhgan Alinia 《Oil Crop Science》 2025年第1期1-8,共8页
The oilseed crop Camelina sativa exhibits salinity tolerance,but the effects on early growth stages across a range of different salts and in combination with salicylic acid(SA)have not been thoroughly evaluated.In thi... The oilseed crop Camelina sativa exhibits salinity tolerance,but the effects on early growth stages across a range of different salts and in combination with salicylic acid(SA)have not been thoroughly evaluated.In this study,seeds were germinated in varying concentrations of six salts(NaCl,CaCl_(2),ZnCl_(2),KCl,MgSO_(4),and Na2SO_(4))with or without 0.5 mM SA.Using the halotime model,we estimated salt thresholds for germination and parameters of seedling growth.Germination and seedling growth parameters of camelina significantly decreased with increasing salt concentration across all salt types.Salts containing Zn and SO_(4) were most detrimental to germination and seedling growth.Except for KCl,0.5 mM SA generally reduced the salinity tolerance threshold(Saltb(50))of camelina.Specifically,Saltb(50)was 21.5%higher for KCl and 16.1%,25.0%,54.9%,21.0%,and 5.6%lower for CaCl_(2),NaCl,MgSO_(4),Na2SO_(4),and ZnCl_(2),respectively,when 0.5 mM SA was compared to 0 mM SA.Furthermore,camelina seedling growth was consistently more sensitive than germination across all salt types.SA did not significantly enhance germination or seedling growth and was harmful when combined with certain salts or at the germination stage.It can be concluded that both the type of salt and the concentration of SA are as critical as the salt concentration in saline irrigation water. 展开更多
关键词 Germination percentage Germination rate Seedling growth Salt tolerance threshold value
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A model for threshold pressure gradient in hydrate-bearing sediments during creep
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作者 Jiangtao Qu Tianle Liu +4 位作者 Gang Lei Shaojun Zheng Wan Cheng Jiaxin Sun Yizhao Wan 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期5206-5223,共18页
The flow behaviors of gas and water in hydrate-bearing sediments(HBS)are significantly affected by the threshold pressure gradient(TPG).During long-term natural gas hydrates(NGHs)mining,there exists creep deformation ... The flow behaviors of gas and water in hydrate-bearing sediments(HBS)are significantly affected by the threshold pressure gradient(TPG).During long-term natural gas hydrates(NGHs)mining,there exists creep deformation in HBS,which significantly alters pore structures,makes the flow path of fluid more complex,and leads to changes in TPG.Thus,clarifying the evolution of TPG in HBS during creep is essential for NGH production,but it also confronts enormous challenges.In this study,based on the nonlinear creep constitutive model,a novel theoretical TPG model of HBS during creep is proposed that considers pore structures and hydrate pore morphology.The established model is validated against experimental data,demonstrating its ability to capture the evolution of TPG and permeability in HBS during creep.Additionally,the relationship between initial hydrate saturation and TPG of HBS during creep is revealed by sensitivity analysis.The creep strain increases with the decrease in initial hydrate saturation,leading to a greater TPG and a lower permeability.The evolution of TPG at the stable creep stage and the accelerated creep stage is primarily controlled by the Kelvin element and visco-plastic element,respectively.This novel proposed model provides a mechanistic understanding of TPG evolution in HBS during creep,and it is of great significance to optimize the exploitation of NGHs. 展开更多
关键词 Hydrate-bearing sediments threshold pressure gradient PERMEABILITY Hydrate pore morphology Creep deformation
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Impact of Hard Segment Structures on Fatigue Threshold of Casting Polyurethane Using Cutting Method
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作者 Guang-Zhi Jin Le-Hang Chen +4 位作者 Yu-Zhen Gong Peng Li Run-Guo Wang Fan-Zhu Li Yong-Lai Lu 《Chinese Journal of Polymer Science》 2025年第2期303-315,共13页
The fatigue resistance of casting polyurethane(CPU)is crucial in various sectors,such as construction,healthcare,and the automotive industry.Despite its importance,no studies have reported on the fatigue threshold of ... The fatigue resistance of casting polyurethane(CPU)is crucial in various sectors,such as construction,healthcare,and the automotive industry.Despite its importance,no studies have reported on the fatigue threshold of CPU.This study employed an advanced Intrinsic Strength Analyzer(ISA)to evaluate the fatigue threshold of CPUs,systematically exploring the effects of three types of isocyanates(PPDI,NDI,TDI)that contribute to hard segment structures based on the cutting method.Employing multiple advanced characterization techniques(XRD,TEM,DSC,AFM),the results indicate that PPDI-based polyurethane exhibits the highest fatigue threshold(182.89 J/m^(2))due to a highest phase separation and a densely packed spherulitic structure,although the hydrogen bonding degree is the lowest(48.3%).Conversely,NDI-based polyurethane,despite having the high hydrogen bonding degree(53.6%),exhibits moderate fatigue performance(122.52 J/m^(2)),likely due to a more scattered microstructure.TDI-based polyurethane,with the highest hydrogen bonding degree(59.1%)but absence of spherulitic structure,shows the lowest fatigue threshold(46.43 J/m^(2)).Compared to common rubbers(NR,NBR,EPDM,BR),the superior fatigue performance of CPU is attributed to its well-organized microstructure,polyurethane possesses a higher fatigue threshold due to its high phase separation degree and orderly and dense spherulitic structure which enhances energy dissipation and reduces crack propagation. 展开更多
关键词 Casting polyurethane Fatigue threshold Cutting method Hard segment structures Materials characterization
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Fault Diagnosis for Key Components of Metro Vehicles based on Wavelet Threshold Denoising and EEMD
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作者 Xichun Luo Haoran Hu 《Journal of Electronic Research and Application》 2025年第3期10-19,共10页
With the increasing adoption of intelligent operation and maintenance technologies in urban rail transit,most maintenance systems have been equipped with fault diagnosis modules targeting key components of metro vehic... With the increasing adoption of intelligent operation and maintenance technologies in urban rail transit,most maintenance systems have been equipped with fault diagnosis modules targeting key components of metro vehicles.However,the integration between engineering-level diagnostic algorithms and advanced academic research remains limited.Two major challenges hinder vibration-based fault diagnosis under real-world operating conditions:the complex noise and interference caused by wheel-rail coupling and the typically weak expression of fault features.Considering the widespread application of wavelet transform in noise reduction and the maturity of ensemble empirical mode decomposition(EEMD)in handling nonlinear and non-stationary signals without parameter tuning,this study proposes a diagnostic method that combines wavelet threshold denoising with EEMD.The method was applied to bearing vibration signals collected from an operational subway line.The diagnostic results were consistent with actual disassembly findings,demonstrating the effectiveness and practical value of the proposed approach. 展开更多
关键词 Metro vehicles Fault diagnosis Wavelet threshold de-noising Ensemble empirical mode decomposition
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