Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this g...Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].展开更多
Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By th...Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By the review of literatures to confirm the first case of human skin infection in the world. Result.From the literatures and the clinical pictures, it is confirmed that this is the first case report of Protothecosis zopfii of skin in the world. Conclusion.The first case of Protothecosis zopfii in human being was reported and successfully treated with local infiltration of Diflucan (fluconazole) 3ml (2mg/ml)/week×4.展开更多
基金supported by the National Natural Science Foundation of China(Grant number 82172326 to W.W.).
文摘Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].
文摘Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By the review of literatures to confirm the first case of human skin infection in the world. Result.From the literatures and the clinical pictures, it is confirmed that this is the first case report of Protothecosis zopfii of skin in the world. Conclusion.The first case of Protothecosis zopfii in human being was reported and successfully treated with local infiltration of Diflucan (fluconazole) 3ml (2mg/ml)/week×4.
