The rising incidence and mortality of chronic diseases,particularly those attributable to persistent pathogenic stimuli and metabolic dysregulation,remain a significant concern.Understanding the mechanisms driving the...The rising incidence and mortality of chronic diseases,particularly those attributable to persistent pathogenic stimuli and metabolic dysregulation,remain a significant concern.Understanding the mechanisms driving these conditions is complicated by their multifactorial and polygenic nature,which has historically impeded the identification of precise pathways.While genetic dysregulation has been a focal point for many years,accumulating evidence highlights the critical role of disruptions in cellular processes,especially protein biosynthesis and metabolic flux,in the pathogenesis of chronic diseases.展开更多
基金supported by the Qiantang Scholars Fund in Hangzhou City University(210000-581835).
文摘The rising incidence and mortality of chronic diseases,particularly those attributable to persistent pathogenic stimuli and metabolic dysregulation,remain a significant concern.Understanding the mechanisms driving these conditions is complicated by their multifactorial and polygenic nature,which has historically impeded the identification of precise pathways.While genetic dysregulation has been a focal point for many years,accumulating evidence highlights the critical role of disruptions in cellular processes,especially protein biosynthesis and metabolic flux,in the pathogenesis of chronic diseases.
