SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifi...SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifier(SUMO)molecules to lysine residues on target proteins,thereby regulating the stability,localization,and activity of these substrates.Despite the low amino acid sequence similarity between SUMO and ubiquitin,they share similar three-dimensional structures and are conjugated onto protein substrates through a comparable three-step catalytic reaction.展开更多
Dear Editor,SUMOylation is a crucial form of post-translational modification in which small ubiquitin-like modifiers(SUMOs)are transferred to lysine residues of target proteins,thereby regulating their stability,local...Dear Editor,SUMOylation is a crucial form of post-translational modification in which small ubiquitin-like modifiers(SUMOs)are transferred to lysine residues of target proteins,thereby regulating their stability,localization,and activity.Proteomic analysis in Arabidopsis has revealed numerous proteins serving as SUMOylation substrates,which play crucial roles in development and stress responses(Elrouby and Coupland,2010).展开更多
基金supported by the Major Program of Guangdong Basic and Applied Research(2019B030302006)the National Natural Science Foundation of China(32270292,32270752)+3 种基金the Natural Science Foundation of Guangdong(2019A1515110330,2018B030308002,2024A1515011071)Guangdong Modern Agro-industry Technology Research System(2023KJ114)the Program for Changjiang Scholars,the Scientific Research Start-up Fund for Ph D of Zhaoqing University(240013)Youth Foundation of Zhaoqing University(QN202439)。
文摘SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifier(SUMO)molecules to lysine residues on target proteins,thereby regulating the stability,localization,and activity of these substrates.Despite the low amino acid sequence similarity between SUMO and ubiquitin,they share similar three-dimensional structures and are conjugated onto protein substrates through a comparable three-step catalytic reaction.
基金supported by the Major Program of Guangdong Basic and Applied Research(2019B030302006)the National Natural Science Foundation of China(32270292,32270752,and 32200436)+2 种基金the Natural Science Foundation of Guangdong(2024A1515011071,2021A1515011151,and 2019A1515110330)the Guangdong Modern Agro-industry Technology Research System(2023KJ114)the Program for Changjiang Scholars.
文摘Dear Editor,SUMOylation is a crucial form of post-translational modification in which small ubiquitin-like modifiers(SUMOs)are transferred to lysine residues of target proteins,thereby regulating their stability,localization,and activity.Proteomic analysis in Arabidopsis has revealed numerous proteins serving as SUMOylation substrates,which play crucial roles in development and stress responses(Elrouby and Coupland,2010).
