SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifi...SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifier(SUMO)molecules to lysine residues on target proteins,thereby regulating the stability,localization,and activity of these substrates.Despite the low amino acid sequence similarity between SUMO and ubiquitin,they share similar three-dimensional structures and are conjugated onto protein substrates through a comparable three-step catalytic reaction.展开更多
基金supported by the Major Program of Guangdong Basic and Applied Research(2019B030302006)the National Natural Science Foundation of China(32270292,32270752)+3 种基金the Natural Science Foundation of Guangdong(2019A1515110330,2018B030308002,2024A1515011071)Guangdong Modern Agro-industry Technology Research System(2023KJ114)the Program for Changjiang Scholars,the Scientific Research Start-up Fund for Ph D of Zhaoqing University(240013)Youth Foundation of Zhaoqing University(QN202439)。
文摘SUMOylation is a reversible posttranslational modification that plays a crucial role in various essential biological processes within eukaryotic cells.This reaction involves the transfer of small ubiquitin-like modifier(SUMO)molecules to lysine residues on target proteins,thereby regulating the stability,localization,and activity of these substrates.Despite the low amino acid sequence similarity between SUMO and ubiquitin,they share similar three-dimensional structures and are conjugated onto protein substrates through a comparable three-step catalytic reaction.
