SARS-CoV-2 expresses four structural proteins,the membrane(M),envelope(E),spike(S),and nucleocapsid(N)proteins,along with a replicated viral genome,and delineates the process of viral assembly[1].S,E,and M are integra...SARS-CoV-2 expresses four structural proteins,the membrane(M),envelope(E),spike(S),and nucleocapsid(N)proteins,along with a replicated viral genome,and delineates the process of viral assembly[1].S,E,and M are integral membrane proteins that are synthesized in the endoplasmic reticulum(ER)[2,3],and N is cytosolic and escorts the viral genome for assembly[4].展开更多
In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of ...In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of Glut3 expression in TIL-Treg cells increased their glucose uptake,which was then used to modify the activity of signaling proteins.The authors specifically investigated the NF-κB subunit c-Rel and showed that its posttranslational modification with O-GlcNAc contributes to the immunosuppressive environment of tumors,opening up possibilities for novel therapeutic approaches.展开更多
基金supported by the National Key R&D Program of China(2021YFA1300800)the National Natural Science Foundation of China(32230024)+1 种基金Project for Young Scientists in Basic Research(YSBR-075)the Strategic Priority Research Program of the CAS(XDB37030205).
文摘SARS-CoV-2 expresses four structural proteins,the membrane(M),envelope(E),spike(S),and nucleocapsid(N)proteins,along with a replicated viral genome,and delineates the process of viral assembly[1].S,E,and M are integral membrane proteins that are synthesized in the endoplasmic reticulum(ER)[2,3],and N is cytosolic and escorts the viral genome for assembly[4].
基金supported by grants from the Deutsche Forschungsgemeinschaft(SCHM1586/6-2 and SCHM1586/11-1)the InnovationsFORUM of the Medical Faculty of the Ruhr University Bochum.
文摘In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of Glut3 expression in TIL-Treg cells increased their glucose uptake,which was then used to modify the activity of signaling proteins.The authors specifically investigated the NF-κB subunit c-Rel and showed that its posttranslational modification with O-GlcNAc contributes to the immunosuppressive environment of tumors,opening up possibilities for novel therapeutic approaches.
