RNA editing is a posttranscriptional process that alters genetic information encoded in genomic DNA.While most known RNA editing occurs in organellar RNAs,adenosine-to-inosine(A-to-I)editing is one of the few types th...RNA editing is a posttranscriptional process that alters genetic information encoded in genomic DNA.While most known RNA editing occurs in organellar RNAs,adenosine-to-inosine(A-to-I)editing is one of the few types that modify nuclear-encoded mRNAs1,2.Since inosine is interpreted as guanosine(G)during translation,A-to-I editing can recode proteins,adding a regulatory layer beyond the central dogma.This raises a key question:What evolutionary advantage does RNA editing provide?Current hypotheses suggest that RNA editing allows regulated production of multiple protein isoforms from a single gene,helping resolve fitness trade-offs from pleiotropy or genetic conflict3,4.展开更多
基金supported by the grants from the National Key R&D Program of China(2022YFA1304400)the National Natural Science Foundation of China(32472521).
文摘RNA editing is a posttranscriptional process that alters genetic information encoded in genomic DNA.While most known RNA editing occurs in organellar RNAs,adenosine-to-inosine(A-to-I)editing is one of the few types that modify nuclear-encoded mRNAs1,2.Since inosine is interpreted as guanosine(G)during translation,A-to-I editing can recode proteins,adding a regulatory layer beyond the central dogma.This raises a key question:What evolutionary advantage does RNA editing provide?Current hypotheses suggest that RNA editing allows regulated production of multiple protein isoforms from a single gene,helping resolve fitness trade-offs from pleiotropy or genetic conflict3,4.
