Myocytes power the movement of all organs in the body.Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases.Apigenin,a kind of flavone,is being used to treat many disorders....Myocytes power the movement of all organs in the body.Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases.Apigenin,a kind of flavone,is being used to treat many disorders.It exerts a host of different pharmacological activities,such as anti-inflammatory,anti-mutagenic,cardioprotective,and antioxidant effects.Accordingly,apigenin is considered a promising candidate for myocyte protection.In this review,we introduced the characteristics of apigenin.The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed.The protective effects can be classified into proliferation-promoting,anti-inflammatory,atrophy-preventing,metabolism-increasing,and antioxidative effects.Additionally,we provided some outlook on the valuable applications of apigenin in sports medicine,which eagerly require further fundamental research.展开更多
This study determined the effects of initial infestation of cowpea seeds （Ife brown variety） with different insect densities （0, 2, 4 and 6 pairs per 50 g seeds） of Callosobruchus maculatus （F.） and evaluated th...This study determined the effects of initial infestation of cowpea seeds （Ife brown variety） with different insect densities （0, 2, 4 and 6 pairs per 50 g seeds） of Callosobruchus maculatus （F.） and evaluated the effects of aqueous leaf extract of Nicotiana tabacum L. on C. maculatus in the laboratory. It was observed that adult beetle population increased significantly （p〈0.05） with increase in insect density. The increase in population of beetles and corresponding weight loss of the seeds in different levels of infestation showed that the cowpea variety was susceptible to beetle infestation, emergence and survival of progeny. Significantly more adults emerged on higher infestation compared to lower and no infestation. In Nigeria, Nicotiana tabacum L. is a locally available plant, with known insecticidal properties. The plant leaf extract was easily extracted with water and confirmed its effectiveness as a protective agent for stored cowpea seeds. Experiment was conducted to assess the effects of aqueous extracts ofN. tabacum at 0, 0.1, 0.2 and 0.3 mL＂ 50 g-1 cowpea seeds on C. maculatus. Data was recorded and showed varying levels of effectiveness against C. maculatus. Result showed that seed appearance was dependent on levels of insect population, while N. tabacum aqueous extract exerted effects on survival of C. maculatus. Aqueous leaf extract of N. tabacum probably contained some insecticidal properties which might have significantly conferred beetle mortality and reduced beetle emergence leading to a decrease in seed weight loss.展开更多
In the delicate normative balance, at European Union （EU） level of the borderline products （i.e., between plant protectants and bio-fertilizers/bio-effectors） containing microbial consortia （MC） instead of singl...In the delicate normative balance, at European Union （EU） level of the borderline products （i.e., between plant protectants and bio-fertilizers/bio-effectors） containing microbial consortia （MC） instead of single microbial strains, the most relevant factors influencing the categorization of the products are the intention of use, the cell density and the mode of action. For the latter, the basic difference between the two types of products is that a plant protectant has a targeted activity on plant pathogens, while a bio-fertilizer acts indirectly by nourishing and fortifying the host plant （healthier plant）, thus inducing a generalized resistance to the onset of pathological status, irrespective of its origin and nature. Case-studies are presented on the effectiveness of MC as bio-fertilizers/bio-effectors on different crops. Bio-fertilizers exhibit a double effect--biotic and abiotic, leading to the fortification of the crop plant linked to its more effective water and nutrient uptakes as well asto a generalized healthier status. This in turn leads to a higher resistance to diseases. In addition, bio-fertilizers play a relevant role on the reduction of environmental impacts due to chemical fertilizers, e.g., by facilitating the uptake of phosphorus （P）, thus reducing the need of P fertilization. Although finding a scientifically-based balance between regulatory need and marketing constraint is not always an easy task, the availability of scientific advancements combined to common sense should help in describing positive effects and risk profiles of MC in agriculture.展开更多
It has previously been shown that tryptophan, the biosynthesis precursor ofPeganum harmala alkaloids, and its derivatives have anti-TMV activity bothin vitro and in vivo. Further exploration of this led to the identif...It has previously been shown that tryptophan, the biosynthesis precursor ofPeganum harmala alkaloids, and its derivatives have anti-TMV activity bothin vitro and in vivo. Further exploration of this led to the identification of NK0238as a highly effective agent for the prevention and control of diseases caused byplant viruses, but the existing routes are unsuitable for its large-scale synthesis.This study optimized a route for two-step synthesis of this virucide candidate viareaction of L-tryptophan with triphosgene to produce L-tryptophan-N-carboxylicanhydride, which then reacts with n-octylamine to give NK0238 at up to 94%yield and nearly 97% HPLC purity. In addition, the route was used for thepreparation of NK0238 on a > 40 g scale permitting further assessment of itsantivirus activity in the greenhouse and field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both ingreenhouse and field experiments. The toxicity tests showed that NK0238 wasnot acutely toxic to birds, fish, honey bees and silkworms. The optimized routeprovides a solid foundation for its large-scale synthesis and subsequent efficacyand toxicity studies, its excellent activity and safety make NK0238 a promisingdrug candidate for further development.展开更多
Black nickel coatings have emerged as a research hotspot in materials science due to their excellent performance and broad application prospects.In this study,nickel-based black coatings were fabricated on low-carbon ...Black nickel coatings have emerged as a research hotspot in materials science due to their excellent performance and broad application prospects.In this study,nickel-based black coatings were fabricated on low-carbon steel substrates via photo-assisted electrodeposition.A systematic investigation was conducted on the effects of cerium ion concentration and nano-ceria(CeO_(2))particle content in the electrolyte on the coating properties,along with an analysis of the temporal evolution of coating’s corrosion resistance.When the cerium ion concentration in the electrolyte was 0.05 mol/L,the coating exhibited a uniform black appearance with a light absorption rate of 95%,an emissivity of 0.87,maximum impedance,and the lowest corrosion tendency,demonstrating optimal comprehensive performance.The coating prepared with a nano-ceria concentration of 6 g/L in the electrolyte exhibited an emissivity of 0.9,achieved a 5B adhesion grade(ASTM D3359-09),and demonstrated a one-order-of-magnitude reduction in corrosion current density compared to coatings fabricated without nano-ceria in the electrolyte.With prolonged storage time,the coating's impedance slightly increased,leading to improved corrosion resistance.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
Cryopreservation plays an essential role in biobanking and cell therapy,but the physiological toxicity of traditional cryoprotectants such as glycerol and dimethyl sulfoxide(DMSO)has raised safety issues for biomedica...Cryopreservation plays an essential role in biobanking and cell therapy,but the physiological toxicity of traditional cryoprotectants such as glycerol and dimethyl sulfoxide(DMSO)has raised safety issues for biomedical applications.Trehalose,a nonreducing disaccharide that accumulates in desiccation-or cold-tolerant organisms,has been considered as a biocompatible cryoprotectant.Herein,a naturally occurring membrane-active cationic peptide,melittin,was utilized to facilitate membraneimpermeable trehalose entry into cells for effective cell cryopreservation.Poly(ethylene glycol)and poly(vinyl pyrrolidone)were applied as macromolecular protectants to improve the stabilization of cell membranes.Upon the optimal protocol,the postthaw recovery of human red blood cells in freezing bags at a hematocrit of~50%could achieve 82.9%with favorable cell morphologies and physiological functions.Furthermore,the cryosurvival of L929 fibroblasts reached 84.3%compared to the conventional method using 10%(v/v)DMSO.In short,this work by using trehalose and melittin provides a biocompatible solvent-free approach for long-term cryostorage of cells.展开更多
PKU:The super fibers combine strength and toughness In impact protection applications such as ballistic armor,vehicle shielding,and aerospace,the dynamic strength and dynamic toughness of fiber materials are critical ...PKU:The super fibers combine strength and toughness In impact protection applications such as ballistic armor,vehicle shielding,and aerospace,the dynamic strength and dynamic toughness of fiber materials are critical performance indicators determining protective efficacy.However,widely used polymeric fibers still face significant challenges preventing full utilization of the material’s intrinsic strength and toughness.展开更多
BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chin...BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.展开更多
Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord inj...Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord injury mainly relies on pharmacological and surgical interventions;however,significant challenges remain in the protection and repair of neural tissues.Autophagy,an intracellular process responsible for the degradation and recycling of macromolecular components,plays a vital role in spinal cord injury,alleviating the severity of injury by inhibiting cell apoptosis and inflammatory responses.In this review,we provide an overview of the physiological mechanisms underlying autophagy and spinal cord injury and detail the crosstalk between autophagy and other modes of cell death in spinal cord injury.In addition,we discuss the potential of targeting autophagy as a therapeutic strategy for spinal cord injury through approaches that focus on promoting or inhibiting this process,targeting specific autophagic substrates or pathways,and combining autophagy modulation with other neuroprotective or restorative interventions.In summary,this review proposes that strict regulation of autophagy may represent a viable strategy for the treatment of spinal cord injury.展开更多
Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of...Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.展开更多
The advent of 5G technology has significantly enhanced the transmission of images over networks,expanding data accessibility and exposure across various applications in digital technology and social media.Consequently...The advent of 5G technology has significantly enhanced the transmission of images over networks,expanding data accessibility and exposure across various applications in digital technology and social media.Consequently,the protection of sensitive data has become increasingly critical.Regardless of the complexity of the encryption algorithm used,a robust and highly secure encryption key is essential,with randomness and key space being crucial factors.This paper proposes a new Robust Deoxyribonucleic Acid(RDNA)nucleotide-based encryption method.The RDNA encryption method leverages the unique properties of DNA nucleotides,including their inherent randomness and extensive key space,to generate a highly secure encryption key.By employing transposition and substitution operations,the RDNA method ensures significant diffusion and confusion in the encrypted images.Additionally,it utilises a pseudorandom generation technique based on the random sequence of nucleotides in the DNA secret key.The performance of the RDNA encryption method is evaluated through various statistical and visual tests,and compared against established encryption methods such as 3DES,AES,and a DNA-based method.Experimental results demonstrate that the RDNA encryption method outperforms its rivals in the literature,and achieves superior performance in terms of information entropy,avalanche effect,encryption execution time,and correlation reduction,while maintaining competitive values for NMAE,PSNR,NPCR,and UACI.The high degree of randomness and sensitivity to key changes inherent in the RDNA method offers enhanced security,making it highly resistant to brute force and differential attacks.展开更多
Acalypha gaumeri(Euphorbiaceae)is the only endemic species of the genus in the Yucatan Peninsula.It is dioecious and has antifungal properties against various phytopathogens.In the present study,molecular identificati...Acalypha gaumeri(Euphorbiaceae)is the only endemic species of the genus in the Yucatan Peninsula.It is dioecious and has antifungal properties against various phytopathogens.In the present study,molecular identification of A.gaumeri was performed using the rbcL region,confirming its belonging to the Acalypha genus.Its genetic diversity was evaluated using 10 SPAR markers(ISSR and DAMD)from 60 individuals collected from female and male plants of the Kiuic,Tinum and Yaxcaba ex-situ populations.The results showed a high level of genetic polymorphism(PIC=0.980)and significant differences among the populations.Ethanol and aqueous extracts from leaves,stems,and roots of both genders and three populations were evaluated against three phytopathogenic fungi.Only the ethanol extracts of the roots showed inhibitory antifungal activity,whereas Kiuic and Tinum,both male and female individuals,showed inhibitory effects at 1000μg/mL against the three pathogens.The ethanol extract of the female flowering plant of Kiuic showed activity at minimum inhibitory concentrations of 250μg/mL against Alternaria chrysanthemi CICY004 and 500μg/mL against Colletotrichum gloeosporioides CICY002 and Penicillium oxalicum ITC25.Chromatographic profile of the ethanol extracts confirmed the presence of alkaloidal components in the ex-situ cultivated plants,which were analyzed by HPLC.The results revealed that the peaks at T_(R) of 7.60,7.88,and 8.49 min were the most abundant components(9.95%-21.93%),with differences between female and male plants of the three populations.This research confirms that A.gaumeri cultivated and genetically characterized is a potential raw material to develop an eco-friendly product for the control of fungal diseases in crops.展开更多
The formation of Zn dendrites and the occurrence of the hydrogen evolution reaction(HER)at Zn anodes represent two major obstacles that significantly impede the widespread commercialization of aqueous Zn-ion batteries...The formation of Zn dendrites and the occurrence of the hydrogen evolution reaction(HER)at Zn anodes represent two major obstacles that significantly impede the widespread commercialization of aqueous Zn-ion batteries.In this work,we propose sorbitan oleate(Span 80)as a novel amphiphilic electrolyte additive for 2 mol/L ZnSO_(4),demonstrating multifunctional performance.The unique ultra-long hydrophobic carbon chains of Span 80 effectively reduce free water molecules at the Zn anode-electrolyte interface,forming a robust hydrophobic interfacial layer that significantly suppresses HER and corrosion reactions.Simultaneously,carbon chains can enhance the desolvation effect of[Zn(H_(2)O)_(6)]^(2+),leading to improve rate performance.Additionally,the hydrophilic sorbitan groups in Span 80 selectively adsorb onto active sites of the Zn anode,promoting uniform Zn^(2+)deposition and suppressing dendrite growth.The optimized Zn||Zn symmetric cell exhibits outstanding cycling stability,sustaining reversible plating/stripping for 570 h at 50 mA/cm^(2) and the Zn||V_(2)O_(5) full cell retains exceptional stability over 2000 cycles at 1 A/g.Our work presents a promising strategy for suppressing interfacial side reactions by constructing a hydrophobic protective layer through the use of ultra-long carbon chain surfactants.This approach offers new insights into enhancing the performance of aqueous Zn-ion batteries.展开更多
Mobile communications are reaching out to every aspect of our daily life,necessitating highefficiency data transmission and support for diverse data types and communication scenarios.Polar codes have emerged as a prom...Mobile communications are reaching out to every aspect of our daily life,necessitating highefficiency data transmission and support for diverse data types and communication scenarios.Polar codes have emerged as a promising solution due to their outstanding error-correction performance and low complexity.Unequal error protection(UEP)involves nonuniform error safeguarding for distinct data segments,achieving a fine balance between error resilience and resource allocation,which ultimately enhancing system performance and efficiency.In this paper,we propose a novel class of UEP rateless polar codes.The codes are designed based on matrix extension of polar codes,and elegant mapping and duplication operations are designed to achieve UEP property while preserving the overall performance of conventional polar codes.Superior UEP performance is attained without significant modifications to conventional polar codes,making it straightforward for compatibility with existing polar codes.A theoretical analysis is conducted on the block error rate and throughput efficiency performance.To the best of our knowledge,this work provides the first theoretical performance analysis of UEP rateless polar codes.Simulation results show that the proposed codes significantly outperform existing polar coding schemes in both block error rate and throughput efficiency.展开更多
Addressing the widespread issues of internal fragmentation within protected areas and the neglect of surrounding critical habitat networks,this study aims to develop an assessment framework for the precise identificat...Addressing the widespread issues of internal fragmentation within protected areas and the neglect of surrounding critical habitat networks,this study aims to develop an assessment framework for the precise identification and remediation of regional conservation gaps.To this end,we introduce the Framework for Conservation Priority Identification(FCPI).The framework integrates Morphological Spatial Pattern Analysis(MSPA),the Remote Sensing Ecological Index(RSEI),Circuit Theory,and the Minimum Cumulative Resistance(MCR)model to formulate a multidimensional conservation priority index.This index facilitates the identification of critical ecological network components and enables the dynamic prioritization of conservation efforts.A case study of Fuzhou City from 2014 to 2020 reveals that despite an overall improvement in regional environmental quality,the functionality of core ecological sources has markedly declined.Between 2014 and 2020,the number of ecological sources grew by 76.9%,yet their total area shrank by 13.9%.Concurrently,the number of ecological corridors rose from 27 to 53,extending their total length by 380.23 km,which indicates an intensifying trend of habitat fragmentation.Furthermore,a significant number of crucial ecological network nodes,particularly within Minhou County,lie explicitly outside the existing protected area system.This confirms the presence of conservation gaps and unveils the spatiotemporal dynamics of shifting conservation priorities.The research validates that the proposed FCPI can effectively diagnose the dynamic deficiencies within conservation systems.It offers scientific decisionsupport for local governments,facilitating a transition from isolated conservation efforts towards systematic and comprehensive ecological network governance.展开更多
Objective:To evaluate the implementation effectiveness of standardized protective care procedures during hydrofluoric acid procedures in the dental department.Methods:This study was conducted from June 2023 to June 20...Objective:To evaluate the implementation effectiveness of standardized protective care procedures during hydrofluoric acid procedures in the dental department.Methods:This study was conducted from June 2023 to June 2025,selecting 90 patients who underwent hydrofluoric acid-related treatments in the outpatient dental department of this hospital during this period as subjects.Forty-five patients treated between June 2023 and June 2024 received conventional protective care(pre-intervention group),while 45 patients treated between June 2024 and June 2025 underwent the standardized protective care protocol(post-intervention group).Thirteen healthcare personnel participated in both pre-and post-intervention treatment phases.Based on the different nursing models,indicators such as the incidence of adverse events in patients and the exposure rate of healthcare personnel before and after implementation were compared to evaluate the effectiveness of the nursing intervention.Results:The incidence of oral mucosal irritation reactions in patients was lower after implementation,p<0.05.Compared with the pre-implementation period,the incidence of procedure-related adverse events decreased after implementation,p<0.05.There was a significant difference in the occupational exposure rate of healthcare personnel before and after implementation,with a higher rate observed before implementation(p<0.05).Post-implementation,healthcare personnel achieved higher compliance scores for pre-procedure preparation,intra-procedure protection,and post-procedure handling(p<0.05).Patient satisfaction with treatment was lower pre-implementation than post-implementation(p<0.05).Conclusion:Adherence to standardized protective care procedures during hydrofluoric acid operations by dental department staff in outpatient settings standardizes practitioner techniques,effectively prevents oral mucosal irritation in patients,reduces occupational exposure risks for staff,minimizes adverse procedural events,and consequently enhances patient treatment satisfaction.This demonstrates significant practical value.展开更多
China Improves Child Welfare,Strengthens Care for Minors China's Ministry of Civil Affairs has released two regulatory documents aimed at improving the approach to child welfare and assistance for minors,both of w...China Improves Child Welfare,Strengthens Care for Minors China's Ministry of Civil Affairs has released two regulatory documents aimed at improving the approach to child welfare and assistance for minors,both of which are set to take effect on April 1.Under the newly formulated interim measures,assistance and protection facilities for minors are established by governments.展开更多
Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method f...Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method for achieving sustainable regional development.Previous studies on multi-objective spatial optimization do not involve spatial corrections to simulation results based on the natural endowment of space resources.This study proposes an Ecological Security-Food Security-Urban Sustainable Development(ES-FS-USD)spatial optimization framework.This framework combines the non-dominated sorting genetic algorithm II(NSGA-II)and patch-generating land use simulation(PLUS)model with an ecological protection importance evaluation,comprehensive agricultural productivity evaluation,and urban sustainable development potential assessment and optimizes the territorial space in the Yangtze River Delta(YRD)region in 2035.The proposed sustainable development(SD)scenario can effectively reduce the destruction of landscape patterns of various land-use types while considering both ecological and economic benefits.The simulation results were further revised by evaluating the land-use suitability of the YRD region.According to the revised spatial pattern for the YRD in 2035,the farmland area accounts for 43.59%of the total YRD,which is 5.35%less than that in 2010.Forest,grassland,and water area account for 40.46%of the total YRD—an increase of 1.42%compared with the case in 2010.Construction land accounts for 14.72%of the total YRD—an increase of 2.77%compared with the case in 2010.The ES-FS-USD spatial optimization framework ensures that spatial optimization outcomes are aligned with the natural endowments of land resources,thereby promoting the sustainable use of land resources,improving the ability of spatial management,and providing valuable insights for decision makers.展开更多
Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this stud...Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this study,we investigated the hypervelocity impact response and protection for highstrength U71 Mn or bainitic steel used in rocket sled tracks.Flyer plate impact experiments using a two-stage light-gas gun were conducted to study the hypervelocity collision response,followed by the microstructural characterization via optical microscope,scanning electron microscopy equipped with electron backscatter diffraction to reveal underlying damage mechanisms.Then,the calibrated thermalmechanical coupled finite element simulations using the Johnson-Cook constitutive model and MieGrüneisen equation of state were carried out.Results indicated that bainitic steel exhibits superior impact resistance with predominantly smooth scratch-dominated damage due to its higher ductility.In contrast,U71 Mn suffered significant material spallation and crack propagation arising from brittle fracture mechanisms.Zinc-rich epoxy primer coatings effectively mitigated stress concentration and temperature rise in the substrate at impacting velocities below 2.4 km/s,so as to suppress the microstructural damage such as adiabatic shear bands and dynamic recrystallization.However,coating protection diminished at ultra-high-speed impacts due to the coating failure.Dimensional analysis established quantitative relationships of the gouge damage size to projectile mass,impact velocity,and material yield strength.This study provides in-depth insights into damage mechanisms in hypervelocity rail systems,demonstrating that bainitic steel combined with protective coatings can significantly enhance impact resistance and system reliability,offering valuable guidance for the design and optimization of hypervelocity testing platforms.展开更多
基金supported by the China Postdoctoral Science Foundation(Grant No.2019M653494)Special Field Projects of Guizhou Education Committee(Grant No.KY2019072)High-level Innovative Talents in Guizhou Province(Grant No.2018-2016-023).
文摘Myocytes power the movement of all organs in the body.Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases.Apigenin,a kind of flavone,is being used to treat many disorders.It exerts a host of different pharmacological activities,such as anti-inflammatory,anti-mutagenic,cardioprotective,and antioxidant effects.Accordingly,apigenin is considered a promising candidate for myocyte protection.In this review,we introduced the characteristics of apigenin.The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed.The protective effects can be classified into proliferation-promoting,anti-inflammatory,atrophy-preventing,metabolism-increasing,and antioxidative effects.Additionally,we provided some outlook on the valuable applications of apigenin in sports medicine,which eagerly require further fundamental research.
文摘This study determined the effects of initial infestation of cowpea seeds （Ife brown variety） with different insect densities （0, 2, 4 and 6 pairs per 50 g seeds） of Callosobruchus maculatus （F.） and evaluated the effects of aqueous leaf extract of Nicotiana tabacum L. on C. maculatus in the laboratory. It was observed that adult beetle population increased significantly （p〈0.05） with increase in insect density. The increase in population of beetles and corresponding weight loss of the seeds in different levels of infestation showed that the cowpea variety was susceptible to beetle infestation, emergence and survival of progeny. Significantly more adults emerged on higher infestation compared to lower and no infestation. In Nigeria, Nicotiana tabacum L. is a locally available plant, with known insecticidal properties. The plant leaf extract was easily extracted with water and confirmed its effectiveness as a protective agent for stored cowpea seeds. Experiment was conducted to assess the effects of aqueous extracts ofN. tabacum at 0, 0.1, 0.2 and 0.3 mL＂ 50 g-1 cowpea seeds on C. maculatus. Data was recorded and showed varying levels of effectiveness against C. maculatus. Result showed that seed appearance was dependent on levels of insect population, while N. tabacum aqueous extract exerted effects on survival of C. maculatus. Aqueous leaf extract of N. tabacum probably contained some insecticidal properties which might have significantly conferred beetle mortality and reduced beetle emergence leading to a decrease in seed weight loss.
文摘In the delicate normative balance, at European Union （EU） level of the borderline products （i.e., between plant protectants and bio-fertilizers/bio-effectors） containing microbial consortia （MC） instead of single microbial strains, the most relevant factors influencing the categorization of the products are the intention of use, the cell density and the mode of action. For the latter, the basic difference between the two types of products is that a plant protectant has a targeted activity on plant pathogens, while a bio-fertilizer acts indirectly by nourishing and fortifying the host plant （healthier plant）, thus inducing a generalized resistance to the onset of pathological status, irrespective of its origin and nature. Case-studies are presented on the effectiveness of MC as bio-fertilizers/bio-effectors on different crops. Bio-fertilizers exhibit a double effect--biotic and abiotic, leading to the fortification of the crop plant linked to its more effective water and nutrient uptakes as well asto a generalized healthier status. This in turn leads to a higher resistance to diseases. In addition, bio-fertilizers play a relevant role on the reduction of environmental impacts due to chemical fertilizers, e.g., by facilitating the uptake of phosphorus （P）, thus reducing the need of P fertilization. Although finding a scientifically-based balance between regulatory need and marketing constraint is not always an easy task, the availability of scientific advancements combined to common sense should help in describing positive effects and risk profiles of MC in agriculture.
基金The authors are grateful to the National Natural Science Foundation of China(21977056,21732002)the Fundamental Research Funds for the Central Universities,Nankai University(63201043)for generous financial support for their programs.
文摘It has previously been shown that tryptophan, the biosynthesis precursor ofPeganum harmala alkaloids, and its derivatives have anti-TMV activity bothin vitro and in vivo. Further exploration of this led to the identification of NK0238as a highly effective agent for the prevention and control of diseases caused byplant viruses, but the existing routes are unsuitable for its large-scale synthesis.This study optimized a route for two-step synthesis of this virucide candidate viareaction of L-tryptophan with triphosgene to produce L-tryptophan-N-carboxylicanhydride, which then reacts with n-octylamine to give NK0238 at up to 94%yield and nearly 97% HPLC purity. In addition, the route was used for thepreparation of NK0238 on a > 40 g scale permitting further assessment of itsantivirus activity in the greenhouse and field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both ingreenhouse and field experiments. The toxicity tests showed that NK0238 wasnot acutely toxic to birds, fish, honey bees and silkworms. The optimized routeprovides a solid foundation for its large-scale synthesis and subsequent efficacyand toxicity studies, its excellent activity and safety make NK0238 a promisingdrug candidate for further development.
文摘Black nickel coatings have emerged as a research hotspot in materials science due to their excellent performance and broad application prospects.In this study,nickel-based black coatings were fabricated on low-carbon steel substrates via photo-assisted electrodeposition.A systematic investigation was conducted on the effects of cerium ion concentration and nano-ceria(CeO_(2))particle content in the electrolyte on the coating properties,along with an analysis of the temporal evolution of coating’s corrosion resistance.When the cerium ion concentration in the electrolyte was 0.05 mol/L,the coating exhibited a uniform black appearance with a light absorption rate of 95%,an emissivity of 0.87,maximum impedance,and the lowest corrosion tendency,demonstrating optimal comprehensive performance.The coating prepared with a nano-ceria concentration of 6 g/L in the electrolyte exhibited an emissivity of 0.9,achieved a 5B adhesion grade(ASTM D3359-09),and demonstrated a one-order-of-magnitude reduction in corrosion current density compared to coatings fabricated without nano-ceria in the electrolyte.With prolonged storage time,the coating's impedance slightly increased,leading to improved corrosion resistance.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
文摘Cryopreservation plays an essential role in biobanking and cell therapy,but the physiological toxicity of traditional cryoprotectants such as glycerol and dimethyl sulfoxide(DMSO)has raised safety issues for biomedical applications.Trehalose,a nonreducing disaccharide that accumulates in desiccation-or cold-tolerant organisms,has been considered as a biocompatible cryoprotectant.Herein,a naturally occurring membrane-active cationic peptide,melittin,was utilized to facilitate membraneimpermeable trehalose entry into cells for effective cell cryopreservation.Poly(ethylene glycol)and poly(vinyl pyrrolidone)were applied as macromolecular protectants to improve the stabilization of cell membranes.Upon the optimal protocol,the postthaw recovery of human red blood cells in freezing bags at a hematocrit of~50%could achieve 82.9%with favorable cell morphologies and physiological functions.Furthermore,the cryosurvival of L929 fibroblasts reached 84.3%compared to the conventional method using 10%(v/v)DMSO.In short,this work by using trehalose and melittin provides a biocompatible solvent-free approach for long-term cryostorage of cells.
文摘PKU:The super fibers combine strength and toughness In impact protection applications such as ballistic armor,vehicle shielding,and aerospace,the dynamic strength and dynamic toughness of fiber materials are critical performance indicators determining protective efficacy.However,widely used polymeric fibers still face significant challenges preventing full utilization of the material’s intrinsic strength and toughness.
基金Supported by the Special Project for Supporting the Development of Biomedicine and Health Industry in Hangzhou City,No.2022WJC123Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2022ZA143.
文摘BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.
基金funded by the National Natural Science Foundation of China,No.82271395(to GL),the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030073(to GL)the grants from University of Macao Research Committee,China,No.MYRG2022-00074-ICMS(to CTV)Guangzhou Science and Technology Program Project,No.2025A04J4740(to GL).
文摘Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord injury mainly relies on pharmacological and surgical interventions;however,significant challenges remain in the protection and repair of neural tissues.Autophagy,an intracellular process responsible for the degradation and recycling of macromolecular components,plays a vital role in spinal cord injury,alleviating the severity of injury by inhibiting cell apoptosis and inflammatory responses.In this review,we provide an overview of the physiological mechanisms underlying autophagy and spinal cord injury and detail the crosstalk between autophagy and other modes of cell death in spinal cord injury.In addition,we discuss the potential of targeting autophagy as a therapeutic strategy for spinal cord injury through approaches that focus on promoting or inhibiting this process,targeting specific autophagic substrates or pathways,and combining autophagy modulation with other neuroprotective or restorative interventions.In summary,this review proposes that strict regulation of autophagy may represent a viable strategy for the treatment of spinal cord injury.
基金Natural Science Foundation of Beijing Municipality under Grant L243004the National Natural Science Foundation of China under Grant 62403060.
文摘Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.
文摘The advent of 5G technology has significantly enhanced the transmission of images over networks,expanding data accessibility and exposure across various applications in digital technology and social media.Consequently,the protection of sensitive data has become increasingly critical.Regardless of the complexity of the encryption algorithm used,a robust and highly secure encryption key is essential,with randomness and key space being crucial factors.This paper proposes a new Robust Deoxyribonucleic Acid(RDNA)nucleotide-based encryption method.The RDNA encryption method leverages the unique properties of DNA nucleotides,including their inherent randomness and extensive key space,to generate a highly secure encryption key.By employing transposition and substitution operations,the RDNA method ensures significant diffusion and confusion in the encrypted images.Additionally,it utilises a pseudorandom generation technique based on the random sequence of nucleotides in the DNA secret key.The performance of the RDNA encryption method is evaluated through various statistical and visual tests,and compared against established encryption methods such as 3DES,AES,and a DNA-based method.Experimental results demonstrate that the RDNA encryption method outperforms its rivals in the literature,and achieves superior performance in terms of information entropy,avalanche effect,encryption execution time,and correlation reduction,while maintaining competitive values for NMAE,PSNR,NPCR,and UACI.The high degree of randomness and sensitivity to key changes inherent in the RDNA method offers enhanced security,making it highly resistant to brute force and differential attacks.
基金supported by the SECIHTI project PDCPN-2015-266,México.
文摘Acalypha gaumeri(Euphorbiaceae)is the only endemic species of the genus in the Yucatan Peninsula.It is dioecious and has antifungal properties against various phytopathogens.In the present study,molecular identification of A.gaumeri was performed using the rbcL region,confirming its belonging to the Acalypha genus.Its genetic diversity was evaluated using 10 SPAR markers(ISSR and DAMD)from 60 individuals collected from female and male plants of the Kiuic,Tinum and Yaxcaba ex-situ populations.The results showed a high level of genetic polymorphism(PIC=0.980)and significant differences among the populations.Ethanol and aqueous extracts from leaves,stems,and roots of both genders and three populations were evaluated against three phytopathogenic fungi.Only the ethanol extracts of the roots showed inhibitory antifungal activity,whereas Kiuic and Tinum,both male and female individuals,showed inhibitory effects at 1000μg/mL against the three pathogens.The ethanol extract of the female flowering plant of Kiuic showed activity at minimum inhibitory concentrations of 250μg/mL against Alternaria chrysanthemi CICY004 and 500μg/mL against Colletotrichum gloeosporioides CICY002 and Penicillium oxalicum ITC25.Chromatographic profile of the ethanol extracts confirmed the presence of alkaloidal components in the ex-situ cultivated plants,which were analyzed by HPLC.The results revealed that the peaks at T_(R) of 7.60,7.88,and 8.49 min were the most abundant components(9.95%-21.93%),with differences between female and male plants of the three populations.This research confirms that A.gaumeri cultivated and genetically characterized is a potential raw material to develop an eco-friendly product for the control of fungal diseases in crops.
基金supported by the financial support from the Guangdong Basic and Applied Basic Research Foundation(No.2023B1515120095)the National Natural Science Foundation of China(Nos.52471229 and 52171210)the Jilin Province Science and Technology Department Program(No.20240101004JJ).
文摘The formation of Zn dendrites and the occurrence of the hydrogen evolution reaction(HER)at Zn anodes represent two major obstacles that significantly impede the widespread commercialization of aqueous Zn-ion batteries.In this work,we propose sorbitan oleate(Span 80)as a novel amphiphilic electrolyte additive for 2 mol/L ZnSO_(4),demonstrating multifunctional performance.The unique ultra-long hydrophobic carbon chains of Span 80 effectively reduce free water molecules at the Zn anode-electrolyte interface,forming a robust hydrophobic interfacial layer that significantly suppresses HER and corrosion reactions.Simultaneously,carbon chains can enhance the desolvation effect of[Zn(H_(2)O)_(6)]^(2+),leading to improve rate performance.Additionally,the hydrophilic sorbitan groups in Span 80 selectively adsorb onto active sites of the Zn anode,promoting uniform Zn^(2+)deposition and suppressing dendrite growth.The optimized Zn||Zn symmetric cell exhibits outstanding cycling stability,sustaining reversible plating/stripping for 570 h at 50 mA/cm^(2) and the Zn||V_(2)O_(5) full cell retains exceptional stability over 2000 cycles at 1 A/g.Our work presents a promising strategy for suppressing interfacial side reactions by constructing a hydrophobic protective layer through the use of ultra-long carbon chain surfactants.This approach offers new insights into enhancing the performance of aqueous Zn-ion batteries.
基金supported by National Natural Science Foundation of China(No.62301008)China Postdoctoral Science Foundation(No.2022M720272)New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘Mobile communications are reaching out to every aspect of our daily life,necessitating highefficiency data transmission and support for diverse data types and communication scenarios.Polar codes have emerged as a promising solution due to their outstanding error-correction performance and low complexity.Unequal error protection(UEP)involves nonuniform error safeguarding for distinct data segments,achieving a fine balance between error resilience and resource allocation,which ultimately enhancing system performance and efficiency.In this paper,we propose a novel class of UEP rateless polar codes.The codes are designed based on matrix extension of polar codes,and elegant mapping and duplication operations are designed to achieve UEP property while preserving the overall performance of conventional polar codes.Superior UEP performance is attained without significant modifications to conventional polar codes,making it straightforward for compatibility with existing polar codes.A theoretical analysis is conducted on the block error rate and throughput efficiency performance.To the best of our knowledge,this work provides the first theoretical performance analysis of UEP rateless polar codes.Simulation results show that the proposed codes significantly outperform existing polar coding schemes in both block error rate and throughput efficiency.
基金supported by the Natural Science Foundation of Fujian Province(2023J01434)the Science and Technology Innovation Special Fund Project of Fujian Agriculture and Forestry University(KFb22028XA)。
文摘Addressing the widespread issues of internal fragmentation within protected areas and the neglect of surrounding critical habitat networks,this study aims to develop an assessment framework for the precise identification and remediation of regional conservation gaps.To this end,we introduce the Framework for Conservation Priority Identification(FCPI).The framework integrates Morphological Spatial Pattern Analysis(MSPA),the Remote Sensing Ecological Index(RSEI),Circuit Theory,and the Minimum Cumulative Resistance(MCR)model to formulate a multidimensional conservation priority index.This index facilitates the identification of critical ecological network components and enables the dynamic prioritization of conservation efforts.A case study of Fuzhou City from 2014 to 2020 reveals that despite an overall improvement in regional environmental quality,the functionality of core ecological sources has markedly declined.Between 2014 and 2020,the number of ecological sources grew by 76.9%,yet their total area shrank by 13.9%.Concurrently,the number of ecological corridors rose from 27 to 53,extending their total length by 380.23 km,which indicates an intensifying trend of habitat fragmentation.Furthermore,a significant number of crucial ecological network nodes,particularly within Minhou County,lie explicitly outside the existing protected area system.This confirms the presence of conservation gaps and unveils the spatiotemporal dynamics of shifting conservation priorities.The research validates that the proposed FCPI can effectively diagnose the dynamic deficiencies within conservation systems.It offers scientific decisionsupport for local governments,facilitating a transition from isolated conservation efforts towards systematic and comprehensive ecological network governance.
基金Construction of Standardized Protective Nursing Plan for Hydrofluoric Acid Operation in Stomatology and Re search on Injury Prevention Effect(Project No.:FZ2025101)。
文摘Objective:To evaluate the implementation effectiveness of standardized protective care procedures during hydrofluoric acid procedures in the dental department.Methods:This study was conducted from June 2023 to June 2025,selecting 90 patients who underwent hydrofluoric acid-related treatments in the outpatient dental department of this hospital during this period as subjects.Forty-five patients treated between June 2023 and June 2024 received conventional protective care(pre-intervention group),while 45 patients treated between June 2024 and June 2025 underwent the standardized protective care protocol(post-intervention group).Thirteen healthcare personnel participated in both pre-and post-intervention treatment phases.Based on the different nursing models,indicators such as the incidence of adverse events in patients and the exposure rate of healthcare personnel before and after implementation were compared to evaluate the effectiveness of the nursing intervention.Results:The incidence of oral mucosal irritation reactions in patients was lower after implementation,p<0.05.Compared with the pre-implementation period,the incidence of procedure-related adverse events decreased after implementation,p<0.05.There was a significant difference in the occupational exposure rate of healthcare personnel before and after implementation,with a higher rate observed before implementation(p<0.05).Post-implementation,healthcare personnel achieved higher compliance scores for pre-procedure preparation,intra-procedure protection,and post-procedure handling(p<0.05).Patient satisfaction with treatment was lower pre-implementation than post-implementation(p<0.05).Conclusion:Adherence to standardized protective care procedures during hydrofluoric acid operations by dental department staff in outpatient settings standardizes practitioner techniques,effectively prevents oral mucosal irritation in patients,reduces occupational exposure risks for staff,minimizes adverse procedural events,and consequently enhances patient treatment satisfaction.This demonstrates significant practical value.
文摘China Improves Child Welfare,Strengthens Care for Minors China's Ministry of Civil Affairs has released two regulatory documents aimed at improving the approach to child welfare and assistance for minors,both of which are set to take effect on April 1.Under the newly formulated interim measures,assistance and protection facilities for minors are established by governments.
基金National Natural Science Foundation of China,No.42301470,No.52270185,No.42171389Capacity Building Program of Local Colleges and Universities in Shanghai,No.21010503300。
文摘Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method for achieving sustainable regional development.Previous studies on multi-objective spatial optimization do not involve spatial corrections to simulation results based on the natural endowment of space resources.This study proposes an Ecological Security-Food Security-Urban Sustainable Development(ES-FS-USD)spatial optimization framework.This framework combines the non-dominated sorting genetic algorithm II(NSGA-II)and patch-generating land use simulation(PLUS)model with an ecological protection importance evaluation,comprehensive agricultural productivity evaluation,and urban sustainable development potential assessment and optimizes the territorial space in the Yangtze River Delta(YRD)region in 2035.The proposed sustainable development(SD)scenario can effectively reduce the destruction of landscape patterns of various land-use types while considering both ecological and economic benefits.The simulation results were further revised by evaluating the land-use suitability of the YRD region.According to the revised spatial pattern for the YRD in 2035,the farmland area accounts for 43.59%of the total YRD,which is 5.35%less than that in 2010.Forest,grassland,and water area account for 40.46%of the total YRD—an increase of 1.42%compared with the case in 2010.Construction land accounts for 14.72%of the total YRD—an increase of 2.77%compared with the case in 2010.The ES-FS-USD spatial optimization framework ensures that spatial optimization outcomes are aligned with the natural endowments of land resources,thereby promoting the sustainable use of land resources,improving the ability of spatial management,and providing valuable insights for decision makers.
基金financial support from the National Key Research and Development Program(Grant No.2024YFA1209801)the National Natural Science Foundation of China(Grant Nos.12302140,12325204)+4 种基金the China Postdoctoral Science Foundation(Grant No.2023M732794)the Fundamental Research Funds for the Central Universities of China(Grant No.sxzy012023213)the Scientific Research Program of Shaanxi Province(Grant No.2023JC-XJ-02)the Young Talent Support Program of Xi'an Science and Technology Association(Grant No.959202413069)Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(Grant No.GZB20230575)。
文摘Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this study,we investigated the hypervelocity impact response and protection for highstrength U71 Mn or bainitic steel used in rocket sled tracks.Flyer plate impact experiments using a two-stage light-gas gun were conducted to study the hypervelocity collision response,followed by the microstructural characterization via optical microscope,scanning electron microscopy equipped with electron backscatter diffraction to reveal underlying damage mechanisms.Then,the calibrated thermalmechanical coupled finite element simulations using the Johnson-Cook constitutive model and MieGrüneisen equation of state were carried out.Results indicated that bainitic steel exhibits superior impact resistance with predominantly smooth scratch-dominated damage due to its higher ductility.In contrast,U71 Mn suffered significant material spallation and crack propagation arising from brittle fracture mechanisms.Zinc-rich epoxy primer coatings effectively mitigated stress concentration and temperature rise in the substrate at impacting velocities below 2.4 km/s,so as to suppress the microstructural damage such as adiabatic shear bands and dynamic recrystallization.However,coating protection diminished at ultra-high-speed impacts due to the coating failure.Dimensional analysis established quantitative relationships of the gouge damage size to projectile mass,impact velocity,and material yield strength.This study provides in-depth insights into damage mechanisms in hypervelocity rail systems,demonstrating that bainitic steel combined with protective coatings can significantly enhance impact resistance and system reliability,offering valuable guidance for the design and optimization of hypervelocity testing platforms.
