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Topological considerations for reinforced concrete modular protection systems against near-field overpressure generated by close-in detonations
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作者 Sangyoung Han Kukjoo Kim +4 位作者 Hyeon-Jin Kim Jang-Woon Baek Hyun-Do Yun Gyu-Yong Kim Sangwoo Park 《Defence Technology(防务技术)》 2025年第11期112-125,共14页
With the increasing demand for secure infrastructure such as hydrogen refueling stations,chemical plants,and energy storage systems,the need for protective structures capable of withstanding close-in detonations has b... With the increasing demand for secure infrastructure such as hydrogen refueling stations,chemical plants,and energy storage systems,the need for protective structures capable of withstanding close-in detonations has become more critical.Existing design guidelines for protective walls(e.g.,UFC 3-340-02)primarily address mid-and far-field explosions,providing limited insights into near-field effects.Considering the effect of slight slopes(<40°)on reducing maximum reflected overpressure is deemed negligible.This study investigated the effectiveness of a reinforced concrete(RC)modular protection system(MPS)incorpo rating a diagonally tapered wall in attenuating re flected overpressures from closein detonations.Full-scale field experiments using a 51.3 kg TNT charge,representing the explosion energy of a typical hydrogen vessel rupture,demonstrated that a wall with a 7°slope significantly outperformed a vertical wall of equivalent concrete volume in terms of blast resistance.Observed structural responses included cracking,horizontal shear failure,and overturning.Complementary simulations using a validated computational fluid dynamics(CFD)model showed that the tapered wall reduced peak overpressure by 30%-40%compared to an equivalent vertical wall.This result highlights the potential of minor geometric modifications to enhance blast resilience.The tapered design effectively redirects incident blast waves,reducing localized damage while also conserving material,thus preserving modular benefits such as ease of transport and reusability.These findings suggest that diagonally tapered RC-based MPSs can offer a practical and resilient solution for industrial and military applications subject to near-field or sequential blast threats. 展开更多
关键词 Modular protective system protective wall Close-in detonation Near-field overpressure Full-scale explosion test
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A Collaborative Protection Mechanism for System-on-Chip Functional Safety and Information Security in Autonomous Driving
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作者 Zhongyi Xu Lei Xin +1 位作者 Zhongbai Huang Deguang Wei 《Journal of Electronic Research and Application》 2025年第2期226-232,共7页
This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip(SoC)functional safety and information security.It i... This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip(SoC)functional safety and information security.It includes an introduction to the functions and information security of autonomous driving SoCs,as well as the main design strategies for the collaborative prevention and control mechanism of SoC functional safety and information security in autonomous driving.The research shows that in the field of autonomous driving,there is a close connection between the functional safety of SoCs and their information security.In the design of the safety collaborative protection mechanism,the overall collaborative protection architecture,SoC functional safety protection mechanism,information security protection mechanism,the workflow of the collaborative protection mechanism,and its strategies are all key design elements.It is hoped that this analysis can provide some references for the collaborative protection of SoC functional safety and information security in the field of autonomous driving,so as to improve the safety of autonomous driving technology and meet its practical application requirements. 展开更多
关键词 Autonomous driving SoC functional safety Information security Collaborative protection mechanism Collaborative protection architecture
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Novel insights into flow mechanics in ablative thermal protection systems
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作者 Hu REN 《Chinese Journal of Aeronautics》 2025年第10期288-289,共2页
1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established... 1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established in the mid-20th century,blunt body theories led to the creation of ablative heat shields that effectively manage thermal loads through thermo-chemo-mechanical decomposition.This paper revisits the development and application of ablative TPS materials,which are single-mission solutions capable of withstanding entry velocities surpassing 10 km/s. 展开更多
关键词 ablative thermal protection systems tps extreme aerodynamic heatingestablished body theories ablative tps Mars mission manage thermal loads atmospheric entrywhere ablative thermal protection systems
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Evolution of the protection system for traditional Chinese medicine varieties and the strategic responses of traditional Chinese medicine enterprises
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作者 Wenli Li Qian Sun +4 位作者 Xiang Li Zhaojun Meng Mengmeng Li Wenxia Ding Pengfei Zhang 《Asian Journal of Traditional Medicines》 2025年第3期130-139,共10页
The protection system for traditional Chinese medicine(TCM)varieties,as an important policy tool to promote the development of TCM,has a long history of over 30 years,from the promulgation of the“Regulations on the P... The protection system for traditional Chinese medicine(TCM)varieties,as an important policy tool to promote the development of TCM,has a long history of over 30 years,from the promulgation of the“Regulations on the Protection of Traditional Chinese Medicine Varieties”in 1992 to the comprehensive revision of the draft for soliciting opinions in 2022.The TCM protection system evolves to meet the needs of innovative development of TCM.This paper reviews the policy developments in TCM varieties protection,collates protection data(1993 to 2024),and analyzes enterprises application strategies amid impending regulatory changes. 展开更多
关键词 protection of traditional Chinese medicine(TCM)varieties policy evolution the exclusive logo of TCM protection patent and TCM protection integration intelligent manufacturing and internationalization
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Development of an improved reverse genetics system for avian metapneumovirus(aMPV):A novel vaccine vector protects against aMPV and infectious bursal disease virus
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作者 Lingzhai Meng Yuntong Chen +14 位作者 Mengmeng Yu Peng Liu Xiaole Qi Xiaoxiao Xue Ru Guo Tao Zhang Mingxue Hu Wenrui Fan Ying Wang Suyan Wang Yanping Zhang Yongzhen Liu Yulu Duan Hongyu Cui Yulong Gao 《Journal of Integrative Agriculture》 2025年第5期1972-1986,共15页
Avian metapneumovirus(aMPV),a paramyxovirus,causes acute respiratory diseases in turkeys and swollen head syndrome in chickens.This study established a reverse genetics system for aMPV subtype B LN16-A strain based on... Avian metapneumovirus(aMPV),a paramyxovirus,causes acute respiratory diseases in turkeys and swollen head syndrome in chickens.This study established a reverse genetics system for aMPV subtype B LN16-A strain based on T7 RNA polymerase.Full-length cDNA of the LN16-A strain was constructed by assembling 5 cDNA fragments between the T7 promoter and hepatitis delta virus ribozyme.Transfection of this plasmid,along with the supporting plasmids encoding the N,P,M2-1,and L proteins of LN16-A into BSR-T7/5 cells,resulted in the recovery of aMPV subtype B.To identify an effective insertion site,the enhanced green fluorescent protein(EGFP)gene was inserted into different sites of the LN16-A genome to generate recombinant LN16-As.The results showed that the expression levels of EGFP at the site between the G and L genes of LN16-A were significantly higher than those at the other two sites(between the leader and N genes or replacing the SH gene).To verify the availability of the site between G and L for foreign gene expression,the VP2 gene of very virulent infectious bursal disease virus(vvIBDV)was inserted into this site,and recombinant LN16-A(rLN16A-vvVP2)was successfully rescued.Single immunization of specificpathogen-free chickens with rLN16A-vvVP2 induced high levels of neutralizing antibodies and provided 100%protection against the virulent aMPV subtype B and vvIBDV.Establishing a reverse genetics system here provides an important foundation for understanding aMPV pathogenesis and developing novel vector vaccines. 展开更多
关键词 avian metapneumovirus reverse genetics system insertion site protectION vector vaccines
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“The key issue is a land question.”–Five decades of forest cover change in the Mount Elgon protected area system,Uganda
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作者 Michele VON KOCEMBA Simon STROBELT +2 位作者 Manasseh MANDE Olaf CONRAD Udo SCHICKHOFF 《Journal of Mountain Science》 2025年第3期776-799,共24页
Deforestation remains one of the most imminent threats to biodiversity in the tropics.As such,its causes and dynamics need to be studied and understood to put a halt to further forest loss and degradation.In tropical ... Deforestation remains one of the most imminent threats to biodiversity in the tropics.As such,its causes and dynamics need to be studied and understood to put a halt to further forest loss and degradation.In tropical countries such as Uganda,agricultural expansion and wood fuel demand are its leading drivers.While the establishment of protected areas is a key tool in conserving remaining forest biodiversity,results indicate that current management does not sufficiently provide alternatives to forest resources utilised by households and income provided from timber and non-timber forest products.Beyond safeguarding ecosystems,protected areas need to ensure the sustainable socioeconomic development of adjacent communities for effective biodiversity conservation–however,both management and research often neglect to consider all dimensions.In this study,we analysed five decades of forest cover change in the Mount Elgon region,Uganda,by conducting a remote sensing analysis of its protected areas using Landsat MSS and TM data from 1973-2023 in combination with literature and subsequent interview analysis to consider both the ecological and socioeconomic dimension.We applied a random forest approach to differentiate forest and non-forest areas and carried out a pixel-based change detection analysis to differentiate temporal and spatial changes.Throughout the study period of 50 years,forest cover has evolved dynamically within the boundaries of the protected areas of Mount Elgon.A significant decline was observed in both Mount Elgon National Park with a loss of-5.98%(-46.83km²)and Mount Elgon Biosphere Reserve with a loss of-14.96%(-134.33km²).Our results showcase a cycle of deforestation and afforestation that could be tied to a series of development initiatives,re-demarcation of boundaries,changes in management and recurring evictions.Overall,the results lead to the conclusion that the lack of sustainable and efficient management and funding has fostered the rate of deforestation and accelerated ecological degradation in the region,but that existing problems are also rooted in the land tenure history of the region.We recommend the proper implementation of participatory and long-term management approaches on the ground and to address the land rights issue to contribute to both socioeconomic wellbeing and sustainable conservation outcomes. 展开更多
关键词 Biodiversity loss CONSERVATION Land use change protected areas Remote sensing
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A Diffusive Ivlev-type Predator-prey System with Smith Growth and a Protection Zone
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作者 Xue XIAO Li-na ZHANG 《Journal of Mathematical Research with Applications》 2025年第2期220-230,共11页
This paper is concerned with a diffusive Ivlev-type predator-prey system with Smith growth and a protection zone. By discussing the existence and non-existence of positive solutions,we discover that the incorporation ... This paper is concerned with a diffusive Ivlev-type predator-prey system with Smith growth and a protection zone. By discussing the existence and non-existence of positive solutions,we discover that the incorporation of the Smith growth function has enabled us to obtain a more precise criterion when judging the structure of bifurcation solutions, and determine a critical size for the protection zone. The results indicate that if the size of the protection zone is below the critical patch size, then the system has no positive steady state solution for excessively high intrinsic growth rates of predators. Conversely, if the size of the protection zone exceeds the critical patch size, there exists positive steady state solution regardless of how large the intrinsic growth rate of the predators is. 展开更多
关键词 Smith growth Ivlev-type functional response protection zone BIFURCATION
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Integrating species diversity, ecosystem services, climate and ecological stability helps to improve spatial representation of protected areas for quadruple win
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作者 Hui Dang Yihe Lü +2 位作者 Xiaofeng Wang Yunqi Hao Bojie Fu 《Geography and Sustainability》 2025年第1期47-57,共11页
Establishing and maintaining protected areas is a pivotal strategy for attaining the post-2020 biodiversity target. The conservation objectives of protected areas have shifted from a narrow emphasis on biodiversity to... Establishing and maintaining protected areas is a pivotal strategy for attaining the post-2020 biodiversity target. The conservation objectives of protected areas have shifted from a narrow emphasis on biodiversity to encompass broader considerations such as ecosystem stability, community resilience to climate change, and enhancement of human well-being. Given these multifaceted objectives, it is imperative to judiciously allocate resources to effectively conserve biodiversity by identifying strategically significant areas for conservation, particularly for mountainous areas. In this study, we evaluated the representativeness of the protected area network in the Qin ling Mountains concerning species diversity, ecosystem services, climate stability and ecological stability. The results indicate that some of the ecological indicators are spatially correlated with topographic gradient effects. The conservation priority areas predominantly lie in the northern foothills, the southeastern, and southwestern parts of the Qinling Mountain with areas concentrated at altitudes between 1,500-2,000 m and slopes between 40°-50° as hotspots. The conservation priority areas identified through the framework of inclusive conservation optimization account for 22.9 % of the Qinling Mountain. Existing protected areas comprise only 6.1 % of the Qinling Mountain and 13.18 % of the conservation priority areas. This will play an important role in achiev ing sustainable development in the region and in meeting the post-2020 biodiversity target. The framework can advance the different objectives of achieving a quadruple win and can also be extended to other regions. 展开更多
关键词 protected areas Nature conservation Ecological representation Qinling Mountains Spatial planning
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Research on Teaching Strategies of Power System Relay Protection Based on OBE Concept
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作者 Yutong Liu Xinda Li +1 位作者 Ming Yang Huida Duan 《Journal of Electronic Research and Application》 2025年第6期84-89,共6页
With the continuous improvement of current science and technology and residents’electricity demand,the power system relay protection course has become a key component of the curriculum for students majoring in power ... With the continuous improvement of current science and technology and residents’electricity demand,the power system relay protection course has become a key component of the curriculum for students majoring in power engineering.In this context,the teaching model of power system relay protection faces both new challenges and opportunities.By integrating the Outcome-Based Education(OBE)concept,teachers can reconstruct curriculum objectives and teaching frameworks by clearly defining learning outcomes,thereby enhancing students’practical competencies and innovative thinking.Based on the core connotation of the OBE concept,this paper analyzes the significance of incorporating OBE into Power System Relay Protection teaching and explores effective implementation strategies.The findings aim to offer practical insights for teaching reform and to strengthen the alignment between academic training and industry requirements. 展开更多
关键词 OBE Power system relay protection Learning outcomes Teaching reform
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Marine environmental changes and ecosystem services of marine protected areas in China:concepts,methods,progress,and policy recommendations
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作者 Chunrong Li Chunlei Ma +1 位作者 Jun Zhao Linbin Zhou 《Acta Oceanologica Sinica》 2025年第10期3-17,共15页
Marine protected areas(MPAs)play a critical role in maintaining marine ecosystem health,conserving biodiversity,and sustaining coastal livelihoods and socio-economic benefits.However,MPAs in China still face significa... Marine protected areas(MPAs)play a critical role in maintaining marine ecosystem health,conserving biodiversity,and sustaining coastal livelihoods and socio-economic benefits.However,MPAs in China still face significant design and management limitations,including a lack of a robust scientific basis for boundary delineation,weak enforcement capacity,poor adaptability to environmental and socio-economic changes,and insufficient integration of the ocean’s three-dimensional characteristics.These limitations are particularly evident in the context of climate change,overexploitation of marine resources,and the complex dynamics of ecosystems.This study systematically reviews the current status and challenges of MPAs in China,with a specific focus on the need for and benefits of dynamic and threedimensional protected areas for marine conservation.Dynamic protected areas,supported by real-time monitoring and flexible boundary adjustments,can more effectively respond to the migratory patterns of marine species and seasonal distribution shifts along China’s coast.On the other hand,three-dimensional protected areas enhance ecosystem protection by incorporating vertical ecological gradients and ocean depth,offering a vital complement to the predominantly two-dimensional protection approach currently in use.The study indicates that,with current technological and data capabilities,effective implementation of these advanced approaches requires precision marine observations,advanced analysis methods,and coordinated efforts among diverse stakeholders.In response,the study synthesizes multiple case studies to illustrate the potential ecological,managerial,and policy-related outcomes of dynamic and three-dimensional MPAs.It proposes strategies for optimization,implementation pathways,and targeted policy recommendations.Ultimately,the study emphasizes the critical role of scientific planning and technological innovation in enhancing the effectiveness of MPAs in China.It calls upon policymakers and the broader society to increase attention and investment in dynamic and three-dimensional marine conservation approaches.This work not only provides a scientific foundation for more precise and efficient marine governance in China,but also lays crucial foundation for achieving ocean-related sustainable development goals aligned with China’s national context. 展开更多
关键词 marine protected areas ecosystem services dynamic management three dimensional stratified rights
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An enhanced fingerprint template protection scheme based on four-dimensional superchaotic system and dynamic DNA coding
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作者 Baiqiang Hu Jiahui Liu Zhe Liu 《Chinese Physics B》 2025年第7期262-272,共11页
With the rapid development of Internet of things technology,the efficiency of data transmission between devices has been significantly improved.However,the open network environment also poses serious security risks.Th... With the rapid development of Internet of things technology,the efficiency of data transmission between devices has been significantly improved.However,the open network environment also poses serious security risks.This paper proposes an innovative fingerprint template protection scheme,which generates key streams through an improved fourdimensional superchaotic system(4CSCS),uses the space-filling property of Hilbert curves to achieve pixel scrambling,and introduces dynamic DNA encoding to improve encryption.Experimental results show that this scheme has a large key space 2^(528),encrypts image information entropy of more than 7.9970,and shows excellent performance in defending against statistical attacks and differential attacks.Compared with existing methods,this scheme has significant advantages in terms of encryption performance and security,and provides a reliable protection mechanism for fingerprint authentication systems in the Internet of things environment. 展开更多
关键词 four-dimensional superchaotic system fingerprint template protection Zernike moments image encryption
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Discussion on the Design and Optimization Strategy of Automatic Sprinkler Fire Extinguishing in Building Fire Protection Systems
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作者 Gaojie Liu 《Journal of Architectural Research and Development》 2025年第6期98-106,共9页
This paper focused on the design and optimization of automatic sprinkler fire extinguishing systems in building fire protection.It was emphasized the importance of considering various factors in design,such as fire ri... This paper focused on the design and optimization of automatic sprinkler fire extinguishing systems in building fire protection.It was emphasized the importance of considering various factors in design,such as fire risk assessment and space utilization.Optimization strategies include enhancing water and energy efficiency,using ecofriendly materials,and smart monitoring.Practical implementation and validation in different building types were presented,along with performance benchmark analysis.Balancing fire safety and resource utilization is crucial,and future research in AI driven tuning and nano materials was promising. 展开更多
关键词 Automatic sprinkler system Optimization strategy Building fire protection
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A comprehensive protection scheme for regenerative braking energy utilization system in electrified railways
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作者 Haitao Hu Kai Yang +3 位作者 Junyu Chen Yinbo Ge Ke Wang Zhengyou He 《Railway Engineering Science》 2025年第3期441-457,共17页
The regenerative braking energy utilization system(RBEUS)stands as a promising technique for improving the efficiency and power quality of electrified railways.Beyond the vital aspects of energy management and control... The regenerative braking energy utilization system(RBEUS)stands as a promising technique for improving the efficiency and power quality of electrified railways.Beyond the vital aspects of energy management and control strategies,ensuring fault protection is paramount for the secure and steady operation of the traction power supply system(TPSS)integrated with RBEUS.This paper introduces an innovative protection scheme tailored to diverse RBEUS application scenarios.Firstly,fault categories are streamlined into three levels:system,equipment,and warning.Subsequently,a novel multi-port active power differential protection method,aligned with RBEUS operational principles,is crafted to serve as a comprehensive and sensitive main protection.Building upon this foundation,a hierarchical protection structure for RBEUS is established,addressing the intricacies and variations in fault types while boosting anti-disturbance capabilities under faulty conditions.Embracing the principle of railway-oriented safety,a collaborative RBEUS-TPSS protection scheme is put forth.Finally,through simulated scenarios encompassing various fault conditions,the proposed scheme’s feasibility and effectiveness are convincingly validated. 展开更多
关键词 Regenerative braking energy utilization system Electrified railway protection scheme
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The Implementation Dilemmas and Solutions of the Appointed Guardianship System from the Perspective of the Protection of the Rights and Interests of the Elderly
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作者 LI Dejian ZHENG Ran JIANG Yu(Translated) 《The Journal of Human Rights》 2025年第4期896-917,共22页
In a deeply aging society,the appointed guardianship system,as an important arrangement for the protection of the rights and interests of the elderly,still faces many practical difficulties.Typical examples include:du... In a deeply aging society,the appointed guardianship system,as an important arrangement for the protection of the rights and interests of the elderly,still faces many practical difficulties.Typical examples include:during the decision-making stage of whether to choose appointed guardianship,the lack of professionalism and availability of appointed guardians can easily hinder the elderly from choosing to apply it;during the establishment stage of appointed guardianship,the limited rules related to the appointed guardianship agreement can easily lead to the frustration of the elderly’s subjective will;during the operation stage of appointed guardianship,the insufficient accountability mechanisms for appointed guardians can easily lead to the infringement of the personal or property rights of the elderly.By reflecting on its jurisprudential causes,it can be found that the current law largely ignores the orientation of appointed guardianship as a welfare for the elderly in social law,the concept of substantive equality in the appointed guardianship agreement,and the theoretical attributes of the appointed guardianship as a fiduciary relationship.Therefore,the appointed guardianship system in China should be systematically improved to fully release its institutional potential in the protection of the rights and interests of the elderly based on these jurisprudential principles.In particular,it is possible to consider actively promoting the“trust+appointed guardianship”model and cultivating a team of appointed guardians by the state based on the concept of elderly welfare;strengthening the protection of notarization procedures and the reasonable design of the appointed guardianship agreement based on the concept of substantive equality;and refining the fiduciary standards of appointed guardians and strengthening guardianship supervision based on the nature of fiduciary relationship. 展开更多
关键词 protection of the rights and interests of the elderly appointed guardianship elderly welfare substantive equality fiduciary relationship
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Early intelligent active assistance in walking for hemiplegic patients under suspension protection: a randomized controlled trial
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作者 Ma Shanxin Zheng Jianling +5 位作者 Cheng Jian Lin Xi Li Qiuyuan Wang Li Zeng Yangkang Song Luping 《中国组织工程研究》 北大核心 2026年第12期3075-3082,共8页
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec... BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function. 展开更多
关键词 hemiplegia stroke suspension protection system personal assistant machine intelligent walking aid early rehabilitation active training walking function NEUROPLASTICITY gait analysis motor function recovery rehabilitation training balance ability
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Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients
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作者 Fu-Gang Luo Hao-Yu Xing +4 位作者 Jun-Jie Wang Wen-Ye Wu Kai-Jie Fang Hai-Dong Song Juan Yan 《World Journal of Psychiatry》 2026年第1期221-232,共12页
BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chin... BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation. 展开更多
关键词 GUANXINNING Antipsychotic drugs Cardiac function SCHIZOPHRENIA Cardiac protection
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Effect of TYLCV Infection on Leaf Anatomical Structure and Protective Enzyme System of Tomato 被引量:7
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作者 张永平 张辉 +1 位作者 朱龙英 朱为民 《Agricultural Science & Technology》 CAS 2009年第4期150-153,共4页
[Objective] The aim was to study the effect of tomato yellow leaf curl virus (TYLCV) infection on leaf anatomical structure and protective enzyme system of tomato. [Method] The anatomical structure of infected and h... [Objective] The aim was to study the effect of tomato yellow leaf curl virus (TYLCV) infection on leaf anatomical structure and protective enzyme system of tomato. [Method] The anatomical structure of infected and healthy leaves of tomato were observed and compared by using paraffin section method. The activity changes of SOD, POD and CAT in the infected leaves of tomato were determined. [ Result] The results revealed that there were some differences in anatomical structure between healthy and infected leaves. Some cells of infected leaves were damaged so that the leaves curled and became yellow, which affected the normal function of organs. Compared with control, enzyme activities in the tomato plants infected by TYLCV were enhanced at the early periods and higher than that in control, then started to decline at the middle and late periods but lower than that in control.[ Conclusion] After infection by TYLCV, the leaf anatomical structure of tomato was changed greatly and the protective enzyme system was damaged severely, and affected the normal physJological metabolic functions of tissues and organs in tomato in further. 展开更多
关键词 TYLCV INFECTION Anatomical structure protective enzyme system
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Effects of two kinds of transgenic poplar on protective enzymes system in the midgut of larvae of American white moth 被引量:10
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作者 丁双阳 孟秀芹 李学锋 《Journal of Forestry Research》 SCIE CAS CSCD 2001年第2期119-122,147,共4页
The leaves of Bt (Bacillus thuringiensis) transgenic poplar (Populus nigra L.) and CpTI (Cowpea trypsin inhibitor) transgenic poplar ((P. tomentosa×P. bolleana)×P. Tomentosa) were taken to feed the 4th-5th-i... The leaves of Bt (Bacillus thuringiensis) transgenic poplar (Populus nigra L.) and CpTI (Cowpea trypsin inhibitor) transgenic poplar ((P. tomentosa×P. bolleana)×P. Tomentosa) were taken to feed the 4th-5th-instar larvae of American white moth (Hyphantria cunea (Drury)) for determination of the activities of the protective enzyme system inside larvae’s body. The physiological and biochemical effects of the transgenic poplars on the larvae were studied. The results showed that the two kinds of transgenic poplars had similar effects on the protective enzyme system in the midgut of larvae. The activities of superoxide dismutase, catalase, and peroxidase in midgut of the larvae increased gradually, reached the highest value at a certain time, and then decreased suddenly. For the larvae that were fed with the leaves of Bt transgenic poplar, the peak value of superoxide dismutase and catalase presented at the time of 24-h feeding, while the peak of peroxidase took place at the time of 12-h feeding. The activities of these protective enzymes for the larvae that were fed with leaves of CpTI transgenic poplar peaked 12 h later than that of those fed with leaves of Bt transgenic poplar. The comparison of activities of the protective enzymes was also carried out between the larvae with different levels of intoxication. It was found that the activities of protective enzyme of the seriously intoxicant larvae were higher than that of the lightly intoxicant larvae. This difference was more obvious in the group treated with CpTI transgenic poplar. 展开更多
关键词 Transgenic poplar American white moth protective enzyme system
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Effects of PQQ on Protective System in Cucumber Cotyledons under Low Temperature Stress 被引量:1
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作者 Zhao Yongfang Liu Weiqun +2 位作者 Zhu Yunji Wang Yonghua Wang Guanfang 《Wuhan University Journal of Natural Sciences》 EI CAS 1998年第2期235-238,共4页
The authors have studied the effects of Pyrroioguinloine quinone (PQQ) on superoxide dismutase (SOD), Ascorbid acid(AsA) peroxidase (AsAPOD), glutathion (GSH) and electrolytic leakage of cotyledon in cucumber seedling... The authors have studied the effects of Pyrroioguinloine quinone (PQQ) on superoxide dismutase (SOD), Ascorbid acid(AsA) peroxidase (AsAPOD), glutathion (GSH) and electrolytic leakage of cotyledon in cucumber seedling under low temperature stress, meanwhile, 8-hydroquinone (8-HQ) and AsA (activeoxiygen scavengers) have been made use of in comparison with PQQ. The results indicate that the activities of SOD, AsAPOD and content of GSH can be increased by PQQ. The relative conductivity of cotyledon in cucumber seedling is decreased for PQQ possesses the ability of cleaning up free redical of oxygen. We came to the conclusion that PQQ can act as a kind of active oxygen scavenger and adjust the metabolism on free radical of oxygen to balance in plants and enhance resistance finally in plants. 展开更多
关键词 pyrroloquinloine quinone (PQQ) protect system low temperatural stress cucumber seedling active oxygen scavenger
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Application and Development of Protected Horticulture Intelligent Monitoring System
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作者 徐磊 郑洪倩 +1 位作者 虞利俊 唐玉邦 《Agricultural Science & Technology》 CAS 2014年第3期512-514,F0003,共4页
Protected horticulture makes use of related facilities, engineering technolo- gy and management technologies to create or improve local environment in order to provide optimal environment concerning controllable tempe... Protected horticulture makes use of related facilities, engineering technolo- gy and management technologies to create or improve local environment in order to provide optimal environment concerning controllable temperature, humidity, and light for farming and breeding industry, as well as product storage. Protected horticulture is independent to some extent, instead of relying greatly on nature, targeting full use of soil, climate and biological potential. The research concluded production characteristics of protected horticulture and analyzed the application of protected hor- ticulture intelligent monitoring system in protected greenhouse cultivation. In addition, the future development was proposed on protected horticulture intelligent monitoring system. 展开更多
关键词 protected horticulture Intelligent monitoring system Prospect and development
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