目的观察参芎葡萄糖注射液联合依达拉奉注射液治疗进展性脑梗死(PCI)的疗效和安全性。方法将58例PCI患者随机分为2组。对照组28例予参芎葡萄糖注射液治疗;治疗组30例在对照组治疗基础上加用依达拉奉注射液治疗。2组均治疗14 d。观察2组...目的观察参芎葡萄糖注射液联合依达拉奉注射液治疗进展性脑梗死(PCI)的疗效和安全性。方法将58例PCI患者随机分为2组。对照组28例予参芎葡萄糖注射液治疗;治疗组30例在对照组治疗基础上加用依达拉奉注射液治疗。2组均治疗14 d。观察2组治疗前后神经功能缺损评分(NDS)、疗效,并检测肝肾功能、血尿常规及心电图。结果治疗组治疗后3 d NDS开始降低,治疗后14 d NDS明显降低(P<0.01),治疗后1个月NDS改善最为明显(P<0.01);对照组治疗后3 d NDS有增加趋势,但治疗后14 d、1个月NDS均有所下降(P<0.05)。2组治疗后任何1个阶段NDS比较差异均有统计学意义(P<0.05,P<0.01),尤其治疗后1个月时差异明显(P<0.01)。治疗组显效率66.7%,总有效率93.4%;对照组显效率42.9%,总有效率85.7%。2组显效率、总有效率比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。结论参芎葡萄糖注射液联合依达拉奉注射液治疗PCI疗效好,安全性高。展开更多
Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic d...Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.展开更多
文摘目的观察参芎葡萄糖注射液联合依达拉奉注射液治疗进展性脑梗死(PCI)的疗效和安全性。方法将58例PCI患者随机分为2组。对照组28例予参芎葡萄糖注射液治疗;治疗组30例在对照组治疗基础上加用依达拉奉注射液治疗。2组均治疗14 d。观察2组治疗前后神经功能缺损评分(NDS)、疗效,并检测肝肾功能、血尿常规及心电图。结果治疗组治疗后3 d NDS开始降低,治疗后14 d NDS明显降低(P<0.01),治疗后1个月NDS改善最为明显(P<0.01);对照组治疗后3 d NDS有增加趋势,但治疗后14 d、1个月NDS均有所下降(P<0.05)。2组治疗后任何1个阶段NDS比较差异均有统计学意义(P<0.05,P<0.01),尤其治疗后1个月时差异明显(P<0.01)。治疗组显效率66.7%,总有效率93.4%;对照组显效率42.9%,总有效率85.7%。2组显效率、总有效率比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。结论参芎葡萄糖注射液联合依达拉奉注射液治疗PCI疗效好,安全性高。
基金financially supported by the National Natural Science Foundation of China(No.81303207)CAMS Innovation Fund for Medical Sciences(CIFMS,No.2016-I2M-1-007)
文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
