The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neu...The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neurons and the distribution of inhibitory neurons postsynaptic to neurons in specific ORB subregions remain poorly characterized.Here we mapped the inputs of five types of projection-specific ORB neurons and ORB outputs to two types of inhibitory neurons.We found that different projection-defined ORB neurons received inputs from similar cortical and thalamic regions,albeit with quantitative variations,particularly in somatomotor areas and medial groups of the dorsal thalamus.By counting parvalbumin(PV)or somatostatin(SST)interneurons innervated by neurons in specific ORB subregions,we found a higher fraction of PV neurons in sensory cortices and a higher fraction of SST neurons in subcortical regions targeted by medial ORB neurons.These results provide insights into understanding and investigating the function of specific ORB neurons.展开更多
The present water pollution situation at watershed level in China has been systematically analyzed.The causes of water pollution are attributed to the extensive economic developmental pattern,poor wastewater treatment...The present water pollution situation at watershed level in China has been systematically analyzed.The causes of water pollution are attributed to the extensive economic developmental pattern,poor wastewater treatment,and a lack of nonpoint pollution control.The problems of water pollution control at watershed level include a lack of thought and approach,developmental delay in the environmental standard system,an inadequate monitoring ability,and an inefficient implementation of laws and regulations.From 2006 to 2020,water pollution control and governance will be a national key specific project of science and technology in China.The strategies of this project include establishing a water pollution control system at watershed level,orienting a healthy aquatic ecosystem,conducting risk management,and using comprehensive methods.The goal is to establish and complete a technological system of pollution control and management in three five-year phases.The main tasks are to develop common technologies,management systems,and mechanisms for lake eutrophication control,river pollution control,urban water environmental pollution control,potable water safety,and water environmental management.The bottlenecks of water pollution control and management in China could be systematically removed,and the demonstration of the system engineering approach will be conducted at selected key watersheds.展开更多
基金supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703)the National Natural Science Foundation of China(31771151 and 32171030 to H.Y.,32100829 to D.L.)+2 种基金the Lingang Lab(Grant LG202104-01-03)Shanghai Municipal Science and Technology Major Project(grant No.2018SHZDZX05)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB32010200).
文摘The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neurons and the distribution of inhibitory neurons postsynaptic to neurons in specific ORB subregions remain poorly characterized.Here we mapped the inputs of five types of projection-specific ORB neurons and ORB outputs to two types of inhibitory neurons.We found that different projection-defined ORB neurons received inputs from similar cortical and thalamic regions,albeit with quantitative variations,particularly in somatomotor areas and medial groups of the dorsal thalamus.By counting parvalbumin(PV)or somatostatin(SST)interneurons innervated by neurons in specific ORB subregions,we found a higher fraction of PV neurons in sensory cortices and a higher fraction of SST neurons in subcortical regions targeted by medial ORB neurons.These results provide insights into understanding and investigating the function of specific ORB neurons.
基金the project of the National Key Specific Project of Science and Technology of China for“Water Pollution Control and Governance,”“Functional zoning of river basin water ecology and water quality target oriented management technology”(Grant No.2008ZX07526).
文摘The present water pollution situation at watershed level in China has been systematically analyzed.The causes of water pollution are attributed to the extensive economic developmental pattern,poor wastewater treatment,and a lack of nonpoint pollution control.The problems of water pollution control at watershed level include a lack of thought and approach,developmental delay in the environmental standard system,an inadequate monitoring ability,and an inefficient implementation of laws and regulations.From 2006 to 2020,water pollution control and governance will be a national key specific project of science and technology in China.The strategies of this project include establishing a water pollution control system at watershed level,orienting a healthy aquatic ecosystem,conducting risk management,and using comprehensive methods.The goal is to establish and complete a technological system of pollution control and management in three five-year phases.The main tasks are to develop common technologies,management systems,and mechanisms for lake eutrophication control,river pollution control,urban water environmental pollution control,potable water safety,and water environmental management.The bottlenecks of water pollution control and management in China could be systematically removed,and the demonstration of the system engineering approach will be conducted at selected key watersheds.
