Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and th...Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and the presence of narrow interests along with stereotypical repetitive behaviors.Recent research has shown that the Sox5 transcription factor plays a significant role in the axonal projection,migration,localization,and communication of newly generated neurons[1].Defects in the Sox5 gene are known to increase the risk of autism.A clinical study on 16 patients with Sox5 gene defects found that Sox5 haploinsufficiency is closely linked to key traits like developmental delay,language delay,behavioral problems,and minor deformities such as a protruding forehead and a wide,flat nasal bridge[2].展开更多
基金supported by the Fujian Provincial Science and Technology Youth Project(2021111)the Technology Innovation Joint Funding Project(2023Y9289)the National Natural Science Foundation of China(82401643).
文摘Dear Editor,Autism is a neurodevelopmental disorder that poses a significant threat to human health,with its primary manifestations including social disability,impairments in verbal and non-verbal communication,and the presence of narrow interests along with stereotypical repetitive behaviors.Recent research has shown that the Sox5 transcription factor plays a significant role in the axonal projection,migration,localization,and communication of newly generated neurons[1].Defects in the Sox5 gene are known to increase the risk of autism.A clinical study on 16 patients with Sox5 gene defects found that Sox5 haploinsufficiency is closely linked to key traits like developmental delay,language delay,behavioral problems,and minor deformities such as a protruding forehead and a wide,flat nasal bridge[2].
