This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data ...This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital(Beijing,China)between January 2011 and December 2022.Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol.A total of 8290 couples were included in the analysis.The mean±standard deviation(s.d.)age of women was 32.0±3.5 years.We categorized groups based on the post-wash TPMSC(×10^(6))levels in the first IUI cycle:group 1(0<TPMSC<1,n=1290),group 2(1≤TPMSC<2,n=863),group 3(2≤TPMSC<3,n=800),group 4(3≤TPMSC<4,n=783),group 5(4≤TPMSC<5,n=1541),group 6(5≤TPMSC<6,n=522),group 7(6≤TPMSC<7,n=547),group 8(7≤TPMSC<8,n=175),group 9(8≤TPMSC<9,n=556),group 10(9≤TPMSC<10,n=192),and group 11(TPMSC≥10,n=1021).The primary outcome was live birth rate of the second IUI cycle.Live birth rates were 7.9%,5.8%,7.6%,7.4%,7.3%,8.4%,7.5%,7.4%,8.8%,8.9%,and 7.6%in each group,respectively.There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC<1×10^(6).In an IUI program for unexplained and mild male factor infertility,the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.展开更多
This paper considers the Bayesian and expected Bayesian（E-Bayesian） estimations of the parameter and reliability function for competing risk model from Gompertz distribution under Type-I progressively hybrid censori...This paper considers the Bayesian and expected Bayesian（E-Bayesian） estimations of the parameter and reliability function for competing risk model from Gompertz distribution under Type-I progressively hybrid censoring scheme（PHCS）. The estimations are obtained based on Gamma conjugate prior for the parameter under squared error（SE） and Linex loss functions. The simulation results are provided for the comparison purpose and one data set is analyzed.展开更多
In this paper, we construct a Bayesian framework combining Type-Ⅰ progressively hybrid censoring scheme and competing risks which are independently distributed as exponentiated Weibull distribution with one scale par...In this paper, we construct a Bayesian framework combining Type-Ⅰ progressively hybrid censoring scheme and competing risks which are independently distributed as exponentiated Weibull distribution with one scale parameter and two shape parameters. Since there exist unknown hyper-parameters in prior density functions of shape parameters, we consider the hierarchical priors to obtain the individual marginal posterior density functions,Bayesian estimates and highest posterior density credible intervals. As explicit expressions of estimates cannot be obtained, the componentwise updating algorithm of Metropolis-Hastings method is employed to compute the numerical results. Finally, it is concluded that Bayesian estimates have a good performance.展开更多
This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)distribution.The SGLE distribution utilizes the sine transformation ...This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)distribution.The SGLE distribution utilizes the sine transformation to enhance its capabilities.The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues.The suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique characteristics.This model includes many well-known lifespan distributions as separate sub-models.The suggested model is accompanied with a range of statistical features.The model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored data.In order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing purposes.The relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models.展开更多
This paper proposes a simple constant-stress accel- erated life test （ALT） model from Burr type XII distribution when the data are Type-I progressively hybrid censored. The maximum likelihood estimation （MLE） of t...This paper proposes a simple constant-stress accel- erated life test （ALT） model from Burr type XII distribution when the data are Type-I progressively hybrid censored. The maximum likelihood estimation （MLE） of the parameters is obtained through the numerical method for solving the likelihood equations. Approxi- mate confidence interval （CI）, based on normal approximation to the asymptotic distribution of MLE and percentile bootstrap Cl is derived. Finally, a numerical example is introduced and then a Monte Carlo simulation study is carried out to illustrate the pro- posed method.展开更多
A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing,bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is studied...A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing,bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is studied.In this research, using a progressive Type-II censored, various inferences of the MOL model parameters oflife are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of themodel parameters and various reliability measures are investigated. Against both symmetric and asymmetric lossfunctions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with theassumption of independent gamma priors. From the Fisher information data and the simulatedMarkovian chains,the approximate asymptotic interval and the highest posterior density interval, respectively, of each unknownparameter are calculated. Via an extensive simulated study, the usefulness of the various suggested strategies isassessedwith respect to some evaluationmetrics such as mean squared errors, mean relative absolute biases, averageconfidence lengths, and coverage percentages. Comparing the Bayesian estimations based on the asymmetric lossfunction to the traditional technique or the symmetric loss function-based Bayesian estimations, the analysisdemonstrates that asymmetric loss function-based Bayesian estimations are preferred. Finally, two data sets,representing vinyl chloride and repairable mechanical equipment items, have been investigated to support theapproaches proposed and show the superiority of the proposed model compared to the other fourteen lifetimemodels.展开更多
Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to...Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to the characteristics of the human vision system. Considering the issue of sharing the secret image at multiple image resolutions with the meaningful shadows, in this paper, we present a friendly progressive visual secret sharing scheme without expanding the image size in the shadows and the reconstructed secret image based on applying a 2x2-sized block-wise operation to generate the shadows block by block. The proposed method can achieve these benefits： 1） the generated shadows are meaningful, and their sizes are not expanded, and 2） the secret image can be recovered at different resolutions by stacking different quantities of shadows together. The experimental results also show that the proposed method is superior to other compared schemes.展开更多
In this article, we consider a new life test scheme called a progressively first-failure censoring scheme introduced by Wu and Kus [1]. Based on this type of censoring, the maximum likelihood, approximate maximum like...In this article, we consider a new life test scheme called a progressively first-failure censoring scheme introduced by Wu and Kus [1]. Based on this type of censoring, the maximum likelihood, approximate maximum likelihood and the least squares method estimators for the unknown parameters of the inverse Weibull distribution are derived. A comparison between these estimators is provided by using extensive simulation and two criteria, namely, absolute bias and mean squared error. It is concluded that the estimators based on the least squares method are superior compared to the maximum likelihood and the approximate maximum likelihood estimators. Real life data example is provided to illustrate our proposed estimators.展开更多
In this article,we consider the statistical inferences of the unknown parameters of a generalized inverted exponential distribution based on the Type II progressively hybrid censored sample.By applying the expectation...In this article,we consider the statistical inferences of the unknown parameters of a generalized inverted exponential distribution based on the Type II progressively hybrid censored sample.By applying the expectation–maximization(EM)algorithm,the maximum likelihood estimators are developed for estimating the unknown parameters.The observed Fisher information matrix is obtained using the missing information principle,and it can be used for constructing asymptotic con-fidence intervals.By applying the bootstrapping technique,the confidence intervals for the parameters are also derived.Bayesian estimates of the unknown parameters are obtained using the Lindley’s approximation.Monte Carlo simulations are imple-mented and observations are given.Finally,a real data set representing the spread factor of micro-drops is analyzed to illustrative purposes.展开更多
On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyo...On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.展开更多
Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly ...Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and dise...Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and diseases.With the progression of agricultural technology and changes in market demands,the cultivation tecchnology of yam is constantly innovating and improving.This paper reviewed recent research advances in yam cultivation tecchnology,covering aspects such as soil improvement,variety selection,technological innovations,green pest control,and harvesting and storage.The goal is to provide references for the sustainable development of the yam industry.展开更多
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas...AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.展开更多
BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two...BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.展开更多
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted th...Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted therapy;however,their clinical benefits are limited.Therefore,developing new models to evaluate the therapeutic potential of novel molecules is essential.Fingolimod and Dimethyl Fumarate(DMF),currently used to treat multiple sclerosis,have recently been shown to have anti-cancer effects in several preclinical tumor models.This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity and in vivo antitumor effects.Methods:In this study,we evaluated for the first time these two drugs in pancreatic preclinical models in vitro using 3D spheroid tumor models and in vivo,which are compared to two standard-of-care consisting of Gemcitabine and Erlotinib.Results:In vitro,both Fingolimod and DMF induced cytotoxicity in spheroids from two pancreatic cell lines.Additionally,Fingolimod and DMF displayed anticancer effects in two subcutaneous xenograft models using PANC-1 and CFPAC-1 cells.Conclusions:Although the responses observed with Fingolimod and DMF were similar to those of Gemcitabine and Erlotinib,these findings indicate a potential emerging interest in Fingolimod and DMF for the treatment of pancreatic cancer.However,further work is still necessary to fully characterize how these drugs affect tumor progression.展开更多
This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides...This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.展开更多
Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge percep...Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.展开更多
基金supported by National Key Research and Development Program(2022YFC2705305)clinical key project of Peking University Third Hospital(BYSYZD2023007)National Science Fund for Distinguished Young Scholars(81925013).
文摘This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital(Beijing,China)between January 2011 and December 2022.Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol.A total of 8290 couples were included in the analysis.The mean±standard deviation(s.d.)age of women was 32.0±3.5 years.We categorized groups based on the post-wash TPMSC(×10^(6))levels in the first IUI cycle:group 1(0<TPMSC<1,n=1290),group 2(1≤TPMSC<2,n=863),group 3(2≤TPMSC<3,n=800),group 4(3≤TPMSC<4,n=783),group 5(4≤TPMSC<5,n=1541),group 6(5≤TPMSC<6,n=522),group 7(6≤TPMSC<7,n=547),group 8(7≤TPMSC<8,n=175),group 9(8≤TPMSC<9,n=556),group 10(9≤TPMSC<10,n=192),and group 11(TPMSC≥10,n=1021).The primary outcome was live birth rate of the second IUI cycle.Live birth rates were 7.9%,5.8%,7.6%,7.4%,7.3%,8.4%,7.5%,7.4%,8.8%,8.9%,and 7.6%in each group,respectively.There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC<1×10^(6).In an IUI program for unexplained and mild male factor infertility,the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.
基金supported by the National Natural Science Foundation of China(7117116471401134+1 种基金71571144)the Natural Science Basic Research Program of Shaanxi Province(2015JM1003)
文摘This paper considers the Bayesian and expected Bayesian（E-Bayesian） estimations of the parameter and reliability function for competing risk model from Gompertz distribution under Type-I progressively hybrid censoring scheme（PHCS）. The estimations are obtained based on Gamma conjugate prior for the parameter under squared error（SE） and Linex loss functions. The simulation results are provided for the comparison purpose and one data set is analyzed.
基金Supported by the National Natural Science Foundation of China（71571144,71401134,71171164,11701406） Supported by the International Cooperation and Exchanges in Science and Technology Program of Shaanxi Province（2016KW-033）
文摘In this paper, we construct a Bayesian framework combining Type-Ⅰ progressively hybrid censoring scheme and competing risks which are independently distributed as exponentiated Weibull distribution with one scale parameter and two shape parameters. Since there exist unknown hyper-parameters in prior density functions of shape parameters, we consider the hierarchical priors to obtain the individual marginal posterior density functions,Bayesian estimates and highest posterior density credible intervals. As explicit expressions of estimates cannot be obtained, the componentwise updating algorithm of Metropolis-Hastings method is employed to compute the numerical results. Finally, it is concluded that Bayesian estimates have a good performance.
基金This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(Grant Number IMSIU-RG23142).
文摘This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)distribution.The SGLE distribution utilizes the sine transformation to enhance its capabilities.The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues.The suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique characteristics.This model includes many well-known lifespan distributions as separate sub-models.The suggested model is accompanied with a range of statistical features.The model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored data.In order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing purposes.The relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models.
基金supported by the National Natural Science Foundation of China(7117116470471057)
文摘This paper proposes a simple constant-stress accel- erated life test （ALT） model from Burr type XII distribution when the data are Type-I progressively hybrid censored. The maximum likelihood estimation （MLE） of the parameters is obtained through the numerical method for solving the likelihood equations. Approxi- mate confidence interval （CI）, based on normal approximation to the asymptotic distribution of MLE and percentile bootstrap Cl is derived. Finally, a numerical example is introduced and then a Monte Carlo simulation study is carried out to illustrate the pro- posed method.
文摘A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing,bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is studied.In this research, using a progressive Type-II censored, various inferences of the MOL model parameters oflife are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of themodel parameters and various reliability measures are investigated. Against both symmetric and asymmetric lossfunctions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with theassumption of independent gamma priors. From the Fisher information data and the simulatedMarkovian chains,the approximate asymptotic interval and the highest posterior density interval, respectively, of each unknownparameter are calculated. Via an extensive simulated study, the usefulness of the various suggested strategies isassessedwith respect to some evaluationmetrics such as mean squared errors, mean relative absolute biases, averageconfidence lengths, and coverage percentages. Comparing the Bayesian estimations based on the asymmetric lossfunction to the traditional technique or the symmetric loss function-based Bayesian estimations, the analysisdemonstrates that asymmetric loss function-based Bayesian estimations are preferred. Finally, two data sets,representing vinyl chloride and repairable mechanical equipment items, have been investigated to support theapproaches proposed and show the superiority of the proposed model compared to the other fourteen lifetimemodels.
文摘Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to the characteristics of the human vision system. Considering the issue of sharing the secret image at multiple image resolutions with the meaningful shadows, in this paper, we present a friendly progressive visual secret sharing scheme without expanding the image size in the shadows and the reconstructed secret image based on applying a 2x2-sized block-wise operation to generate the shadows block by block. The proposed method can achieve these benefits： 1） the generated shadows are meaningful, and their sizes are not expanded, and 2） the secret image can be recovered at different resolutions by stacking different quantities of shadows together. The experimental results also show that the proposed method is superior to other compared schemes.
文摘In this article, we consider a new life test scheme called a progressively first-failure censoring scheme introduced by Wu and Kus [1]. Based on this type of censoring, the maximum likelihood, approximate maximum likelihood and the least squares method estimators for the unknown parameters of the inverse Weibull distribution are derived. A comparison between these estimators is provided by using extensive simulation and two criteria, namely, absolute bias and mean squared error. It is concluded that the estimators based on the least squares method are superior compared to the maximum likelihood and the approximate maximum likelihood estimators. Real life data example is provided to illustrate our proposed estimators.
文摘In this article,we consider the statistical inferences of the unknown parameters of a generalized inverted exponential distribution based on the Type II progressively hybrid censored sample.By applying the expectation–maximization(EM)algorithm,the maximum likelihood estimators are developed for estimating the unknown parameters.The observed Fisher information matrix is obtained using the missing information principle,and it can be used for constructing asymptotic con-fidence intervals.By applying the bootstrapping technique,the confidence intervals for the parameters are also derived.Bayesian estimates of the unknown parameters are obtained using the Lindley’s approximation.Monte Carlo simulations are imple-mented and observations are given.Finally,a real data set representing the spread factor of micro-drops is analyzed to illustrative purposes.
文摘On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.
文摘Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金Supported by Shandong Provincial Key Research and Development Program(2023TZXD034)2024 National Undergraduate Innovation Training Program(202410061062).
文摘Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and diseases.With the progression of agricultural technology and changes in market demands,the cultivation tecchnology of yam is constantly innovating and improving.This paper reviewed recent research advances in yam cultivation tecchnology,covering aspects such as soil improvement,variety selection,technological innovations,green pest control,and harvesting and storage.The goal is to provide references for the sustainable development of the yam industry.
基金Supported by The Eye Hospital of Wenzhou Medical University(No.KYQD20220304)The Fifth Batch of Provincial Ten Thousand Personnel Program Outstanding Talents Funding(No.474092204)+1 种基金Innovative Talents and Teams(2024)-The Fifth Batch of Funding Funds for Scientific and Technological Innovation Leading Talents Under the Provincial Ten Thousand Personnel Program(No.4240924003G)The Key R&D Program of Zhejiang(No.2022C03112).
文摘AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.
文摘BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
基金supported by Porsolt SAS,https://www.porsolt.com/.
文摘Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted therapy;however,their clinical benefits are limited.Therefore,developing new models to evaluate the therapeutic potential of novel molecules is essential.Fingolimod and Dimethyl Fumarate(DMF),currently used to treat multiple sclerosis,have recently been shown to have anti-cancer effects in several preclinical tumor models.This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity and in vivo antitumor effects.Methods:In this study,we evaluated for the first time these two drugs in pancreatic preclinical models in vitro using 3D spheroid tumor models and in vivo,which are compared to two standard-of-care consisting of Gemcitabine and Erlotinib.Results:In vitro,both Fingolimod and DMF induced cytotoxicity in spheroids from two pancreatic cell lines.Additionally,Fingolimod and DMF displayed anticancer effects in two subcutaneous xenograft models using PANC-1 and CFPAC-1 cells.Conclusions:Although the responses observed with Fingolimod and DMF were similar to those of Gemcitabine and Erlotinib,these findings indicate a potential emerging interest in Fingolimod and DMF for the treatment of pancreatic cancer.However,further work is still necessary to fully characterize how these drugs affect tumor progression.
基金Supported by Open Fund Project of the Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian(PP202003).
文摘This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.
基金funded by Qinghai University Postgraduate Research and Practice Innovation Program of Funder,grant number 2025-GMKY-42.
文摘Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.
