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Reprogramming induced neurons from olfactory ensheathing glial cells: A feasible approach for spinal cord injury repair
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作者 Javier Sierra María Portela-Lomba +1 位作者 Diana Simón M.Teresa Moreno-Flores 《Neural Regeneration Research》 2026年第1期296-297,共2页
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin... Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons. 展开更多
关键词 INJURY feasible programming
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Quality-guaranteed Dubins Path Planning for USV Based on Mixed-integer Piecewise linear Programming for Addressing the Extended Minimum-time Intercept Problem
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作者 Xing Zhou Kelin Zhu +3 位作者 Shuang Liu Zhaoqing Li Wenxin Zhang Kang Du 《哈尔滨工程大学学报(英文版)》 2026年第1期216-227,共12页
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive... During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length. 展开更多
关键词 Minimum-time intercept problem Dubins vehicle Mixed-integer piecewise-linear program LINEARIZATION Approximate error trigonometric function USV
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Magneto-soft robots based on multi-materials optimizing and heat-assisted in-situ magnetic domains programming
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作者 Fuzhou Niu Quhao Xue +9 位作者 Qing Cao Xinyang He Taolei Wang HaoChen Wang Chonglei Hao Xiaojian Li Ying Li Hao Yang Huayong Yang Dong Han 《International Journal of Extreme Manufacturing》 2025年第5期447-462,共16页
Soft robots, inspired by the flexibility and versatility of biological organisms, have potential in a variety of applications. Recent advancements in magneto-soft robots have demonstrated their abilities to achieve pr... Soft robots, inspired by the flexibility and versatility of biological organisms, have potential in a variety of applications. Recent advancements in magneto-soft robots have demonstrated their abilities to achieve precise remote control through magnetic fields, enabling multi-modal locomotion and complex manipulation tasks. Nonetheless, two main hurdles must be overcome to advance the field: developing a multi-component substrate with embedded magnetic particles to ensure the requisite flexibility and responsiveness, and devising a cost-effective,straightforward method to program three-dimensional distributed magnetic domains without complex processing and expensive machinery. Here, we introduce a cost-effective and simple heat-assisted in-situ integrated molding fabrication method for creating magnetically driven soft robots with three-dimensional programmable magnetic domains. By synthesizing a composite material with neodymium-iron-boron(NdFeB) particles embedded in a polydimethylsiloxane(PDMS) and Ecoflex matrix(PDMS:Ecoflex = 1:2 mass ratio, 50% magnetic particle concentration), we achieved an optimized balance of flexibility, strength, and magnetic responsiveness. The proposed heat-assisted in-situ magnetic domains programming technique,performed at an experimentally optimized temperature of 120℃, resulted in a 2 times magnetization strength(9.5 mT) compared to that at 20℃(4.8 m T), reaching a saturation level comparable to a commercial magnetizer. We demonstrated the versatility of our approach through the fabrication of six kinds of robots, including two kinds of two-dimensional patterned soft robots(2D-PSR), a circular six-pole domain distribution magnetic robot(2D-CSPDMR), a quadrupedal walking magnetic soft robot(QWMSR), an object manipulation robot(OMR), and a hollow thin-walled spherical magneto-soft robot(HTWSMSR). The proposed method provides a practical solution to create highly responsive and adaptable magneto-soft robots. 展开更多
关键词 magneto-soft robots multi-materials optimizing three-dimensional magnetic domains programming
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Value Iteration-Based Distributed Adaptive Dynamic Programming for Multi-Player Differential Game With Incomplete Information
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作者 Yun Zhang Yuqi Wang Yunze Cai 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期436-447,共12页
In this paper,a distributed adaptive dynamic programming(ADP)framework based on value iteration is proposed for multi-player differential games.In the game setting,players have no access to the information of others&#... In this paper,a distributed adaptive dynamic programming(ADP)framework based on value iteration is proposed for multi-player differential games.In the game setting,players have no access to the information of others'system parameters or control laws.Each player adopts an on-policy value iteration algorithm as the basic learning framework.To deal with the incomplete information structure,players collect a period of system trajectory data to compensate for the lack of information.The policy updating step is implemented by a nonlinear optimization problem aiming to search for the proximal admissible policy.Theoretical analysis shows that by adopting proximal policy searching rules,the approximated policies can converge to a neighborhood of equilibrium policies.The efficacy of our method is illustrated by three examples,which also demonstrate that the proposed method can accelerate the learning process compared with the centralized learning framework. 展开更多
关键词 Distributed adaptive dynamic programming incomplete information multi-player differential game(MPDG) value iteration
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Multistage Stochastic Programming Model for the Portfolio Problem of a Property-Liability Insurance Company 被引量:3
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作者 王春峰 杨建林 蒋祥林 《Transactions of Tianjin University》 EI CAS 2002年第3期203-206,共4页
The current portfolio model for property-liability insurance company is only single period that can not meet the practical demands of portfolio management, and the purpose of this paper is to develop a multiperiod mod... The current portfolio model for property-liability insurance company is only single period that can not meet the practical demands of portfolio management, and the purpose of this paper is to develop a multiperiod model for its portfolio problem. The model is a multistage stochastic programming which considers transaction costs, cash flow between time periods, and the matching of asset and liability; it does not depend on the assumption for normality of return distribution. Additionally, an investment constraint is added. The numerical example manifests that the multiperiod model can more effectively assist the property-liability insurer to determine the optimal composition of insurance and investment portfolio and outperforms the single period one. 展开更多
关键词 property-liability insurance company portfolio management multiperiod model multistage stochastic programming
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Multiple-constraint cooperative guidance based on two-stage sequential convex programming 被引量:15
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作者 Wei DONG Qiuqiu WEN +1 位作者 Qunli XIA Shengjiang YANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第1期296-307,共12页
An improved approach is presented in this paper to implement highly constrained cooperative guidance to attack a stationary target.The problem with time-varying Proportional Navigation(PN)gain is first formulated as a... An improved approach is presented in this paper to implement highly constrained cooperative guidance to attack a stationary target.The problem with time-varying Proportional Navigation(PN)gain is first formulated as a nonlinear optimal control problem,which is difficult to solve due to the existence of nonlinear kinematics and nonconvex constraints.After convexification treatments and discretization,the solution to the original problem can be approximately obtained by solving a sequence of Second-Order Cone Programming(SOCP)problems,which can be readily solved by state-of-the-art Interior-Point Methods(IPMs).To mitigate the sensibility of the algorithm on the user-provided initial profile,a Two-Stage Sequential Convex Programming(TSSCP)method is presented in detail.Furthermore,numerical simulations under different mission scenarios are conducted to show the superiority of the proposed method in solving the cooperative guidance problem.The research indicated that the TSSCP method is more tractable and reliable than the traditional methods and has great potential for real-time processing and on-board implementation. 展开更多
关键词 CONVEX optimization Cooperative GUIDANCE GUIDANCE multiple constraints Second-order cone programming SEQUENTIAL CONVEX programming
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Principal-subordinate hierarchical multi-objective programming model of initial water rights allocation 被引量:5
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作者 Dan WU Feng-ping WU Yan-ping CHEN 《Water Science and Engineering》 EI CAS 2009年第2期105-116,共12页
The principal-subordinate hierarchical multi-objective programming model of initial water rights allocation was developed based on the principle of coordinated and sustainable development of different regions and wate... The principal-subordinate hierarchical multi-objective programming model of initial water rights allocation was developed based on the principle of coordinated and sustainable development of different regions and water sectors within a basin. With the precondition of strictly controlling maximum emissions rights, initial water rights were allocated between the first and the second levels of the hierarchy in order to promote fair and coordinated development across different regions of the basin and coordinated and efficient water use across different water sectors, realize the maximum comprehensive benefits to the basin, promote the unity of quantity and quality of initial water rights allocation, and eliminate water conflict across different regions and water sectors. According to interactive decision-making theory, a principal-subordinate hierarchical interactive iterative algorithm based on the satisfaction degree was developed and used to solve the initial water rights allocation model. A case study verified the validity of the model. 展开更多
关键词 initial water rights allocation principal-subordinate hierarchy multi-objective programming model satisfaction degree
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MAJOR-EFFICIENT SOLUTIONS AND WEAKLY MAJOR-EFFICIENT SOLUTIONS OF MULTIOBJECTIVE PROGRAMMING 被引量:12
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作者 HU YUDA(Dept.of Appl.Math.,Shanghai Jiao Tony Univ.,Shanghai 200030) 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 1994年第1期85-94,共10页
In this papert the theory of major efficiency for multiobjective programmingis established.The major-efficient solutions and weakly major-efficient solutions of multiobjective programming given here are Pareto efficie... In this papert the theory of major efficiency for multiobjective programmingis established.The major-efficient solutions and weakly major-efficient solutions of multiobjective programming given here are Pareto efficient solutions of the same multiobjectiveprogramming problem, but the converse is not true. In a ceratin sense , these solutionsare in fact better than any other Pareto efficient solutions. Some basic theorems whichcharacterize major-efficient solutions and weakly major-efficient solutions of multiobjective programming are stated and proved. Furthermore,the existence and some geometricproperties of these solutions are studied. 展开更多
关键词 multiobjective programming Pareto Efficient Solution Major-EfficientSolution Weakly Major-Efficient Solution.
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Using approximate dynamic programming for multi-ESM scheduling to track ground moving targets 被引量:6
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作者 WAN Kaifang GAO Xiaoguang +1 位作者 LI Bo LI Fei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第1期74-85,共12页
This paper researches the adaptive scheduling problem of multiple electronic support measures(multi-ESM) in a ground moving radar targets tracking application. It is a sequential decision-making problem in uncertain e... This paper researches the adaptive scheduling problem of multiple electronic support measures(multi-ESM) in a ground moving radar targets tracking application. It is a sequential decision-making problem in uncertain environment. For adaptive selection of appropriate ESMs, we generalize an approximate dynamic programming(ADP) framework to the dynamic case. We define the environment model and agent model, respectively. To handle the partially observable challenge, we apply the unsented Kalman filter(UKF) algorithm for belief state estimation. To reduce the computational burden, a simulation-based approach rollout with a redesigned base policy is proposed to approximate the long-term cumulative reward. Meanwhile, Monte Carlo sampling is combined into the rollout to estimate the expectation of the rewards. The experiments indicate that our method outperforms other strategies due to its better performance in larger-scale problems. 展开更多
关键词 sensor scheduling target tracking approximate dynamic programming non-myopic rollout belief state
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Dynamic programming methodology for multi-criteria group decision-making under ordinal preferences 被引量:3
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作者 Wu Li Guanqi Guo +1 位作者 Chaoyuan Yue Yong Zhao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第6期975-980,共6页
A method of minimizing rankings inconsistency is proposed for a decision-making problem with rankings of alternatives given by multiple decision makers according to multiple criteria. For each criteria, at first, the ... A method of minimizing rankings inconsistency is proposed for a decision-making problem with rankings of alternatives given by multiple decision makers according to multiple criteria. For each criteria, at first, the total inconsistency between the rankings of all alternatives for the group and the ones for every decision maker is defined after the decision maker weights in respect to the criteria are considered. Similarly, the total inconsistency between their final rankings for the group and the ones under every criteria is determined after the criteria weights are taken into account. Then two nonlinear integer programming models minimizing respectively the two total inconsistencies above are developed and then transformed to two dynamic programming models to obtain separately the rankings of all alternatives for the group with respect to each criteria and their final rankings. A supplier selection case illustrated the proposed method, and some discussions on the results verified its effectiveness. This work develops a new measurement of ordinal preferences’ inconsistency in multi-criteria group decision-making (MCGDM) and extends the cook-seiford social selection function to MCGDM considering weights of criteria and decision makers and can obtain unique ranking result. 展开更多
关键词 multi-criteria group decision-making (MCGDM) ordinal preference minimum deviation method dynamic programming Cook-Seiford social selection function.
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Approach for uncertain multi-objective programming problems with correlated objective functions under C_(EV) criterion 被引量:2
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作者 MENG Xiangfei WANG Ying +2 位作者 LI Chao WANG Xiaoyang LYU Maolong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第6期1197-1208,共12页
An uncertain multi-objective programming problem is a special type of mathematical multi-objective programming involving uncertain variables. This type of problem is important because there are several uncertain varia... An uncertain multi-objective programming problem is a special type of mathematical multi-objective programming involving uncertain variables. This type of problem is important because there are several uncertain variables in real-world problems.Therefore, research on the uncertain multi-objective programming problem is highly relevant, particularly those problems whose objective functions are correlated. In this paper, an approach that solves an uncertain multi-objective programming problem under the expected-variance value criterion is proposed. First, we define the basic framework of the approach and review concepts such as a Pareto efficient solution and expected-variance value criterion using an order relation between various uncertain variables.Second, the uncertain multi-objective problem is converted into an uncertain single-objective programming problem via a linear weighted method or ideal point method. Then the problem is transformed into a deterministic single objective programming problem under the expected-variance value criterion. Third, four lemmas and two theorems are proved to illustrate that the optimal solution of the deterministic single-objective programming problem is an efficient solution to the original uncertainty problem. Finally, two numerical examples are presented to validate the effectiveness of the proposed approach. 展开更多
关键词 uncertainty theory uncertain multi-objective programming expected-variance value criterion
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Multi-view video color correction using dynamic programming 被引量:1
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作者 Shao Feng Jiang Gangyi Yu Mei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第6期1115-1120,共6页
Color inconsistency between views is an important problem to be solved in multi-view video systems. A multi-view video color correction method using dynamic programming is proposed. Three-dimensional histograms are co... Color inconsistency between views is an important problem to be solved in multi-view video systems. A multi-view video color correction method using dynamic programming is proposed. Three-dimensional histograms are constructed with sequential conditional probability in HSI color space. Then, dynamic programming is used to seek the best color mapping relation with the minimum cost path between target image histogram and source image histogram. Finally, video tracking technique is performed to correct multi-view video. Experimental results show that the proposed method can obtain better subjective and objective performance in color correction. 展开更多
关键词 multi-view video color correction dynamic programming video tracking
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Duality for Multiobjective Bilevel Programming Problems with Extremal-Value Function 被引量:1
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作者 Haijun WANG Ruifang ZHANG 《Journal of Mathematical Research with Applications》 CSCD 2015年第3期311-320,共10页
For a multiobjective bilevel programnfing problem (P) with an extremal-value function, its dual problem is constructed by using the Fenchel-Moreau conjugate of the functions involved. Under some convexity and monoto... For a multiobjective bilevel programnfing problem (P) with an extremal-value function, its dual problem is constructed by using the Fenchel-Moreau conjugate of the functions involved. Under some convexity and monotonicity assumptions, the weak and strong duality assertions are obtained. 展开更多
关键词 multiobjective optimization bilevel programming problems conjugate duality convex programming composed convex functions
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Glia-to-neuron reprogramming to the rescue?
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作者 Jack W.Hickmott Cindi M.Morshead 《Neural Regeneration Research》 SCIE CAS 2025年第5期1395-1396,共2页
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c... Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state. 展开更多
关键词 programming PASSING proof
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Optimal set integer programming algorithm for multiple maneuvering targets tracking in clutter 被引量:1
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作者 Xiaoyan Fu Yingmin Jia Xiaohe Liu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第4期555-563,共9页
The aim of this paper is to solve the problems of multitarget tracking in clutter. Firstly, the data association of measurement-to-target is formulated as an integer programming problem. Through using the linear progr... The aim of this paper is to solve the problems of multitarget tracking in clutter. Firstly, the data association of measurement-to-target is formulated as an integer programming problem. Through using the linear programming (LP) based branchand-bound method and adjusting the constraint conditions, an optimal set integer programming (OSIP) algorithm is then proposed for tracking multiple non-maneuvering targets in clutter. For the case of maneuvering targets, this paper introduces the OSIP algorithm into the filtering step of the interacting multiple model (IMM) algorithm resulting in the IMM based on OSIP algorithm. Extensive Monte Carlo simulations show that the presented algorithms can obtain superior estimations even in the case of high density noises. 展开更多
关键词 data association target tracking integer programming clutter.
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Neurocircuit regeneration by extracellular matrix reprogramming
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作者 Shengzhang Su Ian N.Levasseur Kimberly M.Alonge 《Neural Regeneration Research》 SCIE CAS 2025年第8期2300-2301,共2页
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio... The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases. 展开更多
关键词 MATRIX programming
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Chance-Constrained Approaches for Multiobjective Stochastic Linear Programming Problems 被引量:2
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作者 Justin Dupar Busili Kampempe Monga Kalonda Luhandjula 《American Journal of Operations Research》 2012年第4期519-526,共8页
Multiple objective stochastic linear programming is a relevant topic. As a matter of fact, many practical problems ranging from portfolio selection to water resource management may be cast into this framework. Severe ... Multiple objective stochastic linear programming is a relevant topic. As a matter of fact, many practical problems ranging from portfolio selection to water resource management may be cast into this framework. Severe limitations on objectivity are encountered in this field because of the simultaneous presence of randomness and conflicting goals. In such a turbulent environment, the mainstay of rational choice cannot hold and it is virtually impossible to provide a truly scientific foundation for an optimal decision. In this paper, we resort to the bounded rationality principle to introduce satisfying solution for multiobjective stochastic linear programming problems. These solutions that are based on the chance-constrained paradigm are characterized under the assumption of normality of involved random variables. Ways for singling out such solutions are also discussed and a numerical example provided for the sake of illustration. 展开更多
关键词 Satisfying SOLUTION Chance-Constrained multiOBJECTIVE programming STOCHASTIC programming
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Solving Bilevel Linear Multiobjective Programming Problems 被引量:2
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作者 Calice Olivier Pieume Patrice Marcotte +1 位作者 Laure Pauline Fotso Patrick Siarry 《American Journal of Operations Research》 2011年第4期214-219,共6页
This study addresses bilevel linear multi-objective problem issues i.e the special case of bilevel linear programming problems where each decision maker has several objective functions conflicting with each other. We ... This study addresses bilevel linear multi-objective problem issues i.e the special case of bilevel linear programming problems where each decision maker has several objective functions conflicting with each other. We introduce an artificial multi-objective linear programming problem of which resolution can permit to generate the whole feasible set of the upper level decisions. Based on this result and depending if the leader can evaluate or not his preferences for his different objective functions, two approaches for obtaining Pareto- optimal solutions are presented. 展开更多
关键词 multiOBJECTIVE programming Bilevel programming Feasible Solution PARETO-OPTIMAL SOLUTIONS
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Sufficiency and Duality for Nondif ferentiable Multiobjective Fractional Programming Problems with (Φ,ρ,α)-V-Invexity 被引量:2
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作者 闫春雷 杨舒先 《Journal of Donghua University(English Edition)》 EI CAS 2017年第2期178-183,共6页
A new concept of(Φ,ρ,α)-V-invexity for differentiable vector-valued functions is introduced,which is a generalization of differentiable scalar-valued(Φ,ρ)-invexity.Based upon the(Φ,ρ,α)-V-invex functions,suffi... A new concept of(Φ,ρ,α)-V-invexity for differentiable vector-valued functions is introduced,which is a generalization of differentiable scalar-valued(Φ,ρ)-invexity.Based upon the(Φ,ρ,α)-V-invex functions,sufficient optimality conditions and MondWeir type dual theorems are derived for a class of nondifferentiable multiobjective fractional programming problems in which every component of the objective function and each constraint function contain a term involving the support function of a compact convex set. 展开更多
关键词 nondifferentiable multiobjective fractional programming efficiency ρ α)-V-invexity SUFFICIENCY DUALITY
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An Interactive Intuitionistic Fuzzy Method for Multilevel Linear Programming Problems 被引量:1
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作者 HUANG Chan FANG Debin WAN Zhongping 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2015年第2期113-118,共6页
In this paper, we propose an interactive method for solving the multilevel linear programming problems based on the intuitionistic fuzzy set theory. Firstly, the membership function and the non-membership function are... In this paper, we propose an interactive method for solving the multilevel linear programming problems based on the intuitionistic fuzzy set theory. Firstly, the membership function and the non-membership function are introduced to describe the uncertainty of the decision makers. Secondly, a satisfactory solution is derived by updating the minimum satisfactory degrees with considerations of the overall satisfactory balance among all levels. In addition, the steps of the proposed method are given in this paper. Finally, numerical examples illustrate the feasibility of this method. 展开更多
关键词 intuitionistic fuzzy multilevel linear programming interactive method satisfying degree
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